JP5702604B2 - グリコール酸を生産するための固定化微生物ニトリラーゼの改善 - Google Patents

グリコール酸を生産するための固定化微生物ニトリラーゼの改善 Download PDF

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JP5702604B2
JP5702604B2 JP2010532267A JP2010532267A JP5702604B2 JP 5702604 B2 JP5702604 B2 JP 5702604B2 JP 2010532267 A JP2010532267 A JP 2010532267A JP 2010532267 A JP2010532267 A JP 2010532267A JP 5702604 B2 JP5702604 B2 JP 5702604B2
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Prior art keywords
enzyme catalyst
glutaraldehyde
nitrilase
glycolic acid
seq
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Japanese (ja)
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JP2011501969A5 (enExample
JP2011501969A (ja
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ロバート・ディコージモ
アリー・ベン−バサト
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EIDP Inc
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EI Du Pont de Nemours and Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/584—Recycling of catalysts

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2010532267A 2007-10-31 2008-10-31 グリコール酸を生産するための固定化微生物ニトリラーゼの改善 Expired - Fee Related JP5702604B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/930,550 US7695945B2 (en) 2007-10-31 2007-10-31 Immobilized microbial nitrilase for production of glycolic acid
US11/930,550 2007-10-31
PCT/US2008/081948 WO2009059101A1 (en) 2007-10-31 2008-10-31 Improvement in immobilized microbial nitrilase for production of glycolic acid

Publications (3)

Publication Number Publication Date
JP2011501969A JP2011501969A (ja) 2011-01-20
JP2011501969A5 JP2011501969A5 (enExample) 2011-12-22
JP5702604B2 true JP5702604B2 (ja) 2015-04-15

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JP2010532267A Expired - Fee Related JP5702604B2 (ja) 2007-10-31 2008-10-31 グリコール酸を生産するための固定化微生物ニトリラーゼの改善

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Country Link
US (1) US7695945B2 (enExample)
EP (1) EP2215225B1 (enExample)
JP (1) JP5702604B2 (enExample)
CN (1) CN101965399B (enExample)
DK (1) DK2215225T3 (enExample)
ES (1) ES2563482T3 (enExample)
PL (1) PL2215225T3 (enExample)
WO (1) WO2009059101A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012048865A2 (de) 2010-10-12 2012-04-19 C-Lecta Gmbh Nitrilasen
GB2554708A (en) * 2016-10-05 2018-04-11 Chemoxy Int Process for converting nitriles
CN111848495B (zh) * 2020-06-02 2022-06-21 山东华素制药有限公司 一种1-苄基-3-哌啶醇的合成方法
CN115845880B (zh) * 2022-12-08 2024-06-14 复旦大学 一种水溶性高分子模板原位构筑过渡金属硫化物/碳复合材料及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2175805A (en) * 1937-06-08 1939-10-10 Du Pont Stabilized organic nitrile and process of making
US2890238A (en) * 1957-01-31 1959-06-09 Dow Chemical Co Preparation of glyconitrile
GB1553662A (en) 1978-04-13 1979-09-26 Union Carbide Corp Sterilization of fermentation media
DK146942C (da) * 1978-04-19 1984-07-30 Novo Industri As Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
US4355105A (en) * 1981-03-30 1982-10-19 Miles Laboratories, Inc. Glutaraldehyde/polyethylenimine immobilization of whole microbial cells
US5187301A (en) * 1989-10-26 1993-02-16 W. R. Grace & Co.-Conn. Preparation of iminodiacetonitrile from glycolonitrile
DE69126762T2 (de) * 1990-11-14 1997-10-23 Nitto Chemical Industry Co Ltd Biologisches Verfahren zur Herstellung von Alpha-Hydroxyamid und Alpha-Hydroxysäure
JP3354688B2 (ja) * 1994-01-28 2002-12-09 三菱レイヨン株式会社 微生物によるα−ヒドロキシ酸またはα−ヒドロキシアミドの製造法
US6037155A (en) * 1997-02-27 2000-03-14 Nippon Soda Co., Ltd. Process for preparing α-hydroxy acids using microorganism and novel microorganism
US6251646B1 (en) * 1999-07-12 2001-06-26 E. I. Du Pont De Nemours And Company Method for stabilizing nitrilase activity and preserving microbial cells
US6551804B2 (en) * 1999-07-12 2003-04-22 E. I. Du Pont De Nemours And Company Process for preparing 4-cyanopentanoic acid
KR100501864B1 (ko) * 1999-11-12 2005-07-20 미츠비시 레이온 가부시키가이샤 사멸화 균체
ATE495244T1 (de) * 2000-03-31 2011-01-15 Du Pont Isolierung und expression eines nitrilase-gens von acidovorax facilis 72w
US6416980B1 (en) * 2001-02-23 2002-07-09 E. I. Du Pont De Nemours & Company Method for producing glycolic acid from glycolonitrile using nitrilase
KR100869623B1 (ko) 2004-04-27 2008-11-21 미쓰이 가가쿠 가부시키가이샤 하이드록시 카복실산류의 생산 방법
US7148051B2 (en) * 2004-08-16 2006-12-12 E. I. Du Pont De Nemours And Company Production of 3-hydroxycarboxylic acid using nitrilase
EP1828393B1 (en) 2004-12-22 2012-11-07 E.I. Du Pont De Nemours And Company Process for producing glycolic acid from formaldehyde and hydrogen cyanide
US7198927B2 (en) * 2004-12-22 2007-04-03 E. I. Du Pont De Nemours And Company Enzymatic production of glycolic acid
WO2006071663A1 (en) * 2004-12-22 2006-07-06 E.I. Dupont De Nemours And Company Process for the synthesis of glycolonitrile
US7445917B2 (en) * 2004-12-22 2008-11-04 E.I. Du Pont De Nemours And Company Process for producing glycolic acid from formaldehyde and hydrogen cyanide
CN101278047B (zh) * 2005-09-30 2012-12-12 诺维信公司 酶的固定化

Also Published As

Publication number Publication date
US20090111158A1 (en) 2009-04-30
US7695945B2 (en) 2010-04-13
CN101965399B (zh) 2016-06-08
PL2215225T3 (pl) 2016-05-31
EP2215225B1 (en) 2015-12-02
JP2011501969A (ja) 2011-01-20
WO2009059101A1 (en) 2009-05-07
EP2215225A1 (en) 2010-08-11
ES2563482T3 (es) 2016-03-15
CN101965399A (zh) 2011-02-02
DK2215225T3 (en) 2016-03-07

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