JP5760159B2 - 不活化された内因性遺伝子座を有するトランスジェニックニワトリ - Google Patents

不活化された内因性遺伝子座を有するトランスジェニックニワトリ Download PDF

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JP5760159B2
JP5760159B2 JP2010521188A JP2010521188A JP5760159B2 JP 5760159 B2 JP5760159 B2 JP 5760159B2 JP 2010521188 A JP2010521188 A JP 2010521188A JP 2010521188 A JP2010521188 A JP 2010521188A JP 5760159 B2 JP5760159 B2 JP 5760159B2
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cells
pgc
transgene
gene
chicken
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JP2010536346A5 (ko
JP2010536346A (ja
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デ ラボア, マリー−セシル バン
デ ラボア, マリー−セシル バン
フィリップ アルバート レイトン,
フィリップ アルバート レイトン,
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オリジェン セラピューティクス, インコーポレイテッド
オリジェン セラピューティクス, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/30Bird
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0393Animal model comprising a reporter system for screening tests
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010521188A 2007-08-14 2008-08-14 不活化された内因性遺伝子座を有するトランスジェニックニワトリ Expired - Fee Related JP5760159B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96489107P 2007-08-14 2007-08-14
US60/964,891 2007-08-14
PCT/US2008/073214 WO2009023800A1 (en) 2007-08-14 2008-08-14 Transgenic chickens with an inactivated endogenous gene locus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014197988A Division JP6004290B2 (ja) 2007-08-14 2014-09-29 不活化された内因性遺伝子座を有するトランスジェニックニワトリ

Publications (3)

Publication Number Publication Date
JP2010536346A JP2010536346A (ja) 2010-12-02
JP2010536346A5 JP2010536346A5 (ko) 2011-09-22
JP5760159B2 true JP5760159B2 (ja) 2015-08-05

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010521188A Expired - Fee Related JP5760159B2 (ja) 2007-08-14 2008-08-14 不活化された内因性遺伝子座を有するトランスジェニックニワトリ
JP2014197988A Expired - Fee Related JP6004290B2 (ja) 2007-08-14 2014-09-29 不活化された内因性遺伝子座を有するトランスジェニックニワトリ
JP2016080837A Pending JP2016129519A (ja) 2007-08-14 2016-04-14 不活化された内因性遺伝子座を有するトランスジェニックニワトリ

Family Applications After (2)

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JP2014197988A Expired - Fee Related JP6004290B2 (ja) 2007-08-14 2014-09-29 不活化された内因性遺伝子座を有するトランスジェニックニワトリ
JP2016080837A Pending JP2016129519A (ja) 2007-08-14 2016-04-14 不活化された内因性遺伝子座を有するトランスジェニックニワトリ

Country Status (7)

Country Link
EP (1) EP2187732A4 (ko)
JP (3) JP5760159B2 (ko)
KR (1) KR101563017B1 (ko)
CN (1) CN101868144A (ko)
AU (1) AU2008286791A1 (ko)
CA (1) CA2706224A1 (ko)
WO (1) WO2009023800A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9380769B2 (en) 2011-05-24 2016-07-05 Crystal Bioscience Inc. Transgenic chicken comprising an inactivated immunoglobulin gene
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
KR20180038554A (ko) * 2015-08-27 2018-04-16 크리스탈 바이오사이언스 주식회사 공통 경쇄를 갖는 항체 생산을 위한 유전자도입 동물
AU2018336161A1 (en) * 2017-09-19 2020-03-26 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Genome-edited birds
CN110484549B (zh) * 2018-04-20 2023-10-03 北京大学 基因组靶向修饰方法
MX2021010611A (es) * 2019-03-05 2021-11-12 The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo Aves con genoma editado.
WO2023127903A1 (ja) * 2021-12-28 2023-07-06 国立大学法人北海道大学 始原生殖細胞が富化された胚を調製する方法
CN115120382A (zh) * 2022-05-26 2022-09-30 广东省农业科学院动物科学研究所 一种鸡生殖前体细胞移植受体的制备方法
CN115191404B (zh) * 2022-07-28 2023-04-21 四川省畜牧科学研究院 提高黄羽肉鸡后代公鸡比例的新品种选育方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2357495T3 (es) * 1997-10-16 2011-04-27 University Of Georgia Research Foundation, Inc. Aves transgénicas y producción de proteína.
GB2398784B (en) * 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
MXPA06000562A (es) * 2003-07-15 2006-03-30 Therapeutic Human Polyclonals Loci de inmunoglobulina humanizada.
EP1850659B1 (en) * 2005-02-01 2016-11-23 Synageva BioPharma Corp. Long term culture of chicken primordial germ cells

Also Published As

Publication number Publication date
JP2014239702A (ja) 2014-12-25
JP2016129519A (ja) 2016-07-21
AU2008286791A1 (en) 2009-02-19
EP2187732A1 (en) 2010-05-26
CN101868144A (zh) 2010-10-20
CA2706224A1 (en) 2009-02-19
JP6004290B2 (ja) 2016-10-05
KR101563017B1 (ko) 2015-10-23
KR20100088125A (ko) 2010-08-06
EP2187732A4 (en) 2012-11-07
JP2010536346A (ja) 2010-12-02
WO2009023800A1 (en) 2009-02-19

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