JP5999702B2 - メラノコルチン−１受容体特異的環状ペプチド - Google Patents
メラノコルチン−１受容体特異的環状ペプチド Download PDFInfo
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- JP5999702B2 JP5999702B2 JP2012540141A JP2012540141A JP5999702B2 JP 5999702 B2 JP5999702 B2 JP 5999702B2 JP 2012540141 A JP2012540141 A JP 2012540141A JP 2012540141 A JP2012540141 A JP 2012540141A JP 5999702 B2 JP5999702 B2 JP 5999702B2
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- 0 CS1(C)N*CCC1 Chemical compound CS1(C)N*CCC1 0.000 description 3
- DIHAURBCYGTGCV-UHFFFAOYSA-N CC1N=C(C)NC1 Chemical compound CC1N=C(C)NC1 DIHAURBCYGTGCV-UHFFFAOYSA-N 0.000 description 1
- JJRDXXQLVRWOCP-QLBHTZGESA-N CCCC(N[C@@H](CCC(NCC[C@@H](C(N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](Cc1ccccc1)NC([C@H](Cc1c[nH]cn1)N1)=O)=O)=O)=O)C1=O)=O Chemical compound CCCC(N[C@@H](CCC(NCC[C@@H](C(N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](Cc1ccccc1)NC([C@H](Cc1c[nH]cn1)N1)=O)=O)=O)=O)C1=O)=O JJRDXXQLVRWOCP-QLBHTZGESA-N 0.000 description 1
- ACDAGBYKCHEKFT-GHPHZMLDSA-N CCCC[C@@H](C(N/C(/C(N[C@@H](Cc1c[nH]cn1)C(N[C@H](Cc1ccccc1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CN1)C(N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)=O)=O)=O)=O)=O)=C/C1=O)=O)NC(C)=O Chemical compound CCCC[C@@H](C(N/C(/C(N[C@@H](Cc1c[nH]cn1)C(N[C@H](Cc1ccccc1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CN1)C(N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)=O)=O)=O)=O)=O)=C/C1=O)=O)NC(C)=O ACDAGBYKCHEKFT-GHPHZMLDSA-N 0.000 description 1
- QQVWMYDNTPWWPW-YFTKHDGOSA-N CCCC[C@@H](C(N[C@@H](CCC(NCCC(C(N[C@@H](Cc1c[nH]c2c1cccc2)C(N)=O)=O)NC(C(CCCNC(N)=N)NC([C@@H](Cc1ccccc1)NC([C@H](CCCN)N1)=O)=O)=O)=O)C1=O)=O)NC(C)=O Chemical compound CCCC[C@@H](C(N[C@@H](CCC(NCCC(C(N[C@@H](Cc1c[nH]c2c1cccc2)C(N)=O)=O)NC(C(CCCNC(N)=N)NC([C@@H](Cc1ccccc1)NC([C@H](CCCN)N1)=O)=O)=O)=O)C1=O)=O)NC(C)=O QQVWMYDNTPWWPW-YFTKHDGOSA-N 0.000 description 1
- XCXXRGDGAMTXLG-OHXZUYRXSA-N CCCC[C@@H](C(N[C@@H](CCC(NCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](Cc1ccccc1)NC([C@H](Cc1c[nH]cn1)N1)=O)=O)=O)=O)C1=O)=O)NC(C)=O Chemical compound CCCC[C@@H](C(N[C@@H](CCC(NCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](Cc1ccccc1)NC([C@H](Cc1c[nH]cn1)N1)=O)=O)=O)=O)C1=O)=O)NC(C)=O XCXXRGDGAMTXLG-OHXZUYRXSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26349009P | 2009-11-23 | 2009-11-23 | |
| US61/263,490 | 2009-11-23 | ||
| PCT/US2010/057699 WO2011063366A1 (en) | 2009-11-23 | 2010-11-23 | Melanocortin-1 receptor-specific cyclic peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013511553A JP2013511553A (ja) | 2013-04-04 |
| JP2013511553A5 JP2013511553A5 (https=) | 2014-01-16 |
| JP5999702B2 true JP5999702B2 (ja) | 2016-09-28 |
Family
ID=44060071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540141A Active JP5999702B2 (ja) | 2009-11-23 | 2010-11-23 | メラノコルチン−１受容体特異的環状ペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US8492517B2 (https=) |
| EP (1) | EP2504352B1 (https=) |
| JP (1) | JP5999702B2 (https=) |
| KR (1) | KR101921761B1 (https=) |
| CN (1) | CN102725305B (https=) |
| AU (2) | AU2010321738B2 (https=) |
| BR (1) | BR112012011787B1 (https=) |
| CA (1) | CA2781402C (https=) |
| EA (1) | EA021897B1 (https=) |
| IL (1) | IL219947A (https=) |
| MX (1) | MX2012005862A (https=) |
| NZ (1) | NZ599774A (https=) |
| WO (1) | WO2011063366A1 (https=) |
| ZA (1) | ZA201203330B (https=) |
Families Citing this family (37)
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|---|---|---|---|---|
