JP5993875B2 - 縮合アミノジヒドロチアジン誘導体の合成に有用な方法および化合物 - Google Patents

縮合アミノジヒドロチアジン誘導体の合成に有用な方法および化合物 Download PDF

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JP5993875B2
JP5993875B2 JP2013550622A JP2013550622A JP5993875B2 JP 5993875 B2 JP5993875 B2 JP 5993875B2 JP 2013550622 A JP2013550622 A JP 2013550622A JP 2013550622 A JP2013550622 A JP 2013550622A JP 5993875 B2 JP5993875 B2 JP 5993875B2
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JP2014503001A (ja
JP2014503001A5 (enExample
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ミタセフ，ブランコ
キム，デシク
チャン，フイミン
シュナダーベック，マシュー・ジェイ
ファージング，クリストファー・エヌ
一洋 吉澤
一洋 吉澤
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Eisai R&D Management Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2013550622A 2011-01-21 2012-01-20 縮合アミノジヒドロチアジン誘導体の合成に有用な方法および化合物 Expired - Fee Related JP5993875B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161434849P 2011-01-21 2011-01-21
US61/434,849 2011-01-21
PCT/US2012/022053 WO2012100179A1 (en) 2011-01-21 2012-01-20 Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

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JP2016041508A Division JP6087005B2 (ja) 2011-01-21 2016-03-03 縮合アミノジヒドロチアジン誘導体の合成に有用な方法および化合物

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JP2014503001A JP2014503001A (ja) 2014-02-06
JP2014503001A5 JP2014503001A5 (enExample) 2016-01-28
JP5993875B2 true JP5993875B2 (ja) 2016-09-14

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JP2013550622A Expired - Fee Related JP5993875B2 (ja) 2011-01-21 2012-01-20 縮合アミノジヒドロチアジン誘導体の合成に有用な方法および化合物
JP2016041508A Expired - Fee Related JP6087005B2 (ja) 2011-01-21 2016-03-03 縮合アミノジヒドロチアジン誘導体の合成に有用な方法および化合物

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US (3) US8426584B2 (enExample)
EP (1) EP2665716B1 (enExample)
JP (2) JP5993875B2 (enExample)
CN (2) CN103502231A (enExample)
BR (1) BR112013016241A2 (enExample)
CA (1) CA2814014A1 (enExample)
ES (1) ES2624288T3 (enExample)
IL (1) IL226405A0 (enExample)
MX (1) MX2013005115A (enExample)
RU (1) RU2013138226A (enExample)
SG (2) SG191710A1 (enExample)
WO (1) WO2012100179A1 (enExample)

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BRPI0906962B8 (pt) 2008-01-18 2021-05-25 Eisai R&D Man Co Ltd composto de aminodiidrotiazina fundido
GB0912777D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydropyrimidone derivatives
GB0912778D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
GB201100181D0 (en) 2011-01-06 2011-02-23 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101140D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101139D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
UY34278A (es) 2011-08-25 2013-04-05 Novartis Ag Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades
GB201212816D0 (en) * 2012-07-19 2012-09-05 Eisai Ltd Novel compounds
TWI639607B (zh) 2013-06-18 2018-11-01 美國禮來大藥廠 Ｂａｃｅ抑制劑
CA2963761C (en) * 2014-10-10 2023-10-17 Eisai R&D Management Co., Ltd. Pharmaceutical composition of fused aminodihydrothiazine derivative
KR102630042B1 (ko) 2016-10-27 2024-01-29 에자이 알앤드디 매니지먼트 가부시키가이샤 알츠하이머병의 치료를 위한 항-a베타 원시섬유 항체 및 베타-세크레타제 bace1 억제제를 포함하는 조성물
WO2020023530A2 (en) 2018-07-24 2020-01-30 Eisai R&D Management Co., Ltd. Methods of treatment and prevention of alzheimer's disease

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AU2001258771A1 (en) 2000-05-19 2001-11-26 Takeda Chemical Industries Ltd. -secretase inhibitors
US6562783B2 (en) 2001-05-30 2003-05-13 Neurologic, Inc. Phosphinylmethyl and phosphorylmethyl succinic and glutauric acid analogs as β-secretase inhibitors
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MX2013005115A (es) 2013-06-03
US8802871B2 (en) 2014-08-12
JP2016121177A (ja) 2016-07-07
BR112013016241A2 (pt) 2016-07-12
RU2013138226A (ru) 2015-02-27
EP2665716B1 (en) 2017-03-08
CN106632401A (zh) 2017-05-10
WO2012100179A1 (en) 2012-07-26
US8426584B2 (en) 2013-04-23
JP6087005B2 (ja) 2017-03-01
CA2814014A1 (en) 2012-07-26
JP2014503001A (ja) 2014-02-06
ES2624288T3 (es) 2017-07-13
US20130197244A1 (en) 2013-08-01
IL226405A0 (en) 2013-07-31
CN106632401B (zh) 2020-12-29
US20120190848A1 (en) 2012-07-26
US20140309429A1 (en) 2014-10-16
SG191710A1 (en) 2013-08-30
US8962858B2 (en) 2015-02-24
EP2665716A1 (en) 2013-11-27
CN103502231A (zh) 2014-01-08
SG10201601516QA (en) 2016-03-30

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