IL29607A - Production of high purity radioactive technetium-99m - Google Patents
Production of high purity radioactive technetium-99mInfo
- Publication number
- IL29607A IL29607A IL29607A IL2960768A IL29607A IL 29607 A IL29607 A IL 29607A IL 29607 A IL29607 A IL 29607A IL 2960768 A IL2960768 A IL 2960768A IL 29607 A IL29607 A IL 29607A
- Authority
- IL
- Israel
- Prior art keywords
- technetium
- slurry
- molybdenum
- sterile
- oxidized
- Prior art date
Links
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title claims description 30
- 229940056501 technetium 99m Drugs 0.000 title claims description 30
- 230000002285 radioactive effect Effects 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title description 6
- 238000000034 method Methods 0.000 claims description 33
- 239000000243 solution Substances 0.000 claims description 15
- 239000002002 slurry Substances 0.000 claims description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 13
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 12
- 229950009740 molybdenum mo-99 Drugs 0.000 claims description 11
- ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 claims description 10
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims description 10
- 229910001928 zirconium oxide Inorganic materials 0.000 claims description 10
- 239000012535 impurity Substances 0.000 claims description 7
- 150000003754 zirconium Chemical class 0.000 claims description 6
- JGJLWPGRMCADHB-UHFFFAOYSA-N hypobromite Inorganic materials Br[O-] JGJLWPGRMCADHB-UHFFFAOYSA-N 0.000 claims description 5
- 239000007800 oxidant agent Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 3
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- VKJKEPKFPUWCAS-UHFFFAOYSA-M potassium chlorate Chemical compound [K+].[O-]Cl(=O)=O VKJKEPKFPUWCAS-UHFFFAOYSA-M 0.000 claims description 2
- 239000012286 potassium permanganate Substances 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 229960003328 benzoyl peroxide Drugs 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 239000008174 sterile solution Substances 0.000 claims 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 16
- 229910052750 molybdenum Inorganic materials 0.000 description 15
- 239000011733 molybdenum Substances 0.000 description 15
- 239000000758 substrate Substances 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 6
- 229910052713 technetium Inorganic materials 0.000 description 6
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 5
- 238000010828 elution Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229910052726 zirconium Inorganic materials 0.000 description 5
- JKQOBWVOAYFWKG-UHFFFAOYSA-N molybdenum trioxide Chemical group O=[Mo](=O)=O JKQOBWVOAYFWKG-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical class [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000004993 emission spectroscopy Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- -1 molybdate ions Chemical class 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OYEHPCDNVJXUIW-FTXFMUIASA-N 239Pu Chemical compound [239Pu] OYEHPCDNVJXUIW-FTXFMUIASA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 125000005595 acetylacetonate group Chemical group 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical compound [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 description 1
- 235000018660 ammonium molybdate Nutrition 0.000 description 1
- 239000011609 ammonium molybdate Substances 0.000 description 1
- 229940010552 ammonium molybdate Drugs 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical class OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 239000005078 molybdenum compound Substances 0.000 description 1
- 150000002752 molybdenum compounds Chemical class 0.000 description 1
- WFLYOQCSIHENTM-UHFFFAOYSA-N molybdenum(4+) tetranitrate Chemical compound [N+](=O)([O-])[O-].[Mo+4].[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] WFLYOQCSIHENTM-UHFFFAOYSA-N 0.000 description 1
- ICYJJTNLBFMCOZ-UHFFFAOYSA-J molybdenum(4+);disulfate Chemical compound [Mo+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ICYJJTNLBFMCOZ-UHFFFAOYSA-J 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- JFALSRSLKYAFGM-OIOBTWANSA-N uranium-235 Chemical compound [235U] JFALSRSLKYAFGM-OIOBTWANSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B61/00—Obtaining metals not elsewhere provided for in this subclass
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
Patents Form No. 3
PATENTS AND DESIG S ORDINANCE.
SPECIFICATION.
