JP5697679B2 - Ｃ型肝炎ウイルス阻害剤 - Google Patents
Ｃ型肝炎ウイルス阻害剤 Download PDFInfo
- Publication number
- JP5697679B2 JP5697679B2 JP2012538923A JP2012538923A JP5697679B2 JP 5697679 B2 JP5697679 B2 JP 5697679B2 JP 2012538923 A JP2012538923 A JP 2012538923A JP 2012538923 A JP2012538923 A JP 2012538923A JP 5697679 B2 JP5697679 B2 JP 5697679B2
- Authority
- JP
- Japan
- Prior art keywords
- imidazol
- pyrrolidinyl
- solvent
- methyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc1c(B*c2c(*)[n]c(*)n2)nc(C2N(*)CCC2)[n]1 Chemical compound Cc1c(B*c2c(*)[n]c(*)n2)nc(C2N(*)CCC2)[n]1 0.000 description 7
- YENRRSJOGNVHLX-OVRZELKPSA-N C/C=C\C(\F)=C(\CC(O)=O)/C=C Chemical compound C/C=C\C(\F)=C(\CC(O)=O)/C=C YENRRSJOGNVHLX-OVRZELKPSA-N 0.000 description 1
- MHQZDNQHLGFBRN-UHFFFAOYSA-N C=Cc1c[nH]cn1 Chemical compound C=Cc1c[nH]cn1 MHQZDNQHLGFBRN-UHFFFAOYSA-N 0.000 description 1
- ARVYNIUWNHGVMK-UHFFFAOYSA-N CC(C)(C1)OCCC1C(C(O)=O)NC(OC)=O Chemical compound CC(C)(C1)OCCC1C(C(O)=O)NC(OC)=O ARVYNIUWNHGVMK-UHFFFAOYSA-N 0.000 description 1
- FMWXPWOCDITRKF-UHFFFAOYSA-N CC1C(OCc2ccccc2)=[O]=[I]C1(C1)C23C1OC2CC3 Chemical compound CC1C(OCc2ccccc2)=[O]=[I]C1(C1)C23C1OC2CC3 FMWXPWOCDITRKF-UHFFFAOYSA-N 0.000 description 1
- ZWVBAHITHMYEMS-SECBINFHSA-N CCNC(N[C@@H](C(O)=O)c1ccccc1)=O Chemical compound CCNC(N[C@@H](C(O)=O)c1ccccc1)=O ZWVBAHITHMYEMS-SECBINFHSA-N 0.000 description 1
- JCWUTEGWHABTTF-VIFPVBQESA-N CN(C)[C@H](C(O)=O)c(cccc1)c1F Chemical compound CN(C)[C@H](C(O)=O)c(cccc1)c1F JCWUTEGWHABTTF-VIFPVBQESA-N 0.000 description 1
- OZKZHAPLKMRAQT-UHFFFAOYSA-N CN(CC(O)=O)Cc1ccccc1 Chemical compound CN(CC(O)=O)Cc1ccccc1 OZKZHAPLKMRAQT-UHFFFAOYSA-N 0.000 description 1
- OQZOPIFSTNJPIM-UHFFFAOYSA-N CN(CC1)CCN1C(C(O)=O)c1ccccc1 Chemical compound CN(CC1)CCN1C(C(O)=O)c1ccccc1 OQZOPIFSTNJPIM-UHFFFAOYSA-N 0.000 description 1
- CWLQUGTUXBXTLF-RXMQYKEDSA-N CN(CCC1)[C@H]1C(O)=O Chemical compound CN(CCC1)[C@H]1C(O)=O CWLQUGTUXBXTLF-RXMQYKEDSA-N 0.000 description 1
- ZUOXHVHNWWEXSD-XYOKQWHBSA-N COC(/N=C/C(CCN1CCOCC1)C(O)=O)=O Chemical compound COC(/N=C/C(CCN1CCOCC1)C(O)=O)=O ZUOXHVHNWWEXSD-XYOKQWHBSA-N 0.000 description 1
- JSWJZHLINSQJSP-UHFFFAOYSA-N COC(NC(C1C2COCC1CC2)C(O)=O)=O Chemical compound COC(NC(C1C2COCC1CC2)C(O)=O)=O JSWJZHLINSQJSP-UHFFFAOYSA-N 0.000 description 1
- KURWVNFJNNCXOE-SECBINFHSA-N COC(N[C@@H](C(O)=O)C(C=CCC=C1)=C1Cl)=O Chemical compound COC(N[C@@H](C(O)=O)C(C=CCC=C1)=C1Cl)=O KURWVNFJNNCXOE-SECBINFHSA-N 0.000 description 1
- GOJLQSAREKTKPT-MRVPVSSYSA-N COC(N[C@@H](C(O)=O)c1ccccc1)=O Chemical compound COC(N[C@@H](C(O)=O)c1ccccc1)=O GOJLQSAREKTKPT-MRVPVSSYSA-N 0.000 description 1
