JP6052673B2 - ピラゾール誘導体またはその塩ならびにそれらを含有する医薬組成物 - Google Patents
ピラゾール誘導体またはその塩ならびにそれらを含有する医薬組成物 Download PDFInfo
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- JP6052673B2 JP6052673B2 JP2013092023A JP2013092023A JP6052673B2 JP 6052673 B2 JP6052673 B2 JP 6052673B2 JP 2013092023 A JP2013092023 A JP 2013092023A JP 2013092023 A JP2013092023 A JP 2013092023A JP 6052673 B2 JP6052673 B2 JP 6052673B2
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- Prior art keywords
- group
- methyl
- amino
- phenyl
- pyrazole
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- 150000003839 salts Chemical class 0.000 title claims description 36
- 150000003217 pyrazoles Chemical class 0.000 title claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 19
- -1 Here Chemical group 0.000 claims description 58
- 125000005843 halogen group Chemical group 0.000 claims description 41
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
- 125000001424 substituent group Chemical group 0.000 claims description 41
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 30
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 28
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 19
- 125000004442 acylamino group Chemical group 0.000 claims description 17
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 15
- 229910052799 carbon Inorganic materials 0.000 claims description 15
- 125000005493 quinolyl group Chemical group 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 11
- 230000002265 prevention Effects 0.000 claims description 11
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 10
- 208000036142 Viral infection Diseases 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 230000009385 viral infection Effects 0.000 claims description 9
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 8
- 125000001624 naphthyl group Chemical group 0.000 claims description 8
- 125000004076 pyridyl group Chemical group 0.000 claims description 8
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000000335 thiazolyl group Chemical group 0.000 claims description 5
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 4
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 125000005956 isoquinolyl group Chemical group 0.000 claims description 4
- FTNJQNQLEGKTGD-ZFJHNFROSA-N 1,3-benzodioxole Chemical group C1O[13C]=2[13CH]=[13CH][13CH]=[13CH][13C]=2O1 FTNJQNQLEGKTGD-ZFJHNFROSA-N 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 description 193
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 104
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 96
- 239000000243 solution Substances 0.000 description 88
- 239000002904 solvent Substances 0.000 description 76
- 238000006243 chemical reaction Methods 0.000 description 69
- 238000005160 1H NMR spectroscopy Methods 0.000 description 66
- 239000000203 mixture Substances 0.000 description 57
- 239000007787 solid Substances 0.000 description 57
- 235000019441 ethanol Nutrition 0.000 description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 41
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 39
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 39
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 36
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 36
- OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 33
- 239000012044 organic layer Substances 0.000 description 32
- 238000010898 silica gel chromatography Methods 0.000 description 31
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 29
- 235000002639 sodium chloride Nutrition 0.000 description 29
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 28
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 27
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 27
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 25
- 229940080818 propionamide Drugs 0.000 description 24
- 239000012043 crude product Substances 0.000 description 23
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 22
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 22
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 20
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 20
- 238000000746 purification Methods 0.000 description 19
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- MAKQREKUUHPPIS-UHFFFAOYSA-N 5-amino-1-phenyl-1H-pyrazole-4-carbonitrile Chemical group NC1=C(C#N)C=NN1C1=CC=CC=C1 MAKQREKUUHPPIS-UHFFFAOYSA-N 0.000 description 17
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 17
- 239000012279 sodium borohydride Substances 0.000 description 17
- 229910000033 sodium borohydride Inorganic materials 0.000 description 17
- 239000011541 reaction mixture Substances 0.000 description 16
- MMFBOTSACKFHNW-UHFFFAOYSA-N 5-amino-1-(3-bromophenyl)-3-methylpyrazole-4-carbonitrile Chemical compound NC1=C(C#N)C(C)=NN1C1=CC=CC(Br)=C1 MMFBOTSACKFHNW-UHFFFAOYSA-N 0.000 description 14
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 14
- 0 C*c(cccc1Cl)c1O Chemical compound C*c(cccc1Cl)c1O 0.000 description 14
- 239000002253 acid Substances 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 14
- QLULGIRFKAWHOJ-UHFFFAOYSA-N pyridin-4-ylboronic acid Chemical compound OB(O)C1=CC=NC=C1 QLULGIRFKAWHOJ-UHFFFAOYSA-N 0.000 description 13
- JQZICMDFCWZXPI-UHFFFAOYSA-N CCC(=O)NC1=CC(C=O)=CC(Cl)=C1O Chemical compound CCC(=O)NC1=CC(C=O)=CC(Cl)=C1O JQZICMDFCWZXPI-UHFFFAOYSA-N 0.000 description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 12
- 235000011054 acetic acid Nutrition 0.000 description 12
- 229910052757 nitrogen Inorganic materials 0.000 description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 238000000926 separation method Methods 0.000 description 11
- 239000000725 suspension Substances 0.000 description 11
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
- 238000001816 cooling Methods 0.000 description 10
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 10
