JP5817977B2 - 高濃度かつ高放射能をもつテクネチウム−99m溶液の製造方法 - Google Patents
高濃度かつ高放射能をもつテクネチウム−99m溶液の製造方法 Download PDFInfo
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- JP5817977B2 JP5817977B2 JP2011173260A JP2011173260A JP5817977B2 JP 5817977 B2 JP5817977 B2 JP 5817977B2 JP 2011173260 A JP2011173260 A JP 2011173260A JP 2011173260 A JP2011173260 A JP 2011173260A JP 5817977 B2 JP5817977 B2 JP 5817977B2
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0042—Technetium
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- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
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Description
1)NaOHによるMoO3溶解試験
2)MEKによる溶媒抽出試験
3)アルミナカラムからのレニウム(Re)溶離試験
20…99mTc抽出槽
30…99mTc分離槽
40…不純物除去カラム
50…99mTc濃縮カラム
Claims (4)
- アルカリ溶液による、中性子照射された 99MoO3ペレットの溶解、ケトン系有機溶剤による溶解液からの99mTc抽出、99mTc含有ケトン系有機相と水相の分離、分離された99mTc含有ケトン系有機相を連続した、一段目が塩基性アルミナカラムで、二段目が酸性アルミナカラムである2種類の異なったアルミナカラムを介して、99Moなどを含む不純物の除去及び99mTcの吸着、並びに99mTc吸着酸性アルミナカラムから生理食塩水を用いて溶離する段階とから成る高濃度テクネチウム- 99m溶液の製造方法において、
前記アルカリ溶液が、6M-NaOH溶液又は6M-KOH溶液であることを特徴とする高濃度かつ高放射能をもつテクネチウム- 99m溶液の製造方法。 - 請求項1に記載の製造方法において、前記酸性アルミナカラムに使用するアルミナとして、粒子径が均一なアルミナを0.1M-HNO3中で24時間以上処理した酸性アルミナを使用することを特徴とする高濃度かつ高放射能をもつテクネチウム-99m溶液の製造方法。
- 請求項1又は2に記載の製造方法において、前記2種類の異なったアルミナカラムのうち、99mTcを吸着する酸性アルミナカラムの径がφ10〜14mmの範囲にあることを特徴とする高濃度かつ高放射能をもつテクネチウム-99m溶液の製造方法。
- 請求項1乃至3のいずれかに記載の製造方法において、前記ケトン系有機溶媒がメチルエチルケトン溶液であることを特徴とする高濃度かつ高放射能をもつテクネチウム-99m溶液の製造方法。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011173260A JP5817977B2 (ja) | 2011-08-08 | 2011-08-08 | 高濃度かつ高放射能をもつテクネチウム−99m溶液の製造方法 |
US13/568,891 US20130036871A1 (en) | 2011-08-08 | 2012-08-07 | METHOD OF PRODUCING HIGH-CONCENTRATED TECHNETIUM-99m SOLUTION IN LARGE QUANTITIES |
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JP2011173260A JP5817977B2 (ja) | 2011-08-08 | 2011-08-08 | 高濃度かつ高放射能をもつテクネチウム−99m溶液の製造方法 |
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JP2013035714A JP2013035714A (ja) | 2013-02-21 |
JP5817977B2 true JP5817977B2 (ja) | 2015-11-18 |
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JP2011173260A Active JP5817977B2 (ja) | 2011-08-08 | 2011-08-08 | 高濃度かつ高放射能をもつテクネチウム−99m溶液の製造方法 |
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US (1) | US20130036871A1 (ja) |
JP (1) | JP5817977B2 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014057900A1 (ja) * | 2012-10-10 | 2014-04-17 | 国立大学法人大阪大学 | Riの単離装置 |
JP6377497B2 (ja) * | 2014-11-12 | 2018-08-22 | 住友重機械工業株式会社 | 放射性同位元素の分離装置及び放射性同位元素の分離方法 |
JP6554753B1 (ja) * | 2019-03-11 | 2019-08-07 | 株式会社京都メディカルテクノロジー | テクネチウム99m単離システム及びテクネチウム99m単離方法 |
CN110544548B (zh) * | 2019-08-20 | 2021-04-06 | 西安迈斯拓扑科技有限公司 | 一种基于电子加速器生产99Mo的钼锝处理和分离方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US3382152A (en) * | 1964-09-28 | 1968-05-07 | Union Carbide Corp | Production of high purity radioactive isotopes |
US3436354A (en) * | 1967-01-17 | 1969-04-01 | Union Carbide Corp | Production of a solution containing radioactive technetium |
US4158700A (en) * | 1976-03-08 | 1979-06-19 | Karageozian Hampar L | Method of producing radioactive technetium-99M |
US4041317A (en) * | 1976-05-19 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Multiple pH alumina columns for molybdenum-99/technetium-99m generators |
US4280053A (en) * | 1977-06-10 | 1981-07-21 | Australian Atomic Energy Commission | Technetium-99m generators |
CA1113257A (en) * | 1978-03-14 | 1981-12-01 | Hampar L. Karageozian | Method of producing radioactive technetium-99m |
US5774782A (en) * | 1996-05-22 | 1998-06-30 | Lockheed Martin Energy Systems, Inc. | Technetium-99m generator system |
US5802439A (en) * | 1997-02-19 | 1998-09-01 | Lockheed Martin Idaho Technologies Company | Method for the production of 99m Tc compositions from 99 Mo-containing materials |
US5802438A (en) * | 1997-02-19 | 1998-09-01 | Lockheed Martin Idaho Technologies Company | Method for generating a crystalline 99 MoO3 product and the isolation 99m Tc compositions therefrom |
JP4386631B2 (ja) * | 2002-10-31 | 2009-12-16 | 株式会社化研 | ジルコニウム系無機高分子を使用した選択的モリブデン吸着剤を利用する中性子照射天然モリブデン型テクネチウム99mジェネレータシステム及びその製造装置 |
US20060023829A1 (en) * | 2004-08-02 | 2006-02-02 | Battelle Memorial Institute | Medical radioisotopes and methods for producing the same |
JP5427483B2 (ja) * | 2009-06-19 | 2014-02-26 | 株式会社化研 | 放射性医薬品およびその標識化合物原料としての放射性テクネチウムの濃縮および溶出回収方法、およびシステム |
CN102048717B (zh) * | 2009-10-29 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种稳定的雷沙吉兰组合物 |
JP5598900B2 (ja) * | 2009-11-20 | 2014-10-01 | 独立行政法人日本原子力研究開発機構 | 高純度99mTc濃縮方法及び濃縮装置 |
DE102010006435B3 (de) * | 2010-02-01 | 2011-07-21 | Siemens Aktiengesellschaft, 80333 | Verfahren und Vorrichtung zur Produktion von 99mTc |
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2011
- 2011-08-08 JP JP2011173260A patent/JP5817977B2/ja active Active
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2012
- 2012-08-07 US US13/568,891 patent/US20130036871A1/en not_active Abandoned
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Publication number | Publication date |
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JP2013035714A (ja) | 2013-02-21 |
US20130036871A1 (en) | 2013-02-14 |
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