JP5710977B2 - 抗ウイルス薬としての修飾塩基を含むオリゴヌクレオチドの使用 - Google Patents

抗ウイルス薬としての修飾塩基を含むオリゴヌクレオチドの使用 Download PDF

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JP5710977B2
JP5710977B2 JP2010532629A JP2010532629A JP5710977B2 JP 5710977 B2 JP5710977 B2 JP 5710977B2 JP 2010532629 A JP2010532629 A JP 2010532629A JP 2010532629 A JP2010532629 A JP 2010532629A JP 5710977 B2 JP5710977 B2 JP 5710977B2
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oligonucleotide
oligonucleotides
replication
modified
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JP2011502501A5 (cg-RX-API-DMAC7.html
JP2011502501A (ja
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サールマ，マルト
メリツ，アンドレス
カレルソン，マティ
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バルティック テクノロジー デヴェロプメント，リミテッド
バルティック テクノロジー デヴェロプメント，リミテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3511—Conjugate intercalating or cleaving agent
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2010532629A 2007-11-05 2008-11-05 抗ウイルス薬としての修飾塩基を含むオリゴヌクレオチドの使用 Expired - Fee Related JP5710977B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98554807P 2007-11-05 2007-11-05
US60/985,548 2007-11-05
US5768508P 2008-05-30 2008-05-30
US61/057,685 2008-05-30
PCT/FI2008/050633 WO2009060122A2 (en) 2007-11-05 2008-11-05 Use of oligonucleotides with modified bases as antiviral agents

Publications (3)

Publication Number Publication Date
JP2011502501A JP2011502501A (ja) 2011-01-27
JP2011502501A5 JP2011502501A5 (cg-RX-API-DMAC7.html) 2011-07-21
JP5710977B2 true JP5710977B2 (ja) 2015-04-30

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JP2010532629A Expired - Fee Related JP5710977B2 (ja) 2007-11-05 2008-11-05 抗ウイルス薬としての修飾塩基を含むオリゴヌクレオチドの使用

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US (1) US20110171287A1 (cg-RX-API-DMAC7.html)
EP (1) EP2212420A2 (cg-RX-API-DMAC7.html)
JP (1) JP5710977B2 (cg-RX-API-DMAC7.html)
CN (1) CN101970662A (cg-RX-API-DMAC7.html)
AU (1) AU2008324066A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0819191A2 (cg-RX-API-DMAC7.html)
CA (1) CA2704549A1 (cg-RX-API-DMAC7.html)
MX (1) MX2010004983A (cg-RX-API-DMAC7.html)
WO (1) WO2009060122A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201003234B (cg-RX-API-DMAC7.html)

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CN101970662A (zh) 2011-02-09
WO2009060122A3 (en) 2009-06-25
CA2704549A1 (en) 2009-05-14
US20110171287A1 (en) 2011-07-14
EP2212420A2 (en) 2010-08-04
WO2009060122A2 (en) 2009-05-14
BRPI0819191A2 (pt) 2017-03-21
ZA201003234B (en) 2011-06-29
MX2010004983A (es) 2010-07-29
AU2008324066A1 (en) 2009-05-14
JP2011502501A (ja) 2011-01-27

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