JP5769116B2 - 可撓性試料容器 - Google Patents
可撓性試料容器 Download PDFInfo
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- JP5769116B2 JP5769116B2 JP2012555295A JP2012555295A JP5769116B2 JP 5769116 B2 JP5769116 B2 JP 5769116B2 JP 2012555295 A JP2012555295 A JP 2012555295A JP 2012555295 A JP2012555295 A JP 2012555295A JP 5769116 B2 JP5769116 B2 JP 5769116B2
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- 239000012530 fluid Substances 0.000 claims description 66
- 230000003287 optical effect Effects 0.000 claims description 57
- 238000000034 method Methods 0.000 claims description 21
- 239000002245 particle Substances 0.000 claims description 19
- 238000005259 measurement Methods 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 8
- 230000033001 locomotion Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000012780 transparent material Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- -1 urine Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0364—Cuvette constructions flexible, compressible
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
- G01N2021/8557—Special shaping of flow, e.g. using a by-pass line, jet flow, curtain flow
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
- Microscoopes, Condenser (AREA)
Description
きな泡が通路部分に入るとき、第1の光路を通過する光の量は増加し、第2の基準の光路に沿って通過する光に対する第1の光路を沿って通過する光の比が所定の値を超える場合、泡は検出されたとみなされる。
能とする物理的性質である。本発明において利用される可撓性チューブはほぼ透明な材料から製造されるか、透明な窓部を備えることが好適である。
。
を利用することによって、または圧電モータまたは同様のものによって、互いに対し相対的に動かされる。実際のところ、当業者には、微小機構に適切な任意の種類のモータまたはアクチュエータを用いて平坦化要素同士を互いに対し相対的に動かせることが認められる。
器は、本発明に関連して用いられることに非常によく適合している。
図1には、本発明によるシステムにおいて用いられ得る可撓性チューブを示す。チューブは、外径102、内径101、およびチューブ長さ103を有する。このチューブは、光学グレードのシリコーンなど可撓性材料から製造され得る。
おり、図3Dでは配置溝は平坦化要素202における凹部として形成されている。配置溝の目的は、平坦化されたチューブを光学顕微鏡の測定位置に正確に配置するのを支援することである。配置溝は、レンズ、ウェッジ、偏光フィルタ、密度フィルタ、波長フィルタ、または図3Eに示すようなアパーチャなど、光学要素と組み合わせられてよい。配置溝と光学要素との組み合わせは、例えば、レンズ形状(凹面か凸面の)を配置溝および外壁が有するように、平坦化要素の内壁を選択することによって行われ得る。さらに、平坦化要素の製造される材料がフィルタ機能を有してもよい。
停止されると流体が完全に流れを停止する種類である場合、2つのクランプ521,522は省略されてよい。
Claims (15)
- 流体試料を保持するためのシステムであって、
前記流体試料を保持するための透明な可撓性チューブと、
前記チューブを保持するためのチューブホルダと、
第1の平坦化要素と、
第2の平坦化要素と、を備え、
第1の平坦化要素および第2の平坦化要素は互いに対して移動することによって第1の状態から第2の状態へ前記透明な可撓性チューブを変化させることが可能であり、前記チューブの少なくとも第1の断面寸法は、前記第1の状態におけるよりも前記第2の状態において小さく、前記システムは光学走査機器をさらに備え、該光学走査機器は、少なくとも前記第2の状態において前記可撓性チューブ中に含まれる前記流体試料の像を捕捉するための像捕捉デバイスを含み、前記システムは前記チューブをクランプして前記流体試料を前記像の捕捉の間ほぼ静止に保つように構成された少なくとも第1のクランプをさらに備える、システム。 - 前記光学走査機器は、前記流体試料に関係するパラメータを算出し、前記パラメータから前記可撓性チューブの新たな状態を決定するように適合されている、請求項1に記載のシステム。
- 第1の状態における前記透明な可撓性チューブの内径は、25mm未満である、請求項1または2に記載のシステム。
- 前記可撓性チューブは、入口、出口、またはその両方を有する、請求項1乃至3のいずれか一項に記載のシステム。
- 前記システムは、入口を介して前記チューブへ流体を送り込むのに適合したチューブポンプをさらに備える、請求項4に記載のシステム。
- 前記平坦化要素のうちの少なくとも一方は透明な領域を有する、請求項1乃至5のいずれか一項に記載のシステム。
- 前記透明な領域は内面と外面とを有する、請求項6に記載のシステム。
- 前記内面は、ほぼ平坦である、請求項7に記載のシステム。
- 前記内面は案内溝を備える、請求項7に記載のシステム。
- 前記透明な領域は、レンズ、ウェッジ、偏光子、アパーチャ、フィルタ、および格子から選択される1つ以上の光学要素を含む、請求項6乃至9のいずれか一項に記載のシステム。
- 前記平坦化要素は、平坦化されたチューブの内壁間の距離が、25mm未満であるように作動される、請求項8乃至10のいずれか一項に記載のシステム。
- 光学走査機器に流体試料を提供する方法であって、
透明な可撓性チューブをチューブホルダに配置する工程と、
前記光学走査機器に関連して前記チューブホルダを配置する工程と、
前記チューブに流体を提供する工程と、
第1の平坦化要素および第2の平坦化要素を互いに対して移動させることによって、前記透明な可撓性チューブを第1の状態から第2の状態へ変化させる工程であって、前記チューブの少なくとも第1の断面寸法は、第1の状態におけるよりも第2の状態において小さい、工程と、
前記光学走査機器を使用して、少なくとも前記第2の状態において前記透明な可撓性チューブ中に含まれる前記流体試料から少なくとも1つの像を捕捉する工程であって、前記流体試料は前記像の捕捉の間ほぼ静止している、工程とを備える、方法。 - 前記光学走査機器から1つ以上の像を取得する工程と、
前記像から前記流体に関する1つ以上のパラメータを決定する工程と、
前記1つ以上のパラメータから新たなチューブ厚を決定する工程と、
第1の平坦化要素および第2の平坦化要素を互いに対して移動させることによって、前記透明な可撓性チューブを第3の状態へ変化させる工程と、をさらに備える請求項12に記載の方法。 - 前記1つ以上のパラメータは前記流体における粒子の濃度に関係する、請求項13に記載の方法。
- 光学機器は光学走査機器であり、該光学走査機器は、前記チューブの少なくとも一部を通じて像平面を走査して該光学走査機器に配置された試料の複数の像を得るように適合されているか、前記第1の状態、前記第2の状態、またはその両方における前記透明な可撓性チューブにおいてほぼ静止している前記流体試料から1つ以上の像を取得するように適合されているか、その両方である、請求項12〜14のいずれか一項に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US31049910P | 2010-03-04 | 2010-03-04 | |
DKPA201000170 | 2010-03-04 | ||
DKPA201000170 | 2010-03-04 | ||
US61/310,499 | 2010-03-04 | ||
PCT/DK2011/050064 WO2011107102A1 (en) | 2010-03-04 | 2011-03-02 | Flexible sample container |
Publications (3)
Publication Number | Publication Date |
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JP2013521477A JP2013521477A (ja) | 2013-06-10 |
JP2013521477A5 JP2013521477A5 (ja) | 2014-04-17 |
JP5769116B2 true JP5769116B2 (ja) | 2015-08-26 |
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JP2012555295A Expired - Fee Related JP5769116B2 (ja) | 2010-03-04 | 2011-03-02 | 可撓性試料容器 |
Country Status (10)
Country | Link |
---|---|
US (1) | US9250176B2 (ja) |
EP (1) | EP2542878B1 (ja) |
JP (1) | JP5769116B2 (ja) |
KR (1) | KR20130054240A (ja) |
CN (1) | CN102792148B (ja) |
AU (1) | AU2011223342B2 (ja) |
BR (1) | BR112012022130A2 (ja) |
CA (1) | CA2791428A1 (ja) |
RU (1) | RU2557603C2 (ja) |
WO (1) | WO2011107102A1 (ja) |
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JP2013148521A (ja) * | 2012-01-20 | 2013-08-01 | Sumitomo Electric Ind Ltd | 試料測定用セル、物性測定装置、および物性測定方法 |
US8906320B1 (en) * | 2012-04-16 | 2014-12-09 | Illumina, Inc. | Biosensors for biological or chemical analysis and systems and methods for same |
JP6264741B2 (ja) * | 2013-04-16 | 2018-01-24 | 横河電機株式会社 | 分光分析装置 |
BR112015026037A2 (pt) * | 2013-04-19 | 2017-07-25 | Koninklijke Philips Nv | sistema óptico para determinar uma característica como uma função do tempo de pelo menos uma parte de um volume líquido, e, método de determinação de uma característica como uma função do tempo de um volume líquido compreendendo uma pluralidade de objetos |
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- 2011-03-02 AU AU2011223342A patent/AU2011223342B2/en not_active Ceased
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- 2011-03-02 WO PCT/DK2011/050064 patent/WO2011107102A1/en active Application Filing
- 2011-03-02 CN CN201180012265.8A patent/CN102792148B/zh not_active Expired - Fee Related
- 2011-03-02 JP JP2012555295A patent/JP5769116B2/ja not_active Expired - Fee Related
- 2011-03-02 RU RU2012142187/05A patent/RU2557603C2/ru active
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- 2011-03-02 EP EP11750218.7A patent/EP2542878B1/en active Active
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AU2011223342B2 (en) | 2014-06-05 |
EP2542878A1 (en) | 2013-01-09 |
EP2542878A4 (en) | 2014-07-16 |
WO2011107102A1 (en) | 2011-09-09 |
CN102792148B (zh) | 2016-06-01 |
EP2542878B1 (en) | 2016-09-14 |
KR20130054240A (ko) | 2013-05-24 |
JP2013521477A (ja) | 2013-06-10 |
AU2011223342A1 (en) | 2012-09-20 |
CN102792148A (zh) | 2012-11-21 |
CA2791428A1 (en) | 2011-09-09 |
US20120327404A1 (en) | 2012-12-27 |
RU2012142187A (ru) | 2014-04-10 |
RU2557603C2 (ru) | 2015-07-27 |
US9250176B2 (en) | 2016-02-02 |
BR112012022130A2 (pt) | 2016-10-25 |
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