JP5813505B2 - 新規インフルエンザウイルス免疫エピトープ - Google Patents

新規インフルエンザウイルス免疫エピトープ Download PDF

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JP5813505B2
JP5813505B2 JP2011517725A JP2011517725A JP5813505B2 JP 5813505 B2 JP5813505 B2 JP 5813505B2 JP 2011517725 A JP2011517725 A JP 2011517725A JP 2011517725 A JP2011517725 A JP 2011517725A JP 5813505 B2 JP5813505 B2 JP 5813505B2
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plant
seq
nucleic acid
influenza
protein
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JP2011528223A5 (enExample
JP2011528223A (ja
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マノン クチュール
マノン クチュール
ルイ フィリップ ヴェジナ
ルイ フィリップ ヴェジナ
ナタリー ランドリー
ナタリー ランドリー
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メディカゴ インコーポレイテッド
メディカゴ インコーポレイテッド
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    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
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    • C12N2760/16011Orthomyxoviridae
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    • C12N2760/16011Orthomyxoviridae
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    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16211Influenzavirus B, i.e. influenza B virus
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JP2011517725A 2008-07-18 2009-07-15 新規インフルエンザウイルス免疫エピトープ Expired - Fee Related JP5813505B2 (ja)

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Application Number Priority Date Filing Date Title
US8181108P 2008-07-18 2008-07-18
US61/081,811 2008-07-18
PCT/CA2009/001040 WO2010006452A1 (en) 2008-07-18 2009-07-15 New influenza virus immunizing epitope

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JP2011528223A JP2011528223A (ja) 2011-11-17
JP2011528223A5 JP2011528223A5 (enExample) 2012-09-06
JP5813505B2 true JP5813505B2 (ja) 2015-11-17

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US (1) US9546375B2 (enExample)
EP (1) EP2318530B1 (enExample)
JP (1) JP5813505B2 (enExample)
KR (1) KR101745925B1 (enExample)
CN (1) CN102165062B (enExample)
AU (1) AU2009270404B2 (enExample)
CA (1) CA2730668C (enExample)
DK (1) DK2318530T3 (enExample)
ES (1) ES2593277T3 (enExample)
IL (1) IL210451A (enExample)
MX (2) MX370690B (enExample)
MY (1) MY161965A (enExample)
NZ (1) NZ590351A (enExample)
PT (1) PT2318530T (enExample)
RU (1) RU2546872C2 (enExample)
SG (1) SG192503A1 (enExample)
WO (1) WO2010006452A1 (enExample)
ZA (1) ZA201101231B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CN103122354B (zh) 2007-11-27 2018-03-23 麦迪卡格公司 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
US8771703B2 (en) * 2008-07-08 2014-07-08 Medicago Inc. Soluble recombinant influenza antigens
AU2009270404B2 (en) 2008-07-18 2015-01-29 Medicago Inc. New influenza virus immunizing epitope
CA2762042C (en) 2009-06-24 2012-11-20 Medicago Inc. Chimeric influenza virus-like particles comprising hemagglutinin
CA2766899C (en) 2009-07-02 2021-05-04 Massachusetts Institute Of Technology Compositions and methods for diagnosing and/or treating influenza infection
HRP20171564T1 (hr) 2009-09-22 2017-11-17 Medicago Inc. Postupak za pripremu biljnih čestica sličnih virusu (vlp)
JP2013541528A (ja) 2010-09-21 2013-11-14 マサチューセッツ インスティテュート オブ テクノロジー ヒト適応haポリペプチド、ワクチン、およびインフルエンザの処置
AU2011312178B2 (en) 2010-10-04 2016-05-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
WO2012088428A1 (en) * 2010-12-22 2012-06-28 Novavax Inc. Modified influenza hemagglutinin proteins and uses thereof
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
MX350421B (es) * 2011-06-13 2017-09-06 Medicago Inc Producción de partículas tipo virus de la rabia en plantas.
SI2760882T1 (sl) 2011-09-30 2023-10-30 Medicago Inc. Povečanje količine virusom podobnih delcev v rastlinah
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
JP2016516415A (ja) 2013-03-28 2016-06-09 メディカゴ インコーポレイテッド 植物におけるインフルエンザウイルス様粒子の生成
EP3039036B1 (en) 2013-08-28 2019-05-22 GlaxoSmithKline Biologicals S.A. Novel influenza antigens and antibodies
US10291197B2 (en) 2016-02-03 2019-05-14 Cg Discovery, Inc. Compositions of influenza hemagglutinin with heterologous epitopes and/or altered maturation cleavage sites and methods of use thereof
GB201614485D0 (en) * 2016-08-25 2016-10-12 Univ Oxford Innovation Ltd Immunogenic composition
US20180128545A1 (en) * 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
CA3079486A1 (en) * 2017-10-18 2019-04-25 Xiamen University Mutant of hemagglutinin protein of h3n2 subtype influenza virus and use thereof
MX2020013961A (es) 2018-06-27 2021-03-09 Medicago Inc Mutantes de hemaglutinina del virus de la influenza.

