CA2780819C - Membranes and associated methods for purification of antibodies - Google Patents
Membranes and associated methods for purification of antibodies Download PDFInfo
- Publication number
- CA2780819C CA2780819C CA2780819A CA2780819A CA2780819C CA 2780819 C CA2780819 C CA 2780819C CA 2780819 A CA2780819 A CA 2780819A CA 2780819 A CA2780819 A CA 2780819A CA 2780819 C CA2780819 C CA 2780819C
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- Prior art keywords
- membrane
- biological sample
- polymeric resin
- porous support
- combination
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Classifications
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28095—Shape or type of pores, voids, channels, ducts
- B01J20/28097—Shape or type of pores, voids, channels, ducts being coated, filled or plugged with specific compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/328—Polymers on the carrier being further modified
- B01J20/3282—Crosslinked polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/636,833 US8277649B2 (en) | 2009-12-14 | 2009-12-14 | Membranes and associated methods for purification of antibodies |
| US12/636,833 | 2009-12-14 | ||
| PCT/US2010/060176 WO2011081898A1 (en) | 2009-12-14 | 2010-12-14 | Membranes and associated methods for purification of antibodies |
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| CA2780819A1 CA2780819A1 (en) | 2011-07-07 |
| CA2780819C true CA2780819C (en) | 2018-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2780819A Active CA2780819C (en) | 2009-12-14 | 2010-12-14 | Membranes and associated methods for purification of antibodies |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8277649B2 (enExample) |
| EP (1) | EP2513142B1 (enExample) |
| JP (1) | JP5903385B2 (enExample) |
| CA (1) | CA2780819C (enExample) |
| WO (1) | WO2011081898A1 (enExample) |
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| EP2500413A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| NZ592097A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Viral inactivation during purification of il-12 and il-18 antibodies |
| US8895709B2 (en) | 2008-10-20 | 2014-11-25 | Abbvie Inc. | Isolation and purification of antibodies using protein A affinity chromatography |
| DE102009005479A1 (de) * | 2009-01-21 | 2010-07-22 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren für die Stofftrennung |
| US9650411B2 (en) * | 2012-08-07 | 2017-05-16 | Kyowa Hakko Kirin Co., Ltd. | Method of purifying protein |
| SG11201501597VA (en) * | 2012-09-03 | 2015-04-29 | Kaneka Corp | Mix-mode antibody affinity separation matrix and purification method using same, and target molecule |
| CA2885263C (en) | 2012-09-17 | 2021-11-16 | W. R. Grace & Co.-Conn. | Chromatography media and devices |
| JP6397422B2 (ja) * | 2012-11-13 | 2018-09-26 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | マルチモーダルアニオン交換マトリックス |
| US9448738B2 (en) | 2013-03-15 | 2016-09-20 | Western Digital Technologies, Inc. | Compression and formatting of data for data storage systems |
| US9335950B2 (en) | 2013-03-15 | 2016-05-10 | Western Digital Technologies, Inc. | Multiple stream compression and formatting of data for data storage systems |
| US9274978B2 (en) | 2013-06-10 | 2016-03-01 | Western Digital Technologies, Inc. | Migration of encrypted data for data storage systems |
| JP6047079B2 (ja) | 2013-08-30 | 2016-12-21 | 富士フイルム株式会社 | イオン交換膜、イオン交換膜形成用組成物およびイオン交換膜の製造方法 |
| SG11201602061YA (en) | 2013-09-17 | 2016-04-28 | Kaneka Corp | Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom |
| EP2881163A1 (en) * | 2013-12-05 | 2015-06-10 | Gambro Lundia AB | Composite membrane |
| CN107847907A (zh) | 2014-05-02 | 2018-03-27 | 格雷斯公司 | 官能化载体材料以及制备和使用官能化载体材料的方法 |
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| EP2470290B1 (en) * | 2009-08-26 | 2019-07-24 | Evoqua Water Technologies Pte. Ltd. | Ion exchange membranes |
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- 2010-12-14 JP JP2012543340A patent/JP5903385B2/ja active Active
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| EP2513142A4 (en) | 2015-01-21 |
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| US20110139717A1 (en) | 2011-06-16 |
| JP2013513623A (ja) | 2013-04-22 |
| EP2513142B1 (en) | 2019-04-10 |
| JP5903385B2 (ja) | 2016-04-13 |
| US8277649B2 (en) | 2012-10-02 |
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