JP6063455B2 - 重水素化されたイバカフトルの誘導体 - Google Patents

重水素化されたイバカフトルの誘導体 Download PDF

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Publication number
JP6063455B2
JP6063455B2 JP2014511524A JP2014511524A JP6063455B2 JP 6063455 B2 JP6063455 B2 JP 6063455B2 JP 2014511524 A JP2014511524 A JP 2014511524A JP 2014511524 A JP2014511524 A JP 2014511524A JP 6063455 B2 JP6063455 B2 JP 6063455B2
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compound
pharmaceutically acceptable
deuterium
acceptable salt
acid
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JP2014515351A5 (https=
JP2014515351A (ja
Inventor
アダム ジェイ． モーガン
アダム ジェイ． モーガン
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コンサート ファーマシューティカルズ インコーポレイテッド
コンサート ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2014511524A 2011-05-18 2012-05-17 重水素化されたイバカフトルの誘導体 Active JP6063455B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161487497P 2011-05-18 2011-05-18
US61/487,497 2011-05-18
PCT/US2012/038297 WO2012158885A1 (en) 2011-05-18 2012-05-17 Deuterated derivatives of ivacaftor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016243941A Division JP2017078082A (ja) 2011-05-18 2016-12-16 重水素化されたイバカフトルの誘導体

Publications (3)

Publication Number Publication Date
JP2014515351A JP2014515351A (ja) 2014-06-30
JP2014515351A5 JP2014515351A5 (https=) 2015-07-02
JP6063455B2 true JP6063455B2 (ja) 2017-01-18

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ID=46201810

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JP2014511524A Active JP6063455B2 (ja) 2011-05-18 2012-05-17 重水素化されたイバカフトルの誘導体
JP2016243941A Pending JP2017078082A (ja) 2011-05-18 2016-12-16 重水素化されたイバカフトルの誘導体

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JP2016243941A Pending JP2017078082A (ja) 2011-05-18 2016-12-16 重水素化されたイバカフトルの誘導体

Country Status (20)

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EP (2) EP2709986B1 (https=)
JP (2) JP6063455B2 (https=)
AU (5) AU2012255711B2 (https=)
BR (1) BR112013029240B1 (https=)
CA (1) CA2834574C (https=)
CY (2) CY1119090T1 (https=)
DK (2) DK3235812T3 (https=)
EA (1) EA028378B1 (https=)
ES (2) ES2758028T3 (https=)
HR (2) HRP20170754T1 (https=)
HU (1) HUE032771T2 (https=)
LT (1) LT2709986T (https=)
ME (2) ME02749B (https=)
MX (1) MX349159B (https=)
PL (2) PL2709986T3 (https=)
PT (2) PT3235812T (https=)
RS (2) RS59744B1 (https=)
SI (2) SI3235812T1 (https=)
SM (2) SMT201700302T1 (https=)
WO (1) WO2012158885A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017078082A (ja) * 2011-05-18 2017-04-27 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたイバカフトルの誘導体

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TWI735416B (zh) 2014-10-06 2021-08-11 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
KR20170063954A (ko) 2014-10-07 2017-06-08 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정
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JP6654223B2 (ja) * 2018-08-13 2020-02-26 バーテックス ファーマシューティカルズ （ヨーロッパ） リミテッド 重水素化されたｃｆｔｒ増強物質
TWI848092B (zh) 2019-04-03 2024-07-11 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白調節劑
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WO2022076628A1 (en) 2020-10-07 2022-04-14 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US20230373935A1 (en) 2020-10-07 2023-11-23 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
MX2023004074A (es) 2020-10-07 2023-07-05 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quistica.
EP4225765A2 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2022076629A1 (en) 2020-10-07 2022-04-14 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2022076626A1 (en) 2020-10-07 2022-04-14 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4225446A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US20230374038A1 (en) 2020-10-07 2023-11-23 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4225447A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4225762A1 (en) 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US12324802B2 (en) 2020-11-18 2025-06-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
AU2021397294A1 (en) 2020-12-10 2023-07-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
JP2025505577A (ja) 2022-02-03 2025-02-28 バーテックス ファーマシューティカルズ インコーポレイテッド （６ａ，１２ａ）－１７－アミノ－１２－メチル－６，１５－ビス（トリフルオロメチル）－１３，１９－ジオキサ－３，４，１８－トリアザトリシクロ［１２．３．１．１２，５］ノナデカ－１（１８），２，４，１４，１６－ペンタエン－６－オールの調製方法及び結晶形態
IL314449A (en) 2022-02-03 2024-09-01 Vertex Pharma Methods of treatment for cystic fibrosis
WO2023154291A1 (en) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
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EP4525858A1 (en) 2022-05-16 2025-03-26 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
CA3253977A1 (en) 2022-05-16 2023-11-23 Vertex Pharmaceuticals Incorporated SOLID FORMS OF MACROCYCLIC COMPOUNDS AS CFTR MODULATORS AND THEIR PREPARATION
WO2025076240A1 (en) 2023-10-04 2025-04-10 Vertex Pharmaceuticals Incorporated Solid forms of modulators of cystic fibrosis transmembrane conductance regulator
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017078082A (ja) * 2011-05-18 2017-04-27 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたイバカフトルの誘導体

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ME03652B (me) 2020-07-20
BR112013029240A2 (pt) 2017-01-31
JP2017078082A (ja) 2017-04-27
AU2021200970A1 (en) 2021-03-11
BR112013029240B1 (pt) 2023-05-16
RS59744B1 (sr) 2020-02-28
WO2012158885A1 (en) 2012-11-22
AU2012255711B2 (en) 2017-05-04
HK1244183A1 (en) 2018-08-03
PL3235812T3 (pl) 2020-04-30
AU2021203786A1 (en) 2021-07-08
EA201391615A1 (ru) 2014-03-31
HRP20192114T1 (hr) 2020-02-21
PT3235812T (pt) 2019-12-09
MX2013013450A (es) 2014-02-27
SI2709986T1 (sl) 2017-07-31
DK3235812T3 (da) 2019-11-25
DK2709986T3 (en) 2017-05-08
ES2758028T3 (es) 2020-05-04
CY1119090T1 (el) 2018-01-10
CA2834574C (en) 2019-09-17
AU2019222862B2 (en) 2021-03-11
PT2709986T (pt) 2017-06-26
AU2017208313A1 (en) 2017-08-17
EP2709986A1 (en) 2014-03-26
ES2628465T3 (es) 2017-08-02
SMT201700302T1 (it) 2017-07-18
CY1122498T1 (el) 2021-01-27
RS56096B1 (sr) 2017-10-31
EP3235812A1 (en) 2017-10-25
EP3235812B1 (en) 2019-09-04
SI3235812T1 (sl) 2020-02-28
HUE032771T2 (en) 2017-10-30
JP2014515351A (ja) 2014-06-30
ME02749B (me) 2018-01-20
LT2709986T (lt) 2017-05-25
SMT201900679T1 (it) 2020-01-14
MX349159B (es) 2017-07-14
HRP20170754T1 (hr) 2017-07-28
AU2021203786B2 (en) 2023-03-16
PL2709986T3 (pl) 2017-09-29
AU2021200970B2 (en) 2022-07-14
CA2834574A1 (en) 2012-11-22
EA028378B1 (ru) 2017-11-30
EP2709986B1 (en) 2017-03-22
AU2019222862A1 (en) 2019-09-19

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