JP5770297B2 - 有効成分の送達のための液体医薬組成物 - Google Patents
有効成分の送達のための液体医薬組成物 Download PDFInfo
- Publication number
- JP5770297B2 JP5770297B2 JP2013534288A JP2013534288A JP5770297B2 JP 5770297 B2 JP5770297 B2 JP 5770297B2 JP 2013534288 A JP2013534288 A JP 2013534288A JP 2013534288 A JP2013534288 A JP 2013534288A JP 5770297 B2 JP5770297 B2 JP 5770297B2
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- active ingredient
- eye
- suspension
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Claims (14)
- (a)治療有効量で存在する有効成分の粒子、ならびに
(b)式:
RFRH
(式中、RFは、3〜10個の炭素原子を有する直鎖過フッ素化炭化水素部分であり、および
RHは、3〜10個の炭素原子を有する直鎖アルキル基である)
の半フッ素化アルカンを含む液体ビヒクル
を含有する懸濁液の形態の医薬組成物。 - 界面活性剤を含まない、請求項1に記載の組成物。
- 有効成分が水難溶性であるおよび/または加水分解に対して感受性である、請求項1または2に記載の組成物。
- 有効成分が、室温および中性pHで測定した場合1mg/ml未満の水溶解度を示す、請求項1〜3のいずれか一項に記載の組成物。
- 有効成分の粒子が、主に0.2μm〜200μmの範囲内の大きさを有する、請求項1〜4のいずれか一項に記載の組成物。
- 有効成分の粒子が、レーザー回折によって測定した場合15μm以下の体積平均直径を有する、請求項5に記載の組成物。
- 半フッ素化アルカンが、F4H5、F4H6、F6H6およびF6H8から選択される、請求項1〜6のいずれか一項に記載の組成物。
- 非フッ素化有機液体をさらに含む、請求項1〜7のいずれか一項に記載の組成物。
- 水を含まない、請求項1〜8のいずれか一項に記載の組成物。
- 液体ビヒクルが、20℃で1.29〜1.35の範囲内の屈折率を有する、請求項1〜9のいずれか一項に記載の組成物。
- 薬剤として使用するための、請求項1〜10のいずれか一項に記載の組成物。
- 患者の眼、耳または鼻への局所投与用の薬剤として使用するための、請求項1〜10のいずれか一項に記載の組成物。
- 皮下、経皮、筋肉内または局所領域注射による非経口投与用の薬剤として使用するための、請求項1〜10のいずれか一項に記載の組成物。
- 請求項1〜10のいずれか一項に記載の組成物および該組成物を患者の眼に局所投与するのに適した投薬手段を含む容器であって、前記投薬手段が、該組成物を30μl未満の体積で点滴するのに適する、容器。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10188242A EP2444063A1 (en) | 2010-10-20 | 2010-10-20 | Liquid pharmaceutical compositions for the delivery of active ingredients |
EP10188242.1 | 2010-10-20 | ||
PCT/EP2011/068141 WO2012052418A1 (en) | 2010-10-20 | 2011-10-18 | Liquid pharmaceutical composition for the delivery of active ingredients |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013540140A JP2013540140A (ja) | 2013-10-31 |
JP2013540140A5 JP2013540140A5 (ja) | 2014-11-06 |
JP5770297B2 true JP5770297B2 (ja) | 2015-08-26 |
Family
ID=43608363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013534288A Active JP5770297B2 (ja) | 2010-10-20 | 2011-10-18 | 有効成分の送達のための液体医薬組成物 |
Country Status (16)
Country | Link |
---|---|
US (3) | US9757459B2 (ja) |
EP (2) | EP2444063A1 (ja) |
JP (1) | JP5770297B2 (ja) |
KR (1) | KR101773225B1 (ja) |
CN (1) | CN103153281B (ja) |
AU (1) | AU2011317673B2 (ja) |
BR (1) | BR112013007473B1 (ja) |
CA (1) | CA2813016C (ja) |
DK (1) | DK2629754T3 (ja) |
ES (1) | ES2528105T3 (ja) |
HK (1) | HK1182010A1 (ja) |
IN (1) | IN2013DN02524A (ja) |
MX (1) | MX2013003892A (ja) |
PL (1) | PL2629754T3 (ja) |
PT (1) | PT2629754E (ja) |
WO (1) | WO2012052418A1 (ja) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011113855A2 (en) | 2010-03-17 | 2011-09-22 | Novaliq Gmbh | Pharmaceutical composition for treatment of increased intraocular pressure |
EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
CN103596554A (zh) | 2011-05-25 | 2014-02-19 | 诺瓦利克有限责任公司 | 基于半氟化烷烃类的外用药物组合物 |
