JP5781513B2 - 迅速熱循環のために低い熱不均一性を提供する熱ブロックアセンブリおよび機器 - Google Patents
迅速熱循環のために低い熱不均一性を提供する熱ブロックアセンブリおよび機器 Download PDFInfo
- Publication number
- JP5781513B2 JP5781513B2 JP2012527116A JP2012527116A JP5781513B2 JP 5781513 B2 JP5781513 B2 JP 5781513B2 JP 2012527116 A JP2012527116 A JP 2012527116A JP 2012527116 A JP2012527116 A JP 2012527116A JP 5781513 B2 JP5781513 B2 JP 5781513B2
- Authority
- JP
- Japan
- Prior art keywords
- thermal
- block assembly
- sample
- block
- heat sink
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10W—GENERIC PACKAGES, INTERCONNECTIONS, CONNECTORS OR OTHER CONSTRUCTIONAL DETAILS OF DEVICES COVERED BY CLASS H10
- H10W40/00—Arrangements for thermal protection or thermal control
- H10W40/01—Manufacture or treatment
- H10W40/03—Manufacture or treatment of arrangements for cooling
- H10W40/037—Assembling together parts thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10W—GENERIC PACKAGES, INTERCONNECTIONS, CONNECTORS OR OTHER CONSTRUCTIONAL DETAILS OF DEVICES COVERED BY CLASS H10
- H10W40/00—Arrangements for thermal protection or thermal control
- H10W40/40—Arrangements for thermal protection or thermal control involving heat exchange by flowing fluids
- H10W40/43—Arrangements for thermal protection or thermal control involving heat exchange by flowing fluids by flowing gases, e.g. forced air cooling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
- F28D21/00—Heat-exchange apparatus not covered by any of the groups F28D1/00 - F28D20/00
- F28D2021/0019—Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for
- F28D2021/0028—Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for for cooling heat generating elements, e.g. for cooling electronic components or electric devices
- F28D2021/0029—Heat sinks
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Cooling Or The Like Of Semiconductors Or Solid State Devices (AREA)
- Cooling Or The Like Of Electrical Apparatus (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23901209P | 2009-09-01 | 2009-09-01 | |
| US61/239,012 | 2009-09-01 | ||
| PCT/US2010/047573 WO2011028834A2 (en) | 2009-09-01 | 2010-09-01 | Thermal block assemblies and instruments providing low thermal non-uniformity for rapid thermal cycling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014116441A Division JP2014158505A (ja) | 2009-09-01 | 2014-06-05 | 迅速熱循環のために低い熱不均一性を提供する熱ブロックアセンブリおよび機器 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013504181A JP2013504181A (ja) | 2013-02-04 |
| JP5781513B2 true JP5781513B2 (ja) | 2015-09-24 |
Family
ID=43646772
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527116A Active JP5781513B2 (ja) | 2009-09-01 | 2010-09-01 | 迅速熱循環のために低い熱不均一性を提供する熱ブロックアセンブリおよび機器 |
| JP2014116441A Pending JP2014158505A (ja) | 2009-09-01 | 2014-06-05 | 迅速熱循環のために低い熱不均一性を提供する熱ブロックアセンブリおよび機器 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014116441A Pending JP2014158505A (ja) | 2009-09-01 | 2014-06-05 | 迅速熱循環のために低い熱不均一性を提供する熱ブロックアセンブリおよび機器 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10049895B2 (https=) |
| EP (1) | EP2473893B1 (https=) |
| JP (2) | JP5781513B2 (https=) |
| CN (1) | CN102483642B (https=) |
| IN (1) | IN2012DN02105A (https=) |
| SG (1) | SG178411A1 (https=) |
| WO (1) | WO2011028834A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG184539A1 (en) | 2010-04-09 | 2012-11-29 | Life Technologies Corp | Improved thermal uniformity for thermal cycler instrumentation using dynamic control |
| CA2922854A1 (en) * | 2013-09-16 | 2015-03-19 | Life Technologies Corporation | Apparatuses, systems and methods for providing thermocycler thermal uniformity |
