JP5931897B2 - マイクロｒｎａ−２１、ミスマッチ修復および結腸直腸癌に関連する物質および方法 - Google Patents

マイクロｒｎａ−２１、ミスマッチ修復および結腸直腸癌に関連する物質および方法 Download PDF

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JP5931897B2
JP5931897B2 JP2013538930A JP2013538930A JP5931897B2 JP 5931897 B2 JP5931897 B2 JP 5931897B2 JP 2013538930 A JP2013538930 A JP 2013538930A JP 2013538930 A JP2013538930 A JP 2013538930A JP 5931897 B2 JP5931897 B2 JP 5931897B2
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mir
mirna
hmsh2
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JP2014500871A5 (enExample
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クローセ，カーロ・エム
ヴァレーリ，ニコラ
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Ohio State University Research Foundation
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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  • Urology & Nephrology (AREA)
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  • Food Science & Technology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2013538930A 2010-11-12 2011-11-11 マイクロｒｎａ−２１、ミスマッチ修復および結腸直腸癌に関連する物質および方法 Expired - Fee Related JP5931897B2 (ja)

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US41318010P 2010-11-12 2010-11-12
US61/413,180 2010-11-12
PCT/US2011/060349 WO2012065049A1 (en) 2010-11-12 2011-11-11 Materials and methods related to microrna-21, mismatch repair, and colorectal cancer

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JP2014500871A JP2014500871A (ja) 2014-01-16
JP2014500871A5 JP2014500871A5 (enExample) 2014-09-25
JP5931897B2 true JP5931897B2 (ja) 2016-06-08

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US (2) US8946187B2 (enExample)
EP (1) EP2637673B1 (enExample)
JP (1) JP5931897B2 (enExample)
CN (1) CN103648505B (enExample)
AU (1) AU2011326032B2 (enExample)
CA (1) CA2816603A1 (enExample)
ES (1) ES2606146T3 (enExample)
WO (1) WO2012065049A1 (enExample)

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