JP5746534B2 - 臓器を維持するための組成物、方法及び装置 - Google Patents

臓器を維持するための組成物、方法及び装置 Download PDF

Info

Publication number
JP5746534B2
JP5746534B2 JP2011066448A JP2011066448A JP5746534B2 JP 5746534 B2 JP5746534 B2 JP 5746534B2 JP 2011066448 A JP2011066448 A JP 2011066448A JP 2011066448 A JP2011066448 A JP 2011066448A JP 5746534 B2 JP5746534 B2 JP 5746534B2
Authority
JP
Japan
Prior art keywords
organ
storage
liquid medium
solution
line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2011066448A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011157374A (ja
Inventor
ハッサネイン,ワリード,エイチ.
クーリ,シュクリ,エフ.
クリッテンデン,マイケル,ディー.
バージニウク,ウラジミール
Original Assignee
ザ デパートメント オブ ベテランズ アフェアズ
ザ デパートメント オブ ベテランズ アフェアズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ デパートメント オブ ベテランズ アフェアズ, ザ デパートメント オブ ベテランズ アフェアズ filed Critical ザ デパートメント オブ ベテランズ アフェアズ
Publication of JP2011157374A publication Critical patent/JP2011157374A/ja
Application granted granted Critical
Publication of JP5746534B2 publication Critical patent/JP5746534B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/14Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142Apparatus
    • A01N1/143Apparatus for organ perfusion
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2011066448A 1997-09-23 2011-03-24 臓器を維持するための組成物、方法及び装置 Expired - Lifetime JP5746534B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/936,062 1997-09-23
US08/936,062 US6100082A (en) 1997-09-23 1997-09-23 Perfusion apparatus and method including chemical compositions for maintaining an organ
US09/054,698 1998-04-03
US09/054,698 US6046046A (en) 1997-09-23 1998-04-03 Compositions, methods and devices for maintaining an organ

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000512407A Division JP2001516768A (ja) 1997-09-23 1998-09-23 臓器を維持するための組成物、方法及び装置

Related Child Applications (4)

Application Number Title Priority Date Filing Date
JP2013251147A Division JP5889861B2 (ja) 1997-09-23 2013-12-04 臓器を維持するための組成物、方法及び装置
JP2014108176A Division JP5923551B2 (ja) 1997-09-23 2014-05-26 臓器を維持するための組成物、方法及び装置
JP2014108177A Division JP5923552B2 (ja) 1997-09-23 2014-05-26 臓器を維持するための組成物、方法及び装置
JP2014226896A Division JP5933666B2 (ja) 1997-09-23 2014-11-07 臓器を維持するための組成物、方法及び装置

Publications (2)

Publication Number Publication Date
JP2011157374A JP2011157374A (ja) 2011-08-18
JP5746534B2 true JP5746534B2 (ja) 2015-07-08

Family

ID=25468121

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2011066448A Expired - Lifetime JP5746534B2 (ja) 1997-09-23 2011-03-24 臓器を維持するための組成物、方法及び装置
JP2013251147A Expired - Lifetime JP5889861B2 (ja) 1997-09-23 2013-12-04 臓器を維持するための組成物、方法及び装置
JP2014108176A Expired - Lifetime JP5923551B2 (ja) 1997-09-23 2014-05-26 臓器を維持するための組成物、方法及び装置
JP2014108177A Expired - Lifetime JP5923552B2 (ja) 1997-09-23 2014-05-26 臓器を維持するための組成物、方法及び装置
JP2014226896A Expired - Lifetime JP5933666B2 (ja) 1997-09-23 2014-11-07 臓器を維持するための組成物、方法及び装置
JP2015240537A Expired - Lifetime JP6134771B2 (ja) 1997-09-23 2015-12-09 臓器を維持するための組成物、方法及び装置
JP2015240695A Pending JP2016053081A (ja) 1997-09-23 2015-12-10 臓器を維持するための組成物、方法及び装置
JP2017131257A Expired - Lifetime JP6347565B2 (ja) 1997-09-23 2017-07-04 臓器を維持するための組成物、方法及び装置

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2013251147A Expired - Lifetime JP5889861B2 (ja) 1997-09-23 2013-12-04 臓器を維持するための組成物、方法及び装置
JP2014108176A Expired - Lifetime JP5923551B2 (ja) 1997-09-23 2014-05-26 臓器を維持するための組成物、方法及び装置
JP2014108177A Expired - Lifetime JP5923552B2 (ja) 1997-09-23 2014-05-26 臓器を維持するための組成物、方法及び装置
JP2014226896A Expired - Lifetime JP5933666B2 (ja) 1997-09-23 2014-11-07 臓器を維持するための組成物、方法及び装置
JP2015240537A Expired - Lifetime JP6134771B2 (ja) 1997-09-23 2015-12-09 臓器を維持するための組成物、方法及び装置
JP2015240695A Pending JP2016053081A (ja) 1997-09-23 2015-12-10 臓器を維持するための組成物、方法及び装置
JP2017131257A Expired - Lifetime JP6347565B2 (ja) 1997-09-23 2017-07-04 臓器を維持するための組成物、方法及び装置

Country Status (2)

Country Link
US (2) US6100082A (https=)
JP (8) JP5746534B2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2856618C1 (ru) * 2025-02-19 2026-02-24 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Система и способ прекондиционирования донорской печени ex vivo

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018277A1 (en) 1991-04-12 1992-10-29 A.E. Bishop & Associates Pty. Limited Improvements in method and apparatus for slotting
US5957879A (en) * 1997-01-24 1999-09-28 Heartport, Inc. Methods and devices for maintaining cardiopulmonary bypass and arresting a patient's heart
US6642045B1 (en) 1997-04-14 2003-11-04 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6100082A (en) * 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ
IL124722A0 (en) * 1998-06-02 1999-01-26 Oron Amir Ischemia laser treatment
USRE38533E1 (en) * 1998-09-11 2004-06-15 Life Corporation Portable emergency oxygen and automatic external defibrillator (AED) therapy system
US6327497B1 (en) * 1998-09-11 2001-12-04 Life Corporation Portable emergency oxygen and automatic external defibrillator (AED) therapy system
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6977140B1 (en) * 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
GB9908335D0 (en) * 1999-04-12 1999-06-09 Univ Cambridge Tech Methods and means for extracorporeal organ perfusion
US6582953B2 (en) 1999-04-14 2003-06-24 Breonics, Inc. Organ chamber for exsanguinous metabolic support system
US20040038193A1 (en) * 1999-04-14 2004-02-26 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US20070166292A1 (en) * 1999-04-14 2007-07-19 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US20030040665A1 (en) * 1999-05-28 2003-02-27 E-Monitors, Inc. Systems and methods of pH tissue monitoring
US6567679B1 (en) * 1999-05-28 2003-05-20 E-Monitors, Inc. Method of using a pH tissue monitor
US6736836B2 (en) 2000-02-17 2004-05-18 The Johns Hopkins University Transplant organ external cooling system
US6794182B2 (en) * 2000-03-13 2004-09-21 E. George Wolf, Jr. Hyperbaric oxygen organ preservation system (HOOPS)
US7611830B2 (en) * 2000-04-10 2009-11-03 The United States Of America As Represented By The Department Of Veteran's Affairs Device to lavage a blood vessel
USD468436S1 (en) 2000-08-25 2003-01-07 Organ Recovery Systems, Inc. Organ cassette
CA2420182A1 (en) * 2000-08-25 2002-03-07 Organ Recovery Systems, Inc. Methods of thrombolytic organ treatment and repair
USD453828S1 (en) 2000-08-25 2002-02-19 Organ Recovery Systems, Inc. Organ perfusion apparatus
US20030023072A1 (en) * 2000-09-07 2003-01-30 Yong Quan DNA encoding orphan SNORF9 receptor
US6490880B1 (en) 2000-10-26 2002-12-10 Islet Technology Inc. Regulated organ containment shipping system using dual-layer preservation liquid
DE10121159B4 (de) * 2001-04-30 2004-01-29 Biederer, Jürgen, Dr. med. Künstlicher Thorax
US6677150B2 (en) * 2001-09-14 2004-01-13 Organ Transport Systems, Inc. Organ preservation apparatus and methods
WO2003026419A1 (en) * 2001-09-28 2003-04-03 Hull Harry F A simple, fully transportable device for maintaining an excised heart in optimum condition for transplantation
US6582375B2 (en) * 2001-10-11 2003-06-24 University Of Cincinnati System for study of global uni-or bi-ventricular function of an explanted, reperfused heart
US9993659B2 (en) * 2001-11-01 2018-06-12 Pthera, Llc Low level light therapy for enhancement of neurologic function by altering axonal transport rate
US10683494B2 (en) * 2001-11-01 2020-06-16 Pthera LLC Enhanced stem cell therapy and stem cell production through the administration of low level light energy
US7534255B1 (en) 2003-01-24 2009-05-19 Photothera, Inc Low level light therapy for enhancement of neurologic function
US8308784B2 (en) * 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US7303578B2 (en) 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
US20030144712A1 (en) * 2001-12-20 2003-07-31 Jackson Streeter, M.D. Methods for overcoming organ transplant rejection
US10695577B2 (en) * 2001-12-21 2020-06-30 Photothera, Inc. Device and method for providing phototherapy to the heart
US7316922B2 (en) * 2002-01-09 2008-01-08 Photothera Inc. Method for preserving organs for transplant
US20030149401A1 (en) * 2002-02-06 2003-08-07 Benetti Diaz De Brito Juan Ignacio Systems and methods for monitoring and controlling the temperature of an organ during surgery
US20030215935A1 (en) * 2002-05-14 2003-11-20 Coon David James Apparatus and method for isolating living cells from an encapsulated organ tissue sample
US20040153130A1 (en) * 2002-05-29 2004-08-05 Amir Oron Methods for treating muscular dystrophy
US7572622B2 (en) * 2002-08-14 2009-08-11 Transmedic, Inc. Heart preservation chamber
DE60314154T2 (de) * 2002-08-23 2008-01-24 Organ Recovery Systems, Des Plaines Verbindungsanordnungen, insbesondere für transplantationsorgane
US20040132002A1 (en) * 2002-09-17 2004-07-08 Jackson Streeter Methods for preserving blood
US20060121439A1 (en) * 2002-09-18 2006-06-08 Jan Baker Organ preservation and transportation apparatus and method
WO2004089085A2 (en) * 2003-04-04 2004-10-21 Organ Recovery Systems, Inc. Device for separating gas from a liquid path
USD531319S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Tube frame for organ transporter
US7998725B2 (en) * 2003-04-04 2011-08-16 Organ Recovery Systems Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container
USD531320S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Cassette for organ transporter
US7344555B2 (en) 2003-04-07 2008-03-18 The United States Of America As Represented By The Department Of Health And Human Services Light promotes regeneration and functional recovery after spinal cord injury
US7897327B2 (en) * 2003-06-02 2011-03-01 Organ Recovery Systems, Inc. Method and apparatus for pressure control for maintaining viability of organs
NL1024022C2 (nl) * 2003-07-30 2005-02-01 Technologiestichting Stw Draagbare preservatie-inrichting voor een donororgaan.
DE10340487B4 (de) * 2003-09-03 2007-07-12 Technische Universität Dresden Perfusionskreislauf
EP1684579A1 (en) * 2003-10-22 2006-08-02 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
US20050136125A1 (en) * 2003-10-22 2005-06-23 Roth Mark B. Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
US20050170019A1 (en) * 2003-10-22 2005-08-04 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells
US20050153271A1 (en) * 2004-01-13 2005-07-14 Wenrich Marshall S. Organ preservation apparatus and methods
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
US8741555B2 (en) * 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
US9499780B2 (en) * 2004-05-26 2016-11-22 Octane Biotech Inc. Advanced tissue engineering system
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
IL273422B (en) * 2004-10-07 2022-07-01 Transmedics Inc Methods and systems for extracorporeal organ treatment
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
AU2016222388B2 (en) * 2004-10-07 2017-12-07 Transmedics, Inc. Systems and methods for ex-vivo organ care
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
AU2015246083B9 (en) * 2004-10-07 2016-11-10 Transmedics, Inc. Systems and methods for ex-vivo organ care
US8900804B2 (en) * 2004-11-22 2014-12-02 Cedars-Sinai Medical Center Methods and solutions for tissue preservation
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
US20060148080A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Methods for supporting and producing human cells and tissues in non-human mammal hosts
PT1879599E (pt) * 2005-04-20 2014-01-23 Hutchinson Fred Cancer Res Métodos, composições e artigos de fabrico para aumentar a capacidade de sobrevivência de células, tecidos, órgãos, e organismos
EP1879997A2 (en) * 2005-04-29 2008-01-23 Transplan, Inc. Method and device for organ perfusion
US20100137635A1 (en) * 2005-06-07 2010-06-03 Inbiotex Inc. Radical scavenger and active oxygen eliminating agent
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US20070048725A1 (en) * 2005-08-25 2007-03-01 Arrington Ben O'mar Machine perfusion of tissue grafts for transplantation
US7575856B2 (en) * 2005-10-28 2009-08-18 The United States Of America As Represented By The Department Of Veterans Affairs Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
US20090254154A1 (en) 2008-03-18 2009-10-08 Luis De Taboada Method and apparatus for irradiating a surface with pulsed light
US20070179570A1 (en) * 2006-01-30 2007-08-02 Luis De Taboada Wearable device and method for providing phototherapy to the brain
US10357662B2 (en) * 2009-02-19 2019-07-23 Pthera LLC Apparatus and method for irradiating a surface with light
US7575589B2 (en) 2006-01-30 2009-08-18 Photothera, Inc. Light-emitting device and method for providing phototherapy to the brain
CA2980782C (en) 2006-04-19 2020-10-27 Transmedics, Inc. Systems and methods for ex vivo organ care
US20080221211A1 (en) * 2007-02-02 2008-09-11 Jackson Streeter Method of treatment of neurological injury or cancer by administration of dichloroacetate
AU2008216612B2 (en) * 2007-02-17 2014-12-04 President And Fellows Of Harvard College Compositions and method for tissue preservation
JP5704818B2 (ja) * 2007-03-01 2015-04-22 ライフライン サイエンティフィック インコーポレイテッド 潅流調節
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8771930B2 (en) * 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
US8765364B2 (en) * 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
WO2009003061A1 (en) 2007-06-25 2008-12-31 Fred Hutchinson Cancer Research Center Methods and compositions regarding polychalcogenide compositions
WO2009041806A1 (en) * 2007-09-28 2009-04-02 Organ Assist B.V. Organ transport container system
US9814230B2 (en) * 2008-01-31 2017-11-14 Transmedics, Inc. Systems and methods for ex vivo lung care
WO2009105164A2 (en) 2008-02-15 2009-08-27 President And Fellows Of Harvard College Blood substitute solution
US20110065169A1 (en) * 2008-05-06 2011-03-17 Vivoline Medical Ab Apparatus for housing an organ during evaluation and preservation
ES2328660B1 (es) * 2008-05-14 2010-10-14 Fundacio Privada Clinic Per A La Recerca Biomedica Dispositivo para la preservacion de un injerto hepatico en condiciones de normotermia.
US7848035B2 (en) 2008-09-18 2010-12-07 Photothera, Inc. Single-use lens assembly
WO2011002926A2 (en) 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
SE534527C2 (sv) * 2009-09-24 2011-09-20 Vivoline Medical Ab Förfarande, anordning och vätska för behandling av ett hjärta efter uttagning
US9320269B2 (en) 2009-09-25 2016-04-26 John Brassil Organ preservation system
WO2011037512A1 (en) * 2009-09-25 2011-03-31 Vivoline Medical Ab Container and supporting structure for housing an organ
US20140255906A1 (en) * 2009-11-23 2014-09-11 Dan L. Dietz Electromagnetic blood preservation and storage
CN102160546B (zh) * 2010-02-24 2016-01-20 库克通用生物科技有限责任公司 冷冻保存细胞的系统和方法
WO2011140241A2 (en) 2010-05-04 2011-11-10 The General Hospital Corporation Methods and compositions for preserving tissues and organs
CA2741283A1 (en) * 2010-05-28 2011-11-28 University Health Network Dynamic flow imaging phantom and model therefor
US8374431B2 (en) 2010-07-27 2013-02-12 Aerotec, Llc Method and apparatus for direct detection, location, analysis, identification, and reporting of vegetation clearance violations
US12082575B2 (en) 2010-09-01 2024-09-10 Organ Transport Pty Ltd Perfusion solution
AU2011295629B2 (en) 2010-09-01 2014-05-01 Organ Transport Pty Ltd Perfusion composition
US20120148542A1 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US12279610B2 (en) 2011-03-15 2025-04-22 Paragonix Technonogies, Inc. System for hypothermic transport of samples
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US12096765B1 (en) 2011-03-15 2024-09-24 Paragonix Technologies, Inc. System for hypothermic transport of samples
EP2685814B1 (en) 2011-03-15 2016-08-17 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
WO2012142487A1 (en) 2011-04-14 2012-10-18 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
US9642625B2 (en) 2011-04-29 2017-05-09 Lifeline Scientific, Inc. Cannula for a donor organ with or without an aortic cuff or patch
US9955682B2 (en) 2011-04-29 2018-05-01 Lifeline Scientific, Inc. Portable organ transportation system
US9022978B2 (en) 2011-04-29 2015-05-05 Lifeline Scientific, Inc. Universal sealring cannula
US8828034B2 (en) 2011-04-29 2014-09-09 Lifeline Scientific, Inc. Cannula
CN103747674B (zh) 2011-06-09 2016-06-15 生命线科学有限公司 器官/组织的活力的评价、维持和/或恢复
US9756848B2 (en) 2011-09-02 2017-09-12 Organ Assist B.V. Apparatus, system and method for conditioning and preserving an organ from a donor
EP4091446A1 (en) 2012-01-17 2022-11-23 Tevosol, Inc. Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting
EP2831116A1 (en) 2012-03-28 2015-02-04 Amgen Inc. Dr5 receptor agonist combinations
DE102012007412B4 (de) * 2012-04-16 2023-09-28 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtungen zur Modulation des Arbeitspunktes von Flüssigkeitspumpen in medizinischen Behandlungsvorrichtungen
US20140017665A1 (en) 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Organ transporter with oxygen generation
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
USD692160S1 (en) * 2012-10-26 2013-10-22 Paragonix Technologies, Inc. Tissue suspension adaptor
US20140278468A1 (en) 2013-03-15 2014-09-18 I.D. Therapeutics Llc Apparatus and method for optimizing treatment using medication compliance patterns and glucose sensor
US10420337B2 (en) 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue
US10111418B2 (en) 2013-06-07 2018-10-30 Perfusion Solutions Pty Ltd Organ perfusion system and device
CA2913060C (en) 2013-06-14 2020-09-01 Perfusion Solutions Pty Ltd Cardiac function evaluation system
US10918102B2 (en) 2014-03-13 2021-02-16 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
BR112016021971B1 (pt) * 2014-03-26 2022-05-17 Tevosol, Inc. Sistema portátil para perfusar corações extirpados de doadores
WO2015154170A1 (en) * 2014-04-10 2015-10-15 University Health Network Cannula for connecting medical devices to biological systems
CA3185937A1 (en) 2014-06-02 2015-12-10 Transmedics, Inc. Ex vivo organ care system
EP3188796B1 (en) 2014-09-03 2021-12-22 Symbiox, Inc. Photosynthetic cellular substances
USD765874S1 (en) 2014-10-10 2016-09-06 Paragonix Technologies, Inc. Transporter for a tissue transport system
AU2015361996B2 (en) 2014-12-12 2019-09-26 Transmedics, Inc. Apparatus and method for organ perfusion
DK3824731T3 (da) 2015-09-09 2025-05-26 Transmedics Inc Aortakanyle til ex vivo-organplejesystem
WO2017044861A1 (en) * 2015-09-11 2017-03-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Device for vascularized composite allotransplant preservation and use thereof
CN106581841B (zh) * 2015-10-14 2020-01-21 黑龙江和泽北方生物科技有限公司 温度敏感型干细胞泵注系统
KR102371516B1 (ko) * 2015-12-21 2022-03-07 히베르니아 메디칼 엘엘씨 용존 가스의 전달 및 의료용 유체 라인의 가스 제거를 위한 시스템
US10091986B2 (en) 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
EP4238417A3 (en) 2016-05-30 2023-12-06 Tevosol, Inc. Apparatus and method for ex vivo lung ventilation with a varying exterior pressure
US10602741B2 (en) * 2016-11-28 2020-03-31 Universidad Del Valle Organ-chimerization maintenance apparatus and method of use
DE102016225167B4 (de) 2016-12-15 2018-10-11 Otto-Von-Guericke-Universität Magdeburg Ex vivo-Lungenkreislauf- und Ventilations-Vorrichtung sowie Verfahren zum Training chirurgischer und minimal-invasiver chirurgischer Eingriffe
US11602146B2 (en) * 2017-03-30 2023-03-14 National University Corporation Kitami Institute Of Technology Connector and fluid supply system
CN106962325A (zh) * 2017-05-31 2017-07-21 上海市杨浦区市东医院 一种离体器官保温、血液加温装置
US20210400952A1 (en) 2017-06-07 2021-12-30 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
WO2018226993A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
WO2018232110A1 (en) 2017-06-14 2018-12-20 The General Hospital Corporation High subzero cryopreservation
ES2913665T3 (es) 2017-09-18 2022-06-03 Santersus Ag Método y dispositivo para la purificación de sangre a partir de ADN celular libre en circulación
JP6967434B2 (ja) * 2017-11-28 2021-11-17 株式会社Screenホールディングス 臓器収容器
US12167729B2 (en) 2018-05-30 2024-12-17 The General Hospital Corporation Cryopreservation of tissues and organs
JP2020002062A (ja) * 2018-06-28 2020-01-09 株式会社Screenホールディングス 灌流装置および灌流方法
EP3880299B1 (en) 2018-11-13 2025-09-24 The Methodist Hospital Device for oncomagnetic treatment
US12356982B2 (en) 2019-03-14 2025-07-15 Lifeline Scientific, Inc. Oxygenator device
US20220183272A1 (en) * 2019-04-12 2022-06-16 Uglx Research Ab Method and apparatus for reconditioning organs
CN113677201B (zh) * 2019-04-12 2023-09-26 乌格勒克科学有限公司 用于修复肾脏的方法和装置
EP3982725A4 (en) 2019-06-11 2023-07-19 Paragonix Technologies Inc. ORGAN TRANSPORT CONTAINER WITH ANTIVIRAL THERAPY
JP2021011451A (ja) * 2019-07-08 2021-02-04 株式会社Screenホールディングス 灌流装置
FI4027786T3 (fi) 2019-09-13 2025-10-21 Lifeline Scient Inc Hapetusvaihtoehdolla varustettu elinsäiliö
US12558334B2 (en) 2019-09-18 2026-02-24 The Board Of Trustees Of The Leland Stanford Junior University Controlled nutrient delivery to pancreatic islets using a novel mesoporous silica-based nanoparticle platform
GB2587350B (en) * 2019-09-23 2021-12-15 Royal Papworth Hospital Nhs Found Trust Organ perfusion system and method
WO2021090275A1 (en) * 2019-11-07 2021-05-14 Kci Licensing, Inc. Oxygenated hemoglobin and apparatuses, systems, and methods therefore
DE102019135506A1 (de) * 2019-12-20 2021-06-24 Corlife Ohg Behälter, Verschlussdeckel und Gefäß für Transplantationsobjekte sowie Verfahren und Systeme zur Bereitstellung von dreidimensionalen Strukturdaten und zur Sterilisation eines Transplantationsobjekts
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
EP4106521A1 (en) * 2020-02-20 2022-12-28 DEKA Products Limited Partnership System and method for organ maintenance and transport
EP4168108A4 (en) 2020-06-19 2024-07-17 The Methodist Hospital dba Houston Methodist Hospital METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT
EP4178353B1 (en) * 2020-07-08 2024-08-07 Vascular Perfusion Solutions, Inc. Reciprocating pressure perfusion system and method
TR202014402A2 (tr) * 2020-09-11 2022-03-21 Univ Istanbul Medipol Canlı tam kan organ banyosu
RU2754592C1 (ru) * 2020-09-15 2021-09-03 федеральное государственное бюджетное образовательное учреждение высшего образования «Омский государственный медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО ОмГМУ Минздрава России) Устройство для перфузионной консервации и рекондиционирования донорского сердца
US20220088365A1 (en) * 2020-09-22 2022-03-24 Paul Matlin Autologous blood collection reservoir
ES2921361B2 (es) * 2021-02-16 2023-05-08 Ebers Medical Tech S L Dispositivo de perfusion modular y versatil para preservar un organo en condiciones de operacion regulables
JP7579757B2 (ja) * 2021-06-22 2024-11-08 株式会社Screenホールディングス リーク弁および保存容器
CN113396898B (zh) * 2021-08-02 2021-11-09 中山大学附属第一医院 不中断血流器官灌注装置和灌注方法
WO2023126672A1 (en) * 2021-12-27 2023-07-06 Santersus Ag Method and device for removal of circulating cell free dna
US12392541B2 (en) * 2022-01-25 2025-08-19 Desert Valley Tech Inc. Portable preservation refrigeration system
USD1031028S1 (en) 2022-09-08 2024-06-11 Paragonix Technologies, Inc. Tissue suspension adaptor
US12485064B2 (en) 2023-08-25 2025-12-02 Paragonix Technologies, Inc. Systems and methods for measuring oxygen concentration for lung preservation
US20250248390A1 (en) 2024-02-02 2025-08-07 Paragonix Technologies, Inc. System for perfusion of an organ
WO2025213152A1 (en) * 2024-04-06 2025-10-09 The Board Of Trustees Of The Leland Stanford Junior University Cardiac ex vivo preservation system compatible for use with any oxygenator and pump
CN118370311B (zh) * 2024-06-21 2024-09-06 广东石油化工学院 一种离体肾脏保存装置
WO2026033066A1 (en) * 2024-08-08 2026-02-12 Ainia Organ transport
USD1087382S1 (en) 2025-01-30 2025-08-05 Paragonix Technologies, Inc. Device for transporting a biological sample

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755423A (fr) * 1969-10-06 1971-02-01 Baxter Laboratories Inc Procede et appareil pour la conservation d'organes
US3995444A (en) * 1974-11-08 1976-12-07 American Hospital Supply Corporation Organ perfusion system
WO1988005261A1 (en) * 1987-01-16 1988-07-28 Tops Systems, Inc. Total organ perfusion system
JPH0499701A (ja) * 1988-10-26 1992-03-31 Mckelvey Karen 移植に使用するヒトの臓器の輸送用装置
CA2001553A1 (en) * 1988-10-26 1990-04-26 Karen Mckelvey Device for transportation of human organs used for transplantation
JP2860301B2 (ja) * 1990-09-19 1999-02-24 ヘキスト・マリオン・ルセル株式会社 臓器保存用溶液
US5498427A (en) * 1990-11-20 1996-03-12 Pasteur Merieux Serums Et Vaccines Solutions for the perfusion, preservation and reperfusion of organs
US5217860A (en) * 1991-07-08 1993-06-08 The American National Red Cross Method for preserving organs for transplantation by vitrification
JPH0656601A (ja) * 1992-08-07 1994-03-01 Morishita Roussel Kk 移植臓器用の電解質溶液
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US5362622A (en) * 1993-03-11 1994-11-08 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation apparatus
JPH06305901A (ja) * 1993-04-26 1994-11-01 Akio Kawamura 室温下保存用灌流液およびこれを用いた保存方法
DE9422008U1 (de) * 1993-06-07 1997-08-28 Mayer, Berndt, Priv.-Doz. Dr.med., 10585 Berlin Vorrichtung zur Konservierung von Organen, Extremitäten und Gewebelappen
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
DE4342728A1 (de) * 1993-12-15 1995-06-22 Thomae Gmbh Dr K Verfahren, Apparate und Perfusionslösungen zur Konservierung explantierter Organe
US5511958A (en) * 1994-02-10 1996-04-30 Baxter International, Inc. Blood pump system
EP0759692B1 (en) * 1994-05-20 2009-02-25 Breonics, Inc. Method monitoring viability of transplantable organs
US5586438A (en) * 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
WO1996029865A1 (en) * 1995-03-27 1996-10-03 Organ, Inc. Organ evaluation and resuscitation device and method
US5770149A (en) * 1995-10-31 1998-06-23 Baxter International Extracorporeal blood oxygenation system having integrated blood pump, heat exchanger and membrane oxygenator
US5716378A (en) * 1996-06-06 1998-02-10 Medtronic, Inc. Heart preservation and transportation apparatus and method employing low rate cardiac pacing for improved removal of catabolites from the myocardium
US5807737A (en) * 1996-07-26 1998-09-15 Schill Enterprises, Inc. Heart and lung support assembly
US6100082A (en) * 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2856618C1 (ru) * 2025-02-19 2026-02-24 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Система и способ прекондиционирования донорской печени ex vivo

Also Published As

Publication number Publication date
JP2016104750A (ja) 2016-06-09
JP2015025023A (ja) 2015-02-05
JP2017165789A (ja) 2017-09-21
JP2014148553A (ja) 2014-08-21
JP6347565B2 (ja) 2018-06-27
JP2014040491A (ja) 2014-03-06
JP5889861B2 (ja) 2016-03-22
JP5923552B2 (ja) 2016-05-24
JP2011157374A (ja) 2011-08-18
JP2016053081A (ja) 2016-04-14
JP6134771B2 (ja) 2017-05-24
US6046046A (en) 2000-04-04
JP5923551B2 (ja) 2016-05-24
JP2014177484A (ja) 2014-09-25
JP5933666B2 (ja) 2016-06-15
US6100082A (en) 2000-08-08

Similar Documents

Publication Publication Date Title
JP6347565B2 (ja) 臓器を維持するための組成物、方法及び装置
EP1017274B1 (en) Compositions, methods and devices for maintaining an organ
US9756850B2 (en) Compositions, methods and devices for maintaining an organ
US6953655B1 (en) Compositions, methods and devices for maintaining an organ
US12137683B2 (en) Systems and methods for ex-vivo organ care
US11570985B2 (en) Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US12396454B2 (en) Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
JPH0499701A (ja) 移植に使用するヒトの臓器の輸送用装置
EP1981335A2 (en) Non-recirculating organ perfusion device

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110421

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110421

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20130517

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130604

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130827

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130830

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130925

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130930

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131101

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131204

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140526

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140708

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20141107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150320

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150508

R150 Certificate of patent or registration of utility model

Ref document number: 5746534

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term