JP5940245B2 - 安定な６‐メトキシ‐２’、３’‐ジデオキシグアノシン及びその製造方法、並びにそれを含む医薬組成物 - Google Patents
安定な６‐メトキシ‐２’、３’‐ジデオキシグアノシン及びその製造方法、並びにそれを含む医薬組成物 Download PDFInfo
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- JP5940245B2 JP5940245B2 JP2010542498A JP2010542498A JP5940245B2 JP 5940245 B2 JP5940245 B2 JP 5940245B2 JP 2010542498 A JP2010542498 A JP 2010542498A JP 2010542498 A JP2010542498 A JP 2010542498A JP 5940245 B2 JP5940245 B2 JP 5940245B2
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- JP
- Japan
- Prior art keywords
- dideoxyguanosine
- methoxy
- weight ratio
- producing
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810019227.5 | 2008-01-17 | ||
| CN2008100192275A CN101220071B (zh) | 2008-01-17 | 2008-01-17 | 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物 |
| PCT/CN2008/072646 WO2009089702A1 (en) | 2008-01-17 | 2008-10-10 | Stable 6-methoxy-2',3'-dideoxyguanosine, method for preparing the same and pharmaceutical composition containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011509946A JP2011509946A (ja) | 2011-03-31 |
| JP2011509946A5 JP2011509946A5 (enExample) | 2015-12-03 |
| JP5940245B2 true JP5940245B2 (ja) | 2016-06-29 |
Family
ID=39630174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542498A Active JP5940245B2 (ja) | 2008-01-17 | 2008-10-10 | 安定な６‐メトキシ‐２’、３’‐ジデオキシグアノシン及びその製造方法、並びにそれを含む医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8349811B2 (enExample) |
| EP (1) | EP2241571B1 (enExample) |
| JP (1) | JP5940245B2 (enExample) |
| CN (1) | CN101220071B (enExample) |
| WO (1) | WO2009089702A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101220071B (zh) | 2008-01-17 | 2011-04-06 | 南京长澳医药科技有限公司 | 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物 |
| CN102070691B (zh) * | 2010-12-22 | 2012-09-19 | 南京长澳医药科技有限公司 | 一种美他卡韦晶型,其制备方法以及包含它的药物组合物 |
| CN102552158B (zh) * | 2010-12-22 | 2016-04-27 | 广州一品红制药有限公司 | 美他卡韦肠溶微丸及其制备方法 |
| CN103360448A (zh) * | 2012-04-09 | 2013-10-23 | 南京长澳医药科技有限公司 | 美他卡韦乙醇溶剂化合物的单晶晶型，及制备方法 |
| MX387008B (es) * | 2013-04-08 | 2025-03-19 | Univ Texas | Compuestos de alteración de telómero mediada por telomerasa. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185437A (en) * | 1987-04-09 | 1993-02-09 | Burroughs Wellcome Co. | Therapeutic nucleosides |
| IL86007A0 (en) * | 1987-04-09 | 1988-09-30 | Wellcome Found | 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them |
| DE3739366A1 (de) * | 1987-04-10 | 1988-10-27 | Boehringer Mannheim Gmbh | Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel |
| WO1990006312A1 (de) | 1988-11-29 | 1990-06-14 | Institut Für Molekularbiologie Und Analytik (Ima) Gmbh | 2', 3'-didesoxyribofuranoside und ein verfahren zu ihrer herstellung |
| PT95516A (pt) * | 1989-10-06 | 1991-08-14 | Wellcome Found | Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos |
| CN1309732C (zh) | 2002-10-28 | 2007-04-11 | 南京长澳医药科技有限公司 | 6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法 |
| CN1293884C (zh) | 2002-10-29 | 2007-01-10 | 南京长澳医药科技有限公司 | 6－甲氧基双脱氧鸟苷在制备抗乙肝药物中的应用 |
| CN101147728A (zh) | 2007-10-26 | 2008-03-26 | 中国药科大学 | 6-甲氧基双脱氧鸟苷长循环脂质体制剂及制备方法 |
| CN101220071B (zh) | 2008-01-17 | 2011-04-06 | 南京长澳医药科技有限公司 | 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物 |
-
2008
- 2008-01-17 CN CN2008100192275A patent/CN101220071B/zh active Active
- 2008-10-10 EP EP08871110.6A patent/EP2241571B1/en active Active
- 2008-10-10 US US12/743,898 patent/US8349811B2/en active Active
- 2008-10-10 JP JP2010542498A patent/JP5940245B2/ja active Active
- 2008-10-10 WO PCT/CN2008/072646 patent/WO2009089702A1/zh not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009089702A1 (en) | 2009-07-23 |
| EP2241571A1 (en) | 2010-10-20 |
| US20100311681A1 (en) | 2010-12-09 |
| JP2011509946A (ja) | 2011-03-31 |
| US8349811B2 (en) | 2013-01-08 |
| CN101220071B (zh) | 2011-04-06 |
| CN101220071A (zh) | 2008-07-16 |
| EP2241571A4 (en) | 2012-01-25 |
| EP2241571B1 (en) | 2017-01-18 |
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