CN103725703B - 用于制备包装机器的方法以及包装机器 - Google Patents
用于制备包装机器的方法以及包装机器 Download PDFInfo
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- CN103725703B CN103725703B CN201410005350.7A CN201410005350A CN103725703B CN 103725703 B CN103725703 B CN 103725703B CN 201410005350 A CN201410005350 A CN 201410005350A CN 103725703 B CN103725703 B CN 103725703B
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10041—Use of virus, viral particle or viral elements as a vector
- C12N2795/10042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10111—Myoviridae
- C12N2795/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10111—Myoviridae
- C12N2795/10141—Use of virus, viral particle or viral elements as a vector
- C12N2795/10142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10111—Myoviridae
- C12N2795/10151—Methods of production or purification of viral material
- C12N2795/10152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32233410P | 2010-04-09 | 2010-04-09 | |
| US61/322,334 | 2010-04-09 | ||
| US13/082,466 US8802418B2 (en) | 2010-04-09 | 2011-04-08 | Protein and nucleic acid delivery vehicles, components and mechanisms thereof |
| CN201180030396.9A CN103003431B (zh) | 2010-04-09 | 2011-04-08 | 蛋白质与核酸递送媒介物、其组成部分及它们的机理 |
| US13/082,466 | 2011-04-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180030396.9A Division CN103003431B (zh) | 2010-04-09 | 2011-04-08 | 蛋白质与核酸递送媒介物、其组成部分及它们的机理 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103725703A CN103725703A (zh) | 2014-04-16 |
| CN103725703B true CN103725703B (zh) | 2016-02-10 |
Family
ID=44761088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410005350.7A Active CN103725703B (zh) | 2010-04-09 | 2011-04-08 | 用于制备包装机器的方法以及包装机器 |
| CN201180030396.9A Active CN103003431B (zh) | 2010-04-09 | 2011-04-08 | 蛋白质与核酸递送媒介物、其组成部分及它们的机理 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180030396.9A Active CN103003431B (zh) | 2010-04-09 | 2011-04-08 | 蛋白质与核酸递送媒介物、其组成部分及它们的机理 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8802418B2 (https=) |
| EP (2) | EP2703491B1 (https=) |
| JP (2) | JP5863766B2 (https=) |
| CN (2) | CN103725703B (https=) |
| WO (1) | WO2011125054A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2560045A1 (en) * | 2003-12-17 | 2005-06-30 | The Catholic University Of America | Methods and compositions comprising bacteriophage nanoparticles |
| US9163262B2 (en) * | 2003-12-17 | 2015-10-20 | The Catholic University Of America | In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine |
| US20120214867A1 (en) * | 2011-02-18 | 2012-08-23 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Bacteriophage T4 Nanoparticles for Eukaryotic Delivery |
| US9765122B2 (en) | 2013-01-18 | 2017-09-19 | University Of Washington Through Its Center For Commercialization | Theragnostic particles |
| US9328149B2 (en) | 2013-07-12 | 2016-05-03 | The Catholic University Of America | Mutated and bacteriophage T4 nanoparticle arrayed F1-V immunogens from Yersinia pestis as next generation plague vaccines |
| SG11201600853UA (en) | 2013-08-05 | 2016-03-30 | Twist Bioscience Corp | De novo synthesized gene libraries |
| WO2016115522A2 (en) * | 2015-01-16 | 2016-07-21 | University Of Kentucky Research Foundation | Lipid bilayer-integrated spp1 connector protein nanopore and spp1 connector protein variants for use as lipid bilayer-integrated nanopore |
| US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| EP3350314A4 (en) | 2015-09-18 | 2019-02-06 | Twist Bioscience Corporation | OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF |
| KR102794025B1 (ko) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
| US20180112234A9 (en) | 2016-03-14 | 2018-04-26 | Intellia Therapeutics, Inc. | Methods and compositions for gene editing |
| WO2017165859A1 (en) * | 2016-03-24 | 2017-09-28 | Research Institute At Nationwide Children's Hospital | Modified viral capsid proteins |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| EP4556433A3 (en) | 2017-02-22 | 2025-08-06 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CN106939355A (zh) * | 2017-03-01 | 2017-07-11 | 苏州系统医学研究所 | 一种流感病毒弱毒活疫苗毒株的筛选和鉴定方法 |
| CN108949701A (zh) * | 2017-05-26 | 2018-12-07 | 中国科学院深圳先进技术研究院 | 一种猴类脑区的病毒注射方法及应用 |
