JP5722805B2 - 流体試料送り出しシステム及び方法 - Google Patents
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Description
et al.)に付与された米国特許第5,567,309号明細書に記載されており、この特許文献は、フィルタキャップを備えたフィルタを示しており、薄いメンブレン(薄膜)がキャップの底部に設けられている開口部を覆っている。薄膜は、フィルタ入れ物内に収容された微孔質要素で作られており、そのポロシティは、0.1〜1ミクロンである。フィルタは、多種多様な薄膜層で作られた多層構成を有する場合がある。フィルタメンブレンは、フィルタを通る高い流量を許容するほど薄い。したがって、クラッソンのシステムは、濾過能力を犠牲にしている。さらに、クラッソンは、薄手のフィルタを利用しているので、このフィルタは、しばしば目詰まり状態になって閉塞状態になりがちであり、それにより、動作停止時間が長くなる。
本発明の種々の観点は、試料収容容器であって、液体試料を収容するサンプル収容バイアルと、試料収容バイアル内に摺動可能に設けられたプランジャとを有する試料収容容器にある。プランジャは、フィルタ又は濾過装置を有し、試料は、試料が抜き出されているときにフィルタを通って送り出される。
Claims (15)
- 試料送り出し装置であって、
流体試料を試料収容バイアルから抜き出す流体試料送り出し装置を有し、前記流体試料送り出し装置は、プランジャニードルを有し、このプランジャニードルは、前記プランジャニードルが前記試料収容バイアルの底部に向かって移動するときに、前記試料収容バイアル内の試料としての流体を加圧することによって試料としての流体を前記試料収容バイアルから押し退けて前記流体試料送り出し装置内に送り込むよう構成され、
回転ハブに取り付けられた片持ちカルーセルであって、試料収容バイアルのアレイを前記回転ハブの半径方向外側の片持ちカルーセルの周囲に沿って回転可能に支持すると共に前記試料収容バイアルのうちの少なくとも1つを前記流体試料送り出し装置の下の試料採取ステーションに位置決めする片持ちカルーセルを有し、
前記プランジャニードルがそれぞれの試料収容バイアル中に挿入されると、前記片持ちカルーセルの周囲の一部分を前記流体試料送り出し装置のすぐ隣りで支持すると共に、前記片持ちカルーセルの残部を支持しないように前記試料採取ステーションの下に配置される支持体を有することを特徴とする装置。 - 前記支持体は、前記カルーセルの下に位置決めされる、請求項1記載の装置。
- 前記支持体は、前記カルーセルの下に位置決めされた耐力ころ軸受である、請求項1記載の装置。
- 前記プランジャニードルは、カルーセル表面と実質的に直交する方向に負荷を前記カルーセルに及ぼし、前記支持体は、実質的にこれとは逆の方向で前記カルーセルの下に位置決めされている、請求項1記載の装置。
- 更に、前記プランジャニードルをそれぞれの前記試料収容バイアル内に押し込むモータと、
押し込み中の前記モータに加わる負荷及び押し込み中における前記プランジャニードルの速度のうちの少なくとも一方又はこれら両方に関連した情報をモニタするモータモニタと、
前記モニタされた情報に基づいて試料送り出し流路中の障害物を検出する誤差検出器と、を有する、請求項1記載の装置。 - 更に、それぞれの前記試料収容バイアル内への前記プランジャニードルの挿入度に基づいて試料の抜き出し量を測定する試料送り出し測定手段と、
それぞれの前記試料収容バイアルから抜き出された試料の量に関連した情報を格納する格納手段と、を有する、請求項1記載の装置。 - 前記試料収容バイアルは、フィルタキャップを備え、このフィルタキャップは、その下端部に端ぐり部を備え、このフィルタキャップの下端部の端ぐり部内には、フィルタが取り付けられている請求項1記載の装置。
- 前記フィルタは、固形物を液体試料から濾過により除去するよう構成された第1のフィルタ部材を有し、
前記フィルタは、第2のフィルタ部材を有し、前記第2のフィルタ部材の上流側端部は、前記第1のフィルタ部材の下流側端部に流体結合されており、
前記フィルタは、第3のフィルタ部材を有し、前記第3のフィルタ部材の上流側端部は、前記第2のフィルタ部材の下流側端部に流体結合されており、
前記第2のフィルタ部材は、前記第1のフィルタ部材の場合よりも小さな固形物を前記液体試料から濾過により除去するよう構成され、前記第3のフィルタ部材は、前記第2のフィルタ部材の場合よりも大きな固形物を前記液体試料から濾過により除去するよう構成されている、請求項7記載の装置。 - 前記第1のフィルタ部材及び/又は前記第3のフィルタ部材は、流れ方向に見て前記第2のフィルタ部材よりも長い、請求項8記載の装置。
- 前記第1のフィルタ部材及び/又は前記第3のフィルタ部材は、粒径が約30ミクロン〜約200ミクロンの固形物を濾過により除去するよう構成されている、請求項8記載の装置。
- 前記第2のフィルタ部材は、粒径が約0.1ミクロン〜約2ミクロンの固形物を濾過により除去するよう構成されている、請求項8記載の装置。
- 1つ又は2つ以上の前記フィルタは、フルオロポリマー又はポロゲン(porogen)で作られている、請求項8記載の装置。
- 少なくとも前記第1のフィルタ部材及び前記第2のフィルタ部材は、一体構造の状態に作られている、請求項8記載の装置。
- 請求項7記載の装置を用いて液体試料を濾過する方法であって、
流体試料を試料収容バイアル内に用意するステップと、
流体試料を流体送り出し装置により試料収容バイアルから抜き出すステップと、
流体試料をフィルタに通して濾過するステップと、を有し、
上記流体送り出し装置は、所定の条件に応答して駆動力を調節するように構成されている、方法。 - 請求項8記載の装置を用いて液体試料を濾過する方法であって、
流体試料を試料収容バイアル内に用意するステップと、
流体試料を流体送り出し装置により試料収容バイアルから抜き出すステップと、
液体試料をフィルタに流通させて液体試料が順次、第1のフィルタ部材、第2のフィルタ部材及び第3のフィルタ部材を通って流れるようにするステップと、
濾過済みの流体試料を収集するステップと、
を有する、方法。
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US12/399,786 | 2009-03-06 | ||
US12/399,786 US8776621B2 (en) | 2009-03-06 | 2009-03-06 | Fluid sample delivery system and method |
PCT/US2010/026123 WO2010102061A1 (en) | 2009-03-06 | 2010-03-03 | Fluid sample delivery system and method |
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JP2012519855A5 JP2012519855A5 (ja) | 2013-05-02 |
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-
2009
- 2009-03-06 US US12/399,786 patent/US8776621B2/en active Active
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2010
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- 2010-03-03 CN CN201080019913.8A patent/CN102421495B/zh active Active
- 2010-03-03 WO PCT/US2010/026123 patent/WO2010102061A1/en active Application Filing
- 2010-03-03 JP JP2011553095A patent/JP5722805B2/ja active Active
Also Published As
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JP2012519855A (ja) | 2012-08-30 |
US20100224012A1 (en) | 2010-09-09 |
CN102421495B (zh) | 2015-11-25 |
US8776621B2 (en) | 2014-07-15 |
EP2403623A1 (en) | 2012-01-11 |
WO2010102061A1 (en) | 2010-09-10 |
CN102421495A (zh) | 2012-04-18 |
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