JP5779091B2 - Ｉａｐ阻害剤による免疫調節 - Google Patents

Ｉａｐ阻害剤による免疫調節 Download PDF

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Publication number
JP5779091B2
JP5779091B2 JP2011509678A JP2011509678A JP5779091B2 JP 5779091 B2 JP5779091 B2 JP 5779091B2 JP 2011509678 A JP2011509678 A JP 2011509678A JP 2011509678 A JP2011509678 A JP 2011509678A JP 5779091 B2 JP5779091 B2 JP 5779091B2
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cells
iap
antigen
alkyl
cancer
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JP2011524339A5 (https=
JP2011524339A (ja
Inventor
リー ザウエル，
リー ザウエル，
マイケル ドゥーガン，
マイケル ドゥーガン，
グレン ドラノフ，
グレン ドラノフ，
ブラント， ジー． ファイアストーン，
ブラント， ジー． ファイアストーン，
クリストファー， エス． ストラウブ，
クリストファー， エス． ストラウブ，
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
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    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011509678A 2008-05-16 2009-05-14 Ｉａｐ阻害剤による免疫調節 Active JP5779091B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5394708P 2008-05-16 2008-05-16
US61/053,947 2008-05-16
PCT/US2009/043874 WO2009140447A1 (en) 2008-05-16 2009-05-14 Immunomodulation by iap inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015040113A Division JP5986655B2 (ja) 2008-05-16 2015-03-02 Ｉａｐ阻害剤による免疫調節

Publications (3)

Publication Number Publication Date
JP2011524339A JP2011524339A (ja) 2011-09-01
JP2011524339A5 JP2011524339A5 (https=) 2014-04-24
JP5779091B2 true JP5779091B2 (ja) 2015-09-16

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ID=40823320

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JP2011509678A Active JP5779091B2 (ja) 2008-05-16 2009-05-14 Ｉａｐ阻害剤による免疫調節
JP2015040113A Active JP5986655B2 (ja) 2008-05-16 2015-03-02 Ｉａｐ阻害剤による免疫調節
JP2015236482A Active JP6030739B2 (ja) 2008-05-16 2015-12-03 Ｉａｐ阻害剤による免疫調節

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JP2015040113A Active JP5986655B2 (ja) 2008-05-16 2015-03-02 Ｉａｐ阻害剤による免疫調節
JP2015236482A Active JP6030739B2 (ja) 2008-05-16 2015-12-03 Ｉａｐ阻害剤による免疫調節

Country Status (17)

Country Link
US (4) US9750729B2 (https=)
EP (3) EP2698158B1 (https=)
JP (3) JP5779091B2 (https=)
KR (1) KR20110022608A (https=)
CN (1) CN102099035A (https=)
AU (1) AU2009246347A1 (https=)
BR (1) BRPI0912692A2 (https=)
CA (1) CA2724720A1 (https=)
CL (1) CL2009001195A1 (https=)
EA (1) EA201071316A1 (https=)
ES (2) ES2882855T3 (https=)
IL (1) IL209203A0 (https=)
MA (1) MA32388B1 (https=)
MX (1) MX2010012231A (https=)
TW (1) TW201006834A (https=)
WO (1) WO2009140447A1 (https=)
ZA (1) ZA201008176B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
WO2007048224A1 (en) 2005-10-25 2007-05-03 Aegera Therapeutics Inc. Iap bir domain binding compounds
CN102099035A (zh) * 2008-05-16 2011-06-15 诺瓦提斯公司 Iap抑制剂的免疫调节
JP4995211B2 (ja) * 2008-09-29 2012-08-08 キヤノン株式会社 電子写真画像形成装置
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
KR20160030099A (ko) * 2013-06-25 2016-03-16 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 세포내 감염의 치료 방법
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
AU2017253560B2 (en) * 2016-04-20 2019-03-21 Glaxosmithkline Intellectual Property Development Limited Conjugates comprising RIPK2 inhibitors
CN106496213B (zh) * 2016-09-30 2019-08-20 东南大学 Lcl161前药及其制备方法和应用
WO2020027225A1 (ja) * 2018-07-31 2020-02-06 ファイメクス株式会社 複素環化合物
CN113453678A (zh) 2018-11-26 2021-09-28 德彪药业国际股份公司 Hiv感染的联合治疗
PH12022550721A1 (en) 2019-09-25 2024-05-13 Debiopharm Int Sa Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma

Family Cites Families (18)

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FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6133437A (en) * 1997-02-13 2000-10-17 Apoptogen, Inc. Modulation of IAPs for the treatment of proliferative diseases
ES2415336T3 (es) * 2003-04-11 2013-07-25 Survac Aps Vacuna terapéutica contra el cáncer
CN1938332B (zh) * 2004-02-04 2011-10-19 沃泰克斯药物股份有限公司 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂
WO2005084317A2 (en) 2004-03-01 2005-09-15 Board Of Regents, The University Of Texas System Dimeric small molecule potentiators of apoptosis
AU2005228950B2 (en) * 2004-03-23 2012-02-02 Genentech, Inc. Azabicyclo-octane inhibitors of IAP
DK2253614T3 (da) * 2004-04-07 2013-01-07 Novartis Ag IAP-inhibitorer
US20080234042A1 (en) 2004-05-02 2008-09-25 Hiroshi Uemura Game System
MX2007010371A (es) * 2005-02-25 2008-01-11 Tetralogic Pharmaceuticals Inhibidores dimericos iap.
KR20080080131A (ko) 2005-12-20 2008-09-02 노파르티스 아게 Ｉａｐ-억제제와 탁산의 조합물
US20100056495A1 (en) * 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
PE20110220A1 (es) 2006-08-02 2011-04-11 Novartis Ag DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
WO2008045905A1 (en) 2006-10-12 2008-04-17 Novartis Ag Pyrrolydine derivatives as iap inhibitors
BRPI0717411A2 (pt) 2006-10-19 2013-11-12 Novartis Ag Uso de inibidores de iap
AU2007325280B2 (en) * 2006-11-28 2011-03-10 Dana-Farber Cancer Institute, Inc. Combination of IAP inhibitors and FLT3 inhibitors
EP2126188A1 (en) 2006-12-26 2009-12-02 Arçelik Anonim Sirketi A washer / dryer with output from humidity sensor selectively input to control unit
WO2008109057A1 (en) * 2007-03-02 2008-09-12 Dana-Farber Cancer Institute, Inc. Organic compounds and their uses
CN102099035A (zh) * 2008-05-16 2011-06-15 诺瓦提斯公司 Iap抑制剂的免疫调节

Also Published As

Publication number Publication date
CN102099035A (zh) 2011-06-15
US20110135691A1 (en) 2011-06-09
CL2009001195A1 (es) 2010-06-11
US9750729B2 (en) 2017-09-05
EP2698158A1 (en) 2014-02-19
US20200345714A1 (en) 2020-11-05
EP2296650B1 (en) 2020-05-06
ES2791957T3 (es) 2020-11-06
TW201006834A (en) 2010-02-16
WO2009140447A1 (en) 2009-11-19
ES2882855T3 (es) 2021-12-02
BRPI0912692A2 (pt) 2017-03-21
AU2009246347A1 (en) 2009-11-19
MA32388B1 (fr) 2011-06-01
MX2010012231A (es) 2011-02-18
IL209203A0 (en) 2011-01-31
JP2011524339A (ja) 2011-09-01
EP2296650A1 (en) 2011-03-23
EP2698158B1 (en) 2021-06-30
CA2724720A1 (en) 2009-11-19
US20220296581A1 (en) 2022-09-22
JP2015129170A (ja) 2015-07-16
ZA201008176B (en) 2011-08-31
JP2016094429A (ja) 2016-05-26
JP5986655B2 (ja) 2016-09-06
US10786491B2 (en) 2020-09-29
EA201071316A1 (ru) 2011-06-30
US11382905B2 (en) 2022-07-12
KR20110022608A (ko) 2011-03-07
EP3701947A1 (en) 2020-09-02
US20170368047A1 (en) 2017-12-28
JP6030739B2 (ja) 2016-11-24

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