IN2013DN02524A - - Google Patents

Download PDF

Info

Publication number
IN2013DN02524A
IN2013DN02524A IN2524DEN2013A IN2013DN02524A IN 2013DN02524 A IN2013DN02524 A IN 2013DN02524A IN 2524DEN2013 A IN2524DEN2013 A IN 2524DEN2013A IN 2013DN02524 A IN2013DN02524 A IN 2013DN02524A
Authority
IN
India
Prior art keywords
compositions
active ingredients
useful
subcutaneous
suspensions
Prior art date
Application number
Inventor
Bastian Theisinger
Sonja Theisinger
Bernhard Günther
Original Assignee
Novaliq Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novaliq Gmbh filed Critical Novaliq Gmbh
Publication of IN2013DN02524A publication Critical patent/IN2013DN02524A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0046Ear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.
IN2524DEN2013 2010-10-20 2011-10-18 IN2013DN02524A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10188242A EP2444063A1 (en) 2010-10-20 2010-10-20 Liquid pharmaceutical compositions for the delivery of active ingredients
PCT/EP2011/068141 WO2012052418A1 (en) 2010-10-20 2011-10-18 Liquid pharmaceutical composition for the delivery of active ingredients

Publications (1)

Publication Number Publication Date
IN2013DN02524A true IN2013DN02524A (en) 2015-08-07

Family

ID=43608363

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2524DEN2013 IN2013DN02524A (en) 2010-10-20 2011-10-18

Country Status (16)

Country Link
US (3) US9757459B2 (en)
EP (2) EP2444063A1 (en)
JP (1) JP5770297B2 (en)
KR (1) KR101773225B1 (en)
CN (1) CN103153281B (en)
AU (1) AU2011317673B2 (en)
BR (1) BR112013007473B1 (en)
CA (1) CA2813016C (en)
DK (1) DK2629754T3 (en)
ES (1) ES2528105T3 (en)
HK (1) HK1182010A1 (en)
IN (1) IN2013DN02524A (en)
MX (1) MX2013003892A (en)
PL (1) PL2629754T3 (en)
PT (1) PT2629754E (en)
WO (1) WO2012052418A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102869345B (en) 2010-03-17 2015-02-11 诺瓦利克有限责任公司 Pharmaceutical composition for treatment of increased intraocular pressure
EP2444063A1 (en) 2010-10-20 2012-04-25 Novaliq GmbH Liquid pharmaceutical compositions for the delivery of active ingredients
EP2462921A1 (en) 2010-11-11 2012-06-13 Novaliq GmbH Liquid pharmaceutical compositions for the treatment of a posterior eye disease
PL2714010T3 (en) 2011-05-25 2017-08-31 Novaliq Gmbh Topical pharmaceutical composition based on semifluorinated alkanes
WO2012160180A2 (en) 2011-05-25 2012-11-29 Novaliq Gmbh Pharmaceutical composition for administration to nails
AU2013211645B2 (en) 2012-01-23 2017-06-15 Novaliq Gmbh Stabilised protein compositions based on semifluorinated alkanes
EP3181119B1 (en) 2012-09-12 2019-07-10 Novaliq GmbH Semifluorinated alkane compositions for use in the treatment of keratoconjunctivitis sicca
EP2895158B1 (en) 2012-09-12 2019-11-20 Novaliq GmbH Compositions comprising mixtures of semifluorinated alkanes
WO2014117035A1 (en) 2013-01-24 2014-07-31 Transderm, Inc. COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS
JP6503349B2 (en) 2013-07-23 2019-04-17 ノバリック ゲーエムベーハー Stabilized antibody composition
CA2958315A1 (en) * 2014-09-17 2016-03-24 Panoptica, Inc. Ocular formulations for drug-delivery and protection of the anterior segment of the eye
PT3355990T (en) 2015-09-30 2019-09-11 Novaliq Gmbh Semifluorinated compounds and their compositions
DE202016008739U1 (en) 2015-09-30 2019-04-29 Novaliq Gmbh Semifluorinated compounds
KR102257916B1 (en) 2016-06-23 2021-05-28 노바리크 게엠베하 Kit including drop dispenser
CN109890374A (en) 2016-09-22 2019-06-14 诺瓦利克有限责任公司 For treating the pharmaceutical composition of blear-eye
JP6869336B2 (en) 2016-09-23 2021-05-12 ノバリック ゲーエムベーハー Ophthalmic composition containing cyclosporine
KR20190060787A (en) * 2016-09-28 2019-06-03 노바리크 게엠베하 Compositions comprising cannabinoid receptor binding ligands
US10751295B2 (en) 2016-11-09 2020-08-25 Specialty Drug and Device, LLC Compositions and methods for the removal of ear wax
MX2019007586A (en) * 2016-12-22 2019-12-11 Novaliq Gmbh Compositions comprising tacrolimus for the treatment of intraocular inflammatory eye diseases.
WO2018129364A1 (en) 2017-01-06 2018-07-12 Palvella Therapeutics Llc Anhydrous compositions of mtor inhibitors and methods of use
WO2018193093A1 (en) * 2017-04-21 2018-10-25 Novaliq Gmbh Iodine compositions
WO2018202835A1 (en) 2017-05-05 2018-11-08 Novaliq Gmbh Process for the production of semifluorinated alkanes
CN110650734A (en) 2017-05-12 2020-01-03 诺瓦利克有限责任公司 Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of conditions associated with contact lenses
CN111372566A (en) 2017-09-27 2020-07-03 诺瓦利克有限责任公司 Ophthalmic composition comprising latanoprost for treating ocular diseases
US11896559B2 (en) 2017-10-04 2024-02-13 Novaliq Gmbh Opthalmic compositions comprising F6H8
WO2019166631A1 (en) 2018-03-02 2019-09-06 Novaliq Gmbh Pharmaceutical compositions comprising nebivolol
JP7496778B2 (en) * 2018-03-28 2024-06-07 ノバリック ゲーエムベーハー Pharmaceutical Compositions Containing Timolol
US11000513B2 (en) 2018-07-02 2021-05-11 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use
AU2019345929B2 (en) 2018-09-27 2022-02-03 Dermaliq Therapeutics, Inc. Topical sunscreen formulation
CN112823020A (en) 2018-10-12 2021-05-18 诺瓦利克有限责任公司 Ophthalmic compositions for treating dry eye
WO2024108095A1 (en) * 2022-11-17 2024-05-23 Martin Coffey Semifluorinated alkane antibiotic combination compositions for treatment of ocular disorders

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022A (en) 1853-09-13 Lard-lamp
US2616927A (en) 1950-05-12 1952-11-04 Minnesota Mining & Mfg Fluorocarbon tertiary amines
US4452818A (en) 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
US5077036A (en) 1986-01-14 1991-12-31 Alliance Pharmaceutical Corp. Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid
JPS6452722A (en) 1987-05-01 1989-02-28 Anjierini Pharmaceut Inc Ophthalmic composition
US5518731A (en) 1990-09-27 1996-05-21 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US6458376B1 (en) 1990-09-27 2002-10-01 Allergan, Inc. Nonaqueous fluorinated drug delivery suspensions
US5326566A (en) 1991-05-17 1994-07-05 Bristol-Myers Squibb Company Use of dibutyl adipate and isopropyl myristate in topical and transdermal products
GB9114374D0 (en) 1991-07-03 1991-08-21 Smithkline Beecham Plc Novel process
FR2679150A1 (en) 1991-07-17 1993-01-22 Atta PREPARATIONS CONSISTING OF A FLUOROCARBIDE OR HIGHLY FLUORINE COMPOUND AND A LIPOPHILIC-FLUOROPHILIC ORGANIC COMPOUND, AND THEIR USES.
US5336175A (en) 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
DE4405627A1 (en) 1994-02-22 1995-08-24 Hoechst Ag Oil emulsions containing fluorocarbons
FR2720943B1 (en) 1994-06-09 1996-08-23 Applic Transferts Technolo Stable inverse emulsions with a high concentration of fluorinated compound (s) and their use for the pulmonary administration of medicaments and for the manufacture of multiple emulsions.
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
US5696164A (en) 1994-12-22 1997-12-09 Johnson & Johnson Consumer Products, Inc. Antifungal treatment of nails
US5874481A (en) 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
US5667809A (en) * 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
DE19536504C2 (en) 1995-09-29 1999-09-23 H Meinert Use of fluorinated alkanes
US5874469A (en) 1996-01-05 1999-02-23 Alcon Laboratories, Inc. Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
IN184589B (en) 1996-10-16 2000-09-09 Alza Corp
DE19709704C2 (en) 1997-03-10 1999-11-04 Michael Georgieff Use of a liquid preparation of xenon for intravenous administration when inducing and / or maintaining anesthesia
US5980936A (en) 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US5981607A (en) 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
BR9904780A (en) 1998-02-09 2000-03-08 Macrochem Corp Fungicide nail polish and method of using it
DE19861012A1 (en) 1998-03-18 1999-09-30 Pharm Pur Gmbh Ophthalmological use of fluorocarbon with low dissolved oxygen content, e.g. for treating ischemic retinal disease
DK1105096T3 (en) 1998-08-19 2004-03-08 Skyepharma Canada Inc Injectable aqueous propofol dispersions
US6140374A (en) 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
US6159977A (en) 1998-11-16 2000-12-12 Astan, Inc. Therapeutic anti-fungal nail preparation
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
KR100858856B1 (en) 1999-02-08 2008-09-17 인타르시아 세라퓨틱스 인코포레이티드 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
WO2000054588A1 (en) 1999-03-15 2000-09-21 John Claude Krusz Treatment of acute headaches and chronic pain using rapidly-cleared anesthetic drug at sub-anesthetic dosages
US6177477B1 (en) 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
DE19926890C1 (en) 1999-06-12 2000-07-27 Pharm Pur Gmbh Use of highly fluorinated oligomeric alkanes in ophthalmology, especially as vitreous humor substitutes, retinal tamponade materials, liquid implants, tear fluid substitutes and drug carriers
DE19938668B4 (en) 1999-08-14 2006-01-26 Bausch & Lomb Inc. Artificial tears
JP2001158734A (en) 1999-12-02 2001-06-12 Lion Corp Composition for ophthalmology and method for inhibiting adsorption to soft contact lens
US20030018044A1 (en) 2000-02-18 2003-01-23 Peyman Gholam A. Treatment of ocular disease
DE10024413A1 (en) 2000-05-19 2001-12-06 Mika Pharma Gmbh Pharmaceutical and / or cosmetic preparation
US6399087B1 (en) 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
US20030027833A1 (en) 2001-05-07 2003-02-06 Cleary Gary W. Compositions and delivery systems for administration of a local anesthetic agent
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
US20060153909A1 (en) 2003-06-27 2006-07-13 Soko Motoune Hard capsule
US20050079210A1 (en) 2003-10-09 2005-04-14 Gupta Shyam K. Liposomal delivery system for topical pharmaceutical, cosmeceutical, and cosmetic ingredients
AU2004293027A1 (en) 2003-11-19 2005-06-09 Barnes-Jewish Hospital Enhanced drug delivery
GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
WO2005099718A1 (en) * 2004-04-19 2005-10-27 Centre National De La Recherche Scientifique (C.N.R.S.) Lung surfactant supplements
EP1763336A1 (en) 2004-06-08 2007-03-21 Ocularis Pharma, Inc. Hydrophobic ophthalmic compositions and methods of use
US7063241B2 (en) 2004-06-10 2006-06-20 Allergan, Inc. Dispensing tip
MX2007000208A (en) 2004-07-01 2007-08-07 Schepens Eye Res Inst Compositions and methods for treating eye disorders and conditions.
US7740875B2 (en) 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US20060078580A1 (en) 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
EP1688161A1 (en) 2004-11-02 2006-08-09 Switch Biotech Aktiengesellschaft Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
GB0511499D0 (en) 2005-06-06 2005-07-13 Medpharm Ltd Topical ungual formulations
JP2009503059A (en) 2005-08-05 2009-01-29 ブハラット セルムズ アンド ヴァクシンズ リミテッド Intravenous propofol emulsion composition having antiseptic effect
FR2892023B1 (en) 2005-10-14 2009-09-25 Galderma Sa PHARMACEUTICAL COMPOSITION BASED ON AMOROLFIN AND WATER-SOLUBLE FILMOGENIC AGENT FOR UNIGEAL AND PERI-UNGUEAL APPLICATION
DE102005055811A1 (en) 2005-11-23 2007-05-31 Novaliq Gmbh Using composition containing semifluorinated alkane and/or siloxane for preservation or organs and limbs, ensures proper provision of oxygen
TWI376239B (en) 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
WO2008060359A2 (en) 2006-09-29 2008-05-22 Surmodics, Inc. Biodegradable ocular implants and methods for treating ocular conditions
US9000048B2 (en) 2006-11-28 2015-04-07 Wisconsin Alumni Research Foundation Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics
CA2672527A1 (en) 2006-12-07 2008-06-12 Sun Pharma Advanced Research Company Ltd. Metered drop bottle for dispensing microliter amounts of a liquid in the form of a drop
ITMI20070890A1 (en) 2007-05-04 2008-11-05 Sifi Spa OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA
FR2918891B1 (en) 2007-07-20 2009-09-25 Thea Sa Lab OPHTHALMIC SOLUTION BASED ON PROSTAGLANDINS WITHOUT PRESERVATIVE
US8222292B2 (en) 2007-08-06 2012-07-17 Insys Therapeutics, Inc. Liquid cannabinoid formulations
DE102007055046A1 (en) * 2007-11-19 2009-05-28 Fluoron Gmbh infusion
ATE532505T1 (en) 2008-04-18 2011-11-15 Novaliq Gmbh INHALATIVE AND INSTILLATIVE USE OF SEMIFLUORINATED ALKANES AS ACTIVE CARRIERS IN THE INTRAPULMONAL AREA
US20100006600A1 (en) 2008-07-14 2010-01-14 Dascanio Gustavo A Fluid dispenser including hydrophobic ring
CA2743824A1 (en) 2008-11-26 2010-06-03 Surmodics, Inc. Implantable ocular drug delivery device and methods
US8501800B2 (en) * 2009-03-05 2013-08-06 Insite Vision Incorporated Controlled-release ophthalmic vehicles
IT1393419B1 (en) 2009-03-19 2012-04-20 Medivis S R L OPHTHALMIC COMPOSITIONS OF OMEGA-3 AND OMEGA-6 POLYSATURATED FATTY ACIDS.
WO2010146536A1 (en) 2009-06-18 2010-12-23 Koninklijke Philips Electronics N.V. Suspension of particles with drug
KR101702157B1 (en) 2009-06-25 2017-02-13 라이온 가부시키가이샤 Ophthalmic composition
JP5736635B2 (en) 2009-06-25 2015-06-17 ライオン株式会社 Dry eye treatment
RU2532027C2 (en) 2009-07-24 2014-10-27 Мика Фарма Гезельшафт Фюр Ди Энтвиклюнг Унд Фермарктунг Фармацойтишер Продукте Мбх Foam-forming liquid compositions containing active agents, and methods for preparing and developing thereof
JP2011024841A (en) 2009-07-28 2011-02-10 健太 ▲浜崎▼ Instillation aid
EP2332525A1 (en) 2009-11-23 2011-06-15 Novaliq GmbH Pharmaceutical composition comprising propofol
EP2335735A1 (en) 2009-12-14 2011-06-22 Novaliq GmbH Pharmaceutical composition for treatment of dry eye syndrome
US20110223208A1 (en) 2010-03-09 2011-09-15 Beth Hill Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations
CN102869345B (en) 2010-03-17 2015-02-11 诺瓦利克有限责任公司 Pharmaceutical composition for treatment of increased intraocular pressure
DE102010022567A1 (en) 2010-06-02 2011-12-08 Fluoron Gmbh preparation
EP2444063A1 (en) 2010-10-20 2012-04-25 Novaliq GmbH Liquid pharmaceutical compositions for the delivery of active ingredients
EP2462921A1 (en) 2010-11-11 2012-06-13 Novaliq GmbH Liquid pharmaceutical compositions for the treatment of a posterior eye disease
PT2661280T (en) 2011-01-04 2019-02-25 Novaliq Gmbh O/w-emulsions comprising semifluorinated alkanes
PL2714010T3 (en) 2011-05-25 2017-08-31 Novaliq Gmbh Topical pharmaceutical composition based on semifluorinated alkanes
WO2012160180A2 (en) 2011-05-25 2012-11-29 Novaliq Gmbh Pharmaceutical composition for administration to nails
AU2013211645B2 (en) 2012-01-23 2017-06-15 Novaliq Gmbh Stabilised protein compositions based on semifluorinated alkanes
US9549966B2 (en) 2012-02-21 2017-01-24 Massachusetts Eye & Ear Infirmary Inflammatory eye disorders
US9878000B2 (en) 2012-06-20 2018-01-30 University Of Waterloo Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof
EP2895158B1 (en) 2012-09-12 2019-11-20 Novaliq GmbH Compositions comprising mixtures of semifluorinated alkanes
EP3181119B1 (en) 2012-09-12 2019-07-10 Novaliq GmbH Semifluorinated alkane compositions for use in the treatment of keratoconjunctivitis sicca
EP2935589A1 (en) 2012-12-18 2015-10-28 Novartis AG Compositions and methods that utilize a peptide tag that binds to hyaluronan
EP2783703A1 (en) 2013-03-25 2014-10-01 B. Braun Melsungen AG Semifluorocarbon compound containing contrast agent
JP6503349B2 (en) 2013-07-23 2019-04-17 ノバリック ゲーエムベーハー Stabilized antibody composition
ES2949040T3 (en) 2014-03-31 2023-09-25 Amcor Rigid Plastics Usa Llc Controlled release container
EP2944324A1 (en) 2014-05-13 2015-11-18 LTS LOHMANN Therapie-Systeme AG Use of semifluorinated alkanes in transdermal therapeutic systems
WO2016025560A1 (en) 2014-08-13 2016-02-18 University Of Florida Research Foundation, Inc. Preservative removal from eye drops
DE202016008739U1 (en) 2015-09-30 2019-04-29 Novaliq Gmbh Semifluorinated compounds
PT3355990T (en) 2015-09-30 2019-09-11 Novaliq Gmbh Semifluorinated compounds and their compositions
EP3463344A4 (en) 2016-06-01 2020-02-12 Harold Richard Hellstrom Treatment of dry eye disease with parasympathetic and anti-sympathetic agents
KR102257916B1 (en) 2016-06-23 2021-05-28 노바리크 게엠베하 Kit including drop dispenser
KR20190060787A (en) 2016-09-28 2019-06-03 노바리크 게엠베하 Compositions comprising cannabinoid receptor binding ligands
MX2019007586A (en) 2016-12-22 2019-12-11 Novaliq Gmbh Compositions comprising tacrolimus for the treatment of intraocular inflammatory eye diseases.
JP7032404B2 (en) 2016-12-23 2022-03-08 ノバリック ゲーエムベーハー Ophthalmic composition for the treatment of dry eye disease

Also Published As

Publication number Publication date
US9968678B2 (en) 2018-05-15
JP2013540140A (en) 2013-10-31
US20180221485A1 (en) 2018-08-09
EP2444063A1 (en) 2012-04-25
EP2629754A1 (en) 2013-08-28
US20130266652A1 (en) 2013-10-10
CA2813016C (en) 2017-10-03
KR20130139925A (en) 2013-12-23
EP2629754B1 (en) 2014-11-05
PT2629754E (en) 2015-02-04
US9757459B2 (en) 2017-09-12
MX2013003892A (en) 2013-07-05
HK1182010A1 (en) 2013-11-22
AU2011317673B2 (en) 2014-07-17
AU2011317673A1 (en) 2013-04-11
DK2629754T3 (en) 2015-01-26
CN103153281A (en) 2013-06-12
JP5770297B2 (en) 2015-08-26
US11160865B2 (en) 2021-11-02
CA2813016A1 (en) 2012-04-26
CN103153281B (en) 2015-09-30
BR112013007473B1 (en) 2021-11-03
US20180008710A1 (en) 2018-01-11
KR101773225B1 (en) 2017-09-12
PL2629754T3 (en) 2015-04-30
WO2012052418A1 (en) 2012-04-26
BR112013007473A2 (en) 2016-07-19
ES2528105T3 (en) 2015-02-04

Similar Documents

Publication Publication Date Title
IN2013DN02524A (en)
MY172292A (en) Vectors and sequences for the treatment of diseases
WO2012024620A3 (en) Autotaxin inhibitors and uses thereof
TN2012000126A1 (en) Polycyclic compounds as lysophosphatidic acid receptor antagonists
MX2013007295A (en) Quinoxalines and aza-quinoxalines as crth2 receptor modulators.
BR112012017269A2 (en) tricyclic heterocyclic compounds, compositions and methods of use thereof
IN2014CN02527A (en)
MX2013006040A (en) Lysophosphatidic acid receptor antagonists and their use in the treatment fibrosis.
WO2012054500A3 (en) Compositions for drug administration
EA023222B8 (en) Pyrazolyl quinazoline kinase inhibitors
MX2014004766A (en) Inhibitors of arginase and their therapeutic applications.
WO2013036309A3 (en) Sustained release formulations for delivery of proteins to the eye and methods of preparing same
AR081681A1 (en) METHODS AND COMPOSITIONS FOR THE INTRATECAL ADMINISTRATION OF b-GALACTOCEREBROSIDASA
EP2600834A4 (en) Collagen-based implants for sustained delivery of drugs
WO2012174158A3 (en) Administration of benzodiazepine
WO2012058241A3 (en) Methods and compositions for ameliorating pancreatic cancer
TR201903026T4 (en) S100A4 ANTIBODIES AND THEIR THERAPEUTIC USES.
WO2012064897A3 (en) Bicyclic and tricyclic inhibitors of sumoylation enzymes and methods for their use
WO2012168885A9 (en) Bisacodyl and its analogues as drugs for use in the treatment of cancer
IN2014DN06869A (en)
CY1120648T1 (en) DRUG ADMINISTRATION TECHNOLOGY
MX339196B (en) Aripiprazole compositions and methods for its transdermal delivery.
MX2013013691A (en) A sustained -release composition containing a melanocortin receptor ligand as the active ingredient.
MY167701A (en) Sublingual administration of statins
BR112014019704A8 (en) C-TERMINAL HSP90-INHIBITOR COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPOUNDS AND USE THEREOF FOR THE TREATMENT OR PREVENTION OF A NEURODEGENERATIVE DISORDER