- 238000001914 filtration Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
- GKYOYJHCLLMFCI-UHFFFAOYSA-N NC1=C(C(=NN1C1=NC2=CC=CC=C2C=C1)C)C#N Chemical compound NC1=C(C(=NN1C1=NC2=CC=CC=C2C=C1)C)C#N GKYOYJHCLLMFCI-UHFFFAOYSA-N 0.000 description 9
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- OLRXCKFWRROJFZ-UHFFFAOYSA-N 3-hydrazinylbenzonitrile;hydrochloride Chemical compound [Cl-].[NH3+]NC1=CC=CC(C#N)=C1 OLRXCKFWRROJFZ-UHFFFAOYSA-N 0.000 description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 8
- 150000001298 alcohols Chemical class 0.000 description 8
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 8
- BOSVWXDDFBSSIZ-UHFFFAOYSA-N 2-(1-ethoxyethylidene)propanedinitrile Chemical compound CCOC(C)=C(C#N)C#N BOSVWXDDFBSSIZ-UHFFFAOYSA-N 0.000 description 7
- JBLOYYSZSPIKCB-UHFFFAOYSA-N 5-amino-1-(3-cyanophenyl)-3-methylpyrazole-4-carbonitrile Chemical compound NC1=C(C#N)C(C)=NN1C1=CC=CC(C#N)=C1 JBLOYYSZSPIKCB-UHFFFAOYSA-N 0.000 description 7
- UCDBLYHPJMMFMY-UHFFFAOYSA-N 8-bromoquinoline-4-carbonitrile Chemical compound C1=CN=C2C(Br)=CC=CC2=C1C#N UCDBLYHPJMMFMY-UHFFFAOYSA-N 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 7
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 7
- 235000019270 ammonium chloride Nutrition 0.000 description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 229910052801 chlorine Inorganic materials 0.000 description 7
- 125000001309 chloro group Chemical group Cl* 0.000 description 7
- 150000002170 ethers Chemical class 0.000 description 7
- 239000010410 layer Substances 0.000 description 7
- 239000012299 nitrogen atmosphere Substances 0.000 description 7
- 238000010992 reflux Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 150000003462 sulfoxides Chemical class 0.000 description 7
- 239000003643 water by type Substances 0.000 description 7
- HMHWNJGOHUYVMD-UHFFFAOYSA-N (4-methylanilino)azanium;chloride Chemical compound Cl.CC1=CC=C(NN)C=C1 HMHWNJGOHUYVMD-UHFFFAOYSA-N 0.000 description 6
- NIBQNKBEGIMBSV-UHFFFAOYSA-N 1-methylpyrazole-4-carbonitrile Chemical compound CN1C=C(C#N)C=N1 NIBQNKBEGIMBSV-UHFFFAOYSA-N 0.000 description 6
- ICCYFVWQNFMENX-UHFFFAOYSA-N 2-chloro-6-nitrophenol Chemical compound OC1=C(Cl)C=CC=C1[N+]([O-])=O ICCYFVWQNFMENX-UHFFFAOYSA-N 0.000 description 6
- VWOYPUVIGCTVSC-UHFFFAOYSA-N 5-amino-3-methyl-1-phenylpyrazole-4-carbonitrile Chemical compound NC1=C(C#N)C(C)=NN1C1=CC=CC=C1 VWOYPUVIGCTVSC-UHFFFAOYSA-N 0.000 description 6
- CSJKQOUJYSWKDB-UHFFFAOYSA-N CC1=NN(C(=C1C#N)N)C2=CC=CC(=C2)C3=CC=CC=C3 Chemical compound CC1=NN(C(=C1C#N)N)C2=CC=CC(=C2)C3=CC=CC=C3 CSJKQOUJYSWKDB-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 6
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000002411 adverse Effects 0.000 description 6
- 150000001408 amides Chemical class 0.000 description 6
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 150000008282 halocarbons Chemical class 0.000 description 6
- QPWHEDZASSKIQB-UHFFFAOYSA-N n-(3-chloro-2-hydroxyphenyl)propanamide Chemical compound CCC(=O)NC1=CC=CC(Cl)=C1O QPWHEDZASSKIQB-UHFFFAOYSA-N 0.000 description 6
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- 238000012746 preparative thin layer chromatography Methods 0.000 description 6
- 229920006395 saturated elastomer Polymers 0.000 description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 6
- 235000011121 sodium hydroxide Nutrition 0.000 description 6
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- GXMOSBIOUZALPM-UHFFFAOYSA-N 2-(1-ethoxypropylidene)propanedinitrile Chemical compound CCOC(CC)=C(C#N)C#N GXMOSBIOUZALPM-UHFFFAOYSA-N 0.000 description 5
- CGDACEQOAJDMNY-UHFFFAOYSA-N 3-chloro-4-hydroxy-5-nitrobenzaldehyde Chemical compound OC1=C(Cl)C=C(C=O)C=C1[N+]([O-])=O CGDACEQOAJDMNY-UHFFFAOYSA-N 0.000 description 5
- KBMHWHGNWDKSHL-UHFFFAOYSA-N 5-[(3-amino-4-hydroxyphenyl)methylamino]-3-methyl-1-phenylpyrazole-4-carbonitrile hydrochloride Chemical compound Cl.N#CC=1C(C)=NN(C=2C=CC=CC=2)C=1NCC1=CC=C(O)C(N)=C1 KBMHWHGNWDKSHL-UHFFFAOYSA-N 0.000 description 5
- PWKWYLFGTBDTPW-UHFFFAOYSA-N CC1=CC(=CC(=C1O)N)CNC2=C(C(=NN2C3=CC=CC=C3)C)C#N.Cl Chemical compound CC1=CC(=CC(=C1O)N)CNC2=C(C(=NN2C3=CC=CC=C3)C)C#N.Cl PWKWYLFGTBDTPW-UHFFFAOYSA-N 0.000 description 5
- APOVOOJXQGSQKK-UHFFFAOYSA-N CC1=CC(=CC=C1)C2=CC(=CC=C2)N3C(=C(C(=N3)C)C#N)N Chemical compound CC1=CC(=CC=C1)C2=CC(=CC=C2)N3C(=C(C(=N3)C)C#N)N APOVOOJXQGSQKK-UHFFFAOYSA-N 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 229910052786 argon Inorganic materials 0.000 description 5
- 239000012298 atmosphere Substances 0.000 description 5
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 5
- 239000011261 inert gas Substances 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 235000019260 propionic acid Nutrition 0.000 description 5
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 5
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
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- 229940032147 starch Drugs 0.000 description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- LULAYUGMBFYYEX-UHFFFAOYSA-N 3-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
- OYMIIKBORUBGQN-UHFFFAOYSA-N 4-hydroxy-3-methyl-5-nitrobenzaldehyde Chemical compound CC1=CC(C=O)=CC([N+]([O-])=O)=C1O OYMIIKBORUBGQN-UHFFFAOYSA-N 0.000 description 4
- AUAAPUWDEJJPGO-UHFFFAOYSA-N 5-amino-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazole-4-carbonitrile Chemical compound NC1=C(C#N)C(C)=NN1C1=CC=CC(C(F)(F)F)=C1 AUAAPUWDEJJPGO-UHFFFAOYSA-N 0.000 description 4
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- 239000012448 Lithium borohydride Substances 0.000 description 4
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 150000001721 carbon Chemical group 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 4
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 4