"PROOUCTIOH OF HIGH FORITY RADIOACTIVE TKCHHBTHm-99m,f
«nfmi jroi va »:j*si{?in»vi 399-01* ewaao τί*"«
I / WE , UHXOH CARBXDS CORiwmTIOB,...jof ..57B-Papk-Aventtet
under the law© of th© State of New York, United states of America,
do hereby declare the nature of this invention and in what manner the same is to be performed, to be particularly described aud ascertained in and by the following
statement : -
This invention relates to a novel process for the
production of radioaotive technetium-99m. In one aspect,
this invention relates to a novel process for the production of radioactive technetium-99m in high yields. A further
aspect of this invention is directed to a novel process for
the production of radioaotive technetium-99m which can be
obtained in a high degree of purity.
Recent medical investigation has shown that technetium-99m is an extremely useful tool for diagnosis. High purity
technetium-99m is used primarily as a radioisotope in a variety of medical research and diagnosis. It is well suited for
liver, lung, blood pool and tumor scanning, and is preferred over other radioactive isotopes because of its short half-life which results in reduced exposure of the organs to radiation.
In addition to medical uses, technetium-99m can also' be employed in industrial applications, such as in the measurement of flow rates, process control, radiometric chemistry, and the like. Since the radioisotope sought to be used has such a
short half-life, it is common practice to ship the users of
the isotope the parent element; in this case radioactive
molybdenum-99. The user then extracts the technetium from
the molybdenum-99 as his needs require.
In the past, radioactive technetium-99m has been
produced by a variety of methods. For example, M.S. Faddeeva et al., Zhur. Neorg. Khim. , 3, 165-166 (1958), has disclosed a process for extracting technetium-99m from 6N aqueous K2CO3
solutions containing dissolved molybdenum-99 containing material, using methyl ethyl ketone as the extracting medium, followed by washing the ketone solutions with KgCOg aqueous solution. The teohnetium-99«n recovered by this process, however, was not pure, since the product contained detectable K2C0g and would therefore not be useable for many purposes, such as for medical purposes.
More recently, a process was perfected for the
separation of technetium-99m from molybdenura-99. Separation vrae effected by contacting the molybdenum-99 (in the form of molybdate ions) with alumina, followed by selective removal of technetium-99m (in the form of TcC -ion) from the bonded alumina. Although, to date, the alumina column generally is acceptable, the chemical purity of the eluant barely meets minimum medical requirements and the column itself is at times unstable, producing an eluant unfit for medical purposes.
Finally, J. J. Pinajian, International J. Applied
Radioactive Isotopes, 1£, 664 (1966) reported a method which used hydrous zirconium oxide as the absorbing media for the chromatographic selective adsorption of molybdenum and eluded technetium-99m with acid methyl ethyl ketone (5 vol. # 0.01
MHC1). The methyl ethyl ketone eluant must then be processed to produce a physiologically acceptable solution for parental injection because of its extreme toxicity.
It is therefore an object of this invention to provide a more efficient method for producing radioactive technetium-99m. Another object of this invention is to provide a process for preparing radioactive technetium-99m in a high degree of purity and by an extremely reproducible process. A further object of this invention is to provide a process which avoids the need for separating radioactive products and other impurities. These and other objects will readily become apparent to those skilled in the art in the light of the teachings herein set forth.
It has now been discovered that the aforementioned objects can be achieved by a process which comprises the steps of (a) producing radioactive mblybdenum-99, (b) dissolving the radioactive compound, (c) adjusting the pH of the radioactive
hydrous zirconium oxide, and (e) selectively extracting
technetium-99m from the oxidized substrate.
Operating in the aforesaid manner provides a selective separation of technetium-99m from all other elements in the dissolved radioactive molybdenum-99 compound with very high efficiency, i.e., over 80 per cent.
In addition the process of this invention is readily reproducible and simple to operate.
Although a variety of compounds are suitable for use in the process of this invention the preferred target is
molybdenum trioxide. In the event that other compounds are employed, it is often necessary- to isolate the molybdenum component after irradiation. Illustrative compounds which can be employed as the source of molybdenum-99 include, among others, molybdenum metal, molybdenum nitrate, molybdenum
sulfate, organic molybdenum compounds such as molybdenum
acetylacetonates, and fissionable materials such as uranium- 235 » uranium-238, plutonium- 239 , and the like.
