JP5785546B2 - 脳虚血を予防または処置する方法 - Google Patents
脳虚血を予防または処置する方法 Download PDFInfo
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- JP5785546B2 JP5785546B2 JP2012526918A JP2012526918A JP5785546B2 JP 5785546 B2 JP5785546 B2 JP 5785546B2 JP 2012526918 A JP2012526918 A JP 2012526918A JP 2012526918 A JP2012526918 A JP 2012526918A JP 5785546 B2 JP5785546 B2 JP 5785546B2
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- tocotrienol quinone
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- cerebral
- cerebral ischemic
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| WO2005033092A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| EA035619B1 (ru) * | 2005-06-01 | 2020-07-16 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Композиции для использования в способе лечения митохондриальных нарушений |
| EP1986636B1 (en) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
| PL2220030T3 (pl) | 2007-11-06 | 2016-07-29 | Bioelectron Tech Corp | Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych |
| EP2237664A4 (en) | 2008-01-08 | 2013-05-22 | Edison Pharmaceuticals Inc | (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES |
| WO2009111576A2 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| EP2303824B1 (en) * | 2008-06-25 | 2015-03-25 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| EP2344142B1 (en) | 2008-09-10 | 2024-06-26 | PTC Therapeutics, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| CA2740773A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| WO2010051277A1 (en) | 2008-10-28 | 2010-05-06 | Edison Pharmaceuticals, Inc. | Process for the production of alpha-tocotrienol and derivatives |
| CA2777479C (en) | 2009-04-28 | 2017-10-17 | Ptc Therapeutics, Inc. | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| CA2797644A1 (en) * | 2009-12-31 | 2011-07-07 | Edison Pharmaceuticals, Inc. | Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones |
| AU2011245384C1 (en) * | 2010-04-27 | 2016-09-01 | Bioelectron Technology Corporation | Formulations of quinones for the treatment of ophthalmic diseases |
| JP5809296B2 (ja) | 2011-03-03 | 2015-11-10 | シーチェイド ファーマシューティカルズ，インコーポレーテッド | 抗真菌薬及びそれらの使用 |
| US9464016B2 (en) | 2011-06-14 | 2016-10-11 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| CA2842486C (en) | 2011-07-19 | 2022-09-06 | Edison Pharmaceuticals, Inc. | Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| GB201117808D0 (en) * | 2011-10-14 | 2011-11-30 | Siemens Medical Solutions | SUV correction following dose infiltration |
| KR102236462B1 (ko) * | 2012-03-19 | 2021-04-08 | 시다라 세라퓨틱스, 인코포레이티드 | 에키노칸딘 계열의 화합물에 대한 투여 용법 |
| CA2883879A1 (en) * | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| KR20150082109A (ko) * | 2012-11-13 | 2015-07-15 | 고다겐 파마슈티컬스 피티와이 엘티디 | 토코트리에놀의 경점막 전달 |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| JP2016515526A (ja) | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| RU2578451C1 (ru) * | 2014-12-09 | 2016-03-27 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации | Способ повышения устойчивости головного мозга к ишемии во время реконструктивных операций на брахиоцефальных артериях |
| HUE058877T2 (hu) | 2014-12-16 | 2022-09-28 | Ptc Therapeutics Inc | (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociklohexa-1,4-dienil)butánamid polimorf és amorf alakjai |
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| HUE037592T2 (hu) | 2018-09-28 |
| SI2470168T1 (en) | 2018-05-31 |
| BR112012004167A2 (pt) | 2016-03-29 |
| EA201200355A1 (ru) | 2012-07-30 |
| PL2470168T3 (pl) | 2018-06-29 |
| EP2470168A1 (en) | 2012-07-04 |
| JP2013503168A (ja) | 2013-01-31 |
| CN102647981B (zh) | 2016-09-28 |
| EA028677B1 (ru) | 2017-12-29 |
| CA2772294A1 (en) | 2011-03-03 |
| AU2010286704A1 (en) | 2012-03-22 |
| US20110207828A1 (en) | 2011-08-25 |
| CN102647981A (zh) | 2012-08-22 |
| MX2012002374A (es) | 2012-04-10 |
| US20180344667A1 (en) | 2018-12-06 |
| WO2011025785A1 (en) | 2011-03-03 |
| DK2470168T3 (en) | 2018-05-07 |
| PT2470168T (pt) | 2018-03-28 |
| JP2015091899A (ja) | 2015-05-14 |
| NO2470168T3 (esLanguage) | 2018-06-30 |
| US20170007553A1 (en) | 2017-01-12 |
| EP2470168B1 (en) | 2018-01-31 |
| CA2772294C (en) | 2018-08-21 |
| AU2010286704B2 (en) | 2016-10-20 |
| ES2663709T3 (es) | 2018-04-16 |
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