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 235000019253 formic acid Nutrition 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 235000001727 glucose Nutrition 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
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- VAAASDNGHKVVMV-UHFFFAOYSA-N n-[3-chloro-5-[[[4-cyano-5-methyl-2-[3-(4-methylphenyl)phenyl]pyrazol-3-yl]amino]methyl]-2-hydroxyphenyl]propanamide Chemical compound ClC1=C(O)C(NC(=O)CC)=CC(CNC=2N(N=C(C)C=2C#N)C=2C=C(C=CC=2)C=2C=CC(C)=CC=2)=C1 VAAASDNGHKVVMV-UHFFFAOYSA-N 0.000 description 1
- APVYURIUXOTBLO-UHFFFAOYSA-N n-[3-chloro-5-[[[4-cyano-5-methyl-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]amino]methyl]-2-hydroxyphenyl]propanamide Chemical compound ClC1=C(O)C(NC(=O)CC)=CC(CNC=2N(N=C(C)C=2C#N)C=2C=C(C=CC=2)C(F)(F)F)=C1 APVYURIUXOTBLO-UHFFFAOYSA-N 0.000 description 1
- ASYPCPRISIIZBN-UHFFFAOYSA-N n-[5-[[(4-cyano-5-methyl-2-phenylpyrazol-3-yl)amino]methyl]-2-hydroxy-3-methylphenyl]propanamide Chemical compound CC1=C(O)C(NC(=O)CC)=CC(CNC=2N(N=C(C)C=2C#N)C=2C=CC=CC=2)=C1 ASYPCPRISIIZBN-UHFFFAOYSA-N 0.000 description 1
- QOFFMMSXBYXQJE-UHFFFAOYSA-N n-[5-[[(4-cyano-5-methyl-2-phenylpyrazol-3-yl)amino]methyl]-2-hydroxyphenyl]propanamide Chemical compound C1=C(O)C(NC(=O)CC)=CC(CNC=2N(N=C(C)C=2C#N)C=2C=CC=CC=2)=C1 QOFFMMSXBYXQJE-UHFFFAOYSA-N 0.000 description 1
- HXTFFJFXEGYQTI-UHFFFAOYSA-N n-[5-[[[2-(3-acetamidophenyl)-4-cyano-5-methylpyrazol-3-yl]amino]methyl]-3-chloro-2-hydroxyphenyl]propanamide Chemical compound ClC1=C(O)C(NC(=O)CC)=CC(CNC=2N(N=C(C)C=2C#N)C=2C=C(NC(C)=O)C=CC=2)=C1 HXTFFJFXEGYQTI-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- KPTRDYONBVUWPD-UHFFFAOYSA-N naphthalen-2-ylboronic acid Chemical compound C1=CC=CC2=CC(B(O)O)=CC=C21 KPTRDYONBVUWPD-UHFFFAOYSA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- LXNAVEXFUKBNMK-UHFFFAOYSA-N palladium(II) acetate Substances [Pd].CC(O)=O.CC(O)=O LXNAVEXFUKBNMK-UHFFFAOYSA-N 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- ZAEQTGTVGUJEFV-UHFFFAOYSA-N phenylmethanesulfonate;pyridin-1-ium Chemical compound C1=CC=[NH+]C=C1.[O-]S(=O)(=O)CC1=CC=CC=C1 ZAEQTGTVGUJEFV-UHFFFAOYSA-N 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 229940090181 propyl acetate Drugs 0.000 description 1
- RJSAWRPVTKYGIZ-UHFFFAOYSA-N pyridin-3-ylhydrazine;hydrochloride Chemical compound Cl.NNC1=CC=CN=C1 RJSAWRPVTKYGIZ-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 description 1
- IYTZOVRQMIGNHZ-UHFFFAOYSA-N quinolin-6-ylhydrazine;hydrochloride Chemical compound Cl.N1=CC=CC2=CC(NN)=CC=C21 IYTZOVRQMIGNHZ-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- IRFHMTUHTBSEBK-QGZVFWFLSA-N tert-butyl n-[(2s)-2-(2,5-difluorophenyl)-3-quinolin-3-ylpropyl]carbamate Chemical compound C1([C@H](CC=2C=C3C=CC=CC3=NC=2)CNC(=O)OC(C)(C)C)=CC(F)=CC=C1F IRFHMTUHTBSEBK-QGZVFWFLSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 1
- AVCVDUDESCZFHJ-UHFFFAOYSA-N triphenylphosphane;hydrochloride Chemical compound [Cl-].C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 AVCVDUDESCZFHJ-UHFFFAOYSA-N 0.000 description 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
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Description
即ち、本発明は、下記一般式(I)、
R1は、C1−6アルキル基;C3−8シクロアルキル基;置換基群αから選択される少なくとも1つの置換基を有してもよいフェニル基もしくはナフチル基;または;フェニル基を有してもよいチアゾリル基、ピリジル基、キノリル基もしくはイソキノリル基を表し、
ここで、置換基群αは、ハロゲン原子;シアノ基;ニトロ基;ハロゲン原子を有してもよいC1−6アルキル基;ハロゲン原子を有してもよいC1−6アルコキシ基(結合する炭素原子およびそれに隣接炭素原子と一緒になって、ハロゲン原子を有してもよい1,3−ベンゾジオキソール環を形成してもよい); C1−6アシルアミノ基;または;ハロゲン原子、C1−6アルキル基、C1−6アルコキシ基および(N−C1−6アルキル)C1−6アルキルスルホニルアミノ基からなる群から選択される少なくとも1つの置換基を有してもよいフェニル基、ナフチル基、ピリジル基もしくはキノリル基;であり、
R2は、水素原子、C1−3アルキル基またはフェニル基を表し、
R3は、水素原子、シアノ基またはC1−6アルコキシカルボニル基を表し、
R4およびR6は、それぞれ独立に、水素原子;ハロゲン原子;C1−6アルキル基;C1−6アシルアミノ基;C1−6アルキルアミノカルボニル基;または;C1−6アルコキシ基を有してもよいフェニル基;を表し、但し、R4およびR6の少なくとも一方は、水素原子以外の置換基であり、
R5は、水素原子、水酸基またはC1−6アルコキシ基を表し、但し、R5と、R4もしくはR6と、それぞれが結合する炭素原子と一緒になって、インダゾール環を形成してもよく、
X1は、*−CH=CH−**、*−CH2−NH−**、*−NH−CH2−**または*−N=N−**を表し、ここで、*は上記式中のピラゾール環側との結合、**は上記式中のフェニル環側との結合である)で表されるピラゾール誘導体またはその塩を提供する。
なお、本明細書において、特にことわらない限り、以下のように定義する。
ハロゲン原子とは、フッ素原子、塩素原子、臭素原子またはヨウ素原子を意味する。
C1-6アルキル基とは、メチル、エチル、プロピル、イソプロピル、ブチル、sec−ブチル、イソブチル、tert−ブチル、ペンチル、イソペンチルおよびヘキシル基などの直鎖状または分枝鎖状のC1-6アルキル基を意味する。
C1-3アルキル基とは、メチル、エチル、プロピルまたはイソプロピル基を意味する。
C3-8シクロアルキル基とは、シクロプロピル、シクロブチル、シクロペンチルおよびシクロヘキシル基などのC3-8シクロアルキル基を意味する。
C1-6アルコキシ基とは、メトキシ、エトキシ、プロポキシ、イソプロポキシ、ブトキシ、イソブトキシ、sec−ブトキシ、tert−ブトキシ、ペンチルオキシおよびヘキシルオキシ基などの直鎖状または分枝鎖状のC1-6アルキルオキシ基を意味する。
アシル基とは、ホルミル基、スクシニル基、グルタリル基、マレオイル基、フタロイル基、C2-12アルカノイル基、アロイル基、複素環式カルボニル基または(α−置換)アミノアセチル基を意味する。
C1-6アシルアミノ基とは、−NHC(O)Rで表され、RがC1-6アルキル基である置換基を意味する(炭素数はカルボニル基の炭素数を含まない)。ここで、C1-6アルキル基は、前述の通りである。
C1-6アルキルアミノカルボニル基とは、−C(O)NHRで表され、RがC1-6アルキル基である置換基を意味する(炭素数はカルボニル基の炭素数を含まない)。ここで、C1-6アルキル基は、前述の通りである。
ハロゲン化炭化水素類としては、塩化メチレン、クロロホルムまたはジクロロエタンが挙げられる。
アルコール類としては、メタノール、エタノール、プロパノール、2−プロパノール、ブタノールまたは2−メチル−2−プロパノールが挙げられる。
エーテル類としては、ジエチルエーテル、ジイソプロピルエーテル、ジオキサン、テトラヒドロフラン、アニソール、エチレングリコールジメチルエーテル、ジエチレングリコールジメチルエーテルまたはジエチレングリコールジエチルエーテルが挙げられる。
エステル類としては、酢酸メチル、酢酸エチル、酢酸プロピルまたは酢酸ブチルが挙げられる。
アミド類としては、N,N−ジメチルホルムアミド、N,N−ジメチルアセトアミドまたは1−メチル−2−ピロリドンが挙げられる。
スルホキシド類としては、ジメチルスルホキシドが挙げられる。
芳香族炭化水素類としては、ベンゼン、トルエンまたはキシレンが挙げられる。
上記した塩の中で、好ましい塩としては、薬理学的に許容される塩が挙げられる。
ここで、C1−6アルキル基としては、例えば、メチル基、エチル基およびプロピル基を好適に挙げることができ、より好ましくはメチル基である。
C3−8シクロアルキル基としては、好ましくは、シクロヘキシル基である。
ここで、ハロゲン原子としては、フッ素原子、塩素原子および臭素原子を好適に挙げることができ、より好ましくは、塩素原子である。なお、C1−6アルキル基に置換するハロゲン原子としては、好ましくはフッ素原子である。
C1−6アルキル基としては、例えば、メチル基、エチル基およびプロピル基を好適に挙げることができ、より好ましくは、メチル基である。
C1−6アルコキシ基としては、例えば、メトキシ基およびエトキシ基を好適に挙げることができ、より好ましくは、メトキシ基である。
C1−6アシルアミノ基としては、好ましくは、炭素数(カルボニル基の炭素数を含まない)が1〜3、より好ましくは1〜2、更に好ましくは1である。
ここで、ハロゲン原子としては、好ましくは、塩素原子である。
C1−6アルキル基としては、例えば、メチル基、エチル基およびプロピル基を好適に挙げることができ、より好ましくは、メチル基である。
C1−6アルコキシ基としては、例えば、メトキシ基およびエトキシ基を好適に挙げることができ、より好ましくは、メトキシ基である。
ここで、C1−6アルコキシカルボニル基としては、例えば、メトキシカルボニル基およびエトキシカルボニル基を好適に挙げることができ、より好ましくは、エトキシカルボニル基である。
R4およびR6は、それぞれ独立に、好ましくは、ハロゲン原子、C1−6アシルアミノ基またはC1−6アルキルアミノカルボニル基であり、より好ましくは、ハロゲン原子またはC1−6アシルアミノ基である。R4およびR6の一方が、ハロゲン原子であり、もう一方が、C1−6アシルアミノ基であることがより好ましい。