| CA3065946A1 (en) | 2017-06-05 | 2018-12-13 | Research Institute At Nationwide Children's Hospital | Enhanced modified viral capsid proteins |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| AU2019293286A1 (en) | 2018-06-28 | 2021-01-07 | Crispr Therapeutics Ag | Compositions and methods for genomic editing by insertion of donor polynucleotides |
| WO2020139871A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| JP2022522668A (ja) | 2019-02-26 | 2022-04-20 | ツイスト バイオサイエンス コーポレーション | 抗体を最適化するための変異体核酸ライブラリ |
| CN113766930B (zh) | 2019-02-26 | 2025-07-22 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| US20210047649A1 (en) | 2019-05-08 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crispr/cas all-in-two vector systems for treatment of dmd |
| EP3983542A2 (en) | 2019-06-17 | 2022-04-20 | CRISPR Therapeutics AG | Methods and compositions for improved homology directed repair |
| US11155835B2 (en) * | 2019-08-19 | 2021-10-26 | The Catholic University Of America | Prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells |
| EP4034566A4 (en) | 2019-09-23 | 2024-01-24 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID BANKS FOR CRTH2 |
| JP2022548783A (ja) | 2019-09-23 | 2022-11-21 | ツイスト バイオサイエンス コーポレーション | 単一ドメイン抗体のバリアント核酸ライブラリー |
| WO2021140615A1 (ja) * | 2020-01-09 | 2021-07-15 | 哲朗 近藤 | 新規組換えバクテリオファージ |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1972710A (zh) * | 2003-12-17 | 2007-05-30 | 美国天主教大学 | 包含噬菌体纳米颗粒的方法和组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736388A (en) | 1994-12-30 | 1998-04-07 | Chada; Sunil | Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells |
| CA2585267A1 (en) * | 2004-10-29 | 2007-02-08 | University Of Rochester | Modified bacteriophage vectors and uses thereof |
| MX2009009213A (es) | 2007-03-01 | 2010-03-15 | Univ America Catholic | Bacteriofago t4 unido a un substrato. |
| US9217145B2 (en) * | 2007-05-15 | 2015-12-22 | Wisconsin Alumni Research Foundation | T7 phage peptide display system and uses thereof |
| JP2010529862A (ja) * | 2007-06-16 | 2010-09-02 | スカラブ ゲノミクス, エルエルシー | 核酸パッケージングシステム |
-
2011
- 2011-04-08 EP EP13194914.1A patent/EP2703491B1/en active Active
- 2011-04-08 US US13/082,466 patent/US8802418B2/en active Active
- 2011-04-08 CN CN201410005350.7A patent/CN103725703B/zh active Active
- 2011-04-08 EP EP11765160.4A patent/EP2542681B1/en active Active
- 2011-04-08 JP JP2013503215A patent/JP5863766B2/ja active Active
- 2011-04-08 CN CN201180030396.9A patent/CN103003431B/zh active Active
- 2011-04-08 WO PCT/IB2011/051533 patent/WO2011125054A2/en not_active Ceased
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2013
- 2013-03-12 US US13/796,263 patent/US9365867B2/en active Active
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2014
- 2014-07-02 US US14/322,097 patent/US9523101B2/en active Active
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2015
- 2015-12-22 JP JP2015250577A patent/JP6127124B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1972710A (zh) * | 2003-12-17 | 2007-05-30 | 美国天主教大学 | 包含噬菌体纳米颗粒的方法和组合物 |
Non-Patent Citations (2)
| Title |
|---|
| Mapping of functional sites on the primary structure of the tail lysozyme of bacteriophage T4 by mutational analysis;Shigeki Takeda et al;《Biochimica et Biophysica Acta》;19981231;第1384卷;摘要,表1-表3,第249页右栏第2段 * |
| The N-terminal ATPase Site in the Large Terminase Protein gp17 is Critically Required for DNA Packaging in Bacteriophage T4;Venigalla B. Rao et al;《J. Mol. Biol.》;20011231;第314卷;摘要第1-8,14-16行,第401页左栏第1行至右栏第1行,第401页右栏第2段第7行至402页左栏第2行,第402页第4段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011125054A4 (en) | 2012-06-28 |
| EP2542681B1 (en) | 2019-02-27 |
| US20130196416A1 (en) | 2013-08-01 |
| US9523101B2 (en) | 2016-12-20 |
| JP5863766B2 (ja) | 2016-02-17 |
| JP6127124B2 (ja) | 2017-05-10 |
| US20140335158A1 (en) | 2014-11-13 |
| CN103003431B (zh) | 2014-11-26 |
| US8802418B2 (en) | 2014-08-12 |
| CN103003431A (zh) | 2013-03-27 |
| CN103725703A (zh) | 2014-04-16 |
| WO2011125054A3 (en) | 2012-05-10 |
| US20110250263A1 (en) | 2011-10-13 |
| JP2013526850A (ja) | 2013-06-27 |
| JP2016093183A (ja) | 2016-05-26 |
| EP2703491B1 (en) | 2017-03-08 |
| EP2542681A4 (en) | 2013-10-16 |
| EP2703491A1 (en) | 2014-03-05 |
| US9365867B2 (en) | 2016-06-14 |
| EP2542681A2 (en) | 2013-01-09 |
| WO2011125054A2 (en) | 2011-10-13 |
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