JP6023181B2 (ja) | 2011-05-25 | 2016-11-09 | ノバリック ゲーエムベーハー | 爪に投与するための医薬組成物 |
DK2806886T3 (en) | 2012-01-23 | 2017-06-06 | Novaliq Gmbh | STABILIZED PROTEIN COMPOSITIONS BASED ON SEMIFLUORED ALKANES |
CN104619314B (zh) | 2012-09-12 | 2017-09-22 | 诺瓦利克有限责任公司 | 包含半氟化烷烃的混合物的组合物 |
ES2965828T3 (es) | 2012-09-12 | 2024-04-17 | Novaliq Gmbh | Composiciones de alcano semifluorado |
EP2948134B1 (en) | 2013-01-24 | 2020-03-04 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mtor inhibitors |
WO2015011199A1 (en) | 2013-07-23 | 2015-01-29 | Novaliq Gmbh | Stabilized antibody compositions |
PT3193867T (pt) * | 2014-09-17 | 2021-03-09 | Panoptica Inc | Formulações oculares para administração de fármaco e proteção do segmento anterior do olho |
EP3355990B1 (en) | 2015-09-30 | 2019-06-12 | Novaliq GmbH | Semifluorinated compounds and their compositions |
CN110693825B (zh) | 2015-09-30 | 2022-03-08 | 诺瓦利克有限责任公司 | 用于眼部给药的半氟化化合物 |
WO2017220625A1 (en) * | 2016-06-23 | 2017-12-28 | Novaliq Gmbh | Topical administration method |
PL3515420T3 (pl) | 2016-09-22 | 2024-04-08 | Novaliq Gmbh | Kompozycje farmaceutyczne do zastosowania w terapii zapalenia brzegów powiek |
MX2019003364A (es) | 2016-09-23 | 2019-10-02 | Novaliq Gmbh | Composiciones oftalmicas que comprenden ciclosporina. |
KR20190060787A (ko) * | 2016-09-28 | 2019-06-03 | 노바리크 게엠베하 | 카나비노이드 수용체 결합 리간드를 포함하는 조성물 |
US10751295B2 (en) * | 2016-11-09 | 2020-08-25 | Specialty Drug and Device, LLC | Compositions and methods for the removal of ear wax |
US20190328717A1 (en) * | 2016-12-22 | 2019-10-31 | Novaliq Gmbh | Compositions comprising tacrolimus for the treatment of intraocular inflammatory eye diseases |
IL267869B2 (en) | 2017-01-06 | 2023-10-01 | Palvella Therapeutics Inc | Non-aqueous preparations of mTOR inhibitors and methods of use |
EP3612228B1 (en) | 2017-04-21 | 2023-08-23 | Dermaliq Therapeutics, Inc. | Iodine compositions |
WO2018202835A1 (en) | 2017-05-05 | 2018-11-08 | Novaliq Gmbh | Process for the production of semifluorinated alkanes |
EP3621601A1 (en) | 2017-05-12 | 2020-03-18 | Novaliq GmbH | Pharmaceutical compositions comprosing semifluorinated alkanes for the treatment of contact lense-related conditions |
CA3076776A1 (en) | 2017-09-27 | 2019-04-04 | Novaliq Gmbh | Ophthalmic compositions comprising latanoprost for use in the treatment of ocular diseases |
CN111182893A (zh) | 2017-10-04 | 2020-05-19 | 诺瓦利克有限责任公司 | 包含f6h8的眼用组合物 |
EP3758676A1 (en) | 2018-03-02 | 2021-01-06 | Novaliq GmbH | Pharmaceutical compositions comprising nebivolol |
EP3773469A1 (en) * | 2018-03-28 | 2021-02-17 | Novaliq GmbH | Pharmaceutical composition comprising timolol |
US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
EP3856128B1 (en) | 2018-09-27 | 2023-06-07 | Dermaliq Therapeutics, Inc. | Topical sunscreen formulation |
JP2022502421A (ja) | 2018-10-12 | 2022-01-11 | ノバリック ゲーエムベーハー | 乾性眼疾患の治療のための眼科用組成物 |
