JP5826762B2 - N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 - Google Patents
N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 Download PDFInfo
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- JP5826762B2 JP5826762B2 JP2012543213A JP2012543213A JP5826762B2 JP 5826762 B2 JP5826762 B2 JP 5826762B2 JP 2012543213 A JP2012543213 A JP 2012543213A JP 2012543213 A JP2012543213 A JP 2012543213A JP 5826762 B2 JP5826762 B2 JP 5826762B2
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- methanesulfonylbenzene
- sulfonamide
- carbonyl
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- alkyl
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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- C—CHEMISTRY; METALLURGY
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- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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US61/291,224 | 2009-12-30 | ||
PCT/US2010/059335 WO2011071951A2 (en) | 2009-12-07 | 2010-12-07 | N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives |
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AU2008304200B2 (en) | 2007-09-26 | 2013-12-19 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
WO2011063339A1 (en) * | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
CN105130855B (zh) | 2009-12-07 | 2018-05-25 | 约翰斯霍普金斯大学 | 二酰基化的羟基胺衍生物及其用途 |
US9181213B2 (en) | 2011-10-17 | 2015-11-10 | The Johns Hopkins University | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors |
US9676708B2 (en) * | 2012-11-01 | 2017-06-13 | The Johns Hopkins University | Controlled HNO release through intramolecular cyclization-elimination |
BR112015017251B1 (pt) | 2013-01-18 | 2021-10-26 | Cardioxyl Pharmaceuticals, Inc. | Composições farmacêuticas compreendendo doadores de nitroxil, misturas e usos das referidas composições farmacêuticas |
ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
EP3148983A1 (en) | 2014-05-27 | 2017-04-05 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives as nitroxyl donors |
US9682938B2 (en) | 2014-05-27 | 2017-06-20 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
WO2016210392A1 (en) | 2015-06-26 | 2016-12-29 | The Johns Hopkins University | N-substituted hydroxamic acids with carbon-based leaving groups as efficient hno donors and uses thereof |
EP3348548A4 (en) * | 2015-09-07 | 2019-04-03 | Zhejiang Huahai Pharmaceutical Co., Ltd | STAIN OXIDE-RELIEFING PRODRUG MOLECULE |
JP6957459B2 (ja) * | 2015-10-19 | 2021-11-02 | カルディオキシル ファーマシューティカルズ,インク. | ニトロキシルドナーとしてのn−ヒドロキシルスルホンアミド誘導体 |
EP3365328A1 (en) | 2015-10-19 | 2018-08-29 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
KR20190070912A (ko) | 2016-07-28 | 2019-06-21 | 더 존스 홉킨스 유니버시티 | O-치환된 히드록삼산 |
CA3049003A1 (en) * | 2017-01-03 | 2018-07-12 | Cardioxyl Pharmaceuticals, Inc. | Method of administering nitroxyl donating compounds |
CN108318615A (zh) * | 2018-03-16 | 2018-07-24 | 湖北亿诺瑞生物制药有限公司 | 顶空气相色谱法检测肝素钠中残留溶剂的方法 |
CN113621098B (zh) * | 2020-05-09 | 2022-11-04 | 中国石油天然气股份有限公司 | 丙烯聚合催化剂、丙烯聚合催化剂体系及其制备与应用 |
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WO2011071951A3 (en) | 2012-03-29 |
US20140235636A1 (en) | 2014-08-21 |
CN102753520B (zh) | 2016-06-08 |
US20180050985A1 (en) | 2018-02-22 |
IN2012DN05025A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-10-23 |
EP2509941A2 (en) | 2012-10-17 |
CN102753520A (zh) | 2012-10-24 |
AU2016206369B2 (en) | 2018-01-18 |
AU2010328234B2 (en) | 2016-05-12 |
ES2719101T3 (es) | 2019-07-08 |
MX2012006349A (es) | 2012-10-03 |
AU2016206369A1 (en) | 2016-08-11 |
JP2013512962A (ja) | 2013-04-18 |
CN105919987A (zh) | 2016-09-07 |
US20160046570A1 (en) | 2016-02-18 |
US20110144067A1 (en) | 2011-06-16 |
EP2509941B1 (en) | 2019-01-23 |
WO2011071951A2 (en) | 2011-06-16 |
JP2016094394A (ja) | 2016-05-26 |
CA2782110A1 (en) | 2011-06-16 |
CN105919987B (zh) | 2020-04-03 |
AU2010328234A1 (en) | 2012-06-14 |
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