JP6016800B2 - 抗ノッチ１抗体 - Google Patents

抗ノッチ１抗体 Download PDF

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Publication number
JP6016800B2
JP6016800B2 JP2013543934A JP2013543934A JP6016800B2 JP 6016800 B2 JP6016800 B2 JP 6016800B2 JP 2013543934 A JP2013543934 A JP 2013543934A JP 2013543934 A JP2013543934 A JP 2013543934A JP 6016800 B2 JP6016800 B2 JP 6016800B2
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JP
Japan
Prior art keywords
antibody
notch1
seq
rat
variable region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2013543934A
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English (en)
Japanese (ja)
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JP2014503205A (ja
JP2014503205A5 (https=
Inventor
ジー． ゲレス ケネス
ジー． ゲレス ケネス
ステファン チョウ ビン−ビング
ステファン チョウ ビン−ビング
ゲナディ−ヴナ チスティアコヴァ リオウドミラ
ゲナディ−ヴナ チスティアコヴァ リオウドミラ
ギャオ イジー
ギャオ イジー
バード ジョエル
バード ジョエル
Original Assignee
ワイス・エルエルシー
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Publication of JP2014503205A publication Critical patent/JP2014503205A/ja
Publication of JP2014503205A5 publication Critical patent/JP2014503205A5/ja
Application granted granted Critical
Publication of JP6016800B2 publication Critical patent/JP6016800B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
JP2013543934A 2010-12-15 2011-12-09 抗ノッチ１抗体 Expired - Fee Related JP6016800B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42357810P 2010-12-15 2010-12-15
US61/423,578 2010-12-15
US201161552578P 2011-10-28 2011-10-28
US61/552,578 2011-10-28
PCT/IB2011/055595 WO2012080926A2 (en) 2010-12-15 2011-12-09 Anti-notch1 antibodies

Publications (3)

Publication Number Publication Date
JP2014503205A JP2014503205A (ja) 2014-02-13
JP2014503205A5 JP2014503205A5 (https=) 2015-02-05
JP6016800B2 true JP6016800B2 (ja) 2016-10-26

Family

ID=45444674

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013543934A Expired - Fee Related JP6016800B2 (ja) 2010-12-15 2011-12-09 抗ノッチ１抗体

Country Status (19)

Country Link
US (2) US9127060B2 (https=)
EP (1) EP2651977A2 (https=)
JP (1) JP6016800B2 (https=)
KR (2) KR20150088334A (https=)
CN (2) CN105884896A (https=)
AR (1) AR084315A1 (https=)
AU (2) AU2011342799B2 (https=)
BR (1) BR112013015122A2 (https=)
CA (1) CA2821130C (https=)
CO (1) CO6791565A2 (https=)
MX (1) MX346995B (https=)
NZ (1) NZ611785A (https=)
PE (1) PE20141109A1 (https=)
PH (2) PH12013501255A1 (https=)
RU (1) RU2622083C2 (https=)
SA (1) SA111330060B1 (https=)
SG (1) SG191039A1 (https=)
TW (1) TWI471333B (https=)
WO (1) WO2012080926A2 (https=)

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JP6059985B2 (ja) 2009-06-18 2017-01-11 ファイザー・インク 抗ｎｏｔｃｈ−１抗体
SG191039A1 (en) 2010-12-15 2013-08-30 Wyeth Llc Anti-notch1 antibodies
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WO2014047426A1 (en) * 2012-09-21 2014-03-27 Oncomed Pharmaceuticals, Inc. Methods of treating hematological malignancies with notch1 antibodies
HK1214282A1 (zh) 2012-11-07 2016-07-22 辉瑞公司 抗-notch3抗体及抗体-药物缀合物
CA2952315A1 (en) 2014-07-11 2016-01-14 Genentech, Inc. Notch pathway inhibition
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
CN113862300A (zh) * 2015-10-29 2021-12-31 豪夫迈·罗氏有限公司 具有共同轻链的转基因兔
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
WO2019148067A1 (en) 2018-01-26 2019-08-01 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
AU2019252878B2 (en) * 2018-04-10 2024-02-22 Stichting Sanquin Bloedvoorziening Chimeric Notch receptors
EP3856343A1 (en) * 2018-09-25 2021-08-04 Biolegend, Inc. Anti-tlr9 agents and compositions and methods for making and using the same
KR102499678B1 (ko) * 2020-02-27 2023-02-15 주식회사 베르티스 암의 진단용 조성물
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WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
CN105884896A (zh) 2016-08-24
PH12013501255A1 (en) 2013-08-05
CA2821130C (en) 2017-11-07
TW201302787A (zh) 2013-01-16
WO2012080926A3 (en) 2012-10-04
US20130266594A1 (en) 2013-10-10
JP2014503205A (ja) 2014-02-13
KR20130108430A (ko) 2013-10-02
CN103547594B (zh) 2016-05-11
EP2651977A2 (en) 2013-10-23
KR20150088334A (ko) 2015-07-31
PH12017500864A1 (en) 2017-12-11
CN103547594A (zh) 2014-01-29
TWI471333B (zh) 2015-02-01
RU2013126494A (ru) 2015-01-20
AU2016219704A1 (en) 2016-09-15
KR101580726B1 (ko) 2015-12-29
RU2622083C2 (ru) 2017-06-09
MX2013006875A (es) 2013-07-05
AU2011342799A1 (en) 2013-07-04
SG191039A1 (en) 2013-08-30
MX346995B (es) 2017-04-06
PE20141109A1 (es) 2014-09-24
US9127060B2 (en) 2015-09-08
CO6791565A2 (es) 2013-11-14
HK1194388A1 (zh) 2014-10-17
AR084315A1 (es) 2013-05-08
WO2012080926A2 (en) 2012-06-21
BR112013015122A2 (pt) 2017-05-30
NZ611785A (en) 2015-04-24
CA2821130A1 (en) 2012-06-21
SA111330060B1 (ar) 2015-06-04
AU2011342799B2 (en) 2016-06-09
US20160002331A1 (en) 2016-01-07

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