WO2024108095A1 (en) * | 2022-11-17 | 2024-05-23 | Martin Coffey | Semifluorinated alkane antibiotic combination compositions for treatment of ocular disorders |
Family Cites Families (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10022A (en) | 1853-09-13 | Lard-lamp | ||
US2616927A (en) | 1950-05-12 | 1952-11-04 | Minnesota Mining & Mfg | Fluorocarbon tertiary amines |
US4452818A (en) | 1982-03-19 | 1984-06-05 | Haidt Sterling J | Extraocular method of treating the eye with liquid perfluorocarbons |
US5077036A (en) | 1986-01-14 | 1991-12-31 | Alliance Pharmaceutical Corp. | Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid |
JPS6452722A (en) | 1987-05-01 | 1989-02-28 | Anjierini Pharmaceut Inc | Ophthalmic composition |
US5518731A (en) | 1990-09-27 | 1996-05-21 | Allergan, Inc. | Nonaqueous fluorinated drug delivery vehicle suspensions |
US6458376B1 (en) | 1990-09-27 | 2002-10-01 | Allergan, Inc. | Nonaqueous fluorinated drug delivery suspensions |
US5326566A (en) | 1991-05-17 | 1994-07-05 | Bristol-Myers Squibb Company | Use of dibutyl adipate and isopropyl myristate in topical and transdermal products |
GB9114374D0 (en) | 1991-07-03 | 1991-08-21 | Smithkline Beecham Plc | Novel process |
FR2679150A1 (fr) | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
US5336175A (en) | 1992-10-29 | 1994-08-09 | Mames Robert N | Method for the treatment of retinal detachments |
DE4405627A1 (de) | 1994-02-22 | 1995-08-24 | Hoechst Ag | Fluorkohlenwasserstoffe enthaltende Ölemulsionen |
FR2720943B1 (fr) | 1994-06-09 | 1996-08-23 | Applic Transferts Technolo | Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples. |
US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
US5696164A (en) | 1994-12-22 | 1997-12-09 | Johnson & Johnson Consumer Products, Inc. | Antifungal treatment of nails |
US5874481A (en) | 1995-06-07 | 1999-02-23 | Alliance Pharmaceutical Corp. | Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents |
US5667809A (en) * | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
DE19536504C2 (de) | 1995-09-29 | 1999-09-23 | H Meinert | Verwendung fluorierter Alkane |
US5874469A (en) | 1996-01-05 | 1999-02-23 | Alcon Laboratories, Inc. | Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs |
US5863560A (en) | 1996-09-11 | 1999-01-26 | Virotex Corporation | Compositions and methods for topical application of therapeutic agents |
IN184589B (ja) | 1996-10-16 | 2000-09-09 | Alza Corp | |
DE19709704C2 (de) | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
US5980936A (en) | 1997-08-07 | 1999-11-09 | Alliance Pharmaceutical Corp. | Multiple emulsions comprising a hydrophobic continuous phase |
US5981607A (en) | 1998-01-20 | 1999-11-09 | Allergan | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers |
EP0983037B1 (en) | 1998-02-09 | 2003-05-02 | MacroChem Corporation | Antifungal nail lacquer |
DE19861012A1 (de) | 1998-03-18 | 1999-09-30 | Pharm Pur Gmbh | Behandlungsmittel für die Ophthalmologie |