| RU2016134378A (ru) | 2014-02-18 | 2018-03-22 | Лайф Текнолоджиз Корпорейшн | Устройства, системы и способы для создания термоциклеров в масштабируемом исполнении и изолирования термоэлектрических устройств |
| US11003808B2 (en) * | 2015-09-30 | 2021-05-11 | Siemens Industry Software Inc. | Subtractive design for heat sink improvement |
| US11150032B2 (en) | 2017-01-18 | 2021-10-19 | Bigz Tech Inc. | Transient heat absorption and delayed dissipation by high heat capacity material |
| GB201812192D0 (en) * | 2018-07-26 | 2018-09-12 | Ttp Plc | Variable temperature reactor, heater and control circuit for the same |
| WO2020150007A1 (en) | 2019-01-14 | 2020-07-23 | Bio-Rad Laboratories, Inc. | Heat pump device and assembly |
| US20220184612A1 (en) * | 2019-03-18 | 2022-06-16 | Seegene, Inc. | Thermal cycler comprising sample holder assembly |
| CN212084987U (zh) * | 2020-07-09 | 2020-12-04 | 宁波市哈雷换热设备有限公司 | 一种承压能力强的芯片冷却器 |
| KR20240056761A (ko) * | 2021-10-29 | 2024-04-30 | 주식회사 씨젠 | 열블록 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3566959A (en) * | 1969-07-17 | 1971-03-02 | Controlled Power Corp | Heat sink |
| US3841853A (en) * | 1972-09-05 | 1974-10-15 | Owens Corning Fiberglass Corp | Apparatus for production of thermoplastic materials |
| US4602651A (en) * | 1978-05-30 | 1986-07-29 | Roppatte Jr Michael | Liquid applicator device with hair-parting wand |
| US4345837A (en) * | 1980-06-27 | 1982-08-24 | Farrand Optical Co., Inc. | Enhanced fluorescent emission |
| US5038852A (en) * | 1986-02-25 | 1991-08-13 | Cetus Corporation | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| GB8606641D0 (en) * | 1986-03-18 | 1986-04-23 | British Petroleum Co Plc | Testing device |
| US4753290A (en) * | 1986-07-18 | 1988-06-28 | Unisys Corporation | Reduced-stress heat sink device |
| KR100236506B1 (ko) * | 1990-11-29 | 2000-01-15 | 퍼킨-엘머시터스인스트루먼츠 | 폴리머라제 연쇄 반응 수행 장치 |
| US6703236B2 (en) * | 1990-11-29 | 2004-03-09 | Applera Corporation | Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control |
| US5318361A (en) * | 1993-06-01 | 1994-06-07 | Bell Communications Research, Inc. | Rapid temperature cycling for accelerated stress testing |
| CA2130013C (en) * | 1993-09-10 | 1999-03-30 | Rolf Moser | Apparatus for automatic performance of temperature cycles |
| US5525300A (en) * | 1993-10-20 | 1996-06-11 | Stratagene | Thermal cycler including a temperature gradient block |
| US5849208A (en) * | 1995-09-07 | 1998-12-15 | Microfab Technoologies, Inc. | Making apparatus for conducting biochemical analyses |
| US6039471A (en) * | 1996-05-22 | 2000-03-21 | Integrated Device Technology, Inc. | Device for simulating dissipation of thermal power by a board supporting an electronic component |
| US7133726B1 (en) * | 1997-03-28 | 2006-11-07 | Applera Corporation | Thermal cycler for PCR |
| WO1998043740A2 (en) | 1997-03-28 | 1998-10-08 | The Perkin-Elmer Corporation | Improvements in thermal cycler for pcr |
| US6301779B1 (en) * | 1998-10-29 | 2001-10-16 | Advanced Thermal Solutions, Inc. | Method for fabricating a heat sink having nested extended surfaces |
| GB9826237D0 (en) * | 1998-11-30 | 1999-01-20 | Hybaid Ltd | Thermal cycler |
| EP1045038A1 (en) * | 1999-04-08 | 2000-10-18 | Hans-Knöll-Institut Für Naturstoff-Forschung E.V. | Rapid heat block thermocycler |
| US6337435B1 (en) * | 1999-07-30 | 2002-01-08 | Bio-Rad Laboratories, Inc. | Temperature control for multi-vessel reaction apparatus |
| US6657169B2 (en) * | 1999-07-30 | 2003-12-02 | Stratagene | Apparatus for thermally cycling samples of biological material with substantial temperature uniformity |
| US6496373B1 (en) * | 1999-11-04 | 2002-12-17 | Amerasia International Technology, Inc. | Compressible thermally-conductive interface |