- VBQNMJLWFTYJQQ-PRZNWYJVSA-N COC(N[C@@H](C1(C2)C2OCCC1)C(O)=O)=O Chemical compound COC(N[C@@H](C1(C2)C2OCCC1)C(O)=O)=O VBQNMJLWFTYJQQ-PRZNWYJVSA-N 0.000 description 1
- ZHYQQMPGESIRRQ-ASLNEKEESA-N COC(N[C@@H]([C@@H]1COCCC1)C(O)=O)O Chemical compound COC(N[C@@H]([C@@H]1COCCC1)C(O)=O)O ZHYQQMPGESIRRQ-ASLNEKEESA-N 0.000 description 1
- GHAQIXXBUHNFHR-YUMQZZPRSA-N COC([C@H]([C@@H]1COCCC1)NC(OC)=O)=O Chemical compound COC([C@H]([C@@H]1COCCC1)NC(OC)=O)=O GHAQIXXBUHNFHR-YUMQZZPRSA-N 0.000 description 1
- DYTJEQBUSOPLJD-NTSWFWBYSA-N CO[C@H](CC1)C[C@H]1O Chemical compound CO[C@H](CC1)C[C@H]1O DYTJEQBUSOPLJD-NTSWFWBYSA-N 0.000 description 1
- IYRQAHMILBSLLI-LURJTMIESA-N C[C@@H](C(N1CCCC1)=O)I Chemical compound C[C@@H](C(N1CCCC1)=O)I IYRQAHMILBSLLI-LURJTMIESA-N 0.000 description 1
- PKSHBKQBIJCPDK-LURJTMIESA-N C[C@@H](CC(C1)=O)OC1=C Chemical compound C[C@@H](CC(C1)=O)OC1=C PKSHBKQBIJCPDK-LURJTMIESA-N 0.000 description 1
- ORVYPIPXACDBMU-CRCLSJGQSA-N C[C@@H]([C@@H](C)O)NC(OC)=O Chemical compound C[C@@H]([C@@H](C)O)NC(OC)=O ORVYPIPXACDBMU-CRCLSJGQSA-N 0.000 description 1
- QSGQRCSPXYYLGN-LBPRGKRZSA-N C[C@@H](c1ccccc1)OC(Cc1ccccc1F)=O Chemical compound C[C@@H](c1ccccc1)OC(Cc1ccccc1F)=O QSGQRCSPXYYLGN-LBPRGKRZSA-N 0.000 description 1
- KMAYERAFUKKXME-KSSFIOAISA-N C[C@@H](c1ccccc1)OC([C@H](c(cccc1)c1[I]=C)N(C)C)=O Chemical compound C[C@@H](c1ccccc1)OC([C@H](c(cccc1)c1[I]=C)N(C)C)=O KMAYERAFUKKXME-KSSFIOAISA-N 0.000 description 1
- LGOUUMRFIYBPDO-PSASIEDQSA-N C[C@H](CN)C1=C(C)CC[C@@H](C)C1 Chemical compound C[C@H](CN)C1=C(C)CC[C@@H](C)C1 LGOUUMRFIYBPDO-PSASIEDQSA-N 0.000 description 1
- PXHHIBMOFPCBJQ-ZCFIWIBFSA-N C[C@H]1N(C)CCC1 Chemical compound C[C@H]1N(C)CCC1 PXHHIBMOFPCBJQ-ZCFIWIBFSA-N 0.000 description 1
- LMIZLNPFTRQPSF-SSDOTTSWSA-N N[C@@H](C(O)=O)c(cccc1)c1Cl Chemical compound N[C@@H](C(O)=O)c(cccc1)c1Cl LMIZLNPFTRQPSF-SSDOTTSWSA-N 0.000 description 1
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N N[C@@H](C(O)=O)c1ccccc1 Chemical compound N[C@@H](C(O)=O)c1ccccc1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 description 1
- ALMBVNDWQWJTNP-JPYDVTDNSA-N O=C([C@@H](c1ccccc1)N1CCCCC1)N(CCC1)[C@@H]1c1ncc(C#CC#Cc2cnc([C@H](CCC3)N3C([C@@H](c3ccccc3)N3CCCCC3)=O)[nH]2)[nH]1 Chemical compound O=C([C@@H](c1ccccc1)N1CCCCC1)N(CCC1)[C@@H]1c1ncc(C#CC#Cc2cnc([C@H](CCC3)N3C([C@@H](c3ccccc3)N3CCCCC3)=O)[nH]2)[nH]1 ALMBVNDWQWJTNP-JPYDVTDNSA-N 0.000 description 1
- KGSVNOLLROCJQM-UHFFFAOYSA-N OC(CNCc1ccccc1)=O Chemical compound OC(CNCc1ccccc1)=O KGSVNOLLROCJQM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26056909P | 2009-11-12 | 2009-11-12 | |