EP1105096B1 (en) | 1998-08-19 | 2003-10-29 | Skyepharma Canada Inc. | Injectable aqueous dispersions of propofol |
US6140374A (en) | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
US6159977A (en) | 1998-11-16 | 2000-12-12 | Astan, Inc. | Therapeutic anti-fungal nail preparation |
HUP0200202A3 (en) | 1999-02-08 | 2009-08-28 | Alza Corp | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
WO2000054588A1 (en) | 1999-03-15 | 2000-09-21 | John Claude Krusz | Treatment of acute headaches and chronic pain using rapidly-cleared anesthetic drug at sub-anesthetic dosages |
US6177477B1 (en) | 1999-03-24 | 2001-01-23 | American Home Products Corporation | Propofol formulation containing TRIS |
US6239113B1 (en) * | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
DE19926890C1 (de) | 1999-06-12 | 2000-07-27 | Pharm Pur Gmbh | Verwendung eines hochfluorierten oligomeren Alkans in der Ophthalmologie |
DE19938668B4 (de) | 1999-08-14 | 2006-01-26 | Bausch & Lomb Inc. | Tränenersatzmittel |
JP2001158734A (ja) | 1999-12-02 | 2001-06-12 | Lion Corp | 眼科用組成物及びソフトコンタクトレンズに対する吸着抑制方法 |
US20030018044A1 (en) | 2000-02-18 | 2003-01-23 | Peyman Gholam A. | Treatment of ocular disease |
DE10024413A1 (de) | 2000-05-19 | 2001-12-06 | Mika Pharma Gmbh | Pharmazeutische und/oder kosmetische Zubereitung |
US6399087B1 (en) | 2000-12-20 | 2002-06-04 | Amphastar Pharmaceuticals, Inc. | Propofol formulation with enhanced microbial inhibition |
CA2446060A1 (en) | 2001-05-07 | 2002-11-14 | Corium International | Compositions and delivery systems for administration of a local anesthetic agent |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
JP4654128B2 (ja) | 2003-06-27 | 2011-03-16 | 湧永製薬株式会社 | 硬カプセル剤 |
US20050079210A1 (en) | 2003-10-09 | 2005-04-14 | Gupta Shyam K. | Liposomal delivery system for topical pharmaceutical, cosmeceutical, and cosmetic ingredients |
JP2007511616A (ja) | 2003-11-19 | 2007-05-10 | バーンズ−ジューイッシュ ホスピタル | 増強された薬物送達 |
GB0408164D0 (en) | 2004-04-13 | 2004-05-19 | Immune Targeting Systems Ltd | Antigen delivery vectors and constructs |
ES2387619T3 (es) * | 2004-04-19 | 2012-09-27 | Centre National De La Recherche Scientifique (Cnrs) | Suplementos de tensioactivos pulmonares |
JP2008501806A (ja) | 2004-06-08 | 2008-01-24 | オキュラリス ファーマ, インコーポレイテッド | 疎水性眼用組成物および使用方法 |
US7063241B2 (en) | 2004-06-10 | 2006-06-20 | Allergan, Inc. | Dispensing tip |
CN101043884A (zh) | 2004-07-01 | 2007-09-26 | 谢彭斯眼科研究公司 | 用于治疗眼部疾病和病症的组合物和方法 |
US7740875B2 (en) | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
US20060078580A1 (en) | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
EP1688161A1 (en) | 2004-11-02 | 2006-08-09 | Switch Biotech Aktiengesellschaft | Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis |
GB0511499D0 (en) | 2005-06-06 | 2005-07-13 | Medpharm Ltd | Topical ungual formulations |
ATE420625T1 (de) | 2005-08-05 | 2009-01-15 | Bharat Serums & Vaccines Ltd | Intravenöse propofol-emulsionszusammensetzungen mit konservierendem effekt |