ここで、ハロゲン原子としては、好ましくは塩素原子である。
C1−6アルキル基としては、例えば、メチル基、エチル基およびプロピル基を好適に挙げることができ、より好ましくはメチル基である。
C1−6アシルアミノ基としては、好ましくは、炭素数(カルボニル基の炭素数を含まない)が1〜5、より好ましくは1〜3、更に好ましくは1〜2である。
C1−6アルキルアミノカルボニル基としては、好ましくは、炭素数(カルボニル基の炭素数を含まない)が1〜3、より好ましくは1〜2、更に好ましくは2である。
フェニル基に置換するC1−6アルコキシ基としては、メトキシ基およびエトキシ基を好適に挙げることができ、より好ましくは、メトキシ基である。
R5は、好ましくは、水酸基またはC1−6アルコキシ基であり、より好ましくは、水酸基である。ここで、C1−6アルコキシ基としては、例えば、エトキシ基およびメトキシ基を好適に挙げることができ、より好ましくは、メトキシ基である。
R7は、ハロゲン原子、C1−6アルキル基およびC1−6アルコキシ基からなる群から選択される少なくとも1つの置換基を有してもよいフェニル基を有するフェニル基;または;キノリル基を表し、
R8は、C1−3アルキル基を表し、
R9およびR10は、一方が、ハロゲン原子であり、もう一方が、C1−6アシルアミノ基を表す。)
ここで、ハロゲン原子としては、好ましくは、塩素原子である。
C1−6アルキル基としては、例えば、メチル基、エチル基およびプロピル基を好適に挙げることができ、より好ましくは、メチル基である。
C1−6アルコキシ基としては、例えば、メトキシ基およびエトキシ基を好適に挙げることができ、より好ましくは、メトキシ基である。
・(E)−N−(3−クロロ−5−((4−シアノ−1−シクロヘキシル−3−メチル−1H−ピラゾール−5−イル)ジアゼニル)−2−ヒドロキシフェニル)プロピオンアミド
・(E)−N−(3−クロロ−2−ヒドロキシ−5−((1−フェニル−1H−ピラゾール−5−イル)ジアゼニル)フェニル)プロピオンアミド
・(E)−N−(3−クロロ−5−((4−シアノ−3−メチル−1−フェニル−1H−ピラゾール−5−イル)ジアゼニル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−フェニル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−(キノリン−7−イル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)ブタンアミド
・N−(5−(((1−((1,1'−ビフェニル)−3−イル)−4−シアノ−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−3−クロロ−2−ヒドロキシフェニル)ブタンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−(3−メチルフェニル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(5−(((1−(3−ブロモフェニル)−4−シアノ−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−3−クロロ−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−(3−(トリフルオロメチル)フェニル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−1−(3−フルオロフェニル)−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−1−(キノリン−2−イル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−(ピリジン−2−イル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(5−(((1−([1,1’−ビフェニル]−3−イル)−4−シアノ−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−3−クロロ−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−(3−(キノリン−3−イル)フェニル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−(2’−メチル−[1,1’−ビフェニル]−3−イル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((1−(2’−クロロ−[1,1’−ビフェニル]−3−イル)−4−シアノ−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((1−(3’−クロロ−[1,1’−ビフェニル]−3−イル)−4−シアノ−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((1−(4’−クロロ−[1,1’−ビフェニル]−3−イル)−4−シアノ−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−1−(2’−メトキシ−[1,1’−ビフェニル]−3−イル)−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−1−(3’−メトキシ−[1,1’−ビフェニル]−3−イル)−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−1−(4’−メトキシ−[1,1’−ビフェニル]−3−イル)−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
・(E)−N−(3−クロロ−5−(2−(4−シアノ−3−メチル−1−フェニル−1H−ピラゾール−5−イル)ビニル)−2−ヒドロキシフェニル)プロピオンアミド
・N−(3−クロロ−5−(((4−シアノ−3−メチル−1−(3−(ナフタレン−2−イル)フェニル)−1H−ピラゾール−5−イル)アミノ)メチル)−2−ヒドロキシフェニル)プロピオンアミド
[製造法1]
一般式A3で表される化合物は、酸の存在下あるいは不存在化、一般式A1で表される化合物を一般式A2で表される化合物と反応させることによって製造することができる。
この反応に使用される溶媒としては、反応に悪影響を及ぼさないものであれば特に限定されない。例えば、脂肪族炭化水素類、ハロゲン化炭化水素類、エーテル類、エステル類、アルコール類、アミド類、スルホキシド類、芳香族炭化水素類、アセトニトリルなどが挙げられる。これらは混合して使用してもよい。
酸の使用量は、一般式A1で表される化合物に対して1〜10倍モル、好ましくは、1〜2、より好ましくは、0.1〜1倍モルである。
(1−2)
一般式A4で表される化合物は、酸の存在下あるいは不存在化、一般式A3で表される化合物を還元剤と反応させることによって製造することができる。
この反応に使用される溶媒としては、反応に悪影響を及ぼさないものであれば特に限定されない。例えば、脂肪族炭化水素類、ハロゲン化炭化水素類、エーテル類、エステル類、アルコール類、アミド類、スルホキシド類、芳香族炭化水素類、アセトニトリル、水などが挙げられる。これらは混合して使用してもよい。好ましい溶媒としては、メタノール、エタノール、テトラヒドロフランおよび塩化メチレンなどが挙げられる。
この反応に使用される溶媒としては、反応に悪影響を及ぼさないものであれば特に限定されない。例えば、脂肪族炭化水素類、ハロゲン化炭化水素類、エーテル類、ケトン類、エステル類、アルコール類、アミド類、スルホキシド類、芳香族炭化水素類、アセトニトリルおよび水などが挙げられる。これらは混合して使用してもよい。
塩基の使用量は、一般式A4−1で表される化合物に対して1〜50倍モル、好ましくは、1〜10倍モル、より好ましくは、2〜5倍モルである。
この反応に所望により使用されるリガンドの使用量は、一般式A4−1で表される化合物に対して0.00001〜5倍モル、好ましくは、0.1〜2倍モルである。
この反応に使用されるリガンドとしては、2−ジ−tert−ブチルホスフィノ−2’,4’,6’−トリイソプロピルビフェニル、4,5−ビス(ジフェニルホスフィノ)−9,9−ジメチルキサンテンなどが挙げられる。この反応に所望により使用されるリガンドの使用量は、一般式A4−1で表される化合物に対して0.00001〜1倍モル、好ましくは、0.001〜0.1倍モルである。
この反応に使用される溶媒としては、反応に悪影響を及ぼさないものであれば特に限定されない。例えば、脂肪族炭化水素類、ハロゲン化炭化水素類、エーテル類、エステル類、アルコール類、アミド類、スルホキシド類、アセトニトリルおよび水などが挙げられる。これらは混合して使用してもよい。
酸の使用量は、一般式A1で表される化合物に対して1倍モルないし溶媒として用いてもよく、好ましくは、溶媒として用いることである。
ジアゾ化剤の使用量は、一般式A1で表される化合物に対して1倍モル〜10倍モル、好ましくは、1倍モル〜5倍モル、より好ましくは、1倍モル〜2倍モルである。
この反応に使用される溶媒としては、反応に悪影響を及ぼさないものであれば特に限定されない。例えば、脂肪族炭化水素類、エーテル類、アルコール類、スルホキシド類、芳香族炭化水素類などが挙げられる。これらは混合して使用してもよい。
塩基の使用量は、一般式A8で表される化合物に対して1倍モル〜5倍モル、好ましくは、1倍モル〜2倍モルである。
[製造法A]
この反応に使用される溶媒としては、反応に悪影響を及ぼさないものであれば特に限定されない。例えば、脂肪族炭化水素類、ハロゲン化炭化水素類、エーテル類、エステル類、アルコール類、アミド類、スルホキシド類、芳香族炭化水素類、アセトニトリルなどが挙げられる。これらは混合して使用してもよい。好ましい溶媒としては、アルコール類が挙げられる。
特に、RNAウイルスであるHIVとDNAウイルスであるHSVの治療および/または予防などの処置のための医薬組成物として好適に使用することができる。
上記各種薬剤は、通常の方法により製剤化される。
ニウム塩、ラウリル硫酸ナトリウム、尿素および酵素などの吸収促進剤;デンプン、乳糖、カオリン、ベントナイト、無水ケイ酸、含水二酸化ケイ素、メタケイ酸アルミン酸マグネシウムおよびコロイド状ケイ酸などの吸収・吸着担体などの固形製剤化用医薬用添加物を用い、常法に従い調製すればよい。
カプセル剤は、上記で例示した各種の医薬品と混合し、硬質ゼラチンカプセルおよび軟質カプセルなどに充填して調製される。
また、溶剤、増量剤、等張化剤、溶解補助剤、乳化剤、懸濁化剤、増粘剤などの上記した各種の液体製剤化用添加物を用い、常法に従い調製して、水性または油性の懸濁液、溶液、シロップおよびエリキシル剤とすることもできる。
本発明製剤の有効成分の投与量は、用法、患者の年齢、性別、疾患の形態、その他の条件などに応じて適宜選択されるが、通常成人に対して1日0.1〜500mgを1回から数回に分割して投与すればよく、好ましくは、1日40〜500mgを1回から数回に分割して投与すればよい。
特に記載のない場合、カラムクロマトグラフィーによる精製は、自動精製装置ISOLERA(Biotage社)または中圧液体クロマトグラフYFLC W-prep 2XY(山善株式会社)を使用し、シリカゲルカラムクロマトグラフィーにおける担体は、SNAP KPSilCartridge(Biotage社)、ハイフラッシュカラムW001、W002、W003、W004またはW005(山善株式会社)を使用し、NHシリカは、SNAP KP-NH Cartridge(Biotage社)を使用し、分取薄層シリカゲルクロマトグラフィーは、PLCガラスプレートシリカゲルF60(メルク株式会社)を使用し、マイクロウェーブ反応装置は、Initiator Sixty(Biotage社)を使用し、フロー式水素化反応装置は、H-Cube(ThalesNano社)を使用し、逆相分取HPLCには、Waters 2998 Photodiode Array(PDA)Detector(Waters社)およびWaters 600 Controller(Waters社)、Waters 2767 Sample Manager(Waters社)一式およびYMC-Actus ProC18,30X50mmカラム(YMC社)を使用し、MSスペクトルは、ACQUITY SQD LC/MS System(Waters社、イオン化法:ESI(Electro Spray Ionization、エレクトロスプレーイオン化)法またはLCMS-2010EV(島津製作所、イオン化法:ESIおよびAPCI(Atomospheric Pressure ChemicalIonization、大気圧化学イオン化)を同時に行うイオン化法を用いて測定した。
社)を用いて測定し、全δ値をppmで示した。
NMR測定における略号は、以下の意味を有する。
s:シングレット
br:ブロード
d:ダブレット
dd:ダブルダブレット
t:トリプレット
q:クアルテット
m:マルチプレット
DMSO-d6:重ジメチルスルホキシド
Ac:アセチル
Bn:ベンジル
Et:エチル
Me:メチル
Ph:フェニル
Pr:プロピル
MSm/z(M+H):144.
