JP5917164B2 - 抗菌・殺菌剤及びアトピー性皮膚炎の治療・予防剤 - Google Patents
抗菌・殺菌剤及びアトピー性皮膚炎の治療・予防剤 Download PDFInfo
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- JP5917164B2 JP5917164B2 JP2012012673A JP2012012673A JP5917164B2 JP 5917164 B2 JP5917164 B2 JP 5917164B2 JP 2012012673 A JP2012012673 A JP 2012012673A JP 2012012673 A JP2012012673 A JP 2012012673A JP 5917164 B2 JP5917164 B2 JP 5917164B2
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Description
上記抗菌・殺菌剤は、黄色ブドウ球菌を増殖抑制及び/又は殺菌するために用いられるものであってもよい。
このような抗菌・殺菌剤は、洗浄剤、化粧料、アトピー性皮膚炎、ニキビの予防・治療剤等の皮膚外用剤、各種食品等に配合することができる。
更に、本発明の抗菌・殺菌剤は、化粧料等の皮膚外用剤だけではなく、医薬品、健康食品、家庭用や業務用の抗菌剤、殺菌剤等において使用することができる。
上記薬効成分としては、アボガドエキス、アマチャエキス、アルテアエキス、アルニカエキス、アンズエキス、アンズ核エキス、イチョウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、エチナシ葉エキス、オウバクエキス、オオムギエキス、オランダカラシエキス、オレンジエキス、加水分解コムギ末、加水分解シルク、カモミラエキス、カロットエキス、カワラヨモギエキス、カルカデエキス、キウイエキス、キナエキス、キューカンバーエキス、グアノシン、クマザサエキス、クルミエキス、グレープフルーツエキス、クレマティスエキス、酵母エキス、コンフリーエキス、コケモモエキス、サイコエキス、サイタイ抽出液、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、シイタケエキス、ジオウエキス、シコンエキス、シナノキエキス、シモツケソウエキス、ショウブ根エキス、シラカバエキス、スギナエキス、スイカズラエキス、セイヨウキズナエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、ゼニアオイエキス、センブリエキス、タイソウエキス、タイムエキス、チョウジエキス、チガヤエキス、トマトエキス、納豆エキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、パセリエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、フキタンポポエキス、フキノ蜂蜜、トウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、プロポリス、ヘチマエキス、ペパーミントエキス、ボダイジュエキス、ホップエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、モモ葉エキス、ヤグルマギクエキス、ユーカリエキス、リンゴエキス、レタスエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス等が挙げられる。
ハバルディア・メキシカーナ樹皮粉末500gに対し、15L純水を加えて、低温(4℃)、5日間抽出したのち、遠心分離(5000rpm×30分間)によって沈殿を除去し、上澄みを凍結乾燥し、ハバルディア・メキシカーナ樹皮の水抽出物(81g)を得た。
微量液体希釈法により、ハバルディア・メキシカーナ抽出物の黄色ブドウ球菌に対する最小発育阻止濃度を測定した。黄色ブドウ球菌をソイビーンカゼインダイジェスト培地に接種し32℃×24時間培養後、菌数を5.0×105cfu/mLに調整して試験菌液とした。
ハバルディア・メキシカーナ樹皮の抽出物は最高濃度を0.2質量%として調整し2倍希釈系列を作成した。
32℃、24時間培養後、培養液をソイビーンカセインダイジェスト寒天培地に移植し、更に32℃、24時間培養して、菌の発育を観察し最小発育阻止濃度を判定した。
黄色ブドウ球菌に対して、ハバルディア・メキシカーナ樹皮の抽出物の最小発育阻止濃度が500ppmであった。上記結果から、ハバルディア・メキシカーナ樹皮の抽出物は、優れた殺菌効果を有するものであることが明らかになった。
常法に準じて純水で0.5%、1%ハバルディア・メキシカーナ樹皮の抽出物の水溶液を調製し、0.45μLのフィルターにてろ過し、被験物として試験に供する。試験操作としては、Staphylococcus aureus(黄色ブドウ球菌)またはStyphylococcus epidermidis(表皮ブドウ球菌)の菌液100μLを塗沫したMSA寒天培地上にペーパーディスク(ADVANTEC THICK 8mm)を置き、被験物50μLを浸み込ませ、37℃48時間培養する。培養してからノギスを用いて被験物の阻止円の大きさを測定する。
(i)Staphylococcus aureus(黄色ブドウ球菌)
被験物添加なし:阻止円の大きさ:0mm
ハバルディア・メキシカーナ樹皮の抽出物0.5%水溶液:4.27±0.85mm
ハバルディア・メキシカーナ樹皮の抽出物1.0%水溶液:12.36±1.20mm
被験物添加なし:阻止円の大きさ:0mm
ハバルディア・メキシカーナ樹皮の抽出物0.5%水溶液:0mm
ハバルディア・メキシカーナ樹皮の抽出物1.0%水溶液:4.46±1.75mm
以上の結果より、ハバルディア・メキシカーナ樹皮の抽出物が黄色ブドウ球菌の増殖を選択的に抑制することが明らかである。
Claims (2)
- マメ目マメ科ハバルディア属ハバルディア・メキシカーナ樹皮の抽出物を有効成分とする抗菌・殺菌剤。
- 黄色ブドウ球菌を増殖抑制及び/又は殺菌するために用いられるものである請求項1記載の抗菌・殺菌剤。
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