JP5913807B2 - Ｈｅｒ２に対する親和性を有する新規なポリペプチド - Google Patents

Ｈｅｒ２に対する親和性を有する新規なポリペプチド Download PDF

Info

Publication number
JP5913807B2
JP5913807B2 JP2010538788A JP2010538788A JP5913807B2 JP 5913807 B2 JP5913807 B2 JP 5913807B2 JP 2010538788 A JP2010538788 A JP 2010538788A JP 2010538788 A JP2010538788 A JP 2010538788A JP 5913807 B2 JP5913807 B2 JP 5913807B2
Authority
JP
Japan
Prior art keywords
her2
polypeptide
amino acid
affibody
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2010538788A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011507497A5 (enExample
JP2011507497A (ja
Inventor
ラーシュ・アブラフムセン
ニーナ・ヘルネ
ヨーアヒム・フェルトヴィシュ
シュリストフェル・レンデル
ヴラディミール・トルマシェヴ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affibody AB
Original Assignee
Affibody AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affibody AB filed Critical Affibody AB
Publication of JP2011507497A publication Critical patent/JP2011507497A/ja
Publication of JP2011507497A5 publication Critical patent/JP2011507497A5/ja
Application granted granted Critical
Publication of JP5913807B2 publication Critical patent/JP5913807B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010538788A 2007-12-21 2008-12-22 Ｈｅｒ２に対する親和性を有する新規なポリペプチド Active JP5913807B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07150395.7 2007-12-21
EP07150395A EP2072525A1 (en) 2007-12-21 2007-12-21 New polypeptides having affinity for HER2
PCT/EP2008/068167 WO2009080810A1 (en) 2007-12-21 2008-12-22 New polypeptides having affinity for her2

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014211333A Division JP2015061838A (ja) 2007-12-21 2014-10-16 Ｈｅｒ２に対する親和性を有する新規なポリペプチド

Publications (3)

Publication Number Publication Date
JP2011507497A JP2011507497A (ja) 2011-03-10
JP2011507497A5 JP2011507497A5 (enExample) 2012-01-19
JP5913807B2 true JP5913807B2 (ja) 2016-04-27

Family

ID=39148791

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010538788A Active JP5913807B2 (ja) 2007-12-21 2008-12-22 Ｈｅｒ２に対する親和性を有する新規なポリペプチド
JP2014211333A Pending JP2015061838A (ja) 2007-12-21 2014-10-16 Ｈｅｒ２に対する親和性を有する新規なポリペプチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014211333A Pending JP2015061838A (ja) 2007-12-21 2014-10-16 Ｈｅｒ２に対する親和性を有する新規なポリペプチド

Country Status (11)

