JP5875597B2 - ヒト万能性幹細胞の成長を阻害する薬剤および方法 - Google Patents

ヒト万能性幹細胞の成長を阻害する薬剤および方法 Download PDF

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JP5875597B2
JP5875597B2 JP2013543140A JP2013543140A JP5875597B2 JP 5875597 B2 JP5875597 B2 JP 5875597B2 JP 2013543140 A JP2013543140 A JP 2013543140A JP 2013543140 A JP2013543140 A JP 2013543140A JP 5875597 B2 JP5875597 B2 JP 5875597B2
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differentiation
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JP2014501518A (ja
JP2014501518A5 (cg-RX-API-DMAC7.html
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シュルツ，トーマス
ロビンス，アラン
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ヴィアサイト，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
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  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
JP2013543140A 2010-12-08 2010-12-08 ヒト万能性幹細胞の成長を阻害する薬剤および方法 Expired - Fee Related JP5875597B2 (ja)

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PCT/US2010/059586 WO2012078153A1 (en) 2010-12-08 2010-12-08 Agents and methods for inhibiting human pluripotent stem cell growth

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JP2014501518A JP2014501518A (ja) 2014-01-23
JP2014501518A5 JP2014501518A5 (cg-RX-API-DMAC7.html) 2014-03-13
JP5875597B2 true JP5875597B2 (ja) 2016-03-02

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US (2) US9365830B2 (cg-RX-API-DMAC7.html)
EP (1) EP2649177B1 (cg-RX-API-DMAC7.html)
JP (1) JP5875597B2 (cg-RX-API-DMAC7.html)
CN (1) CN103354835B (cg-RX-API-DMAC7.html)
AU (1) AU2010365057B2 (cg-RX-API-DMAC7.html)
CA (1) CA2820419A1 (cg-RX-API-DMAC7.html)
ES (1) ES2690663T3 (cg-RX-API-DMAC7.html)
WO (1) WO2012078153A1 (cg-RX-API-DMAC7.html)

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ES2674567T3 (es) 2010-05-21 2018-07-02 Merrimack Pharmaceuticals, Inc. Proteínas de fusión biespecíficas
JP6312591B2 (ja) 2011-06-21 2018-04-18 ノヴォ ノルディスク アー／エス 多能性幹細胞からの胚体内胚葉の効率的な誘導
EP2980207B1 (en) 2013-03-25 2018-12-05 Foundation for Biomedical Research and Innovation at Kobe Cell sorting method
EP3006558B1 (en) * 2013-05-30 2020-05-13 Ajinomoto Co., Inc. Medium for culturing stem cells
WO2015025967A1 (ja) * 2013-08-23 2015-02-26 住友化学株式会社 網膜組織及び網膜関連細胞の製造方法
WO2015112581A1 (en) 2014-01-21 2015-07-30 The Medical College Of Wisconsin, Inc. Methods for selective inhibition of pluripotent stem cells
CA2944393C (en) * 2014-03-31 2019-02-05 Ajinomoto Co., Inc. Medium for stem cell use
EP3334820B1 (en) 2015-08-13 2024-05-15 Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd. Induced extended pluripotent stem cells, methods of making and using
EP3355907B1 (en) 2015-10-02 2021-01-20 Silver Creek Pharmaceuticals, Inc. Bi-specific therapeutic proteins for tissue repair
US20190018000A1 (en) 2016-01-12 2019-01-17 Cedars-Sinai Medical Center A method of non destructive monitoring of biological processes in microfluidic tissue culture systems
US11913022B2 (en) * 2017-01-25 2024-02-27 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
EP3587560A4 (en) * 2017-01-27 2020-12-16 Kaneka Corporation Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells
JP2020509759A (ja) * 2017-03-07 2020-04-02 プレートレット バイオジェネシス， インコーポレイテッド 再循環バイオリアクタ
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2018225705A1 (ja) 2017-06-05 2018-12-13 テルモ株式会社 細胞培養物の製造方法
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
CN108570443A (zh) * 2017-12-05 2018-09-25 皓昇莱生物制药有限公司 一种用于培养尿液来源细胞的培养基
EP3768823B1 (en) 2018-03-23 2025-12-31 Cedars-Sinai Medical Center METHODS FOR USING CELLS FROM PANCREATIC ISLETS
US12291727B2 (en) * 2018-03-28 2025-05-06 Osaka University Method for producing stem cell-derived lacrimal gland tissue
US11981918B2 (en) 2018-04-06 2024-05-14 Cedars-Sinai Medical Center Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
EP3775161A4 (en) 2018-04-06 2022-04-06 Cedars-Sinai Medical Center NEURODEGENERATIVE DISEASE MODELS DERIVED FROM HUMAN PLURIPOTENTIC STEM CELLS ON A MICROFLUIDIC CHIP
CN110684714B (zh) * 2018-07-05 2023-05-09 广东博溪生物科技有限公司 一种屏障功能弱化模型的构建方法
US12157872B2 (en) 2018-07-19 2024-12-03 Stellular Bio, Inc. Stacked recirculating bioreactor
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
EP3854869A4 (en) * 2018-09-19 2022-09-07 Takeda Pharmaceutical Company Limited INSULIN-PRODUCING CELLS
EP3739040B1 (en) 2018-09-27 2023-07-05 Osaka University Sheeting method for pluripotent stem cell-derived cells
US20220364065A1 (en) * 2018-12-21 2022-11-17 National University Corporation Hokkaido University Composition for removing pluripotent stem cells and method of removing pluripotent stem cells
CN110373375A (zh) * 2019-03-19 2019-10-25 杭州原生生物科技有限公司 一种制备纤维细胞作为细胞培养基的方法和用途
KR20220052370A (ko) 2019-09-05 2022-04-27 크리스퍼 테라퓨틱스 아게 보편적 공여자 세포
US11116798B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
EP4196611A1 (en) 2020-08-15 2023-06-21 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)
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TW202523836A (zh) * 2023-12-12 2025-06-16 佛教慈濟醫療財團法人 選擇性去除未分化多潛能幹細胞的方法

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US8597947B2 (en) * 2004-12-29 2013-12-03 Hadasit Medical Research Services & Development Limited Undifferentiated stem cell culture systems
US20080070303A1 (en) * 2005-11-21 2008-03-20 West Michael D Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
WO2011011632A1 (en) * 2009-07-22 2011-01-27 Tufts University Methods and compositions for modulating membrane potential to influence cell behavior

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CN103354835B (zh) 2016-03-02
US20160281058A1 (en) 2016-09-29
EP2649177B1 (en) 2018-09-05
US20130280802A1 (en) 2013-10-24
EP2649177A4 (en) 2014-04-23
AU2010365057A1 (en) 2013-06-20
ES2690663T3 (es) 2018-11-21
CN103354835A (zh) 2013-10-16
CA2820419A1 (en) 2012-06-14
EP2649177A1 (en) 2013-10-16
AU2010365057B2 (en) 2016-12-22
US9365830B2 (en) 2016-06-14
WO2012078153A1 (en) 2012-06-14
JP2014501518A (ja) 2014-01-23

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