PL2235044T3 - Nowe polipeptydy mające powinowactwo do HER2 - Google Patents
Nowe polipeptydy mające powinowactwo do HER2Info
- Publication number
- PL2235044T3 PL2235044T3 PL08864430T PL08864430T PL2235044T3 PL 2235044 T3 PL2235044 T3 PL 2235044T3 PL 08864430 T PL08864430 T PL 08864430T PL 08864430 T PL08864430 T PL 08864430T PL 2235044 T3 PL2235044 T3 PL 2235044T3
- Authority
- PL
- Poland
- Prior art keywords
- her2
- affinity
- new polypeptides
- polypeptides
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07150395A EP2072525A1 (en) | 2007-12-21 | 2007-12-21 | New polypeptides having affinity for HER2 |
| PCT/EP2008/068167 WO2009080810A1 (en) | 2007-12-21 | 2008-12-22 | New polypeptides having affinity for her2 |
| EP08864430.7A EP2235044B1 (en) | 2007-12-21 | 2008-12-22 | New polypeptides having affinity for her2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2235044T3 true PL2235044T3 (pl) | 2014-03-31 |
Family
ID=39148791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08864430T PL2235044T3 (pl) | 2007-12-21 | 2008-12-22 | Nowe polipeptydy mające powinowactwo do HER2 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8501909B2 (enExample) |
| EP (2) | EP2072525A1 (enExample) |
| JP (2) | JP5913807B2 (enExample) |
| CN (2) | CN104327179A (enExample) |
| AU (1) | AU2008339976B2 (enExample) |
| CA (1) | CA2709915C (enExample) |
| DK (1) | DK2235044T3 (enExample) |
| ES (1) | ES2440919T3 (enExample) |
| HK (1) | HK1202880A1 (enExample) |
| PL (1) | PL2235044T3 (enExample) |
| WO (1) | WO2009080810A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9187535B2 (en) | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| US20120165650A1 (en) * | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| WO2010120514A2 (en) * | 2009-03-31 | 2010-10-21 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| EP2496598B1 (en) | 2009-11-04 | 2017-08-02 | Affibody AB | Her3 binding polypeptides |
| WO2011110515A1 (en) * | 2010-03-08 | 2011-09-15 | Affibody Ab | Immunoglobulin g fc region binding polypeptide |
| DE102010026061A1 (de) | 2010-06-30 | 2012-01-05 | Siemens Aktiengesellschaft | 11C-markiertes Peptid zur Detektion eines Tumors, der einen Her2/neu-Rezeptor exprimiert |
| TWI486617B (zh) * | 2010-10-21 | 2015-06-01 | Iner Aec Executive Yuan | 一種測定對鎝（Ｔｃ－９９ｍ）與錸（Ｒｅ－１８６、Ｒｅ－１８８）具有穩定錯合力之含硫螯合劑在凍晶劑中之含量與均一性的固態樣品分析技術 |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| EP2654803B1 (en) * | 2010-12-22 | 2021-08-18 | General Electric Company | Radiolabeled her2-binding peptide conjugates |
| US9061080B2 (en) | 2010-12-22 | 2015-06-23 | Ge Healthcare Limited | HER2 binding peptides labeled with aluminium-[18] fluoride complexed by NOTA |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| NZ612327A (en) * | 2010-12-22 | 2015-03-27 | Ge Healthcare Ltd | Her2 binding peptides labelled with a 18f - containing organosilicon compound |
| CN102690345B (zh) * | 2011-03-24 | 2014-03-19 | 江苏靶标生物医药研究所有限公司 | 人膜联蛋白v变体及其表达、制备和应用 |
