JP5802127B2 - Ｓｙｋ又はｊａｋキナーゼ阻害剤としての２，６−ジアミノ−ピリミジン−５−イル−カルボキサミド類 - Google Patents

Ｓｙｋ又はｊａｋキナーゼ阻害剤としての２，６−ジアミノ−ピリミジン−５−イル−カルボキサミド類 Download PDF

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JP5802127B2
JP5802127B2 JP2011505030A JP2011505030A JP5802127B2 JP 5802127 B2 JP5802127 B2 JP 5802127B2 JP 2011505030 A JP2011505030 A JP 2011505030A JP 2011505030 A JP2011505030 A JP 2011505030A JP 5802127 B2 JP5802127 B2 JP 5802127B2
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pyrimidine
carboxamide
phenylamino
aminocyclohexylamino
alkyl
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JP2011518157A (ja
JP2011518157A5 (https=
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チャオチョン・ジェイ・ジア
チャンドラセカル・ベンカタラマニ
ウォリン・フアン
ムクンド・メーロトラ
ヨンホン・ソン
スー・キン
ショーン・エム・バウアー
アンジャリ・パンディ
ブライアン・ケイン
ジャック・ダブリュー・ローズ
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ポートラ ファーマシューティカルズ， インコーポレイテッド
ポートラ ファーマシューティカルズ， インコーポレイテッド
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2011505030A 2008-04-16 2009-04-16 Ｓｙｋ又はｊａｋキナーゼ阻害剤としての２，６−ジアミノ−ピリミジン−５−イル−カルボキサミド類 Active JP5802127B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4549908P 2008-04-16 2008-04-16
US4540608P 2008-04-16 2008-04-16
US61/045,406 2008-04-16
US61/045,499 2008-04-16
US12034608P 2008-12-05 2008-12-05
US12034808P 2008-12-05 2008-12-05
US61/120,348 2008-12-05
US61/120,346 2008-12-05
PCT/US2009/002401 WO2009136995A2 (en) 2008-04-16 2009-04-16 Inhibitors of syk protein kinase

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JP2014232987A Division JP2015091806A (ja) 2008-04-16 2014-11-17 Ｓｙｋ又はｊａｋキナーゼ阻害剤としての２，６−ジアミノ−ピリミジン−５−イル−カルボキサミド類

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JP2011518157A JP2011518157A (ja) 2011-06-23
JP2011518157A5 JP2011518157A5 (https=) 2012-06-07
JP5802127B2 true JP5802127B2 (ja) 2015-10-28

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JP2014232987A Pending JP2015091806A (ja) 2008-04-16 2014-11-17 Ｓｙｋ又はｊａｋキナーゼ阻害剤としての２，６−ジアミノ−ピリミジン−５−イル−カルボキサミド類

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EP (1) EP2323993B1 (https=)
JP (2) JP5802127B2 (https=)
KR (3) KR101773313B1 (https=)
CN (2) CN104230911A (https=)
CA (1) CA2728893C (https=)
CR (1) CR11793A (https=)
DO (1) DOP2010000309A (https=)
MA (1) MA32442B1 (https=)
MX (1) MX315135B (https=)
SG (2) SG2014015085A (https=)
SV (1) SV2010003705A (https=)
VN (1) VN29259A1 (https=)
WO (1) WO2009136995A2 (https=)

Cited By (1)

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RU2805606C2 (ru) * 2016-11-04 2023-10-20 Дзе Чилдрен'З Хоспитал Оф Филадельфия Композиции, способы и применения переноса генов для лечения нейродегенеративных заболеваний

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US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
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US8338439B2 (en) * 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
AU2010219097A1 (en) * 2009-01-13 2011-08-04 Glaxo Group Limited Pyrimidinecarboxamide derivatives as inhibitors of SYK kinase
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
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SG181857A1 (en) 2009-12-23 2012-07-30 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
WO2012002577A1 (ja) 2010-06-30 2012-01-05 富士フイルム株式会社 新規なニコチンアミド誘導体またはその塩
CN105566229A (zh) 2010-08-10 2016-05-11 西建阿维拉米斯研究公司 Btk抑制剂的苯磺酸盐及其用途和制备方法
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JP2014005206A (ja) * 2010-10-22 2014-01-16 Astellas Pharma Inc アリールアミノヘテロ環カルボキサミド化合物
US20130317029A1 (en) * 2010-11-01 2013-11-28 Portola Pharmaceuticals, Inc. Oxypyrimidines as syk modulators
EP2635556B1 (en) * 2010-11-01 2017-06-21 Portola Pharmaceuticals, Inc. Benzamides and nicotinamides as syk modulators
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