Irradiation of compounds to produce molybdenum-99 Is a well known technique and can be effected by placing the proper compound in the irradiation zone of a nuclear reactor, particle generator, or neutron isotopic source.
Thereafter, the irradiated compound is dissolved in a suitable solvent. In the case of molybdenum trioxide it may be necessary to employ a basic solvent such as sodium hydroxide, ammonium hydroxide, and the like, the techniques to dissolve and isolate a pure molybdenum-99 solution are well known in the art.
In contrast to the work disclosed by Pinajian,
wherein hydrous zirconium oxide was employed, it has now been unexpectedly and surprisingly found that when a zirconium salt, such as hydrous zirconium oxide, is contacted with an
selectively adsorbs molybdenum but does not appear to adsorb technetium. It is also surprising that ^
(a) the loading capacity of the system exceeds all other
known systems which yielc". equivalent amounts of
technetium when using physiological saline,
(b) that the saline containing the technetium product
has unexpectedly lower elemental impurities due to
the molybdenum absorbing substrate, and
(c) that the saline contains appreciably more technetium
and less molybdenum than comparable systems heretofore
known.
In accordance with the process of the present invention molybdenum solution, such as aqueous ammonium molybdate is contacted with oxidized zirconium salts. The oxidized
zirconium salts are prepared by contacting a compound, such as hydrous zirconium oxide, with an oxidizing agent, in the presence of an acid. Suitable oxidizing agents which can be employed include, among others, bromine water, chlorine water, iodide water, permanganate salts, such as potassium permanganate, chlorate salts, such as potassium chlorate, hydrogen peroxide, organic peroxides, such as benzoyl peroxide and the like.
Thereafter, the pH of the contacted solution is adjusted to a range between 2 to 7 and more preferably between 3.5 and
6.0. Normally, it is preferable to heat the solution during pH adjustment and control and to maintain this heat for a duration of approximately twenty minutes to insure adsorption of the molybdenum on the zirconium substrate. Temperature is not
necessarily critical and need only be sufficient to insure
complete reaction of the molybdenum and the oxidized zirconium salt. In practice, temperatures greater than 70°C, have
been found satisfactory, with the preferred temperature being
The zirconium substrate containing the molybdenum is then transferred to an appropriate elution system such as a column, or vessel, preferably glass, or other inert material. The supernatant liquid is allowed to drain or removed by filtration or decantation and the substrate washed with
isotonic saline.
The technetium-99m in the column or vessel which contains 99Mo-99mTc activity can subsequently be isolated, e.g., milked, filtered, centrifuged or the like for technetium-99m as it is formed with an acidic, neutral or basic solution. Preferably, it has been observed that best results are obtained when the system is eluted with 20 milliliter portions of isotonic saline solutions. This is done by contacting the substract with the desired volume of saline and collecting the liquid portion.
Numerous variations of the preferred embodiment described above may be practiced, as will be apparent to those skilled In the art, without departing from the basic concepts of the present invention.
As previously indicated, the process of the present invention provides a simple method for the preparation of technetium-99m in a high degree of efficiency. By this process recovery of technetium-99m can be effected with isotonic saline in efficiencies as high as 95 and higher, over a pH range of about 4.0 to about 7.0 without appreciable dissolution of the zirconium substrate or removal of any molybdenum from the zirconium substrate.
A further advantage characteristic of the process of this invention, is that the substrate and/or the entire elution system can be sterilized, i.e., by autoclaving at the normally prescribed temperatures and pressures.
In contrast, the previously known hydrous zirconium oxide, which are loaded with an acid solution containing
molybdenum can not be efficiently eluted for technetium with isotonic saline.
The following example is illustrative:
EXAMPLE 1
To 100 grams of Bio Rad hydrous zirconium oxide
(100-200 mesh) was added 100 milliliters of 0.1 MHC1 and 10 milliliters of saturated bromine water. The mixture was stirred and allowed to stand for 10 minutes. Thereafter 15 milliliters of 1 M NaOH was added to the slurry. A sufficient volume of
this slurry was transferred into a 150 milliliter beaker to provide 1 milliliter of slurry per 57 milligrams of molybdenum.