Country Link
US (2) US8501909B2 (enExample)
EP (2) EP2072525A1 (enExample)
JP (2) JP5913807B2 (enExample)
CN (2) CN104327179A (enExample)
AU (1) AU2008339976B2 (enExample)
CA (1) CA2709915C (enExample)
DK (1) DK2235044T3 (enExample)
ES (1) ES2440919T3 (enExample)
HK (1) HK1202880A1 (enExample)
PL (1) PL2235044T3 (enExample)
WO (1) WO2009080810A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
US9187535B2 (en) 2007-12-19 2015-11-17 Affibody Ab Polypeptide derived from protein A and able to bind PDGF
EP2072525A1 (en) * 2007-12-21 2009-06-24 Affibody AB New polypeptides having affinity for HER2
EP2331140B1 (en) 2008-08-11 2018-07-04 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
US20120165650A1 (en) * 2010-12-22 2012-06-28 General Electric Company Her2 binders
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
JP5960598B2 (ja) 2009-11-04 2016-08-02 アフィボディ・アーベー Ｈｅｒ３結合ポリペプチド
EP2544785B1 (en) * 2010-03-08 2015-09-30 GE Healthcare Bio-Sciences AB Immunoglobulin g fc region binding polypeptide
DE102010026061A1 (de) 2010-06-30 2012-01-05 Siemens Aktiengesellschaft 11C-markiertes Peptid zur Detektion eines Tumors, der einen Her2/neu-Rezeptor exprimiert
TWI486617B (zh) * 2010-10-21 2015-06-01 Iner Aec Executive Yuan 一種測定對鎝（Ｔｃ－９９ｍ）與錸（Ｒｅ－１８６、Ｒｅ－１８８）具有穩定錯合力之含硫螯合劑在凍晶劑中之含量與均一性的固態樣品分析技術
KR20180042442A (ko) * 2010-12-22 2018-04-25 제너럴 일렉트릭 캄파니 방사성표지 ｈｅｒ２ 결합 펩티드
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US9061080B2 (en) 2010-12-22 2015-06-23 Ge Healthcare Limited HER2 binding peptides labeled with aluminium-[18] fluoride complexed by NOTA
KR20130132939A (ko) * 2010-12-22 2013-12-05 지이 헬쓰케어 리미티드 １８ｆ - 함유 유기실리콘 화합물로 표지된 ｈｅｒ２ 결합 펩티드
CN102690345B (zh) * 2011-03-24 2014-03-19 江苏靶标生物医药研究所有限公司 人膜联蛋白v变体及其表达、制备和应用
US20140088021A1 (en) 2011-05-27 2014-03-27 Nektar Therapeutics Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
WO2013126006A1 (en) 2012-02-20 2013-08-29 Swedish Orphan Biovitrum Ab (Publ) Polypeptides binding to human complement c5
WO2014013016A1 (en) 2012-07-20 2014-01-23 Affibody Ab Method for determining the her2 status of a malignancy
KR102191655B1 (ko) * 2012-10-05 2020-12-16 애피바디 에이비 Her3 결합 폴리펩티드
WO2014076179A1 (en) 2012-11-14 2014-05-22 Affibody Ab New polypeptide
CN105579851A (zh) * 2013-06-27 2016-05-11 通用电气健康护理有限公司 Her2结合剂的应用
KR102497083B1 (ko) 2013-08-28 2023-02-07 애피바디 에이비 돌연변이된 스캐폴드를 갖는 결합 폴리펩티드
PT3038633T (pt) 2013-08-28 2021-01-14 Ipc Res Llc Polipéptidos estáveis que se ligam ao complemento humano c5
ES2723774T3 (es) 2014-03-11 2019-09-02 Molecular Templates Inc Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal
SI3604333T1 (sl) 2014-03-11 2021-08-31 Molecular Templates, Inc. Proteini, ki obsegajo aminoterminalne proksimalne Shiga toksin podenota A efektorske regije in celico-ciljajoče vezavne regije imunogobulinskega tipa, ki so sposobne specifične vezave CD38
CN104292308B (zh) * 2014-08-22 2017-09-15 广州安辰医药科技有限公司 肿瘤抗原环肽
KR20170074243A (ko) 2014-10-31 2017-06-29 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 변형된 t 세포의 생성 방법 및 조성물
EP3224277B1 (en) 2014-11-25 2020-08-26 Bristol-Myers Squibb Company Novel pd-l1 binding polypeptides for imaging
CN107207379B (zh) 2014-11-25 2021-08-10 百时美施贵宝公司 用于生物制品的18f-放射性标记的方法和组合物
MX2017015493A (es) 2015-05-30 2018-02-09 Molecular Templates Inc Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden.
KR20180030085A (ko) 2015-07-26 2018-03-21 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
KR102397783B1 (ko) 2016-06-01 2022-05-12 브리스톨-마이어스 스큅 컴퍼니 Pd-l1 결합 폴리펩티드에 의한 pet 영상화
WO2017210335A1 (en) 2016-06-01 2017-12-07 Bristol-Myers Squibb Company Imaging methods using 18f-radiolabeled biologics
AU2018213194B2 (en) 2017-01-25 2023-01-12 Molecular Templates, Inc. Cell-targeting molecules comprising de-immunized, Shiga toxin A Subunit effectors and CD8+ T-cell epitopes
CA3097178A1 (en) 2018-04-17 2019-10-24 Molecular Templates, Inc. Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds
CA3157675A1 (en) 2019-12-18 2021-06-24 Erika Reitano Anti-her2 polypeptides derivatives as new diagnostic molecular probes
WO2021122729A1 (en) 2019-12-18 2021-06-24 Bracco Imaging Spa Anti-her2 polypeptides derivatives as new diagnostic molecular probes
WO2022171892A1 (en) 2021-02-15 2022-08-18 Affibody Ab New her2-binding polypeptide
CN112999369B (zh) * 2021-03-03 2022-02-25 江苏元本生物科技有限公司 一种her2亲合体放射性核素标记物组合物及其应用
CN116063397B (zh) * 2022-07-04 2025-05-02 中国药科大学 一类靶向her2蛋白的多肽及其在制备多肽偶联药物中的应用
CN117430670A (zh) * 2022-07-20 2024-01-23 中国科学院上海药物研究所 一种her2靶向肽分子及其应用
KR20250047787A (ko) 2022-08-10 2025-04-04 교와 가부시키가이샤 어피바디 미셀 약물 복합체
WO2025158010A1 (en) 2024-01-25 2025-07-31 Affibody Ab Her2-binding polypeptide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
SE0301987D0 (sv) * 2003-07-04 2003-07-04 Affibody Ab New polypeptide
CA2531238C (en) * 2003-07-04 2015-02-24 Affibody Ab Polypeptides having binding affinity for her2
GB0524788D0 (en) * 2005-12-05 2006-01-11 Affibody Ab Polypeptides
US8124725B2 (en) * 2007-12-19 2012-02-28 General Electric Company PDGF-Rβ binders
US8937047B2 (en) * 2007-12-19 2015-01-20 General Electric Company Biokinetics of fast-clearing polypeptides
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
ES2373832T3 (es) 2007-12-19 2012-02-09 Affibody Ab Polipéptido derivado de proteína a y capaz de unirse a pdgf.
EP2072525A1 (en) * 2007-12-21 2009-06-24 Affibody AB New polypeptides having affinity for HER2

Also Published As

Publication number Publication date
US20110020223A1 (en) 2011-01-27
US8501909B2 (en) 2013-08-06
EP2235044A1 (en) 2010-10-06
HK1153207A1 (en) 2012-03-23
EP2235044B1 (en) 2013-10-09
CA2709915A1 (en) 2009-07-02
CN101952302A (zh) 2011-01-19
ES2440919T3 (es) 2014-01-31
US8883120B2 (en) 2014-11-11
WO2009080810A1 (en) 2009-07-02
DK2235044T3 (da) 2014-01-06
CN101952302B (zh) 2014-11-12
PL2235044T3 (pl) 2014-03-31
JP2015061838A (ja) 2015-04-02
JP2011507497A (ja) 2011-03-10
AU2008339976B2 (en) 2013-05-30
US20130280164A1 (en) 2013-10-24
HK1202880A1 (en) 2015-10-09
AU2008339976A1 (en) 2009-07-02
EP2072525A1 (en) 2009-06-24
CN104327179A (zh) 2015-02-04
CA2709915C (en) 2016-05-24

Similar Documents

Publication Publication Date Title
JP5913807B2 (ja) Ｈｅｒ２に対する親和性を有する新規なポリペプチド
JP5689022B2 (ja) Ｈｅｒ２に対する結合親和性を有するポリペプチド
KR20210059048A (ko) 방사성표지 ｈｅｒ２ 결합 펩티드
JP6440618B2 (ja) Ｈｅｒ３結合ポリペプチド
JP7498971B2 (ja) がん診断及び治療のための新規ｐｓｍａ特異的結合タンパク質
CN1816563B (zh) 对her2具有结合亲和力的多肽
US20240124533A1 (en) New her2-binding polypeptide
HK1153207B (en) New polypeptides having affinity for her2
WO2025158010A1 (en) Her2-binding polypeptide
WO2024181930A1 (en) Asparaginyl peptide ligase-mediated radiolabelling of single-domain antibodies
CN121195076A (zh) 天冬酰胺酰肽连接酶介导的单域抗体放射性标记
WO2014013016A1 (en) Method for determining the her2 status of a malignancy
JP2023507423A (ja) 新規診断用分子プローブとしての抗ｈｅｒ２ポリペプチド誘導体
HK1092481B (en) Polypeptides having binding affinity for her2

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111125

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130827

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131126

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131203

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140617

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20141127

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160404

R150 Certificate of patent or registration of utility model

Ref document number: 5913807

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250