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428147A (en) 1983-04-15 1995-06-27 Mycogen Plant Science, Inc. Octopine T-DNA promoters
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5100792A (en) 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
WO1986003224A1 (en) 1984-11-29 1986-06-05 Scripps Clinic And Research Foundation Polypeptides and antibodies related to deglycosylated viral glycoproteins
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
US5312746A (en) * 1993-01-08 1994-05-17 Life Technologies, Inc. Cloning and expressing restriction endonucleases and modification methylases from caryophanon
GB9414118D0 (en) 1994-07-13 1994-08-31 Axis Genetics Ltd Modified plant viruses as vectors of heterologous peptides
GB9524350D0 (en) 1995-11-29 1996-01-31 Lynxvale Ltd Enhancer-increased gene expression in plants
US6042832A (en) * 1996-08-28 2000-03-28 Thomas Jefferson University Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins
US5945326A (en) * 1997-03-20 1999-08-31 New England Biolabs, Inc. Method for cloning and producing the Spel restriction endonuclease
US20010006950A1 (en) * 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6489537B1 (en) * 1998-08-07 2002-12-03 The Trustees Of The University Of Pennsylvania Phytochelatin synthases and uses therefor
US6287570B1 (en) 1998-11-23 2001-09-11 Patricia L. Foley Vaccine against swine influenza virus
US7125978B1 (en) * 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
WO2001029242A2 (en) 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
WO2001031045A1 (en) 1999-10-26 2001-05-03 Plant Research International B.V. Mammalian-type glycosylation in plants
CN100385006C (zh) 2001-01-19 2008-04-30 陶氏化学公司 利用植物细胞分泌性生产具有人型糖链的糖蛋白的方法
HUE050222T2 (hu) * 2002-02-13 2020-11-30 Wisconsin Alumni Res Found Szignál influenzavírus-vektorok pakolására
EP1485492B1 (en) * 2002-03-19 2011-12-21 Stichting Dienst Landbouwkundig Onderzoek Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta(1,4)-n-acetylglucosaminyltransferase iii) expression in plants
JP4532118B2 (ja) * 2002-03-19 2010-08-25 スティヒティング ディーンスト ランドバウクンディフ オンデルズーク 植物体内のグリカンプロセシングの最適化
US20040264870A1 (en) 2002-08-20 2004-12-30 Skunes Timothy A. Optical alignment mount with height adjustment
PL224786B1 (pl) 2003-01-22 2017-01-31 Glycart Biotechnology Ag Wyizolowany kwas nukleinowy, ssaczy wektor ekspresyjny, komórki gospodarza, fuzja polipeptydowa i sposób jej wytwarzania, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji polipeptydu wytwarzanego przez komórki gospodarza
DE602004028004D1 (de) * 2003-05-05 2010-08-19 Thompson Boyce Plant Res Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen
CA2816222A1 (en) * 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US8592197B2 (en) * 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
US7723569B2 (en) 2004-04-30 2010-05-25 National Institute Of Agrobiological Sciences Method for producing ubiquinone-10 in plant
WO2006119516A2 (en) 2005-04-29 2006-11-09 University Of Cape Town Expression of viral proteins in plants
MX2008000890A (es) 2005-07-19 2008-03-18 Dow Global Technologies Inc Vacunas de influenza (flu) recombinantes.
US7871626B2 (en) 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
BRPI0617486A2 (pt) 2005-10-18 2011-07-26 Novavax Inc vacina que compreende partÍculas similares a vÍrus da gripe funcionais (vlp) e uso de uma vlp de gripe
WO2007051036A2 (en) * 2005-10-26 2007-05-03 Protelix, Inc. Influenza combinatorial antigen vaccine
AU2007215080A1 (en) 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
WO2007130327A2 (en) * 2006-05-01 2007-11-15 Technovax, Inc. Influenza virus-like particle (vlp) compositions
BRPI0713671A2 (pt) * 2006-06-16 2013-12-03 Dow Agrosciences Llc Sequências de dna, vetores e proteínas de hemaglutinina de influenza aviária
RU2499053C2 (ru) 2007-06-15 2013-11-20 Медикаго Инк. Способ синтеза белка с модифицированным профилем n-гликозилирования в растениях
KR100964462B1 (ko) 2007-07-10 2010-06-16 성균관대학교산학협력단 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
IL203018A (en) 2007-07-13 2015-01-29 Medicago Inc Influenza virus-like particles containing megalotinin produced in a plant
CN103122354B (zh) 2007-11-27 2018-03-23 麦迪卡格公司 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
KR101956910B1 (ko) 2008-01-21 2019-03-12 메디카고 인코포레이티드 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(VLPs)
AU2009270404B2 (en) 2008-07-18 2015-01-29 Medicago Inc. New influenza virus immunizing epitope

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ZA201101231B (en) 2011-10-26
DK2318530T3 (en) 2016-10-03
ES2593277T3 (es) 2016-12-07
NZ590351A (en) 2012-11-30
RU2011105885A (ru) 2012-08-27
IL210451A0 (en) 2011-03-31
AU2009270404A1 (en) 2010-01-21
WO2010006452A1 (en) 2010-01-21
CN102165062A (zh) 2011-08-24
PT2318530T (pt) 2016-09-30
SG192503A1 (en) 2013-08-30
CA2730668A1 (en) 2010-01-21
RU2546872C2 (ru) 2015-04-10
KR101745925B1 (ko) 2017-06-12
CN102165062B (zh) 2017-09-08
US20110191915A1 (en) 2011-08-04
EP2318530A4 (en) 2012-01-25
IL210451A (en) 2015-04-30
KR20110031966A (ko) 2011-03-29
AU2009270404B2 (en) 2015-01-29
CA2730668C (en) 2020-04-28
MX2011000657A (es) 2011-03-21
JP2011528223A (ja) 2011-11-17
MX370690B (es) 2019-12-19
EP2318530A1 (en) 2011-05-11
US9546375B2 (en) 2017-01-17
MY161965A (en) 2017-05-15
EP2318530B1 (en) 2016-06-22

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