JP5922128B2 - ヒスタミンｈ４受容体リガンドとしてのベンザゾール誘導体 - Google Patents

ヒスタミンｈ４受容体リガンドとしてのベンザゾール誘導体 Download PDF

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JP5922128B2
JP5922128B2 JP2013529673A JP2013529673A JP5922128B2 JP 5922128 B2 JP5922128 B2 JP 5922128B2 JP 2013529673 A JP2013529673 A JP 2013529673A JP 2013529673 A JP2013529673 A JP 2013529673A JP 5922128 B2 JP5922128 B2 JP 5922128B2
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methyl
methylpiperidin
yloxy
benzimidazol
phenyl
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JP2013537898A5 (Direct
JP2013537898A (ja
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イザベル・ベルビ−ベルトラン
グザヴィエ・ビヨ
ティエリー・カルメル
マルク・カペ
ドゥニ・ダンヴィ
ステファーヌ・クリーフ
オリヴィエ・ラビウ
ジャンヌ−マリー・ルコント
ニコラ・ルヴォワン
グザヴィエ・リニョ
フィリップ・ロベール
ジャン−シャルル・シュヴァルツ
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ビオポロジェ
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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JP2013529673A 2010-09-27 2011-09-27 ヒスタミンｈ４受容体リガンドとしてのベンザゾール誘導体 Active JP5922128B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10306038.0 2010-09-27
EP20100306038 EP2447263A1 (en) 2010-09-27 2010-09-27 Benzazole derivatives as histamine H4 receptor ligands
PCT/EP2011/066782 WO2012041860A1 (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands

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JP2013537898A JP2013537898A (ja) 2013-10-07
JP2013537898A5 JP2013537898A5 (Direct) 2016-04-14
JP5922128B2 true JP5922128B2 (ja) 2016-05-24

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US (2) US8802664B2 (Direct)
EP (2) EP2447263A1 (Direct)
JP (1) JP5922128B2 (Direct)
CN (1) CN103228643B (Direct)
CA (1) CA2812686C (Direct)
CY (1) CY1117416T1 (Direct)
DK (1) DK2621916T3 (Direct)
ES (1) ES2571335T3 (Direct)
HR (1) HRP20160398T1 (Direct)
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Families Citing this family (9)

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CN103648639B (zh) 2011-04-19 2016-10-12 沙特基础工业公司 碳负载的钴和钼催化剂
JP6180514B2 (ja) * 2012-05-04 2017-08-16 ノバルティス アーゲー 補体経路モジュレーターおよびその使用
EP2671870A1 (en) * 2012-06-05 2013-12-11 Bioprojet Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications
PL2858647T3 (pl) 2012-06-08 2018-10-31 Sensorion Inhibitory receptora h4 do leczenia szumów usznych
CN106800524A (zh) * 2015-02-13 2017-06-06 佛山市赛维斯医药科技有限公司 一类含双酰肼和萘基结构的化合物、制备方法及其用途
CN118684652A (zh) * 2017-09-11 2024-09-24 克鲁松制药公司 SHP2的八氢环戊二烯并[c]吡咯别构抑制剂
DK3486243T3 (da) * 2017-11-15 2020-06-08 Bioprojet Soc Civ Benzimidazolderivater som dobbelthistamin H1 og histamin H4-receptorligander
CN113278409B (zh) * 2021-06-22 2022-04-29 西南石油大学 一种高温酸化缓蚀剂
CN119086786B (zh) * 2024-11-08 2025-02-14 南京恒远科技开发有限公司 叔丁基-(s)-[2-(2-氰基-4,4-二氟吡咯烷-1-基)-2-氧乙基]氨基甲酸酯光学异构体的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI803127L (fi) * 1979-10-03 1981-04-04 Glaxo Group Ltd Heterocykliska foereningar
IT1154888B (it) * 1980-11-12 1987-01-21 Menarini Sas Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
JPH05339266A (ja) * 1992-06-05 1993-12-21 Kaken Pharmaceut Co Ltd 新規なピペリジン誘導体
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
CN1596255A (zh) 2001-12-21 2005-03-16 阿诺麦德股份有限公司 具有强效的与趋化因子受体结合的杂环化合物
JP4767857B2 (ja) * 2003-09-30 2011-09-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ベンゾイミダゾール化合物
NZ546259A (en) * 2003-09-30 2009-05-31 Janssen Pharmaceutica Nv Benzoimidazole compounds
EP1642577A1 (en) * 2004-09-07 2006-04-05 Laboratorios del Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of central neuropathic pain
US7557103B2 (en) 2005-04-05 2009-07-07 Eli Lilly And Company Imidazopyridazine compounds
CA2707441A1 (en) 2008-01-09 2009-07-16 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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JP2013537898A (ja) 2013-10-07
RS54737B1 (sr) 2016-10-31
DK2621916T3 (en) 2016-04-18
EP2447263A1 (en) 2012-05-02
MX2013003479A (es) 2013-06-24
CN103228643B (zh) 2015-11-25
CA2812686A1 (en) 2012-04-05
WO2012041860A1 (en) 2012-04-05
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US20130231329A1 (en) 2013-09-05
HRP20160398T1 (hr) 2016-05-20
CN103228643A (zh) 2013-07-31
EP2621916A1 (en) 2013-08-07
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