JP5948332B2 - Ｍｌｌ再構成白血病の治療法 - Google Patents

Ｍｌｌ再構成白血病の治療法 Download PDF

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JP5948332B2
JP5948332B2 JP2013528366A JP2013528366A JP5948332B2 JP 5948332 B2 JP5948332 B2 JP 5948332B2 JP 2013528366 A JP2013528366 A JP 2013528366A JP 2013528366 A JP2013528366 A JP 2013528366A JP 5948332 B2 JP5948332 B2 JP 5948332B2
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cell
mll
romidepsin
cells
hdac inhibitor
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JP2013540734A (ja
JP2013540734A5 (enExample
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スタム ロナルド
スタム ロナルド
ジェイ．ピー．エム．ストウムペル ドミニクエ
ジェイ．ピー．エム．ストウムペル ドミニクエ
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Celgene Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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JP2013528366A 2010-09-13 2011-09-12 Ｍｌｌ再構成白血病の治療法 Active JP5948332B2 (ja)

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US38245910P 2010-09-13 2010-09-13
US61/382,459 2010-09-13
PCT/US2011/051173 WO2012037008A2 (en) 2010-09-13 2011-09-12 Therapy for mll-rearranged leukemia

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JP2013540734A JP2013540734A (ja) 2013-11-07
JP2013540734A5 JP2013540734A5 (enExample) 2015-01-08
JP5948332B2 true JP5948332B2 (ja) 2016-07-06

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US (1) US8859502B2 (enExample)
EP (1) EP2616054A2 (enExample)
JP (1) JP5948332B2 (enExample)
WO (1) WO2012037008A2 (enExample)

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AU2007342030B2 (en) * 2006-12-29 2013-08-15 Celgene Corporation Romidepsin-based treatments for cancer
MX2015016114A (es) * 2013-05-24 2016-07-21 4Sc Ag Biomarcadores de expresion de gen y sus usos para aplicacion de diagnosis y prognosis en pacientes potencialmente en necesidad de tratamiento de inhibidor de histona desacetilasa (hdac).
NZ630311A (en) * 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
GB2530470A (en) * 2014-04-17 2016-03-30 Imp Innovations Ltd Methods
EA201790142A1 (ru) 2014-07-07 2017-07-31 Эситайлон Фармасьютикалз, Инк. Лечение лейкоза ингибиторами гистондеацетилазы
JP7538241B2 (ja) * 2020-03-11 2024-08-21 サムスン ライフ パブリック ウェルフェア ファウンデーション ホスホジエステラーゼ５抑制剤を含む、ｎｋ－ｔ細胞リンパ腫またはｎｋ細胞白血病予防または治療用薬学的組成物

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