JP5903385B2 - 抗体精製用のメンブラン及び関連方法 - Google Patents

抗体精製用のメンブラン及び関連方法 Download PDF

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Publication number
JP5903385B2
JP5903385B2 JP2012543340A JP2012543340A JP5903385B2 JP 5903385 B2 JP5903385 B2 JP 5903385B2 JP 2012543340 A JP2012543340 A JP 2012543340A JP 2012543340 A JP2012543340 A JP 2012543340A JP 5903385 B2 JP5903385 B2 JP 5903385B2
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Prior art keywords
membrane
antibody
polymer resin
interaction
compounds
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Japanese (ja)
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JP2013513623A5 (enExample
JP2013513623A (ja
Inventor
マレンファント，パトリック・ローランド・ルシアン
オルセン，キャサリン・エレン
ピッチ，ヴィンセント・フランシス
イェーガー，ゲーリー・ウィリアム
ドゥシェ，ロバート・スコット
リンド，パー・オラ
ホールグレン，スティナ・エリザベス
モリソン，アニカ
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General Electric Co
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General Electric Co
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Publication of JP2013513623A5 publication Critical patent/JP2013513623A5/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28095—Shape or type of pores, voids, channels, ducts
    • B01J20/28097—Shape or type of pores, voids, channels, ducts being coated, filled or plugged with specific compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/328—Polymers on the carrier being further modified
    • B01J20/3282—Crosslinked polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP2012543340A 2009-12-14 2010-12-14 抗体精製用のメンブラン及び関連方法 Active JP5903385B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/636,833 US8277649B2 (en) 2009-12-14 2009-12-14 Membranes and associated methods for purification of antibodies
US12/636,833 2009-12-14
PCT/US2010/060176 WO2011081898A1 (en) 2009-12-14 2010-12-14 Membranes and associated methods for purification of antibodies

Publications (3)

Publication Number Publication Date
JP2013513623A JP2013513623A (ja) 2013-04-22
JP2013513623A5 JP2013513623A5 (enExample) 2014-01-09
JP5903385B2 true JP5903385B2 (ja) 2016-04-13

Family

ID=44141747

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012543340A Active JP5903385B2 (ja) 2009-12-14 2010-12-14 抗体精製用のメンブラン及び関連方法

Country Status (5)

Country Link
US (1) US8277649B2 (enExample)
EP (1) EP2513142B1 (enExample)
JP (1) JP5903385B2 (enExample)
CA (1) CA2780819C (enExample)
WO (1) WO2011081898A1 (enExample)

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US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
TW201516149A (zh) 2006-09-13 2015-05-01 Abbvie Inc 細胞培養改良
CA2932207A1 (en) 2008-10-20 2010-12-09 Abbvie Inc. Isolation and purification of antibodies using protein a affinity chromatography
CN104974251A (zh) 2008-10-20 2015-10-14 Abbvie公司 在抗体纯化过程中的病毒灭活
DE102009005479A1 (de) * 2009-01-21 2010-07-22 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren für die Stofftrennung
US9650411B2 (en) * 2012-08-07 2017-05-16 Kyowa Hakko Kirin Co., Ltd. Method of purifying protein
SG11201501597VA (en) * 2012-09-03 2015-04-29 Kaneka Corp Mix-mode antibody affinity separation matrix and purification method using same, and target molecule
MY178616A (en) 2012-09-17 2020-10-19 Grace W R & Co Chromatography media and devices
CN104797332B (zh) 2012-11-13 2018-05-29 通用电气医疗集团生物工艺研发股份公司 多元阴离子交换基质
US9448738B2 (en) 2013-03-15 2016-09-20 Western Digital Technologies, Inc. Compression and formatting of data for data storage systems
US9335950B2 (en) 2013-03-15 2016-05-10 Western Digital Technologies, Inc. Multiple stream compression and formatting of data for data storage systems
US9274978B2 (en) 2013-06-10 2016-03-01 Western Digital Technologies, Inc. Migration of encrypted data for data storage systems
JP6047079B2 (ja) 2013-08-30 2016-12-21 富士フイルム株式会社 イオン交換膜、イオン交換膜形成用組成物およびイオン交換膜の製造方法
KR20160054597A (ko) 2013-09-17 2016-05-16 가부시키가이샤 가네카 신규 항체 정제 방법 및 그로부터 얻어지는 항체, 및 양이온 교환기를 사용한 신규 항체 정제법 및 그로부터 얻어지는 항체
EP2881163A1 (en) * 2013-12-05 2015-06-10 Gambro Lundia AB Composite membrane
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 官能化担体材料並びに官能化担体材料を作製及び使用する方法
CN107921407B (zh) 2015-06-05 2022-07-05 格雷斯公司 生物处理吸附澄清剂及其制备和使用方法
US11162880B2 (en) * 2015-11-09 2021-11-02 University Of Notre Dame Du Lac Particle size purification method and devices
WO2018048696A1 (en) 2016-09-09 2018-03-15 3M Innovative Properties Company Functionalized copolymers and use thereof
CN111818980B (zh) 2018-03-08 2022-10-11 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂
TWI903214B (zh) * 2018-05-02 2025-11-01 美商里珍納龍藥品有限公司 用於評估生化過濾器的適合性的方法
US12485364B2 (en) 2018-08-10 2025-12-02 Clemson University Research Foundation Multi-modal ion-exchange membranes for rapid separations
CA3118156A1 (en) 2018-12-12 2020-06-18 Purilogics, LLC Affinity membrane and method of preparation
CN114040815B (zh) 2019-09-05 2024-06-28 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂
TWI774425B (zh) 2020-06-17 2022-08-11 美商恩特葛瑞斯股份有限公司 離子交換膜、過濾器及方法
CN114471199B (zh) * 2022-03-31 2023-11-03 天津工业大学 一种具有分离/吸附双功能的聚醚砜膜及其制备方法

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Also Published As

Publication number Publication date
EP2513142B1 (en) 2019-04-10
CA2780819C (en) 2018-09-04
EP2513142A1 (en) 2012-10-24
US20110139717A1 (en) 2011-06-16
EP2513142A4 (en) 2015-01-21
JP2013513623A (ja) 2013-04-22
CA2780819A1 (en) 2011-07-07
WO2011081898A1 (en) 2011-07-07
US8277649B2 (en) 2012-10-02

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