MSm/z(M+H):200.
MSm/z(M-H):228.
MSm/z(M+H):205.
1H-NMR(CDCl3)δ:7.98(1H,d,J=2.0Hz),7.89(1H,s),7.83(1H,d,J=2.0Hz),4.89-4.84(1H,m),2.57(2H,q,J=7.5Hz),2.43(3H,s),2.05-1.16(13H,m).
MSm/z(M+H):415.
1H-NMR(CDCl3)δ:8.54-8.51(1H,brs),8.10(1H,d,J=2.3Hz),7.77-7.73(3H,m),7.68(1H,d,J=2.3Hz),7.63-7.41(4H,m),6.70(1H,d,J=2.3Hz),2.53(2H,q,J=7.0Hz),1.30(3H,t,J=7.2Hz).
MSm/z(M+H):370.
MSm/z(M+H):409.
MSm/z(M+H):200.
MSm/z(M+H):172.
MSm/z(M+H):228.
MSm/z(M+H):213.
MSm/z(M+H):212.
1H-NMR(CDCl3)δ:7.56-7.28(8H,m),4.99-4.96(1H,m),4.56(2H,d,J=5.9Hz),2.41(2H,q,J=7.7Hz),2.32(3H,s),1.29-1.20(3H,m).
MSm/z(M+H):394.
1H-NMR(CDCl3)δ:7.73(1H,s),7.66(1H,s),7.57-7.44(6H,m),7.09(1H,d,J=2.0Hz),4.64-4.62(1H,m),4.57(2H,d,J=5.3Hz),2.48(2H,q,J=7.5Hz),1.31-1.27(3H,m).
MSm/z(M+H):396.
1H-NMR(CDCl3)δ:7.88-7.85(2H,m),7.58-7.55(1H,m),7.13(1H,d,J=1.3Hz),4.50(2H,d,J=5.9Hz),4.24-4.21(1H,m),3.68-3.66(1H,m),2.48(2H,q,J=7.5Hz),2.24(3H,s),1.90-1.17(13H,m).
MSm/z(M+H):416.
1H-NMR(CDCl3)δ:7.61-7.65(2H,m),7.55(1H,t,J=7.6Hz),7.35-7.36(4H,m),7.28(1H,d,J=2.0Hz),7.22(1H,d,J=4.0Hz),7.14(1H,dd,J=8.6,2.0Hz),6.99(1H,d,J=7.9Hz),5.54(1H,s),4.54-4.60(3H,m),2.42(3H,s),2.35(3H,s).
MSm/z(M+H):429.
1H-NMR(CDCl3)δ:7.70-7.66(1H,brs),7.70(1H,d,J=2.0Hz),7.55-7.41(5H,m),7.09(1H,d,J=2.0Hz),4.63-4.58(1H,brm),4.55(2H,d,J=5.3Hz),2.48(2H,q,J=7.5Hz),2.33(3H,s),1.27(4H,t,J=7.6Hz).
MSm/z(M+H):410.
1H-NMR(CDCl3)δ:7.76-7.73(1H,brs),7.64(1H,s),7.54-7.42(4H,m),7.34-7.31(1H,m),7.12(1H,d,J=2.0Hz),5.31(1H,s),4.16(2H,d,J=5.0Hz),4.12-4.07(1H,brs),2.47(2H,q,J=7.5Hz),2.22(3H,s),1.27(3H,t,J=7.2Hz).
MSm/z(M+H):385.
MSm/z(M+H):210.
MSm/z(M+H):316.
MSm/z(M+H):436.
1H-NMR(THF-d8)δ:9.68-9.51(1H,brs),9.22-9.16(1H,brs),7.50(1H,d,J=2.0Hz),7.10(1H,d,J=2.0Hz),6.95-6.91(3H,m),6.14(1H,t,J=6.4Hz),6.01(2H,s),4.50(2H,d,J=6.6Hz),2.42(2H,q,J=7.0Hz),2.15(3H,s),1.18(3H,t,J=7.2Hz).
MSm/z(M+H):454.
MSm/z(M+H):242.
1H-NMR(CD3OD)δ:8.46(1H,d,J=8.9Hz),8.30(1H,brs),8.11(1H,d,J=8.9Hz),7.91(1H,s),7.79-7.726(1H,m),7.65-7.55(3H,m),7.30(1H,d,J=2.3Hz),4.89(1H,s),4.86(2H,d,J=2.3Hz),2.40(2H,t,J=7.4Hz),2.30(3H,s),1.70-1.65(2H,m),0.95(3H,t,J=7.4Hz).
MSm/z(M+H):475.
実施例5において、5−アミノ−1−フェニル−1H−ピラゾール−4−カルボニトリルを用いた代わりに1−((1,1'−ビフェニル)−3−イル)−5−アミノ−3−メチル−1H−ピラゾール−4−カルボニトリル(化合物0044−1)を、N−(3−クロロ−5−ホルミル−2−ヒドロキシフェニル)プロピオンアミドの代わりにN−(3−クロロ−5−ホルミル−2−ヒドロキシフェニル)ブタンアミド(化合物0011−1)を用いたこと以外は実施例5と同様の方法で、N−(5−(((1−((1,1'−ビフェニル)−3−イル)−4−シアノ−3−メチル−1H−ピラゾール−5−イル)アミノ)メチル)−3−クロロ−2−ヒドロキシフェニル)ブタンアミドを得た。
1H-NMR(CDCl3)δ:7.65-7.58(7H,m),7.48-7.36(4H,m),7.11(1H,d,J=2.0Hz),4.66(1H,t,J=6.3Hz),4.56(2H,d,J=5.9Hz),2.40(2H,t,J=7.4Hz),2.34(3H,s),1.82-1.70(2H,m),1.01(3H,t,J=7.4Hz).
MSm/z(M+H):500.
MSm/z(M+H):200.
MSm/z(M+H):228.
1H-NMR(CDCl3)δ:12.97(1H,s),7.57-7.35(7H,m),6.67(1H,s),4.76(1H,t,J=6.3Hz),4.51(2H,d,J=6.6Hz),3.54-3.45(2H,m),2.31(3H,s),1.30-1.26(3H,m).
MSm/z(M+H):410.
MSm/z(M+H):350.
MSm/z(M+H):320.
1H-NMR(CDCl3)δ:8.81(1H,s),7.49-7.42(6H,m),7.04(1H,s),7.00-6.99(2H,m),4.55(3H,s),2.49(2H,t,J=7.6Hz),2.32(3H,s),1.31-1.24(3H,m).
MSm/z(M+H):376.
MSm/z(M+H):202.
MSm/z(M+H):384.
MSm/z(M+H):354.
1H-NMR(CDCl3)δ:7.87(1H,s),7.69(1H,s),7.61(1H,s),7.54-7.50(2H,m),7.43-7.42(3H,m),7.08(1H,d,J=2.0Hz),4.66(1H,t,J=6.3Hz),4.53(2H,d,J=6.6Hz),2.31(3H,s),2.24(3H,s).
MSm/z(M+H):396.
MSm/z(M+H):182.
MSm/z(M+H):364.
MSm/z(M+H):334.
1H-NMR(CDCl3)δ:8.76(1H,s),7.48-7.42(6H,m),6.90(1H,s),6.84-6.83(1H,m),4.51(3H,s),2.50(2H,q,J=7.5Hz),2.33(3H,s),2.26(3H,s),1.33-1.24(3H,m).
MSm/z(M+H):390.
MSm/z(M+H):398.
MSm/z(M+H):368.