Thereafter the slurry was washed three times with water and four drops of saturated bromine water added. To the slurry was added a solution containing 1 gram of irradiated molybdenum material as the molybdate in 20 milliliters of 20 per cent
ammonium hydroxide. The mixture was heated with stirring and 6M HNO3 was slowly added until pH was between 4 to 6. Additional HNO3 was added to maintain this pH until the chemical reaction was complete. Thereafter, the slurry was heated for 20 minutes and cooled. The slurry was then transferred into a column and
washed with isotonic saline solution. After the technetium-99m had built up in the generator it was eluted with isotonic saline solution.
The column was tested for molybdenum break-through by radiometric analysis and no molybdenum-99 was observed.
Chemical purity was tested by emission spectroscopy for the major elements of the column substrate, i.e., zirconium, and none was detectable.
EXAMPLE 2
A comparison of adsorption-elution characteristics
with a recent method, wherein an alumina column 18 employee the data obtained is set forth in Table I below:
TABLE I
COMPARISON OP ADSORPTION-ELUTION CHARACTERISTICS OF
ZIRCO IA AND ALUMINA SYSTEMS
Alumina Zlrconia
Mo loading
(mg Mo/ml adsorber) < 2 >57
99mTc Recovery (#)
in isotonic saline
solution
sterile 60-80/30 ml > 9Ο/3Ο ml
non-sterile 80/20 ml >80/20 ml
metal impurity (ppm)
sterile >1 <1
non-sterile >50 <1
stability fair excellent
As previously indicated radiometric analysis of the eluted technetium-99m indicates that it contains up to 95 per cent of the available technetium-99m and the radionuclidic purity is greater thar 99.99 per jent. The total metal element impurity is less than 1 p rt per million as determined by emission spectroscopy techniques.
The substrate and/or the entire elution system can be sterilized b acceptable autoclave techniques with no reduction in radionuclidic impurity, no increase in the metal element impurities and no reduction in the amount of technetium-99m recoverable.
Although the invention has been illustrated by the preceding example, it is not to be construed as being limited to the materials employed therein, but rather, the invention encompasses the generic area as hereinbefore disclosed. Various
modifications and embodiments of this invention can be made without departing from the spirit and scope thereof.
Claims (11)
1. A process for producing radioactive teohnetium-99m which comprises the steps of: (a) contacting an oxidized zirconium salt with a solution containing radioaotlve molybdenum 99; to produce a slurry; (b) adjusting and maintaining the pH of said slurry to within the range of from 2 to 7; (c) heating said slurry above 40eC. until etatio conditions of pH are observed; (d) selectively extracting said slurry with a solvent to separate technetium-99m from its radioactive parent molybdenum-99 that is deposited on the slurry.
2. The process of claim 1 wherein said oxidized zirconium salt is oxidized hydrous zirconium oxide.
3. The process of claim 2 wherein said oxidized hydrous zirconium oxide is obtained by contacting hydrous zirconium oxide with an oxidizing agent.
4. The process of claim 3 wherein said oxidizing agent is selected from the group consisting of bromine water, chlorine water, iodine water, potassium permanganate, potassium chlorate, hydrogen peroxide, and benzoylperoxide.
5. The process of claim 3 wherein said oxidizing agent is bromine water.
6. The process of claim 1 wherein technetium-99m is selectively extracted with Isotonic saline.
7. The process of claim 1 wherein said slurry is 29607/2 '·
8. The process of claim 7 wherein said sterile slurry is extracted with sterile isotonic saline to provide a sterile solution containing technetium-99m.
9. A sterile, isotonic saline solution consisting of technetium-99m and having a radionuclidlc purity greater than 99.99 percent and a total metal element impurity of less than 1 part per million.
