DK2235044T3 - Nye polypeptider med bindingsaffinitet til HER2 - Google Patents
Nye polypeptider med bindingsaffinitet til HER2Info
- Publication number
- DK2235044T3 DK2235044T3 DK08864430.7T DK08864430T DK2235044T3 DK 2235044 T3 DK2235044 T3 DK 2235044T3 DK 08864430 T DK08864430 T DK 08864430T DK 2235044 T3 DK2235044 T3 DK 2235044T3
- Authority
- DK
- Denmark
- Prior art keywords
- her2
- binding affinity
- novel polypeptides
- polypeptides
- novel
- Prior art date
Links
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 title 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07150395A EP2072525A1 (en) | 2007-12-21 | 2007-12-21 | New polypeptides having affinity for HER2 |
| PCT/EP2008/068167 WO2009080810A1 (en) | 2007-12-21 | 2008-12-22 | New polypeptides having affinity for her2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2235044T3 true DK2235044T3 (da) | 2014-01-06 |
Family
ID=39148791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08864430.7T DK2235044T3 (da) | 2007-12-21 | 2008-12-22 | Nye polypeptider med bindingsaffinitet til HER2 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8501909B2 (enExample) |
| EP (2) | EP2072525A1 (enExample) |
| JP (2) | JP5913807B2 (enExample) |
| CN (2) | CN104327179A (enExample) |
| AU (1) | AU2008339976B2 (enExample) |
| CA (1) | CA2709915C (enExample) |
| DK (1) | DK2235044T3 (enExample) |
| ES (1) | ES2440919T3 (enExample) |
| HK (1) | HK1202880A1 (enExample) |
| PL (1) | PL2235044T3 (enExample) |
| WO (1) | WO2009080810A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| US9187535B2 (en) | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| EP2331140B1 (en) | 2008-08-11 | 2018-07-04 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| US20120165650A1 (en) * | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| US8728479B2 (en) | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| JP5960598B2 (ja) | 2009-11-04 | 2016-08-02 | アフィボディ・アーベー | Ｈｅｒ３結合ポリペプチド |
| EP2544785B1 (en) * | 2010-03-08 | 2015-09-30 | GE Healthcare Bio-Sciences AB | Immunoglobulin g fc region binding polypeptide |
| DE102010026061A1 (de) | 2010-06-30 | 2012-01-05 | Siemens Aktiengesellschaft | 11C-markiertes Peptid zur Detektion eines Tumors, der einen Her2/neu-Rezeptor exprimiert |
| TWI486617B (zh) * | 2010-10-21 | 2015-06-01 | Iner Aec Executive Yuan | 一種測定對鎝（Ｔｃ－９９ｍ）與錸（Ｒｅ－１８６、Ｒｅ－１８８）具有穩定錯合力之含硫螯合劑在凍晶劑中之含量與均一性的固態樣品分析技術 |
| KR20180042442A (ko) * | 2010-12-22 | 2018-04-25 | 제너럴 일렉트릭 캄파니 | 방사성표지 ｈｅｒ２ 결합 펩티드 |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| US9061080B2 (en) | 2010-12-22 | 2015-06-23 | Ge Healthcare Limited | HER2 binding peptides labeled with aluminium-[18] fluoride complexed by NOTA |
| KR20130132939A (ko) * | 2010-12-22 | 2013-12-05 | 지이 헬쓰케어 리미티드 | １８ｆ - 함유 유기실리콘 화합물로 표지된 ｈｅｒ２ 결합 펩티드 |
| CN102690345B (zh) * | 2011-03-24 | 2014-03-19 | 江苏靶标生物医药研究所有限公司 | 人膜联蛋白v变体及其表达、制备和应用 |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
| WO2014013016A1 (en) | 2012-07-20 | 2014-01-23 | Affibody Ab | Method for determining the her2 status of a malignancy |
| KR102191655B1 (ko) * | 2012-10-05 | 2020-12-16 | 애피바디 에이비 | Her3 결합 폴리펩티드 |
| WO2014076179A1 (en) | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| CN105579851A (zh) * | 2013-06-27 | 2016-05-11 | 通用电气健康护理有限公司 | Her2结合剂的应用 |
| KR102497083B1 (ko) | 2013-08-28 | 2023-02-07 | 애피바디 에이비 | 돌연변이된 스캐폴드를 갖는 결합 폴리펩티드 |
| PT3038633T (pt) | 2013-08-28 | 2021-01-14 | Ipc Res Llc | Polipéptidos estáveis que se ligam ao complemento humano c5 |
| ES2723774T3 (es) | 2014-03-11 | 2019-09-02 | Molecular Templates Inc | Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal |
| SI3604333T1 (sl) | 2014-03-11 | 2021-08-31 | Molecular Templates, Inc. | Proteini, ki obsegajo aminoterminalne proksimalne Shiga toksin podenota A efektorske regije in celico-ciljajoče vezavne regije imunogobulinskega tipa, ki so sposobne specifične vezave CD38 |
| CN104292308B (zh) * | 2014-08-22 | 2017-09-15 | 广州安辰医药科技有限公司 | 肿瘤抗原环肽 |
| KR20170074243A (ko) | 2014-10-31 | 2017-06-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 변형된 t 세포의 생성 방법 및 조성물 |
| EP3224277B1 (en) | 2014-11-25 | 2020-08-26 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
| MX2017015493A (es) | 2015-05-30 | 2018-02-09 | Molecular Templates Inc | Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden. |
| KR20180030085A (ko) | 2015-07-26 | 2018-03-21 | 몰레큘러 템플레이츠, 인코퍼레이션. | 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| KR102397783B1 (ko) | 2016-06-01 | 2022-05-12 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-l1 결합 폴리펩티드에 의한 pet 영상화 |
| WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
| AU2018213194B2 (en) | 2017-01-25 | 2023-01-12 | Molecular Templates, Inc. | Cell-targeting molecules comprising de-immunized, Shiga toxin A Subunit effectors and CD8+ T-cell epitopes |
| CA3097178A1 (en) | 2018-04-17 | 2019-10-24 | Molecular Templates, Inc. | Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds |
| CA3157675A1 (en) | 2019-12-18 | 2021-06-24 | Erika Reitano | Anti-her2 polypeptides derivatives as new diagnostic molecular probes |
| WO2021122729A1 (en) | 2019-12-18 | 2021-06-24 | Bracco Imaging Spa | Anti-her2 polypeptides derivatives as new diagnostic molecular probes |
| WO2022171892A1 (en) | 2021-02-15 | 2022-08-18 | Affibody Ab | New her2-binding polypeptide |
| CN112999369B (zh) * | 2021-03-03 | 2022-02-25 | 江苏元本生物科技有限公司 | 一种her2亲合体放射性核素标记物组合物及其应用 |
| CN116063397B (zh) * | 2022-07-04 | 2025-05-02 | 中国药科大学 | 一类靶向her2蛋白的多肽及其在制备多肽偶联药物中的应用 |
| CN117430670A (zh) * | 2022-07-20 | 2024-01-23 | 中国科学院上海药物研究所 | 一种her2靶向肽分子及其应用 |
| KR20250047787A (ko) | 2022-08-10 | 2025-04-04 | 교와 가부시키가이샤 | 어피바디 미셀 약물 복합체 |
| WO2025158010A1 (en) | 2024-01-25 | 2025-07-31 | Affibody Ab | Her2-binding polypeptide |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| SE0301987D0 (sv) * | 2003-07-04 | 2003-07-04 | Affibody Ab | New polypeptide |
| CA2531238C (en) * | 2003-07-04 | 2015-02-24 | Affibody Ab | Polypeptides having binding affinity for her2 |
| GB0524788D0 (en) * | 2005-12-05 | 2006-01-11 | Affibody Ab | Polypeptides |
| US8124725B2 (en) * | 2007-12-19 | 2012-02-28 | General Electric Company | PDGF-Rβ binders |
| US8937047B2 (en) * | 2007-12-19 | 2015-01-20 | General Electric Company | Biokinetics of fast-clearing polypeptides |
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| ES2373832T3 (es) | 2007-12-19 | 2012-02-09 | Affibody Ab | Polipéptido derivado de proteína a y capaz de unirse a pdgf. |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
-
2007
- 2007-12-21 EP EP07150395A patent/EP2072525A1/en not_active Withdrawn
-
2008
- 2008-12-22 WO PCT/EP2008/068167 patent/WO2009080810A1/en not_active Ceased
- 2008-12-22 ES ES08864430.7T patent/ES2440919T3/es active Active
- 2008-12-22 CN CN201410529294.7A patent/CN104327179A/zh active Pending
- 2008-12-22 CA CA2709915A patent/CA2709915C/en active Active
- 2008-12-22 CN CN200880126835.4A patent/CN101952302B/zh active Active
- 2008-12-22 DK DK08864430.7T patent/DK2235044T3/da active
- 2008-12-22 AU AU2008339976A patent/AU2008339976B2/en active Active
- 2008-12-22 PL PL08864430T patent/PL2235044T3/pl unknown
- 2008-12-22 US US12/735,068 patent/US8501909B2/en active Active
- 2008-12-22 EP EP08864430.7A patent/EP2235044B1/en active Active
- 2008-12-22 JP JP2010538788A patent/JP5913807B2/ja active Active
-
2011
- 2011-07-13 HK HK15103379.8A patent/HK1202880A1/xx unknown
-
2013
- 2013-06-27 US US13/928,522 patent/US8883120B2/en active Active
-
2014
- 2014-10-16 JP JP2014211333A patent/JP2015061838A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20110020223A1 (en) | 2011-01-27 |
| US8501909B2 (en) | 2013-08-06 |
| EP2235044A1 (en) | 2010-10-06 |
| HK1153207A1 (en) | 2012-03-23 |
| EP2235044B1 (en) | 2013-10-09 |
| CA2709915A1 (en) | 2009-07-02 |
| CN101952302A (zh) | 2011-01-19 |
| ES2440919T3 (es) | 2014-01-31 |
| US8883120B2 (en) | 2014-11-11 |
| WO2009080810A1 (en) | 2009-07-02 |
| CN101952302B (zh) | 2014-11-12 |
| PL2235044T3 (pl) | 2014-03-31 |
| JP5913807B2 (ja) | 2016-04-27 |
| JP2015061838A (ja) | 2015-04-02 |
| JP2011507497A (ja) | 2011-03-10 |
| AU2008339976B2 (en) | 2013-05-30 |
| US20130280164A1 (en) | 2013-10-24 |
| HK1202880A1 (en) | 2015-10-09 |
| AU2008339976A1 (en) | 2009-07-02 |
| EP2072525A1 (en) | 2009-06-24 |
| CN104327179A (zh) | 2015-02-04 |
| CA2709915C (en) | 2016-05-24 |
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