FR2892023B1 (fr) | 2005-10-14 | 2009-09-25 | Galderma Sa | Composition pharmaceutique a base d'amorolfine et d'agent filmogene hydrosoluble pour application ungueale et peri-ungueale |
DE102005055811A1 (de) | 2005-11-23 | 2007-05-31 | Novaliq Gmbh | Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen |
TWI376239B (en) | 2006-02-01 | 2012-11-11 | Andrew Xian Chen | Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof |
CA2664879C (en) | 2006-09-29 | 2015-03-24 | Surmodics, Inc. | Biodegradable ocular implants and methods for treating ocular conditions |
JP5569899B2 (ja) | 2006-11-28 | 2014-08-13 | ウィスコンシン・アラムナイ・リサーチ・ファウンデーション | 揮発性のフッ化麻酔薬を静脈内送達するためのフルオロポリマーベースのエマルション |
AU2007330356B2 (en) | 2006-12-07 | 2013-05-02 | Sun Pharma Advanced Research Company Ltd | Metered drop bottle for dispensing microliter amounts of a liquid in the form of a drop |
ITMI20070890A1 (it) | 2007-05-04 | 2008-11-05 | Sifi Spa | Composizioni oftalmiche per il trattamento della ipertensione oculare e del glaucoma |
FR2918891B1 (fr) | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
US8222292B2 (en) | 2007-08-06 | 2012-07-17 | Insys Therapeutics, Inc. | Liquid cannabinoid formulations |
DE102007055046A1 (de) * | 2007-11-19 | 2009-05-28 | Fluoron Gmbh | Infusionslösung |
DK2110126T3 (da) | 2008-04-18 | 2012-02-27 | Novaliq Gmbh | Inhalations- og instillationsanvendelse af semifluorerede alkaner som aktiv bestanddel-bærere inden for det intrapulmonale område |
US20100006600A1 (en) | 2008-07-14 | 2010-01-14 | Dascanio Gustavo A | Fluid dispenser including hydrophobic ring |
JP2012509737A (ja) | 2008-11-26 | 2012-04-26 | サーモディクス,インコーポレイティド | 埋め込み式の眼薬送達器具および眼薬送達方法 |
US8501800B2 (en) * | 2009-03-05 | 2013-08-06 | Insite Vision Incorporated | Controlled-release ophthalmic vehicles |
IT1393419B1 (it) | 2009-03-19 | 2012-04-20 | Medivis S R L | Composizioni oftalmiche a base di acidi grassi polinsaturi omega-3 e omega-6. |
WO2010146536A1 (en) | 2009-06-18 | 2010-12-23 | Koninklijke Philips Electronics N.V. | Suspension of particles with drug |
JP5549669B2 (ja) | 2009-06-25 | 2014-07-16 | ライオン株式会社 | 眼科用組成物、ドライアイ治療剤及びビタミンaの安定化方法 |
JP5736635B2 (ja) | 2009-06-25 | 2015-06-17 | ライオン株式会社 | ドライアイ治療剤 |
US20110269704A1 (en) | 2009-07-24 | 2011-11-03 | Seigfried Bernd G | Method for developing a liquid composition to be applied to the skin as a foam and a composition that can be applied topically |
JP2011024841A (ja) | 2009-07-28 | 2011-02-10 | 健太 ▲浜崎▼ | 点眼補助具 |
EP2332525A1 (en) | 2009-11-23 | 2011-06-15 | Novaliq GmbH | Pharmaceutical composition comprising propofol |
EP2335735A1 (en) | 2009-12-14 | 2011-06-22 | Novaliq GmbH | Pharmaceutical composition for treatment of dry eye syndrome |
US20110223208A1 (en) | 2010-03-09 | 2011-09-15 | Beth Hill | Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations |
WO2011113855A2 (en) | 2010-03-17 | 2011-09-22 | Novaliq Gmbh | Pharmaceutical composition for treatment of increased intraocular pressure |
DE102010022567A1 (de) | 2010-06-02 | 2011-12-08 | Fluoron Gmbh | Zubereitung |
EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
EP3202421B1 (en) | 2011-01-04 | 2018-03-28 | Novaliq GmbH | O/w-emulsions comprising semifluorinated alkanes |
CN103596554A (zh) | 2011-05-25 | 2014-02-19 | 诺瓦利克有限责任公司 | 基于半氟化烷烃类的外用药物组合物 |
JP6023181B2 (ja) | 2011-05-25 | 2016-11-09 | ノバリック ゲーエムベーハー | 爪に投与するための医薬組成物 |
DK2806886T3 (en) | 2012-01-23 | 2017-06-06 | Novaliq Gmbh | STABILIZED PROTEIN COMPOSITIONS BASED ON SEMIFLUORED ALKANES |
US9549966B2 (en) | 2012-02-21 | 2017-01-24 | Massachusetts Eye & Ear Infirmary | Inflammatory eye disorders |
US9878000B2 (en) | 2012-06-20 | 2018-01-30 | University Of Waterloo | Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof |
ES2965828T3 (es) | 2012-09-12 | 2024-04-17 | Novaliq Gmbh | Composiciones de alcano semifluorado |
CN104619314B (zh) | 2012-09-12 | 2017-09-22 | 诺瓦利克有限责任公司 | 包含半氟化烷烃的混合物的组合物 |
AU2013362909A1 (en) | 2012-12-18 | 2015-05-21 | Novartis Ag | Compositions and methods that utilize a peptide tag that binds to hyaluronan |
EP2783703A1 (en) | 2013-03-25 | 2014-10-01 | B. Braun Melsungen AG | Semifluorocarbon compound containing contrast agent |
WO2015011199A1 (en) | 2013-07-23 | 2015-01-29 | Novaliq Gmbh | Stabilized antibody compositions |
EP3125852B1 (en) | 2014-03-31 | 2023-04-12 | Amcor Rigid Plastics USA, LLC | Controlled release container |
EP2944324A1 (de) | 2014-05-13 | 2015-11-18 | LTS LOHMANN Therapie-Systeme AG | Verwendung von semifluorierten Alkanen in transdermalen therapeutischen Systemen |
AU2015301761B2 (en) | 2014-08-13 | 2020-05-21 | University Of Florida Research Foundation, Inc. | Preservative removal from eye drops |
EP3355990B1 (en) | 2015-09-30 | 2019-06-12 | Novaliq GmbH | Semifluorinated compounds and their compositions |
CN110693825B (zh) | 2015-09-30 | 2022-03-08 | 诺瓦利克有限责任公司 | 用于眼部给药的半氟化化合物 |
KR20190003997A (ko) | 2016-06-01 | 2019-01-10 | 해롤드 리차드 헬스트롬 | 부교감 신경제와 항교감 신경제를 이용한 안구 건조증의 치료 |
WO2017220625A1 (en) | 2016-06-23 | 2017-12-28 | Novaliq Gmbh | Topical administration method |
KR20190060787A (ko) | 2016-09-28 | 2019-06-03 | 노바리크 게엠베하 | 카나비노이드 수용체 결합 리간드를 포함하는 조성물 |
US20190328717A1 (en) | 2016-12-22 | 2019-10-31 | Novaliq Gmbh | Compositions comprising tacrolimus for the treatment of intraocular inflammatory eye diseases |
BR112019012791A2 (pt) | 2016-12-23 | 2019-12-03 | Novaliq Gmbh | composição oftálmica para o tratamento da doença do olho seco |
-
2010
- 2010-10-20 EP EP10188242A patent/EP2444063A1/en not_active Withdrawn
-
2011
- 2011-10-18 KR KR1020137009743A patent/KR101773225B1/ko active IP Right Grant
- 2011-10-18 US US13/824,048 patent/US9757459B2/en active Active
- 2011-10-18 BR BR112013007473-6A patent/BR112013007473B1/pt active IP Right Grant
- 2011-10-18 PL PL11770454T patent/PL2629754T3/pl unknown
- 2011-10-18 DK DK11770454.4T patent/DK2629754T3/en active
