JP5988436B2 - 腫瘍の診断と治療のための組成物と方法 - Google Patents

腫瘍の診断と治療のための組成物と方法 Download PDF

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JP5988436B2
JP5988436B2 JP2012554083A JP2012554083A JP5988436B2 JP 5988436 B2 JP5988436 B2 JP 5988436B2 JP 2012554083 A JP2012554083 A JP 2012554083A JP 2012554083 A JP2012554083 A JP 2012554083A JP 5988436 B2 JP5988436 B2 JP 5988436B2
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antibody
polypeptide
tat
seq
cells
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JP2013520174A5 (enExample
JP2013520174A (ja
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ポール ポラキス，
ポール ポラキス，
ジョティー アスンディ，
ジョティー アスンディ，
ロン ファイアスタイン，
ロン ファイアスタイン，
ロバート エフ． ケリー，
ロバート エフ． ケリー，
クリスタ マカッチャン，
クリスタ マカッチャン，
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/80—Vaccine for a specifically defined cancer
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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JP2012554083A 2010-02-23 2011-02-22 腫瘍の診断と治療のための組成物と方法 Expired - Fee Related JP5988436B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30733810P 2010-02-23 2010-02-23
US61/307,338 2010-02-23
US30879110P 2010-02-26 2010-02-26
US61/308,791 2010-02-26
PCT/US2011/025642 WO2011106297A2 (en) 2010-02-23 2011-02-22 Compositions and methods for the diagnosis and treatment of tumor

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JP2013520174A JP2013520174A (ja) 2013-06-06
JP2013520174A5 JP2013520174A5 (enExample) 2014-04-10
JP5988436B2 true JP5988436B2 (ja) 2016-09-07

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US (2) US8877897B2 (enExample)
EP (1) EP2538981B1 (enExample)
JP (1) JP5988436B2 (enExample)
KR (1) KR20130004579A (enExample)
CN (1) CN102985113B (enExample)
AR (1) AR080243A1 (enExample)
AU (1) AU2011221226A1 (enExample)
BR (1) BR112012020373A8 (enExample)
CA (1) CA2787657A1 (enExample)
CL (2) CL2012002328A1 (enExample)
CO (1) CO6571892A2 (enExample)
CR (1) CR20120473A (enExample)
EC (1) ECSP12012165A (enExample)
IL (1) IL220974A0 (enExample)
MA (1) MA34057B1 (enExample)
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NZ (1) NZ601293A (enExample)
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PH (1) PH12012501680A1 (enExample)
RU (1) RU2595389C2 (enExample)
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