1H-NMR(CDCl3)δ:8.32(1H,d,J=2.0Hz),7.76(1H,s),7.56-7.39(5H,m),7.08(1H,d,J=2.3Hz),4.62-4.55(3H,brs),3.89(3H,s),2.45(2H,q,J=7.6Hz),2.33(3H,s),1.27(3H,t,J=7.5Hz).
MSm/z(M+H):424.
1H-NMR(CDCl3)δ:7.68(2H,d,J=1.7Hz),7.70-7.63(1H,brs),7.55-7.41(5H,m),7.10(1H,d,J=2.0Hz),4.64-4.57(1H,brm),4.55(2H,d,J=5.0Hz),2.42(2H,t,J=7.4Hz),2.32(3H,s),1.84-1.72(2H,m),1.02(3H,t,J=7.4Hz).
MSm/z(M+H): 424.
1H-NMR(CDCl3)δ:7.72(1H,s),7.64(1H,d,J=1.7Hz),7.54-7.37(5H,m),7.09(1H,d,J=2.0Hz),4.64-4.58(1H,brm),4.54(2H,d,J=5.9Hz),2.43(2H,t,J=7.4Hz),2.32(3H,s),1.79-1.69(2H,m),1.40-1.32(4H,m),0.92(3H,t,J=7.2Hz).
MSm/z(M+H):452.
1H-NMR(CDCl3)δ:4.20-4.10(2H,brs),3.58(3H,s),2.24(3H,s).
MSm/z(M+H):348.
1H-NMR(CDCl3)δ:4.47(2H,q,J=6.8Hz),2.67(2H,q,J=7.5Hz),1.46(3H,t,J=6.9Hz),1.30-1.24(3H,m).
MSm/z(M+H):213.
1H-NMR(CD3OD)δ:7.60-7.46(6H,m),7.09(1H,d,J=2.0Hz),4.49(2H,s),2.62-2.60(2H,m),2.48-2.46(2H,m),1.26-1.21(6H,m).
MSm/z(M+H):424.
1H-NMR(CD3OD)δ:7.69-7.59(5H,m),4.20(2H,q,J=7.0Hz),1.34(3H,t,J=7.3Hz).
MSm/z(M+H):261.
1H-NMR(CD3OD)δ:7.85-7.82(2H,m),7.61-7.55(6H,m),7.46-7.41(3H,m),7.13(1H,d,J=2.0Hz),4.59-4.55(2H,m),2.47(2H,q,J=7.5Hz),1.26-1.18(3H,m).
MSm/z(M+H):472
MSm/z(M+H):184.
MSm/z(M+H):246.
1H-NMR(CD3OD)δ:7.52-7.42(5H,m),7.17(1H,s),6.68(1H,d,J=2.0Hz),4.31(2H,q,J=7.0Hz),3.86(2H,s),2.44(2H,q,J=7.5Hz),2.32(3H,s),1.37-1.15(8H,m).
MSm/z(M+H):457.
MSm/z(M+H):213.
1H-NMR(CD3OD)δ:7.52(1H,s),7.35(4H,q,J=8.4Hz),7.07(1H,d,J=1.3Hz),4.47(2H,s),2.46(2H,t,J=7.6Hz),2.42(3H,s),2.21(3H,s),1.21(3H,t,J=7.3Hz).
MSm/z(M+H):424.
MSm/z(M+H):213.
1H-NMR(CD3OD)δ:7.54(1H,s),7.44-7.41(1H,m),7.32-7.26(3H,m),7.07(1H,s),4.48(2H,s),2.48-2.45(2H,m),2.42(3H,s),2.22(3H,s),1.23-1.21(3H,m).
MSm/z(M+H):424.
MSm/z(M+H):213.
1H-NMR(CD3OD)δ:7.46-7.37(5H,m),7.05(1H,s),4.44(2H,s),4.09(1H,q,J=7.3Hz),2.47(2H,q,J=7.5Hz),2.23(3H,s),2.07(3H,s),1.29-1.19(3H,m).
MSm/z(M+H):424.
MSm/z(M+H):277,279.
1H-NMR(CDCl3)δ:7.77(2H,d,J=5.9Hz),7.68-7.67(4H,m),7.30-7.26(1H,m),7.10(1H,d,J=2.0Hz),4.56-4.54(3H,m),2.48(2H,q,J=7.5Hz),2.33(3H,s),1.29-1.19(3H,m).
MSm/z(M+H):488,490.
MSm/z(M+H):267.
1H-NMR(CDCl3)δ:7.77(2H,d,J=5.9Hz),7.68(3H,d,J=1.3Hz),7.63(1H,s),7.10(1H,d,J=2.0Hz),4.56-4.54(3H,m),2.48(2H,q,J=7.5Hz),2.33(3H,s),1.28-1.23(4H,m).
MSm/z(M+H):478.
MSm/z(M+H):267.
1H-NMR(CDCl3)δ:7.74-7.66(2H,m),7.40-7.39(3H,m),7.10(1H,d,J=2.0Hz),4.60-4.56(3H,m),2.47(2H,q,J=7.5Hz),2.30(3H,s),1.26(3H,m,J=9.2,5.9Hz).
MSm/z(M+H):480.
MSm/z(M+H):229.
1H-NMR(CDCl3)δ:7.82(1H,s),7.45-7.42(2H,m),7.37-7.34(1H,m),7.09-7.04(3H,m),4.52(3H,s),3.84(3H,s),2.46(2H,q,J=7.5Hz),2.31(3H,s),1.26(4H,td,J=7.4,1.8Hz).
MSm/z(M+H):440.
MSm/z(M+H):244.
1H-NMR(CDCl3)δ:8.38(1H,t,J=2.3Hz),8.26-8.24(1H,m),7.89(1H,d,J=7.9Hz),7.75-7.71(2H,m),7.12(1H,d,J=2.0Hz),4.58(3H,s),2.49(2H,q,J=7.5Hz),2.34(3H,s),1.28-1.25(4H,m).
MSm/z(M+H):455.
MSm/z(M+H):249.
1H-NMR(CDCl3)δ:8.00-7.95(2H,m),7.62-7.53(4H,m),7.46(1H,s),7.40-7.39(1H,m),6.96(1H,d,J=2.0Hz),4.48(2H,d,J=6.6Hz),4.27(1H,t,J=6.6Hz),2.46(2H,q,J=7.5Hz),2.37(3H,s),1.32-1.19(5H,m).
MSm/z(M+H):460.
MSm/z(M+H):217.
1H-NMR(CDCl3)δ:7.77(1H,s),7.63(1H,s),7.51-7.46(1H,m),7.21-7.13(3H,m),4.62-4.57(3H,m),2.48(2H,q,J=7.5Hz),2.32(3H,s),1.30-1.24(5H,m).
MSm/z(M+H):427.
MSm/z(M+H):250.
1H-NMR(CDCl3)δ:9.02(1H,d,J=8.6Hz),8.26(2H,t,J=5.0Hz),7.86(2H,t,J=5.6Hz),7.78-7.60(5H,m),7.20(1H,d,J=2.0Hz),4.73(2H,d,J=6.6Hz),2.47(2H,q,J=7.5Hz),2.40(3H,s),1.26(3H,t,J=7.6Hz).
MSm/z(M+H):461.
MSm/z(M+H):264.
1H-NMR(DMSO-d6)δ:10.04(2H,s),9.82(1H,s),8.57(1H,d,J=8.6Hz),8.11-8.05(2H,m),7.61(1H,s),7.49(1H,s),7.27(1H,s),4.79(2H,d,J=5.9Hz),2.73(2H,s),2.62(2H,d,J=7.3Hz),1.26(3H,t,J=7.6Hz),1.05(3H,t,J=7.6Hz).
MSm/z(M+H):475.
MSm/z(M+H):236.
1H-NMR(DMSO-d6)δ:10.03(1H,t,J=10.0Hz),9.81(1H,s),8.60(1H,d,J=9.2Hz),8.15-8.05(4H,m),7.83(1H,t,J=6.9Hz),7.63(1H,t,J=6.9Hz),7.50(1H,s),7.27(1H,s),4.81(2H,d,J=5.9Hz),2.40(2H,q,J=7.5Hz),1.05(3H,t,J=7.6Hz).
MSm/z(M+H):447.
MSm/z(M+H):134.
MSm/z(M+H):224.
1H-NMR(CDCl3)δ:7.87-7.63(5H,m),7.07(1H,d,J=15.2Hz),4.56(2H,t,J=5.3Hz),2.48(2H,dd,J=15.2,7.9Hz),2.32(3H,s),1.32-1.26(3H,m).
MSm/z(M+H):435.
