JP6545137B2 - 後眼部疾患の治療のための液体医薬組成物 - Google Patents
後眼部疾患の治療のための液体医薬組成物 Download PDFInfo
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61P27/06—Antiglaucoma agents or miotics
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Description
(表1)
−眼圧上昇の管理に有用なプロスタグランジン類似体、例えばラタノプロスト、ビマトプロスト、タフルプロスト、トラボプロストおよびウノプロストンなど;
−炎症過程の管理に有用なコルチコステロイド、例えばトリアムシノロン、デキサメタゾン、フルオロメトロン、ヒドロコルチゾン、プレドニゾロン、およびリメキソロンなど;
−抗生物質、例えばオーレオマイシン、アジスロマイシン、ゲンタマイシン、シプロフロキサシン、オフロキサシン、フシジン酸、カナマイシン、レボフロキサシン、ロメフロキサシン、オキシテトラサイクリン、トブラマイシン、ナタマイシン、ゲンタマイシン、およびモキシフロキサシンなど;
−眼内圧を低下させるために有用なβアドレナリン遮断薬、例えばカルテオロール、チモロール、メチプラノロール、ベタキソロール、ピンドロール、およびレボブノロールなど;
−緑内障の管理に有用なコリン系薬物、例えばブリモニジン、クロニジン、ジピベフリン、アプラクロニジン、カルバコール、およびピロカルピンなど;
−緑内障の管理に有用な炭酸脱水酵素阻害剤、例えばブリンゾラミドおよびドルゾラミドなど;
−眼科用投与に有用なウイルス抑止剤(virustatic agents)、例えばアシクロビル、トリフルリジン、およびガンシクロビルなど;ならびに
−非ステロイド性抗炎症薬、例えば、ジクロフェナク、ブロムフェナク、ケトロラック、フルルビプロフェン、およびインドメタシンなど
が、そのいずれの塩および溶媒和物も含めて挙げられる。
Claims (9)
- 患者の後眼部の組織に活性成分を送達するため、または患者の後眼部に付随する組織の疾患若しくは症状を治療するための医薬組成物であって、前記組成物が、F4H5(F(CF2)4(CH2)5H)、F6H6(F(CF2)6(CH2)6H)およびF6H8(F(CF2)6(CH2)8H)から選ばれる、少なくとも1.2g/mlの密度を有する非水性の生理学的に許容できる液体ビヒクルと、溶解または分散形態の活性成分を含み、かつ、前記治療が、前記組成物の眼の表面への局所投与を含むものであり、 前記治療において、前記患者は前記組成物を投与部位から前記後眼部の部位へ移動させるのに十分な期間、上方に顔を向ける仰臥位の状態に置かれる、医薬組成物。
- 前記患者が、加齢性黄斑変性、糖尿病性網膜症、緑内障、網膜色素変性症、およびサイトメガロウイルス網膜炎から選択される疾患または状態に罹患している、請求項1に記載の医薬組成物。
- 前記液体ビヒクルの密度が少なくとも1.35g/mlである、請求項1〜2のいずれか一項に記載の医薬組成物。
- 前記液体ビヒクルの沸点が少なくとも120℃である、請求項1〜3のいずれか一項に記載の医薬組成物。
- 5mPas以下の動的粘度を有する、請求項1〜4のいずれか一項に記載の医薬組成物。
- 前記液体ビヒクルの屈折率が、20℃で1.29〜1.35の範囲内である、請求項1〜5のいずれか一項に記載の医薬組成物。
- 溶解または分散形態の活性医薬成分を含み、その活性成分が、所望により、ラタノプロスト、ビマトプロスト、タフルプロスト、トラボプロスト、ウノプロストン、トリアムシノロン、デキサメタゾン、フルオロメトロン、ヒドロコルチゾン、プレドニゾロン、リメキソロン、オーレオマイシン、アジスロマイシン、ゲンタマイシン、シプロフロキサシン、オフロキサシン、フシジン酸、カナマイシン、レボフロキサシン、ロメフロキサシン、オキシテトラサイクリン、トブラマイシン、ナタマイシン、ゲンタマイシン、モキシフロキサシン、カルテオロール、チモロール、メチプラノロール、ベタキソロール、ピンドロール、レボブノロール、ブリモニジン、クロニジン、ジピベフリン、アプラクロニジン、カルバコール、ピロカルピン、ブリンゾラミド、ドルゾラミド、アシクロビル、トリフルリジン、ガンシクロビル、ジクロフェナク、ブロムフェナク、ケトロラック、フルルビプロフェン、およびインドメタシン、及びそれらの任意の塩もしくは溶媒和物から選択される、請求項1〜6のいずれか一項に記載の医薬組成物。
- 共溶媒、界面活性剤、安定剤、抗酸化薬、防腐剤、および着色剤から選択される1以上の賦形剤をさらに含む、請求項1〜7のいずれか一項に記載の医薬組成物。
- 少なくとも24時間の期間にわたって活性成分の持続放出をもたらすように処方されている、請求項1〜8のいずれか一項に記載の医薬組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10190832A EP2462921A1 (en) | 2010-11-11 | 2010-11-11 | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
EP10190832.5 | 2010-11-11 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013538191A Division JP2013542239A (ja) | 2010-11-11 | 2011-11-10 | 後眼部疾患の治療のための液体医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017019842A JP2017019842A (ja) | 2017-01-26 |
JP6545137B2 true JP6545137B2 (ja) | 2019-07-17 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013538191A Pending JP2013542239A (ja) | 2010-11-11 | 2011-11-10 | 後眼部疾患の治療のための液体医薬組成物 |
JP2016175104A Active JP6545137B2 (ja) | 2010-11-11 | 2016-09-08 | 後眼部疾患の治療のための液体医薬組成物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013538191A Pending JP2013542239A (ja) | 2010-11-11 | 2011-11-10 | 後眼部疾患の治療のための液体医薬組成物 |
Country Status (8)
Country | Link |
---|---|
US (2) | US9241900B2 (ja) |
EP (3) | EP2462921A1 (ja) |
JP (2) | JP2013542239A (ja) |
KR (1) | KR20140032935A (ja) |
CN (2) | CN106924180B (ja) |
AU (2) | AU2011328102B2 (ja) |
CA (1) | CA2813851C (ja) |
WO (1) | WO2012062834A1 (ja) |
Families Citing this family (35)
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US20210069016A1 (en) * | 2008-11-13 | 2021-03-11 | Gholam A. Peyman | Neurodegenerative Disorder Treatment Method |
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EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
AU2012260787B2 (en) | 2011-05-25 | 2017-02-02 | Dermaliq Therapeutics, Inc. | Topical pharmaceutical composition based on semifluorinated alkanes |
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BR112020006072A2 (pt) | 2017-09-27 | 2020-10-06 | Novaliq Gmbh | composições oftalmáticas compreendendo latanoprost para uso no tratamento de doenças oculares |
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CA2813851A1 (en) | 2012-05-18 |
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CN106924180B (zh) | 2020-12-22 |
JP2013542239A (ja) | 2013-11-21 |
EP2462921A1 (en) | 2012-06-13 |
EP2637642A1 (en) | 2013-09-18 |
US10064944B2 (en) | 2018-09-04 |
CN106924180A (zh) | 2017-07-07 |
EP3466408A1 (en) | 2019-04-10 |
AU2017200608A1 (en) | 2017-02-23 |
US9241900B2 (en) | 2016-01-26 |
WO2012062834A1 (en) | 2012-05-18 |
KR20140032935A (ko) | 2014-03-17 |
US20130303473A1 (en) | 2013-11-14 |
JP2017019842A (ja) | 2017-01-26 |
AU2011328102B2 (en) | 2016-11-03 |
US20160101178A1 (en) | 2016-04-14 |
AU2017200608B2 (en) | 2018-02-15 |
CN103200931B (zh) | 2016-10-19 |
AU2011328102A1 (en) | 2013-05-02 |
CA2813851C (en) | 2017-10-03 |
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