| TW487298U (en) * | 2000-12-19 | 2002-05-11 | Global Win Technology Co Ltd | Non-uniform heat dissipation fins |
| US6677151B2 (en) * | 2002-01-30 | 2004-01-13 | Applera Corporation | Device and method for thermal cycling |
| US6659638B1 (en) * | 2002-05-17 | 2003-12-09 | Atlas Material Testing Technology, L.L.C. | Dynamic temperature controlled accelerated weathering test apparatus |
| US6730883B2 (en) * | 2002-10-02 | 2004-05-04 | Stratagene | Flexible heating cover assembly for thermal cycling of samples of biological material |
| US7079394B2 (en) * | 2003-01-08 | 2006-07-18 | Lenovo (Singapore) Pte. Ltd. | Compact cooling device |
| US20040241048A1 (en) * | 2003-05-30 | 2004-12-02 | Applera Corporation | Thermal cycling apparatus and method for providing thermal uniformity |
| US6874566B1 (en) * | 2003-09-19 | 2005-04-05 | Dell Products L.P. | Heat sink with intermediate fan element |
| US7051536B1 (en) * | 2004-11-12 | 2006-05-30 | Bio-Rad Laboratories, Inc. | Thermal cycler with protection from atmospheric moisture |
| US7274571B2 (en) * | 2005-03-08 | 2007-09-25 | Intel Corporation | Heatsink |
| US7213636B2 (en) * | 2005-03-15 | 2007-05-08 | Delphi Technologies, Inc. | Cooling assembly with impingement cooled heat sink |
| ES2401437T3 (es) * | 2005-04-04 | 2013-04-19 | Roche Diagnostics Gmbh | Termociclado de un bloque que comprende múltiples muestras |
| US7472742B2 (en) * | 2005-12-01 | 2009-01-06 | General Electric Company | Heat sink assembly |
| US7251136B2 (en) | 2005-12-29 | 2007-07-31 | Fu Zhun Precision Industry (Shen Zhen) Co., Ltd. | Heat dissipation device having a ventilating duct |
| JP2007329253A (ja) * | 2006-06-07 | 2007-12-20 | Toyota Industries Corp | 電子機器の冷却構造 |
| US7629124B2 (en) * | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
| US8962306B2 (en) * | 2006-09-08 | 2015-02-24 | Thermo Fisher Scientific Oy | Instruments and method relating to thermal cycling |
| US20080128118A1 (en) * | 2006-12-01 | 2008-06-05 | Foxconn Technology Co., Ltd. | Heat dissipation device with a heat pipe |
| US9920939B2 (en) | 2007-01-22 | 2018-03-20 | Klas C. Haglid | Dehumidifer/cooler and method |
| WO2008091626A1 (en) | 2007-01-22 | 2008-07-31 | Wafergen, Inc. | Apparatus for high throughput chemical reactions |
| US20080266806A1 (en) * | 2007-04-27 | 2008-10-30 | Lakin Eric D | Electronic assembly that includes a heat sink which cools multiple electronic components |
| US20090139311A1 (en) | 2007-10-05 | 2009-06-04 | Applied Biosystems Inc. | Biological Analysis Systems, Devices, and Methods |
| WO2009105499A1 (en) * | 2008-02-20 | 2009-08-27 | Termaat Joel R | Thermocycler and sample vessel for rapid amplification of dna |
| CN201230438Y (zh) * | 2008-07-07 | 2009-04-29 | 鸿富锦精密工业(深圳)有限公司 | 散热装置组合 |
| WO2011087117A1 (ja) * | 2010-01-18 | 2011-07-21 | 古河電気工業株式会社 | ヒートシンク |
| US20130032323A1 (en) * | 2011-08-02 | 2013-02-07 | Hsu Takeho | Heat sink structure |
| FR3062460B1 (fr) * | 2017-02-01 | 2020-11-13 | Valeo Vision | Module lumineux pour projecteur de vehicule |
-
2010
- 2010-09-01 US US12/874,112 patent/US10049895B2/en active Active
- 2010-09-01 WO PCT/US2010/047573 patent/WO2011028834A2/en not_active Ceased
- 2010-09-01 JP JP2012527116A patent/JP5781513B2/ja active Active
- 2010-09-01 IN IN2105DEN2012 patent/IN2012DN02105A/en unknown
- 2010-09-01 SG SG2012010278A patent/SG178411A1/en unknown
- 2010-09-01 CN CN201080038911.3A patent/CN102483642B/zh not_active Expired - Fee Related
- 2010-09-01 EP EP10814448.6A patent/EP2473893B1/en active Active
-
2014
- 2014-06-05 JP JP2014116441A patent/JP2014158505A/ja active Pending
-
2018
- 2018-08-09 US US16/059,622 patent/US20180350628A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013504181A (ja) | 2013-02-04 |
| EP2473893A4 (en) | 2017-03-01 |
