JP5936821B2 - チロシンキナーゼ型受容体ｋｉｔによって媒介される増殖性疾患のイマチニブによる処置を最適化する方法 - Google Patents

チロシンキナーゼ型受容体ｋｉｔによって媒介される増殖性疾患のイマチニブによる処置を最適化する方法 Download PDF

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JP5936821B2
JP5936821B2 JP2010544393A JP2010544393A JP5936821B2 JP 5936821 B2 JP5936821 B2 JP 5936821B2 JP 2010544393 A JP2010544393 A JP 2010544393A JP 2010544393 A JP2010544393 A JP 2010544393A JP 5936821 B2 JP5936821 B2 JP 5936821B2
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imatinib
kit
patient
treatment
cmin
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JP2011510086A (ja
JP2011510086A5 (https=
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ワン，ヤンフェン
ウェラ，エリザベス
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ノバルティス アーゲー
ノバルティス アーゲー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5753—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the stomach or small intestine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010544393A 2008-01-23 2009-01-21 チロシンキナーゼ型受容体ｋｉｔによって媒介される増殖性疾患のイマチニブによる処置を最適化する方法 Expired - Fee Related JP5936821B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2294508P 2008-01-23 2008-01-23
US61/022,945 2008-01-23
PCT/US2009/031510 WO2009094360A1 (en) 2008-01-23 2009-01-21 Method of optimizing the treatment of proliferative diseases mediated by the tyrosine kinase receptor kit with imatinib

Related Child Applications (1)

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JP2013261728A Division JP5881671B2 (ja) 2008-01-23 2013-12-18 チロシンキナーゼ型受容体ｋｉｔによって媒介される増殖性疾患のイマチニブによる処置を最適化する方法

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JP2011510086A JP2011510086A (ja) 2011-03-31
JP2011510086A5 JP2011510086A5 (https=) 2013-05-09
JP5936821B2 true JP5936821B2 (ja) 2016-06-22

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JP2010544393A Expired - Fee Related JP5936821B2 (ja) 2008-01-23 2009-01-21 チロシンキナーゼ型受容体ｋｉｔによって媒介される増殖性疾患のイマチニブによる処置を最適化する方法
JP2013261728A Expired - Fee Related JP5881671B2 (ja) 2008-01-23 2013-12-18 チロシンキナーゼ型受容体ｋｉｔによって媒介される増殖性疾患のイマチニブによる処置を最適化する方法

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JP2013261728A Expired - Fee Related JP5881671B2 (ja) 2008-01-23 2013-12-18 チロシンキナーゼ型受容体ｋｉｔによって媒介される増殖性疾患のイマチニブによる処置を最適化する方法

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US (3) US20100298338A1 (https=)
EP (1) EP2237783B1 (https=)
JP (2) JP5936821B2 (https=)
KR (1) KR101579993B1 (https=)
CN (1) CN101951910B (https=)
AU (1) AU2009206566A1 (https=)
BR (1) BRPI0906504A2 (https=)
CA (1) CA2712087A1 (https=)
ES (1) ES2526537T3 (https=)
MX (1) MX2010008103A (https=)
PL (1) PL2237783T3 (https=)
PT (1) PT2237783E (https=)
RU (1) RU2537223C2 (https=)
WO (1) WO2009094360A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2753391C1 (ru) * 2020-09-29 2021-08-13 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ оптимизации лечения стромальных опухолей желудочно-кишечного тракта

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125875B2 (en) * 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
GB0127922D0 (en) * 2001-11-21 2002-01-16 Novartis Ag Organic compounds
RU2362562C2 (ru) * 2003-11-18 2009-07-27 Новартис Аг Ингибиторы мутантной формы киназы kit
US7329495B2 (en) * 2004-06-09 2008-02-12 Board Of Regents, The University Of Texas System Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
MY148074A (en) * 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
WO2008036792A2 (en) * 2006-09-22 2008-03-27 Novartis Ag Method of optimizing the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitors
NZ577320A (en) 2006-11-07 2012-01-12 Novartis Ag CRYSTALLINE FORMS OF ALISKIREN HEMIFUMARATE N-(3-amino-2,2-dimethyl-3-oxopropyl)-2,7-di(1-methylethyl)-4-hydroxy-5-amino-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide

Also Published As

Publication number Publication date
JP5881671B2 (ja) 2016-03-09
KR101579993B1 (ko) 2015-12-23
RU2537223C2 (ru) 2014-12-27
JP2011510086A (ja) 2011-03-31
BRPI0906504A2 (pt) 2015-07-14
EP2237783B1 (en) 2014-11-19
US9763944B2 (en) 2017-09-19
CN101951910A (zh) 2011-01-19
US20160045501A1 (en) 2016-02-18
EP2237783A1 (en) 2010-10-13
AU2009206566A1 (en) 2009-07-30
WO2009094360A1 (en) 2009-07-30
PT2237783E (pt) 2014-12-23
ES2526537T3 (es) 2015-01-13
US20100298338A1 (en) 2010-11-25
CA2712087A1 (en) 2009-07-30
US20170035757A1 (en) 2017-02-09
MX2010008103A (es) 2010-08-23
RU2010134916A (ru) 2012-02-27
JP2014094946A (ja) 2014-05-22
CN101951910B (zh) 2013-07-17
PL2237783T3 (pl) 2015-04-30
KR20100105778A (ko) 2010-09-29

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