- 2011-10-18 WO PCT/EP2011/068141 patent/WO2012052418A1/en active Application Filing
- 2011-10-18 MX MX2013003892A patent/MX2013003892A/es active IP Right Grant
- 2011-10-18 CA CA2813016A patent/CA2813016C/en active Active
- 2011-10-18 ES ES11770454.4T patent/ES2528105T3/es active Active
- 2011-10-18 EP EP11770454.4A patent/EP2629754B1/en active Active
- 2011-10-18 IN IN2524DEN2013 patent/IN2013DN02524A/en unknown
- 2011-10-18 CN CN201180049413.3A patent/CN103153281B/zh active Active
- 2011-10-18 PT PT117704544T patent/PT2629754E/pt unknown
- 2011-10-18 JP JP2013534288A patent/JP5770297B2/ja active Active
- 2011-10-18 AU AU2011317673A patent/AU2011317673B2/en active Active
-
2013
- 2013-08-09 HK HK13109363.5A patent/HK1182010A1/xx unknown
-
2017
- 2017-07-24 US US15/658,187 patent/US9968678B2/en active Active
-
2018
- 2018-04-04 US US15/945,587 patent/US11160865B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9968678B2 (en) | 2018-05-15 |
CN103153281A (zh) | 2013-06-12 |
EP2629754B1 (en) | 2014-11-05 |
DK2629754T3 (en) | 2015-01-26 |
JP2013540140A (ja) | 2013-10-31 |
WO2012052418A1 (en) | 2012-04-26 |
AU2011317673B2 (en) | 2014-07-17 |
BR112013007473A2 (pt) | 2016-07-19 |
US20180008710A1 (en) | 2018-01-11 |
CN103153281B (zh) | 2015-09-30 |
HK1182010A1 (en) | 2013-11-22 |
MX2013003892A (es) | 2013-07-05 |
EP2629754A1 (en) | 2013-08-28 |
IN2013DN02524A (ja) | 2015-08-07 |
US20180221485A1 (en) | 2018-08-09 |
PT2629754E (pt) | 2015-02-04 |
AU2011317673A1 (en) | 2013-04-11 |
US11160865B2 (en) | 2021-11-02 |
KR20130139925A (ko) | 2013-12-23 |
CA2813016A1 (en) | 2012-04-26 |
US9757459B2 (en) | 2017-09-12 |
CA2813016C (en) | 2017-10-03 |
PL2629754T3 (pl) | 2015-04-30 |
ES2528105T3 (es) | 2015-02-04 |
US20130266652A1 (en) | 2013-10-10 |
KR101773225B1 (ko) | 2017-09-12 |
EP2444063A1 (en) | 2012-04-25 |
BR112013007473B1 (pt) | 2021-11-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5770297B2 (ja) | 有効成分の送達のための液体医薬組成物 | |
JP6545137B2 (ja) | 後眼部疾患の治療のための液体医薬組成物 | |
CA2788060C (en) | Pharmaceutical composition for treatment of increased intraocular pressure | |
CA2776860C (en) | Pharmaceutical composition for treatment of dry eye syndrome | |
JP2021515758A (ja) | ネビボロールを含む医薬組成物 | |
JP7496778B2 (ja) | チモロールを含む医薬組成物 | |
JP2021518352A (ja) | チモロールを含む医薬組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140911 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140911 |
|
A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20140911 |
|
A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20141008 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20141112 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150225 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150410 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150603 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150624 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5770297 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |