JP5889783B2 - 免疫細胞へオリゴヌクレオチドを送達する方法 - Google Patents

免疫細胞へオリゴヌクレオチドを送達する方法 Download PDF

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Publication number
JP5889783B2
JP5889783B2 JP2012509952A JP2012509952A JP5889783B2 JP 5889783 B2 JP5889783 B2 JP 5889783B2 JP 2012509952 A JP2012509952 A JP 2012509952A JP 2012509952 A JP2012509952 A JP 2012509952A JP 5889783 B2 JP5889783 B2 JP 5889783B2
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lipid
peg
nucleic acid
cells
alkyl
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Expired - Fee Related
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Japanese (ja)
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JP2012526134A (ja
JP2012526134A5 (enExample
Inventor
タチアナ・ノヴォブランツェヴァ
アキン・アキンク
司 菅生
司 菅生
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Arbutus Biopharma Corp
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Tekmira Pharmaceuticals Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012509952A 2009-05-05 2010-05-05 免疫細胞へオリゴヌクレオチドを送達する方法 Expired - Fee Related JP5889783B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US17577709P 2009-05-05 2009-05-05
US61/175,777 2009-05-05
US23404509P 2009-08-14 2009-08-14
US61/234,045 2009-08-14
US24276109P 2009-09-15 2009-09-15
US61/242,761 2009-09-15
US25199109P 2009-10-15 2009-10-15
US61/251,991 2009-10-15
US25884809P 2009-11-06 2009-11-06
US61/258,848 2009-11-06
PCT/US2010/033747 WO2010129687A1 (en) 2009-05-05 2010-05-05 Methods of delivering oligonucleotides to immune cells

Related Child Applications (1)

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JP2015203615A Division JP6113809B2 (ja) 2009-05-05 2015-10-15 免疫細胞へオリゴヌクレオチドを送達する方法

Publications (3)

Publication Number Publication Date
JP2012526134A JP2012526134A (ja) 2012-10-25
JP2012526134A5 JP2012526134A5 (enExample) 2014-06-26
JP5889783B2 true JP5889783B2 (ja) 2016-03-22

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JP2012509952A Expired - Fee Related JP5889783B2 (ja) 2009-05-05 2010-05-05 免疫細胞へオリゴヌクレオチドを送達する方法
JP2015203615A Expired - Fee Related JP6113809B2 (ja) 2009-05-05 2015-10-15 免疫細胞へオリゴヌクレオチドを送達する方法
JP2017048255A Expired - Fee Related JP6382380B2 (ja) 2009-05-05 2017-03-14 免疫細胞へオリゴヌクレオチドを送達する方法
JP2018142235A Pending JP2018168197A (ja) 2009-05-05 2018-07-30 免疫細胞へオリゴヌクレオチドを送達する方法
JP2019209596A Active JP6932760B2 (ja) 2009-05-05 2019-11-20 免疫細胞へオリゴヌクレオチドを送達する方法
JP2021133425A Pending JP2021181490A (ja) 2009-05-05 2021-08-18 免疫細胞へオリゴヌクレオチドを送達する方法

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JP2015203615A Expired - Fee Related JP6113809B2 (ja) 2009-05-05 2015-10-15 免疫細胞へオリゴヌクレオチドを送達する方法
JP2017048255A Expired - Fee Related JP6382380B2 (ja) 2009-05-05 2017-03-14 免疫細胞へオリゴヌクレオチドを送達する方法
JP2018142235A Pending JP2018168197A (ja) 2009-05-05 2018-07-30 免疫細胞へオリゴヌクレオチドを送達する方法
JP2019209596A Active JP6932760B2 (ja) 2009-05-05 2019-11-20 免疫細胞へオリゴヌクレオチドを送達する方法
JP2021133425A Pending JP2021181490A (ja) 2009-05-05 2021-08-18 免疫細胞へオリゴヌクレオチドを送達する方法

Country Status (6)

Country Link
US (3) US20100285112A1 (enExample)
EP (3) EP3504967A1 (enExample)
JP (6) JP5889783B2 (enExample)
AU (5) AU2010245933B2 (enExample)
CA (2) CA3045126A1 (enExample)
WO (1) WO2010129687A1 (enExample)

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