CN103502231A - 用于稠合氨基二氢噻嗪衍生物的合成的方法和化合物 - Google Patents

用于稠合氨基二氢噻嗪衍生物的合成的方法和化合物 Download PDF

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Publication number
CN103502231A
CN103502231A CN201280004193.7A CN201280004193A CN103502231A CN 103502231 A CN103502231 A CN 103502231A CN 201280004193 A CN201280004193 A CN 201280004193A CN 103502231 A CN103502231 A CN 103502231A
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China
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compound
salt
mixture
formula
alkyl
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English (en)
Chinese (zh)
Inventor
B.米塔塞夫
金大式
张慧明
M.J.施纳德贝克
C.N.法兴
K.尤施扎瓦
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Sanitary Material R&d Management Co ltd
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Sanitary Material R&d Management Co ltd
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Priority to CN201610875412.9A priority Critical patent/CN106632401B/zh
Publication of CN103502231A publication Critical patent/CN103502231A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201280004193.7A 2011-01-21 2012-01-20 用于稠合氨基二氢噻嗪衍生物的合成的方法和化合物 Pending CN103502231A (zh)

Priority Applications (1)

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CN201610875412.9A CN106632401B (zh) 2011-01-21 2012-01-20 用于稠合氨基二氢噻嗪衍生物的合成的方法和化合物

Applications Claiming Priority (3)

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US201161434849P 2011-01-21 2011-01-21
US61/434,849 2011-01-21
PCT/US2012/022053 WO2012100179A1 (en) 2011-01-21 2012-01-20 Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

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CN201610875412.9A Expired - Fee Related CN106632401B (zh) 2011-01-21 2012-01-20 用于稠合氨基二氢噻嗪衍生物的合成的方法和化合物

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Country Status (12)

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US (3) US8426584B2 (enExample)
EP (1) EP2665716B1 (enExample)
JP (2) JP5993875B2 (enExample)
CN (2) CN103502231A (enExample)
BR (1) BR112013016241A2 (enExample)
CA (1) CA2814014A1 (enExample)
ES (1) ES2624288T3 (enExample)
IL (1) IL226405A0 (enExample)
MX (1) MX2013005115A (enExample)
RU (1) RU2013138226A (enExample)
SG (2) SG191710A1 (enExample)
WO (1) WO2012100179A1 (enExample)

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GB0912778D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
GB201100181D0 (en) 2011-01-06 2011-02-23 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101139D0 (en) * 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101140D0 (en) * 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
UY34278A (es) 2011-08-25 2013-04-05 Novartis Ag Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades
GB201212816D0 (en) * 2012-07-19 2012-09-05 Eisai Ltd Novel compounds
JO3318B1 (ar) 2013-06-18 2019-03-13 Lilly Co Eli مثبطات bace
CN110214146B (zh) * 2016-10-27 2023-08-29 卫材研究发展管理有限公司 用于治疗阿尔茨海默病的含有抗Aβ初原纤维抗体和β-分泌酶BACE1抑制剂的组合物
US20210324056A1 (en) 2018-07-24 2021-10-21 Eisai R&D Management Co., Ltd. Methods of treatment and prevention of alzheimer's disease

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CN107106568A (zh) * 2014-10-10 2017-08-29 卫材R&D管理有限公司 稠合氨基二氢噻嗪衍生物的药物组合物
CN107106568B (zh) * 2014-10-10 2023-09-26 卫材R&D管理有限公司 稠合氨基二氢噻嗪衍生物的药物组合物

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JP2016121177A (ja) 2016-07-07
US20140309429A1 (en) 2014-10-16
MX2013005115A (es) 2013-06-03
IL226405A0 (en) 2013-07-31
WO2012100179A1 (en) 2012-07-26
JP6087005B2 (ja) 2017-03-01
CA2814014A1 (en) 2012-07-26
US8802871B2 (en) 2014-08-12
RU2013138226A (ru) 2015-02-27
ES2624288T3 (es) 2017-07-13
SG10201601516QA (en) 2016-03-30
EP2665716A1 (en) 2013-11-27
CN106632401B (zh) 2020-12-29
US20120190848A1 (en) 2012-07-26
JP5993875B2 (ja) 2016-09-14
JP2014503001A (ja) 2014-02-06
SG191710A1 (en) 2013-08-30
BR112013016241A2 (pt) 2016-07-12
CN106632401A (zh) 2017-05-10
US8426584B2 (en) 2013-04-23
US8962858B2 (en) 2015-02-24
EP2665716B1 (en) 2017-03-08
US20130197244A1 (en) 2013-08-01

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Application publication date: 20140108