| BR112012011780A2 (pt) | 2009-11-23 | 2019-09-24 | Palatin Technologies, Inc | peptídeo linear,composição farmacêutica,métodopara tratamento de umadoença,indicação,condição ou sídrome mediadsa por receptor de melanocortina emum mamífero humano ou não humano e método para tratamento de uma condição responsiva ás alterações em função de receptor de melanocortina em um mamifero humano ou não humano |
| JP5999702B2 (ja) | 2009-11-23 | 2016-09-28 | パラティン テクノロジーズ, インコーポレイテッドPalatin Technologies, Inc. | メラノコルチン−１受容体特異的環状ペプチド |
| EP2814501A4 (en) | 2012-03-13 | 2016-03-02 | Tensive Controls Inc | MELANOCORTINANALOGA WITH INCREASED EFFECTIVENESS AND TRANSPORTATION OF THEREOF |
| CA2892144C (en) * | 2012-11-21 | 2020-04-28 | University Of Cincinnati | Pharmaceutical compositions and therapeutic methods of use comprising selective agonists of melanocortin 1 receptor |
| WO2015063102A1 (en) | 2013-10-28 | 2015-05-07 | Clinuvel Ag | Alpha-msh analogues for use in bullous disease |
| WO2015063099A1 (en) | 2013-10-28 | 2015-05-07 | Clinuvel Ag | Alpha-msh analogues for use in the treatment of hailey-hailey disease |
| WO2015067503A1 (en) | 2013-11-07 | 2015-05-14 | Clinuvel Ag | Alpha-msh analogues for use in the treatment of psoriasis |
| US20160354437A1 (en) | 2014-02-13 | 2016-12-08 | Northwestern University | Compositions and methods for modulation of immune response |
| WO2016066700A1 (en) | 2014-10-28 | 2016-05-06 | Clinuvel Ag | New indication for alpha-msh analogues |
| US20170360896A1 (en) | 2014-10-28 | 2017-12-21 | Clinuvel Ag | Inflammatory disease |
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| AU2016298175B2 (en) | 2015-07-28 | 2022-01-06 | University Of Iowa Research Foundation | Compositions and methods of treating cancer |
| AU2017281940C1 (en) | 2016-06-24 | 2024-11-07 | University Of Iowa Research Foundation | Compositions and methods of treating melanoma |
| CN109803979B (zh) * | 2016-10-04 | 2023-01-31 | 帝斯曼知识产权资产管理有限公司 | 黑皮质素-1-受体激动剂 |
| ES2985745T3 (es) * | 2017-02-01 | 2024-11-07 | Vallaurix Mc S A R L | Análogos de alfa-MSH utilizados en el tratamiento de Xeroderma Pigmentosum |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| CA3095036A1 (en) * | 2018-03-23 | 2019-09-26 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery |
| GB201810327D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to IL-17 |
| GB201810325D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to PSMA |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201810316D0 (en) * | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| JP7657151B2 (ja) | 2018-11-27 | 2025-04-04 | ノバルティス アーゲー | 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド |
| PY1998404A (es) | 2018-11-27 | 2021-06-17 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) para el tratamiento de trastornos metabólicos |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| WO2020128527A1 (en) | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| CN115515617A (zh) * | 2020-02-03 | 2022-12-23 | 帕拉丁科技公司 | 二胺连接的受体特异性环状肽 |
| US11529335B2 (en) | 2020-07-31 | 2022-12-20 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
| AU2021322934A1 (en) | 2020-08-03 | 2023-03-30 | Bicycletx Limited | Peptide-based linkers |
| WO2023091689A1 (en) | 2021-11-19 | 2023-05-25 | University Of Iowa Research Foundation | Combined use of mcr1-directed radiotherapy and immune checkpoint inhibition in the treatment of melanoma |
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| GB9827500D0 (en) | 1998-12-14 | 1999-02-10 | Wapharm Ab | Compounds for control of eating, growth and body weight |
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