MSm/z(M+H):250.
1H-NMR(CD3OD)δ:8.93-8.95(1H,m),8.53(1H,d,J=7.3Hz),8.21(1H,d,J=8.6Hz),8.14(1H,d,J=2.6Hz),7.88(1H,dd,J=9.2,2.6Hz),7.61-7.67(2H,m),7.11(1H,d,J=2.0Hz),4.52(2H,s),2.48(2H,q,J=7.5Hz),2.26(3H,s),1.22(3H,t,J=7.5Hz).
MSm/z(M+H):461
MSm/z(M+H):200.
1H-NMR(CDCl3)δ:9.56(1H,t,J=6.4Hz),8.34-8.31(1H,m),7.91(1H,d,J=8.3Hz),7.86-7.79(2H,m),7.64-7.60(1H,brm),7.61(1H,s),7.21(1H,d,J=2.0Hz),7.17-7.12(1H,m),4.73(2H,d,J=6.3Hz),2.48(2H,q,J=7.6Hz),2.31(3H,s),1.27(3H,t,J=7.6Hz).
MSm/z(M+H):411.
MSm/z(M+H):200
1H-NMR(CDCl3)δ:8.75(1H,d,J=2.3Hz),8.64(1H,d,J=4.8Hz),7.88-7.83(1H,m),7.80-7.75(1H,brs),7.75(1H,s),7.48(1H,dd,J=8.3,4.6Hz),7.09(1H,d,J=2.0Hz),4.69-4.62(1H,brs),4.56(2H,d,J=5.9Hz),2.47(2H,q,J=7.5Hz),2.33(3H,s),1.25(3H,t,J=7.5Hz).
MSm/z(M+H):411.
MSm/z(M+H):250.
1H-NMR(DMSO-d6)δ:10.04(1H,t,J=6.6Hz),10.00(1H,s),9.83(1H,s),8.57(1H,d,J=8.6Hz),8.15(1H,d,J=8.3Hz),8.06(1H,d,J=9.2Hz),8.02(1H,d,J=7.5Hz),7.82(1H,ddd,J=7.8,7.0,1.5Hz),7.61(1H,ddd,J=7.9,6.9,1.6Hz),7.48(1H,d,J=1.5Hz),7.26(1H,d,J=1.7Hz),4.79(2H,d,J=6.6Hz),2.40(2H,q,J=7.5Hz),2.24(3H,s),1.05(3H,t,J=7.6Hz).
MSm/z(M+H):461.
MSm/z(M+H):282.
1H-NMR(THF-d6)δ:9.88-9.78(1H,br.s),9.26-9.24(1H,br.s),8.72-8.66(1H,br.m),7.76-7.71(2H,m),7.54(1H,d,J=2.3Hz),7.52(1H,s),7.39-7.25(4H,m),4.79(2H,d,J=5.6Hz),2.42(2H,q,J=7.6Hz),2.26(3H,s),1.15(3H,t,J=7.4Hz).
MSm/z(M-H2O+H):475.
MSm/z(M+H):166.
MSm/z(M+H):256.
1H-NMR(CDCl3)δ:8.67(1H,s),8.41(1H,s),8.04(1H,s),7.86-7.81(2H,m),7.66(1H,d,J=7.6Hz),7.50(1H,t,J=8.0Hz),4.86(1H,t,J=6.5Hz),4.62(2H,d,J=6.3Hz),2.54(2H,q,J=7.6Hz),2.29(3H,s),2.26(3H,s),1.32(3H,t,J=7.6Hz).
MSm/z(M+H):467.
MSm/z(M+H):275.
1H-NMR(CDCl3)δ:7.66-7.58(7H,m),7.48-7.33(4H,m),7.10(1H,d,J=2.0Hz),4.66(1H,t,J=6.3Hz),4.55(2H,d,J=5.9Hz),2.45(2H,q,J=7.5Hz),2.34(3H,s),1.40-1.19(4H,m).
MSm/z(M+H):486.
1H-NMR(MeOD)δ:8.62-8.60(2H,m),7.89-7.85(2H,m),7.74-7.71(3H,m),7.64-7.60(2H,m),7.11-7.10(1H,m),4.51(2H,s),2.46-2.43(2H,m),2.25(3H,s),1.18(3H,t,J=12.9Hz).
MSm/z(M+H):487.
1H-NMR(DMSO-d6)δ:9.71(1H,s),9.33(1H,d,J=2.0Hz),8.75(1H,d,J=2.6Hz),8.07-8.02(4H,m),7.83-7.49(5H,m),7.37(1H,t,J=6.6Hz),7.13(1H,d,J=2.0Hz),4.47(2H,d,J=6.6Hz),2.38(2H,q,J=7.7Hz),2.17(3H,s),1.01(3H,t,J=7.6Hz).
MSm/z(M+H):537.
1H-NMR(CDCl3)δ:7.62-7.55(4H,m),7.41-7.39(3H,m),7.22-7.20(2H,m),7.09(1H,d,J=2.0Hz),4.63(1H,t,J=5.3Hz),4.56(2H,d,J=5.9Hz),2.46(2H,q,J=7.5Hz),2.32(3H,s),2.24(3H,s),1.26(3H,t,J=7.6Hz).
MSm/z(M+H):500.
1H-NMR(CDCl3)δ:7.76(2H,d,J=27.1Hz),7.60-7.57(2H,m),7.51-7.44(4H,m),7.34-7.30(3H,m),7.11(1H,d,J=2.0Hz),4.75(1H,t,J=6.3Hz),4.57(2H,d,J=5.9Hz),2.46(2H,q,J=7.7Hz),2.32(3H,s),1.32-1.19(3H,m).
MSm/z(M+H):520.
1H-NMR(CDCl3)δ:7.65-7.56(5H,m),7.37-7.32(4H,m),7.20(1H,d,J=6.6Hz),7.09(1H,d,J=2.0Hz),4.66(1H,t,J=6.6Hz),4.55(2H,d,J=5.9Hz),2.46(2H,q,J=7.6Hz),2.45(3H,s),2.33(3H,s),1.27-1.24(3H,m).
MSm/z(M+H):500.
1H-NMR(CDCl3)δ:7.73-7.56(6H,m),7.45-7.37(5H,m),7.12-7.09(1H,m),4.62-4.57(3H,m),2.46(2H,q,J=7.3Hz),2.34(3H,s),1.28-1.23(3H,m).
MSm/z(M+H):520.
1H-NMR(CDCl3)δ:7.65-7.62(4H,m),7.56(1H,t,J=7.9Hz),7.47(2H,d,J=7.9Hz),7.38-7.34(1H,m),7.24(1H,s),7.10(1H,d,J=2.0Hz),4.64(1H,t,J=5.9Hz),4.55(2H,d,J=5.9Hz),2.45(2H,q,J=7.5Hz),2.40(3H,s),2.33(3H,s),1.27-1.24(3H,m).
MSm/z(M+H):500.
1H-NMR(CDCl3)δ:7.65-7.47(11H,m),7.09(1H,d,J=2.0Hz),4.65(1H,t,J=6.3Hz),4.55(2H,d,J=5.9Hz),2.46(2H,q,J=7.5Hz),2.33(3H,s),1.26-1.21(3H,m).
MSm/z(M+H):520.
1H-NMR(CDCl3)δ:7.74-7.35(9H,m),7.08(1H,d,J=2.0Hz),4.64(1H,t,J=5.9Hz),4.55(2H,d,J=5.9Hz),2.49-2.42(2H,m),2.33(3H,s),1.27-1.24(4H,m).
MSm/z(M+H):554,556.
MSm/z(M+H):289.
1H-NMR(CDCl3)δ:8.04(1H,s),7.71(1H,s),7.63-7.60(2H,m),7.54-7.48(2H,m),7.36-7.31(5H,m),7.21-7.20(1H,m),4.80(2H,d,J=5.9Hz),4.64(1H,t,J=5.9Hz),2.39(3H,s),2.35(3H,s).
MSm/z(M+H):419.
MSm/z(M+H):249.
1H-NMR(CDCl3)δ:8.00(1H,d,J=9.2Hz),7.95-7.88(3H,m),7.76(1H,s),7.63-7.52(4H,m),7.39(1H,s),7.10(1H,d,J=2.0Hz),4.72(1H,t,J=6.3Hz),4.57(2H,d,J=5.9Hz),2.48(2H,q,J=7.7Hz),2.35(3H,s)1.28(3H,t,J=7.3Hz).
MSm/z(M+H):460.
1H-NMR(CDCl3)δ:7.81(1H,s),7.61-7.56(5H,m),7.41-7.29(3H,m),7.12(1H,d,J=2.0Hz),7.06-6.97(2H,m),4.80(1H,t,J=6.3Hz),4.58(2H,d,J=6.6Hz),3.73(3H,s),2.46(2H,q,J=7.7Hz),2.33(3H,s),1.26(3H,t,J=7.6Hz).
MSm/z(M+H):516.
1H-NMR(CDCl3)δ:7.66-7.54(6H,m),7.40-7.35(2H,m),7.16-7.11(3H,m),6.93(1H,dd,J=9.2,2.6Hz),4.62(1H,d,J=5.3Hz),4.56(2H,d,J=5.9Hz),3.86(3H,s),2.46(2H,q,J=7.5Hz),2.34(3H,s),1.26(3H,t,J=7.6Hz).
MSm/z(M+H):516.
実施例58の化合物
1H-NMR(CDCl3)δ:7.66(1H,d,J=2.0Hz),7.63-7.50(7H,m),7.34(1H,d,J=7.9Hz),7.11(1H,d,J=2.0Hz),6.98(2H,dd,J=6.6,2.0Hz),4.63(1H,d,J=5.9Hz),4.56(2H,d,J=5.9Hz),3.86(3H,s),2.46(2H,q,J=7.5Hz),2.34(3H,s),1.26(t,J=7.6Hz,3H).
MSm/z(M+H):516.
実施例59の化合物
1H-NMR(CDCl3)δ:7.69-7.68(2H,m),7.61-7.31(10H,m),7.02-6.91(5H,m),4.61(2H,d,J=5.3Hz),3.84(6H,s),2.47(2H,q,J=7.5Hz),2.34(3H,s),1.26(3H,t,J=7.6Hz).
MSm/z(M+H):588.
1H-NMR(CDCl3)δ:7.74(1H,s),7.62-7.56(6H,m),7.47-7.41(4H,m),7.10(1H,d,J=2.0Hz),4.56(3H,d,J=4.0Hz),3.37(3H,s),2.88(3H,s),2.47(2H,q,J=7.7Hz),2.34(3H,s),1.26(3H,t,J=7.9Hz).
MSm/z(M+H):593.
MSm/z(M+H):232.
1H-NMR(CDCl3)δ:9.90(1H,s),8.81(1H,d,J=1.7Hz),7.71(1H,d,J=1.8Hz),7.50-7.46(1H,brs),7.46-7.37(5H,m),5.16(2H,s),2.08(2H,q,J=7.5Hz),1.07(3H,t,J=7.6Hz).
MSm/z(M+H):497.
1H-NMR(CDCl3)δ:8.21-8.18(1H,brm),7.61(1H,d,J=2.0Hz),7.58-7.42(7H,m),7.25(1H,d,J=2.3Hz),6.66(1H,d,J=16.5Hz),2.49(2H,q,J=7.6Hz),2.46(3H,s),1.28(3H,t,J=7.6Hz).
MSm/z(M+H):407.
MSm/z(M+H):266.
1H-NMR(CDCl3)δ:9.89(1H,s),7.59-7.42(5H,m),2.53(3H,s).
1H-NMR(CDCl3)δ:7.57-7.45(5H,m),7.09-7.04(1H,m),7.08(1H,t,J=8.0Hz),6.92(1H,s),6.76(1H,d,J=7.9Hz),6.25(1H,dd,J=8.3,1.7Hz),4.45(2H,d,J=6.3Hz),4.03(1H,t,J=6.2Hz),2.41(3H,s),2.14(3H,s).
MSm/z(M+H):346.
MSm/z(M+H):325.
1H-NMR(CDCl3)δ:8.04(1H,s),7.94-7.41(13H,m),7.11(1H,d,J=1.3Hz),4.68(1H,t,J=5.9Hz),4.57(2H,d,J=5.9Hz),2.41(2H,q,J=7.6Hz),2.35(3H,s),1.28-1.19(3H,m).
MSm/z(M+H):536.
本発明の抗HIV活性の評価は、 [Journal of Clinical Microbiology, 2008, 46, 792-795]に記載の方法に従って行った。即ち、NCK45-β-Gal/SEAP細胞を96ウェル平底プレートに1×104 細胞/ウェルになるように播種し、24時間培養後、上記で合成された化合物の適宜希釈液を含む培地に置換した。続けてHIV-1 (IIIB株)を60NCKユニットで感染させた。48時間の培養後、HIV-1感染細胞をX-galで染色し、カウントした。各種化合物の抗HIV-1活性は、HIV-1感染を50%阻止する濃度、EC50 (50% effective concentration)として算出した。上記で合成された実施例化合物を用いて得られたEC50値をA(100nM以下)、B(100nM以上1000nM未満)、C(1000nM以上10000nM未満)、D(10000nM以上)として表1に示す。
Claims (11)
- 下記一般式(I)、
R1は、C3-8シクロアルキル基;置換基群αから選択される少なくとも1つの置換基を有してもよいフェニル基もしくはナフチル基;または;フェニル基を有してもよいチアゾリル基、ピリジル基、キノリル基もしくはイソキノリル基を表し、
ここで、置換基群αは、ハロゲン原子;シアノ基;ニトロ基;ハロゲン原子を有してもよいC1-6アルキル基;ハロゲン原子を有してもよいC1-6アルコキシ基(結合する炭素原子およびそれに隣接炭素原子と一緒になって、ハロゲン原子を有してもよい1,3−ベンゾジオキソール環を形成してもよい); C1-6アシルアミノ基;または;ハロゲン原子、C1-6アルキル基、C1-6アルコキシ基および(N−C1-6アルキル)C1-6アルキルスルホニルアミノ基からなる群から選択される少なくとも1つの置換基を有してもよいフェニル基、ナフチル基、ピリジル基もしくはキノリル基;であり、
R2は、水素原子、C1-3アルキル基またはフェニル基を表し、
R3は、水素原子、シアノ基またはC1-6アルコキシカルボニル基を表し、
R4およびR6は、それぞれ独立に、水素原子;ハロゲン原子;C1-6アルキル基;C1-6アシルアミノ基;C1-6アルキルアミノカルボニル基;または;C1-6アルコキシ基を有してもよいフェニル基;を表し、但し、R4およびR6の少なくとも一方は、水素原子以外の置換基であり、
R5は、水素原子、水酸基またはC1-6アルコキシ基を表し、但し、R5と、R4もしくはR6と、それぞれが結合する炭素原子と一緒になって、インダゾール環を形成してもよく、
X1は、*−CH2−NH−**、*−NH−CH2−**または*−N=N−**を表し、ここで、*は上記式中のピラゾール環側との結合、**は上記式中のフェニル環側との結合である)で表されることを特徴とするピラゾール誘導体またはその塩。 - 前記R1が、C3-8シクロアルキル基;置換基群αから選択される少なくとも1つの置換基を有してもよいフェニル基もしくはナフチル基;または;フェニル基を有してもよいチアゾリル基、ピリジル基もしくはキノリル基である請求項1に記載のピラゾール誘導体またはその塩。
- 前記置換基群αが、ハロゲン原子; C1-6アルキル基;C1-6アルコキシ基;または;ハロゲン原子、C1-6アルキル基およびC1-6アルコキシ基からなる群から選択される少なくとも1つの置換基を有してもよいフェニル基である請求項1または2に記載のピラゾール誘導体またはその塩。
- 前記R2が、水素原子またはC1-3アルキル基である請求項1〜3のうちいずれか一項に記載のピラゾール誘導体またはその塩。
- 前記R3が、水素原子またはシアノ基である請求項1〜4のうちいずれか一項に記載のピラゾール誘導体またはその塩。
- 前記R4およびR6が、それぞれ独立に、ハロゲン原子、C1-6アシルアミノ基またはC1-6アルキルアミノカルボニル基である請求項1〜5のうちいずれか一項に記載のピラゾール誘導体またはその塩。
- 前記R5が、水酸基またはC1-6アルコキシ基である請求項1〜6のうちいずれか一項に記載のピラゾール誘導体またはその塩。
- 請求項1〜8のうちいずれか一項に記載のピラゾール誘導体またはその塩を含有する医薬組成物。
- ウイルス感染症の治療および/または予防の処置のための請求項9記載の医薬組成物。
- 前記ウイルスがヒト免疫不全ウイルス(HIV)である請求項10記載の医薬組成物。
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