10. The process of claim 1 wherein technetium-99m is selectively extracted with methyl ethyl ketone.
11. The process of claim 1 wherein technetium-99m is selectively extracted with an aqueous solution of an inorganic acid. Attorney for Applicants.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64645367A | 1967-06-16 | 1967-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL29607A true IL29607A (en) | 1971-10-20 |
Family
ID=24593130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL29607A IL29607A (en) | 1967-06-16 | 1968-03-08 | Production of high purity radioactive technetium-99m |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3468808A (en) |
| BE (1) | BE716569A (en) |
| DE (1) | DE1758118C3 (en) |
| FR (1) | FR1561828A (en) |
| GB (1) | GB1207246A (en) |
| IL (1) | IL29607A (en) |
| NL (1) | NL6804929A (en) |
| SE (1) | SE350954B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL165321C (en) * | 1971-03-02 | 1981-03-16 | Byk Mallinckrodt Cil Bv | METHOD FOR THE MANUFACTURE OF A RADIO ISOTOPE GENERATOR GENERATOR. |
| US4010109A (en) * | 1973-07-02 | 1977-03-01 | Kurt Sauerwein | Device for marking fluent materials |
| US4158700A (en) * | 1976-03-08 | 1979-06-19 | Karageozian Hampar L | Method of producing radioactive technetium-99M |
| US4280053A (en) * | 1977-06-10 | 1981-07-21 | Australian Atomic Energy Commission | Technetium-99m generators |
| US4206358A (en) * | 1977-10-19 | 1980-06-03 | Australian Atomic Energy Commission | Technetium-99 generators |
| US8449850B2 (en) * | 2010-02-19 | 2013-05-28 | Babcock & Wilcox Technical Services Group, Inc. | Method and apparatus for the extraction and processing of molybdenum-99 |
| GB201112051D0 (en) * | 2011-07-13 | 2011-08-31 | Mallinckrodt Llc | Process |
| EP2862181B1 (en) | 2012-06-15 | 2017-04-19 | Dent International Research, Inc. | Apparatus and methods for transmutation of elements |
| US9842664B2 (en) | 2013-09-26 | 2017-12-12 | Los Alamos National Security, Llc | Recovering and recycling uranium used for production of molybdenum-99 |
| US9793023B2 (en) | 2013-09-26 | 2017-10-17 | Los Alamos National Security, Llc | Recovery of uranium from an irradiated solid target after removal of molybdenum-99 produced from the irradiated target |
| WO2016022848A1 (en) * | 2014-08-06 | 2016-02-11 | Research Triangle Institute | High efficiency neutron capture products production |
| US20180244535A1 (en) * | 2017-02-24 | 2018-08-30 | BWXT Isotope Technology Group, Inc. | Titanium-molybdate and method for making the same |
| AR115584A1 (en) * | 2018-06-20 | 2021-02-03 | Bwxt Isotope Tech Group Inc | SYSTEM AND METHOD FOR EVALUATING THE EVALUATION EFFECTIVENESS AND RADIOPURITY OF Tc-99m GENERATORS |
| JP6554753B1 (en) * | 2019-03-11 | 2019-08-07 | 株式会社京都メディカルテクノロジー | Technetium 99m isolation system and technetium 99m isolation method |
| CN114121330B (en) * | 2021-11-11 | 2024-05-14 | 中国核动力研究设计院 | Molybdenum technetium generator, preparation method and device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB896758A (en) * | 1959-11-13 | 1962-05-16 | Atomic Energy Authority Uk | Improvements in or relating to the separation of technetium from fission product solutions |
-
1967
- 1967-06-16 US US646453A patent/US3468808A/en not_active Expired - Lifetime
-
1968
- 1968-03-08 IL IL29607A patent/IL29607A/en unknown
- 1968-04-05 DE DE1758118A patent/DE1758118C3/en not_active Expired
- 1968-04-08 NL NL6804929A patent/NL6804929A/xx unknown
- 1968-04-16 GB GB07816/68A patent/GB1207246A/en not_active Expired
- 1968-05-08 FR FR1561828D patent/FR1561828A/fr not_active Expired
- 1968-06-05 SE SE07522/68A patent/SE350954B/xx unknown
- 1968-06-14 BE BE716569D patent/BE716569A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1758118B2 (en) | 1973-10-18 |
| NL6804929A (en) | 1968-12-17 |
| GB1207246A (en) | 1970-09-30 |
| DE1758118C3 (en) | 1974-05-30 |
| SE350954B (en) | 1972-11-13 |
| DE1758118A1 (en) | 1970-12-23 |
| FR1561828A (en) | 1969-03-28 |
| BE716569A (en) | 1968-12-16 |
| US3468808A (en) | 1969-09-23 |
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