| US61/260,569 | 2009-11-12 | ||
| US12/942,183 US20110281910A1 (en) | 2009-11-12 | 2010-11-09 | Hepatitis C Virus Inhibitors |
| US12/942,183 | 2010-11-09 | ||
| PCT/US2010/056114 WO2011060000A1 (en) | 2009-11-12 | 2010-11-10 | Hepatitis c virus inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013510857A JP2013510857A (ja) | 2013-03-28 |
| JP2013510857A5 JP2013510857A5 (OSRAM) | 2013-12-05 |
| JP5697679B2 true JP5697679B2 (ja) | 2015-04-08 |
Family
ID=43334735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538923A Expired - Fee Related JP5697679B2 (ja) | 2009-11-12 | 2010-11-10 | Ｃ型肝炎ウイルス阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20110281910A1 (OSRAM) |
| EP (1) | EP2499132B1 (OSRAM) |
| JP (1) | JP5697679B2 (OSRAM) |
| CN (1) | CN102712628B (OSRAM) |
| WO (1) | WO2011060000A1 (OSRAM) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2567047T3 (es) | 2008-12-23 | 2016-04-19 | Abbvie Inc. | Derivados de pirimidina anti-virales |
| EP2367823A1 (en) | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Anti-viral compounds |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP5734956B2 (ja) * | 2009-04-15 | 2015-06-17 | アッヴィ・インコーポレイテッド | 抗ウィルス化合物 |
| MX363732B (es) | 2009-05-13 | 2019-04-01 | Gilead Pharmasset Llc Star | Compuestos antivirales. |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| AR077060A1 (es) | 2009-06-11 | 2011-07-27 | Abbott Lab | Compuestos antivirales |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| JP2012533569A (ja) | 2009-07-16 | 2012-12-27 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体 |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2794145A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| RU2452735C1 (ru) * | 2010-11-30 | 2012-06-10 | Александр Васильевич Иващенко | Замещенные азолы, противовирусный активный компонент, фармацевтическая композиция, способ получения и применения |
| WO2012087976A2 (en) * | 2010-12-21 | 2012-06-28 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
| EP2709613B2 (en) | 2011-09-16 | 2020-08-12 | Gilead Pharmasset LLC | Methods for treating hcv |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| AU2013217224B2 (en) | 2012-02-10 | 2017-04-06 | Lupin Limited | Antiviral compounds with a dibenzooxaheterocycle moiety |
| PL2950786T3 (pl) | 2013-01-31 | 2020-05-18 | Gilead Pharmasset Llc | Formulacja skojarzona dwóch związków przeciwwirusowych |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| US9334291B2 (en) * | 2013-06-06 | 2016-05-10 | AB Pharma Ltd. | Antiviral compounds highly effective as HCV-NS5A inhibitor |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| WO2015009744A1 (en) | 2013-07-17 | 2015-01-22 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of hcv |
| PL3038601T3 (pl) | 2013-08-27 | 2020-08-24 | Gilead Pharmasset Llc | Formulacja złożona dwóch związków przeciwwirusowych |
| EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
| CN105985356B (zh) * | 2015-02-05 | 2018-06-22 | 四川大学 | 咪唑[2,1-b]噻唑衍生物及其制备方法和用途 |
| WO2017023631A1 (en) | 2015-08-06 | 2017-02-09 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| GB2552919A (en) * | 2015-11-18 | 2018-02-21 | Azad Pharmaceutical Ingredients Ag | Stable amorphous form of daclatasvir |
| CN117460734A (zh) | 2021-05-21 | 2024-01-26 | 吉利德科学公司 | 作为寨卡病毒抑制剂的五环衍生物 |
| WO2022246072A1 (en) | 2021-05-21 | 2022-11-24 | Gilead Sciences, Inc. | Tetracyclic compounds for the treatment of zika virus infection |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5654451B1 (en) | 1993-01-14 | 2000-02-22 | Magainin Pharma | Amino acids and peptides having modified c-terminals and modified n-terminals |
| EP0679153A4 (en) | 1993-01-14 | 1996-05-15 | Magainin Pharma | FINALLY MODIFIED AMINO ACIDS AND PEPTIDES. |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| AU2003249977A1 (en) | 2002-07-05 | 2004-01-23 | Axxima Pharmaceuticals Ag | Imidazole compounds for the treatment of hepatitis c virus infections |
| US20050069522A1 (en) | 2002-08-12 | 2005-03-31 | Richard Colonno | Combination pharmaceutical agents as inhibitors of HCV replication |
| US7135462B2 (en) | 2003-11-20 | 2006-11-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| DE102004036971B4 (de) | 2004-07-30 | 2009-07-30 | Advanced Micro Devices, Inc., Sunnyvale | Technik zur Bewertung lokaler elektrischer Eigenschaften in Halbleiterbauelementen |
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- 2010-11-10 EP EP10779401.8A patent/EP2499132B1/en not_active Not-in-force
- 2010-11-10 JP JP2012538923A patent/JP5697679B2/ja not_active Expired - Fee Related
- 2010-11-10 WO PCT/US2010/056114 patent/WO2011060000A1/en not_active Ceased
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|---|---|
| CN102712628A (zh) | 2012-10-03 |
| CN102712628B (zh) | 2014-10-15 |
| WO2011060000A1 (en) | 2011-05-19 |
| US20130012540A1 (en) | 2013-01-10 |
| US20110281910A1 (en) | 2011-11-17 |
| EP2499132A1 (en) | 2012-09-19 |
| US20140018389A1 (en) | 2014-01-16 |
| JP2013510857A (ja) | 2013-03-28 |
| US8618153B2 (en) | 2013-12-31 |
| EP2499132B1 (en) | 2017-02-15 |
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