| WO2012166555A1 (en) | 2011-05-27 | 2012-12-06 | Nektar Therapeutics | Water - soluble polymer - linked binding moiety and drug compounds |
| KR102149028B1 (ko) | 2012-02-20 | 2020-08-27 | 스위디쉬 오르펀 바이오비트럼 에이비 (피유비엘) | 인간 보체 c5에 결합하는 폴리펩티드 |
| WO2014013016A1 (en) | 2012-07-20 | 2014-01-23 | Affibody Ab | Method for determining the her2 status of a malignancy |
| WO2014053586A1 (en) * | 2012-10-05 | 2014-04-10 | Affibody Ab | Her3 binding polypeptides |
| WO2014076179A1 (en) | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| KR20160055728A (ko) * | 2013-06-27 | 2016-05-18 | 지이 헬쓰케어 리미티드 | Her2 결합제의 용도 |
| US9982022B2 (en) * | 2013-08-28 | 2018-05-29 | Affibody Ab | Binding polypeptides having a mutated scaffold |
| WO2015028558A1 (en) | 2013-08-28 | 2015-03-05 | Swedish Orphan Biovitrum Ab (Publ) | Stable polypeptides binding to human complement c5 |
| ES2864124T3 (es) | 2014-03-11 | 2021-10-13 | Molecular Templates Inc | Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal |
| PT3604333T (pt) | 2014-03-11 | 2021-06-07 | Molecular Templates Inc | Proteínas compreendendo regiões efetoras da subunidade a da toxina shiga próximas de amino-terminais e regiões de ligação do tipo imunoglobulina de direcionamento celular capazes de se ligarem especificamente a cd38 |
| CN104292308B (zh) * | 2014-08-22 | 2017-09-15 | 广州安辰医药科技有限公司 | 肿瘤抗原环肽 |
| PL3212225T3 (pl) | 2014-10-31 | 2026-03-30 | The Trustees Of The University Of Pennsylvania | Sposoby i kompozycje zmodyfikowanych limfocytów t |
| WO2016086036A2 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Methods and compositions for 18f-radiolabeling of biologics |
| JP6622814B2 (ja) * | 2014-11-25 | 2019-12-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | イメージングのための新規ｐｄ−ｌ１結合ポリペプチド |
| CN114656573B (zh) | 2015-05-30 | 2024-09-27 | 分子模板公司 | 去免疫化的志贺毒素a亚基支架和包含它们的细胞靶向分子 |
| MX2018001208A (es) | 2015-07-26 | 2018-03-26 | Molecular Templates Inc | Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+. |
| CN109562195A (zh) | 2016-06-01 | 2019-04-02 | 百时美施贵宝公司 | 用pd-l1结合多肽进行pet成像 |
| WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
| KR102590672B1 (ko) | 2017-01-25 | 2023-10-18 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| KR20200143634A (ko) | 2018-04-17 | 2020-12-24 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 스캐폴드를 포함하는 her2-표적화 분자 |
| WO2021122729A1 (en) | 2019-12-18 | 2021-06-24 | Bracco Imaging Spa | Anti-her2 polypeptides derivatives as new diagnostic molecular probes |
| CN114829388B (zh) * | 2019-12-18 | 2026-02-03 | 伯拉考成像股份公司 | 抗her2多肽衍生物作为新的诊断分子探针 |
| EP3842452A1 (en) | 2019-12-26 | 2021-06-30 | Universitat Autònoma de Barcelona | Scaffold proteins and therapeutic nanoconjugates based on nidogen |
| CN112220931B (zh) * | 2020-10-16 | 2022-03-08 | 上海交通大学 | 用于肿瘤主动靶向治疗的亲和体-细胞毒素偶联物及其纳米颗粒、制备方法、应用 |
| WO2022171892A1 (en) | 2021-02-15 | 2022-08-18 | Affibody Ab | New her2-binding polypeptide |
| CN112999369B (zh) * | 2021-03-03 | 2022-02-25 | 江苏元本生物科技有限公司 | 一种her2亲合体放射性核素标记物组合物及其应用 |
| CN116063397B (zh) * | 2022-07-04 | 2025-05-02 | 中国药科大学 | 一类靶向her2蛋白的多肽及其在制备多肽偶联药物中的应用 |
| CN117430670A (zh) * | 2022-07-20 | 2024-01-23 | 中国科学院上海药物研究所 | 一种her2靶向肽分子及其应用 |
| CN119677787A (zh) | 2022-08-10 | 2025-03-21 | 兴和株式会社 | 亲和体微胞药物复合体 |
| WO2025158010A1 (en) | 2024-01-25 | 2025-07-31 | Affibody Ab | Her2-binding polypeptide |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| SE0301987D0 (sv) * | 2003-07-04 | 2003-07-04 | Affibody Ab | New polypeptide |
| CA2531238C (en) * | 2003-07-04 | 2015-02-24 | Affibody Ab | Polypeptides having binding affinity for her2 |
| GB0524788D0 (en) * | 2005-12-05 | 2006-01-11 | Affibody Ab | Polypeptides |
| US8937047B2 (en) | 2007-12-19 | 2015-01-20 | General Electric Company | Biokinetics of fast-clearing polypeptides |
| US8124725B2 (en) | 2007-12-19 | 2012-02-28 | General Electric Company | PDGF-Rβ binders |
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| ES2373832T3 (es) | 2007-12-19 | 2012-02-09 | Affibody Ab | Polipéptido derivado de proteína a y capaz de unirse a pdgf. |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
-
2007
- 2007-12-21 EP EP07150395A patent/EP2072525A1/en not_active Withdrawn
-
2008
- 2008-12-22 CA CA2709915A patent/CA2709915C/en active Active
- 2008-12-22 EP EP08864430.7A patent/EP2235044B1/en active Active
- 2008-12-22 WO PCT/EP2008/068167 patent/WO2009080810A1/en not_active Ceased
- 2008-12-22 CN CN201410529294.7A patent/CN104327179A/zh active Pending
- 2008-12-22 CN CN200880126835.4A patent/CN101952302B/zh active Active
- 2008-12-22 US US12/735,068 patent/US8501909B2/en active Active
- 2008-12-22 PL PL08864430T patent/PL2235044T3/pl unknown
- 2008-12-22 AU AU2008339976A patent/AU2008339976B2/en active Active
- 2008-12-22 JP JP2010538788A patent/JP5913807B2/ja active Active
- 2008-12-22 ES ES08864430.7T patent/ES2440919T3/es active Active
- 2008-12-22 DK DK08864430.7T patent/DK2235044T3/da active
-
2011
- 2011-07-13 HK HK15103379.8A patent/HK1202880A1/xx unknown
-
2013
- 2013-06-27 US US13/928,522 patent/US8883120B2/en active Active
-
2014
- 2014-10-16 JP JP2014211333A patent/JP2015061838A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011507497A (ja) | 2011-03-10 |
| CN104327179A (zh) | 2015-02-04 |
| US8501909B2 (en) | 2013-08-06 |
| JP2015061838A (ja) | 2015-04-02 |
| US8883120B2 (en) | 2014-11-11 |
| EP2235044B1 (en) | 2013-10-09 |
| CA2709915A1 (en) | 2009-07-02 |
| AU2008339976A1 (en) | 2009-07-02 |
| DK2235044T3 (da) | 2014-01-06 |
| JP5913807B2 (ja) | 2016-04-27 |
| US20130280164A1 (en) | 2013-10-24 |
| CN101952302B (zh) | 2014-11-12 |
| US20110020223A1 (en) | 2011-01-27 |
| AU2008339976B2 (en) | 2013-05-30 |
| HK1202880A1 (en) | 2015-10-09 |
| CN101952302A (zh) | 2011-01-19 |
| WO2009080810A1 (en) | 2009-07-02 |
| ES2440919T3 (es) | 2014-01-31 |
| EP2235044A1 (en) | 2010-10-06 |
| CA2709915C (en) | 2016-05-24 |
| EP2072525A1 (en) | 2009-06-24 |
| HK1153207A1 (en) | 2012-03-23 |
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