JP5863766B2 - タンパク質および核酸送達媒体、その成分および機構 - Google Patents

タンパク質および核酸送達媒体、その成分および機構 Download PDF

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JP5863766B2
JP5863766B2 JP2013503215A JP2013503215A JP5863766B2 JP 5863766 B2 JP5863766 B2 JP 5863766B2 JP 2013503215 A JP2013503215 A JP 2013503215A JP 2013503215 A JP2013503215 A JP 2013503215A JP 5863766 B2 JP5863766 B2 JP 5863766B2
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dna
head
packaging
bacteriophage
protein
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ビー． ラオ，ヴェニガラ
ビー． ラオ，ヴェニガラ
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Catholic University of America
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10151—Methods of production or purification of viral material
    • C12N2795/10152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2013503215A 2010-04-09 2011-04-08 タンパク質および核酸送達媒体、その成分および機構 Active JP5863766B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32233410P 2010-04-09 2010-04-09
US61/322,334 2010-04-09
US13/082,466 US8802418B2 (en) 2010-04-09 2011-04-08 Protein and nucleic acid delivery vehicles, components and mechanisms thereof
PCT/IB2011/051533 WO2011125054A2 (en) 2010-04-09 2011-04-08 Protein and nucleic acid delivery vehicles, components and mechanisms thereof
US13/082,466 2011-04-08

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JP2015250577A Division JP6127124B2 (ja) 2010-04-09 2015-12-22 タンパク質および核酸送達媒体、その成分および機構

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JP2013526850A JP2013526850A (ja) 2013-06-27
JP2013526850A5 JP2013526850A5 (https=) 2014-04-03
JP5863766B2 true JP5863766B2 (ja) 2016-02-17

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JP2015250577A Active JP6127124B2 (ja) 2010-04-09 2015-12-22 タンパク質および核酸送達媒体、その成分および機構

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US (3) US8802418B2 (https=)
EP (2) EP2703491B1 (https=)
JP (2) JP5863766B2 (https=)
CN (2) CN103725703B (https=)
WO (1) WO2011125054A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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CA2560045A1 (en) * 2003-12-17 2005-06-30 The Catholic University Of America Methods and compositions comprising bacteriophage nanoparticles
US9163262B2 (en) * 2003-12-17 2015-10-20 The Catholic University Of America In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine
US20120214867A1 (en) * 2011-02-18 2012-08-23 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Bacteriophage T4 Nanoparticles for Eukaryotic Delivery
US9765122B2 (en) 2013-01-18 2017-09-19 University Of Washington Through Its Center For Commercialization Theragnostic particles
US9328149B2 (en) 2013-07-12 2016-05-03 The Catholic University Of America Mutated and bacteriophage T4 nanoparticle arrayed F1-V immunogens from Yersinia pestis as next generation plague vaccines
SG11201600853UA (en) 2013-08-05 2016-03-30 Twist Bioscience Corp De novo synthesized gene libraries
WO2016115522A2 (en) * 2015-01-16 2016-07-21 University Of Kentucky Research Foundation Lipid bilayer-integrated spp1 connector protein nanopore and spp1 connector protein variants for use as lipid bilayer-integrated nanopore
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3350314A4 (en) 2015-09-18 2019-02-06 Twist Bioscience Corporation OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF
KR102794025B1 (ko) 2015-09-22 2025-04-09 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
US20180112234A9 (en) 2016-03-14 2018-04-26 Intellia Therapeutics, Inc. Methods and compositions for gene editing
WO2017165859A1 (en) * 2016-03-24 2017-09-28 Research Institute At Nationwide Children's Hospital Modified viral capsid proteins
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
EP4556433A3 (en) 2017-02-22 2025-08-06 Twist Bioscience Corporation Nucleic acid based data storage
CN106939355A (zh) * 2017-03-01 2017-07-11 苏州系统医学研究所 一种流感病毒弱毒活疫苗毒株的筛选和鉴定方法
CN108949701A (zh) * 2017-05-26 2018-12-07 中国科学院深圳先进技术研究院 一种猴类脑区的病毒注射方法及应用
CA3065946A1 (en) 2017-06-05 2018-12-13 Research Institute At Nationwide Children's Hospital Enhanced modified viral capsid proteins
CN111565834B (zh) 2017-10-20 2022-08-26 特韦斯特生物科学公司 用于多核苷酸合成的加热的纳米孔
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
AU2019293286A1 (en) 2018-06-28 2021-01-07 Crispr Therapeutics Ag Compositions and methods for genomic editing by insertion of donor polynucleotides
WO2020139871A1 (en) 2018-12-26 2020-07-02 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
JP2022522668A (ja) 2019-02-26 2022-04-20 ツイスト バイオサイエンス コーポレーション 抗体を最適化するための変異体核酸ライブラリ
CN113766930B (zh) 2019-02-26 2025-07-22 特韦斯特生物科学公司 Glp1受体的变异核酸文库
US20210047649A1 (en) 2019-05-08 2021-02-18 Vertex Pharmaceuticals Incorporated Crispr/cas all-in-two vector systems for treatment of dmd
EP3983542A2 (en) 2019-06-17 2022-04-20 CRISPR Therapeutics AG Methods and compositions for improved homology directed repair
US11155835B2 (en) * 2019-08-19 2021-10-26 The Catholic University Of America Prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells
EP4034566A4 (en) 2019-09-23 2024-01-24 Twist Bioscience Corporation VARIANT NUCLEIC ACID BANKS FOR CRTH2
JP2022548783A (ja) 2019-09-23 2022-11-21 ツイスト バイオサイエンス コーポレーション 単一ドメイン抗体のバリアント核酸ライブラリー
WO2021140615A1 (ja) * 2020-01-09 2021-07-15 哲朗 近藤 新規組換えバクテリオファージ

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US5736388A (en) 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
CA2560045A1 (en) * 2003-12-17 2005-06-30 The Catholic University Of America Methods and compositions comprising bacteriophage nanoparticles
CA2585267A1 (en) * 2004-10-29 2007-02-08 University Of Rochester Modified bacteriophage vectors and uses thereof
MX2009009213A (es) 2007-03-01 2010-03-15 Univ America Catholic Bacteriofago t4 unido a un substrato.
US9217145B2 (en) * 2007-05-15 2015-12-22 Wisconsin Alumni Research Foundation T7 phage peptide display system and uses thereof
JP2010529862A (ja) * 2007-06-16 2010-09-02 スカラブ ゲノミクス， エルエルシー 核酸パッケージングシステム

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WO2011125054A4 (en) 2012-06-28
EP2542681B1 (en) 2019-02-27
US20130196416A1 (en) 2013-08-01
US9523101B2 (en) 2016-12-20
JP6127124B2 (ja) 2017-05-10
US20140335158A1 (en) 2014-11-13
CN103003431B (zh) 2014-11-26
US8802418B2 (en) 2014-08-12
CN103003431A (zh) 2013-03-27
CN103725703A (zh) 2014-04-16
WO2011125054A3 (en) 2012-05-10
US20110250263A1 (en) 2011-10-13
JP2013526850A (ja) 2013-06-27
JP2016093183A (ja) 2016-05-26
EP2703491B1 (en) 2017-03-08
EP2542681A4 (en) 2013-10-16
EP2703491A1 (en) 2014-03-05
US9365867B2 (en) 2016-06-14
EP2542681A2 (en) 2013-01-09
WO2011125054A2 (en) 2011-10-13
CN103725703B (zh) 2016-02-10

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