| WO2011028834A2 (en) | 2011-03-10 |
| WO2011028834A3 (en) | 2011-07-07 |
| CN102483642B (zh) | 2014-12-24 |
| SG178411A1 (en) | 2012-04-27 |
| IN2012DN02105A (https=) | 2015-08-21 |
| CN102483642A (zh) | 2012-05-30 |
| US10049895B2 (en) | 2018-08-14 |
| EP2473893B1 (en) | 2021-07-28 |
| US20110056661A1 (en) | 2011-03-10 |
| EP2473893A2 (en) | 2012-07-11 |
| JP2014158505A (ja) | 2014-09-04 |
| US20180350628A1 (en) | 2018-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5781513B2 (ja) | 迅速熱循環のために低い熱不均一性を提供する熱ブロックアセンブリおよび機器 | |
| JP6117694B2 (ja) | 動的制御を用いた熱サイクラ器具に対する熱均一性改良 | |
| US11339425B2 (en) | Systems and methods for biological analysis | |
| CN103411996B (zh) | 固体材料导热系数测量装置及测量方法 | |
| JP2008278896A (ja) | Pcrのための熱サイクラの改良 | |
| JP2010502930A (ja) | サーマルサイクリングに関する機器及び方法 | |
| Pua et al. | Natural and forced convection heat transfer coefficients of various finned heat sinks for miniature electronic systems | |
| WO2012176596A1 (ja) | 核酸増幅装置及び核酸分析装置 | |
| JP2002310965A (ja) | 分散配置された熱抵抗器を有する熱分析アセンブリ、および、種々の冷却装置を取り付けるための一体化フランジ | |
| Lin et al. | Optimum design and heat transfer correlation equation of a mini radiator with jet impingement cooling | |
| JP6496417B2 (ja) | 実験設計および分析のための方法およびシステム | |
| Ali et al. | The effect of square tube location in a vertical array of square tubes on natural convection heat transfer | |
| Binninger et al. | Customized measuring station for Peltier modules | |
| Hosseini et al. | Experimental study of air pressure effects on natural convection from a horizontal cylinder | |
| Kou et al. | Optimum thermal analysis of a heat sink with various fin cross-sections by adjusting fin length and cross-section | |
| Divya et al. | Digital interferometric measurement of forced convection fields in compact channels | |
| JP2018511786A (ja) | 結合性染料を較正するためのシステム及び方法 | |
| JP2005140509A (ja) | 複合材の等価熱伝導率算出装置および等価熱伝導率算出方法 | |
| Mathew et al. | Experimental validation of a thermal model of counterflow microchannel heat exchangers subjected to external heat flux | |
| JP6465582B2 (ja) | 断熱容器内の温度算出装置、方法及びコンピュータプログラム | |
| Li et al. | Simulation analysis of temperature field characteristics of fast nucleic acid analyzer based on finite element method | |
| Loiola et al. | Experimental evaluation of the conjugate cooling of a protruding heater in a duct | |
| Li et al. | Multi-factor coupled thermal simulation of flat-panel digital PCR structure | |
| CN118090819A (zh) | 一种基于导热硅胶的导热性能测试方法及系统 | |
| CN118010796A (zh) | 一种针对超声导航设备的导热硅胶性能测试方法及系统 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20131129 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131205 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140304 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140311 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140404 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140411 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140502 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140513 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140605 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140731 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140930 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20141007 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141128 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150126 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150424 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150526 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150629 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150715 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5781513 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |