JP5727484B2 - I型インターフェロン診断法 - Google Patents

I型インターフェロン診断法 Download PDF

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JP5727484B2
JP5727484B2 JP2012528058A JP2012528058A JP5727484B2 JP 5727484 B2 JP5727484 B2 JP 5727484B2 JP 2012528058 A JP2012528058 A JP 2012528058A JP 2012528058 A JP2012528058 A JP 2012528058A JP 5727484 B2 JP5727484 B2 JP 5727484B2
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ifnα
ifn
type
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ifi44
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JP2013503642A5 (enExample
JP2013503642A (ja
Inventor
ヒッグズ,ブランドン
ズー,ウェイ
モアハウス,クリス
ホワイト,バーバラ
ジャラル,バイジャ
ヤオ,イホン
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メディミューン,エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39583Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012528058A 2009-09-03 2010-09-02 I型インターフェロン診断法 Expired - Fee Related JP5727484B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23963009P 2009-09-03 2009-09-03
US61/239,630 2009-09-03
PCT/US2010/047721 WO2011028933A1 (en) 2009-09-03 2010-09-02 Type 1 interferon diagnostic

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015075518A Division JP2015147788A (ja) 2009-09-03 2015-04-02 I型インターフェロン診断法

Publications (3)

Publication Number Publication Date
JP2013503642A JP2013503642A (ja) 2013-02-04
JP2013503642A5 JP2013503642A5 (enExample) 2013-10-17
JP5727484B2 true JP5727484B2 (ja) 2015-06-03

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JP2012528058A Expired - Fee Related JP5727484B2 (ja) 2009-09-03 2010-09-02 I型インターフェロン診断法
JP2015075518A Pending JP2015147788A (ja) 2009-09-03 2015-04-02 I型インターフェロン診断法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015075518A Pending JP2015147788A (ja) 2009-09-03 2015-04-02 I型インターフェロン診断法

Country Status (23)

Country Link
US (3) US20120251546A1 (enExample)
EP (1) EP2473636B1 (enExample)
JP (2) JP5727484B2 (enExample)
KR (1) KR20120101340A (enExample)
CN (1) CN102753704A (enExample)
AU (1) AU2010289383B2 (enExample)
BR (1) BR112012004781A2 (enExample)
CA (1) CA2772921A1 (enExample)
CY (1) CY1118566T1 (enExample)
DK (1) DK2473636T3 (enExample)
ES (1) ES2613055T3 (enExample)
HR (1) HRP20170091T1 (enExample)
HU (1) HUE032917T2 (enExample)
LT (1) LT2473636T (enExample)
ME (1) ME02599B (enExample)
MX (1) MX2012002640A (enExample)
PL (1) PL2473636T3 (enExample)
PT (1) PT2473636T (enExample)
RS (1) RS55641B1 (enExample)
RU (1) RU2012112802A (enExample)
SI (1) SI2473636T1 (enExample)
SM (2) SMT201700063T1 (enExample)
WO (1) WO2011028933A1 (enExample)

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AU2003237889A1 (en) * 2002-06-11 2003-12-22 Idaho Research Foundation Type i interferon-inducible proteins to detect viral infection
EP2077858A4 (en) * 2006-12-06 2011-07-20 Medimmune Llc INTERFERON ALPHA-INDUCED PHARMACODYNAMIC MARKERS
JP2010526107A (ja) * 2007-05-03 2010-07-29 メディミューン,エルエルシー 自己免疫疾患の自己抗体マーカー
EP2701742A4 (en) * 2011-04-26 2015-03-18 Genentech Inc COMPOSITIONS AND METHOD FOR TREATING AUTOIMMUNE DISEASES
WO2013101771A2 (en) * 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
US9493570B2 (en) * 2012-06-13 2016-11-15 Medimmune, Llc Fixed dosage regimens for anti-type I interferon receptor (IFNAR) antibodies
JP6531306B2 (ja) * 2015-02-20 2019-06-19 一三 西野 炎症性筋疾患鑑別マーカー及びそれを用いた炎症性筋疾患と非炎症性筋疾患の鑑別方法
CN105316404B (zh) * 2015-02-27 2017-02-22 中南大学湘雅二医院 系统性红斑狼疮生物标志物及其诊断试剂盒
MX2018010771A (es) 2016-03-10 2019-05-15 Viela Bio Inc Moleculas de union al transcrito 7 similar a inmunoglobulina (ilt7) y metodos de uso de las mismas.
CN105567861B (zh) * 2016-03-16 2018-12-14 宫蕊 Ifi27作为冠心病诊断标志物的用途
WO2020165437A1 (en) * 2019-02-15 2020-08-20 Astrazeneca Ab Type i interferon-mediated disorders
EP4058060B1 (en) 2019-11-11 2025-02-19 Astrazeneca AB Type i interferon inhibition in systemic lupus erythematosus
EP4566667A3 (en) 2020-05-29 2025-09-03 AstraZeneca AB Treatment of cardiometabolic disease with inhibitors of type i interferon signalling
CN116234553A (zh) * 2020-10-02 2023-06-06 新基公司 治疗系统性红斑狼疮的方法和作为对疗法临床敏感性的预测指标的生物标志物的用途
TW202237647A (zh) 2020-10-08 2022-10-01 瑞典商阿斯特捷利康公司 狼瘡發作之治療
AU2021383537A1 (en) 2020-11-18 2023-06-29 Astrazeneca Ab Steroid sparing
PL4192882T3 (pl) 2021-04-23 2025-04-28 Astrazeneca Ab Leczenie toczniowego zapalenia nerek przeciwciałem przeciwko receptorowi typu i inf anifrolumabem
EP4326322A1 (en) 2021-04-23 2024-02-28 Astrazeneca AB Treatment of cutaneous lupus erythematous
KR20250092298A (ko) 2021-04-23 2025-06-23 아스트라제네카 아베 피하 주사용 항-ifnar1 투여 요법
EP4333877A1 (en) * 2021-05-04 2024-03-13 Viela Bio, Inc. Methods of treatment of autoimmune disorders using ilt7 binding proteins
EP4337696A1 (en) 2021-05-12 2024-03-20 Astrazeneca AB Inhibitor of type 1 interferon receptor steroid sparing in systemic lupus erythematosus patients
CA3226744A1 (en) 2021-07-27 2023-02-02 Astrazeneca Ab Treatment of lupus
KR20240082399A (ko) 2021-10-04 2024-06-10 아스트라제네카 아베 루푸스의 치료
AU2023339761A1 (en) 2022-09-14 2025-03-20 Viatris Asia Pacific Pte. Ltd. S1p 1 receptor modulators for use in the treatment of type 1 ifn mediated diseases
JP2025533978A (ja) 2022-10-13 2025-10-09 アストラゼネカ・アクチエボラーグ ループスの治療
WO2024241156A1 (en) 2023-05-19 2024-11-28 Astrazeneca Ab Treatment of lupus
WO2025022280A1 (en) 2023-07-21 2025-01-30 Astrazeneca Ab Treatment of neurodegenerative diseases
GB202315831D0 (en) 2023-10-16 2023-11-29 Astrazeneca Ab Treatment of skin disease
GB202402824D0 (en) 2024-02-28 2024-04-10 Astrazeneca Ab Treatment of chronic kidney disease

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Also Published As

Publication number Publication date
CN102753704A (zh) 2012-10-24
CY1118566T1 (el) 2017-07-12
LT2473636T (lt) 2017-02-10
US20120251546A1 (en) 2012-10-04
BR112012004781A2 (pt) 2017-02-14
ES2613055T3 (es) 2017-05-22
PL2473636T3 (pl) 2017-05-31
EP2473636B1 (en) 2016-10-26
PT2473636T (pt) 2017-02-06
RS55641B1 (sr) 2017-06-30
RU2012112802A (ru) 2013-10-10
ME02599B (me) 2017-06-20
US20160024205A1 (en) 2016-01-28
CA2772921A1 (en) 2011-03-10
JP2013503642A (ja) 2013-02-04
DK2473636T3 (en) 2017-02-06
WO2011028933A1 (en) 2011-03-10
EP2473636A4 (en) 2013-02-27
AU2010289383B2 (en) 2015-04-16
EP2473636A1 (en) 2012-07-11
HRP20170091T1 (hr) 2017-03-24
AU2010289383A1 (en) 2012-04-19
MX2012002640A (es) 2012-06-25
HUE032917T2 (hu) 2017-11-28
JP2015147788A (ja) 2015-08-20
US20150191788A1 (en) 2015-07-09
SI2473636T1 (sl) 2017-04-26
SMT201700063T1 (it) 2017-03-08
SMT201700063B (it) 2017-03-08
KR20120101340A (ko) 2012-09-13

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