JP5903385B2 - 抗体精製用のメンブラン及び関連方法 - Google Patents

抗体精製用のメンブラン及び関連方法 Download PDF

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Publication number
JP5903385B2
JP5903385B2 JP2012543340A JP2012543340A JP5903385B2 JP 5903385 B2 JP5903385 B2 JP 5903385B2 JP 2012543340 A JP2012543340 A JP 2012543340A JP 2012543340 A JP2012543340 A JP 2012543340A JP 5903385 B2 JP5903385 B2 JP 5903385B2
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Prior art keywords
membrane
antibody
polymer resin
interaction
compounds
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English (en)
Japanese (ja)
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JP2013513623A (ja
JP2013513623A5 (enExample
Inventor
マレンファント，パトリック・ローランド・ルシアン
オルセン，キャサリン・エレン
ピッチ，ヴィンセント・フランシス
イェーガー，ゲーリー・ウィリアム
ドゥシェ，ロバート・スコット
リンド，パー・オラ
ホールグレン，スティナ・エリザベス
モリソン，アニカ
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General Electric Co
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General Electric Co
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Publication of JP2013513623A5 publication Critical patent/JP2013513623A5/ja
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28095—Shape or type of pores, voids, channels, ducts
    • B01J20/28097—Shape or type of pores, voids, channels, ducts being coated, filled or plugged with specific compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/328—Polymers on the carrier being further modified
    • B01J20/3282—Crosslinked polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP2012543340A 2009-12-14 2010-12-14 抗体精製用のメンブラン及び関連方法 Active JP5903385B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/636,833 2009-12-14
US12/636,833 US8277649B2 (en) 2009-12-14 2009-12-14 Membranes and associated methods for purification of antibodies
PCT/US2010/060176 WO2011081898A1 (en) 2009-12-14 2010-12-14 Membranes and associated methods for purification of antibodies

Publications (3)

Publication Number Publication Date
JP2013513623A JP2013513623A (ja) 2013-04-22
JP2013513623A5 JP2013513623A5 (enExample) 2014-01-09
JP5903385B2 true JP5903385B2 (ja) 2016-04-13

Family

ID=44141747

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012543340A Active JP5903385B2 (ja) 2009-12-14 2010-12-14 抗体精製用のメンブラン及び関連方法

Country Status (5)

Country Link
US (1) US8277649B2 (enExample)
EP (1) EP2513142B1 (enExample)
JP (1) JP5903385B2 (enExample)
CA (1) CA2780819C (enExample)
WO (1) WO2011081898A1 (enExample)

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US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
TWI610936B (zh) 2008-10-20 2018-01-11 艾伯維有限公司 使用蛋白質ａ親和性層析進行抗體之分離及純化
TW201028433A (en) 2008-10-20 2010-08-01 Abbott Lab Viral inactivation during purification of antibodies
DE102009005479A1 (de) * 2009-01-21 2010-07-22 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren für die Stofftrennung
US9650411B2 (en) 2012-08-07 2017-05-16 Kyowa Hakko Kirin Co., Ltd. Method of purifying protein
EP2894159A4 (en) * 2012-09-03 2016-01-20 Kaneka Corp MIXING MODE ANTIBODY SAFFINITY MIXTURE AND PURIFICATION PROCESS WITH AND TARGET MOLECULE
IN2015DN02055A (enExample) 2012-09-17 2015-08-14 Grace W R & Co
WO2014077762A1 (en) * 2012-11-13 2014-05-22 Ge Healthcare Bio-Sciences Ab Multimodal anion exchange matrices
US9335950B2 (en) 2013-03-15 2016-05-10 Western Digital Technologies, Inc. Multiple stream compression and formatting of data for data storage systems
US9448738B2 (en) 2013-03-15 2016-09-20 Western Digital Technologies, Inc. Compression and formatting of data for data storage systems
US9274978B2 (en) 2013-06-10 2016-03-01 Western Digital Technologies, Inc. Migration of encrypted data for data storage systems
JP6047079B2 (ja) 2013-08-30 2016-12-21 富士フイルム株式会社 イオン交換膜、イオン交換膜形成用組成物およびイオン交換膜の製造方法
JPWO2015041218A1 (ja) 2013-09-17 2017-03-02 株式会社カネカ 新規抗体精製方法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎＭｅｔｈｏｄａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎｍｅｔｈｏｄｕｓｉｎｇＣａｔｉｏｎＥｘｃｈａｎｇｅｒａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）
EP2881163A1 (en) * 2013-12-05 2015-06-10 Gambro Lundia AB Composite membrane
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
ES2896897T3 (es) 2015-06-05 2022-02-28 Grace W R & Co Agentes de clarificación para el bioprocesamiento de adsorbentes y métodos para producir y usar los mismos
US11162880B2 (en) * 2015-11-09 2021-11-02 University Of Notre Dame Du Lac Particle size purification method and devices
JP7085533B2 (ja) 2016-09-09 2022-06-16 スリーエム イノベイティブ プロパティズ カンパニー 官能化コポリマー及びその使用
WO2019173731A1 (en) * 2018-03-08 2019-09-12 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode chromatography resin
TWI903214B (zh) * 2018-05-02 2025-11-01 美商里珍納龍藥品有限公司 用於評估生化過濾器的適合性的方法
US12485364B2 (en) 2018-08-10 2025-12-02 Clemson University Research Foundation Multi-modal ion-exchange membranes for rapid separations
CN113195519B (zh) 2018-12-12 2024-08-30 唐纳森公司 亲和膜及其制备方法
US11896969B2 (en) 2019-09-05 2024-02-13 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode chromatography resins
JP2023530938A (ja) * 2020-06-17 2023-07-20 インテグリス・インコーポレーテッド イオン交換膜、フィルタ及び方法
CN114471199B (zh) * 2022-03-31 2023-11-03 天津工业大学 一种具有分离/吸附双功能的聚醚砜膜及其制备方法

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Also Published As

Publication number Publication date
CA2780819C (en) 2018-09-04
JP2013513623A (ja) 2013-04-22
CA2780819A1 (en) 2011-07-07
WO2011081898A1 (en) 2011-07-07
EP2513142A1 (en) 2012-10-24
EP2513142A4 (en) 2015-01-21
US20110139717A1 (en) 2011-06-16
EP2513142B1 (en) 2019-04-10
US8277649B2 (en) 2012-10-02

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