JP5695397B2 - 防カビ剤、それを用いる防カビ方法、生育阻止剤およびそれを用いる生育阻止方法 - Google Patents
防カビ剤、それを用いる防カビ方法、生育阻止剤およびそれを用いる生育阻止方法 Download PDFInfo
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- JP5695397B2 JP5695397B2 JP2010262158A JP2010262158A JP5695397B2 JP 5695397 B2 JP5695397 B2 JP 5695397B2 JP 2010262158 A JP2010262158 A JP 2010262158A JP 2010262158 A JP2010262158 A JP 2010262158A JP 5695397 B2 JP5695397 B2 JP 5695397B2
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- antifungal
- amide compound
- carboxylic acid
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- 229940121375 antifungal agent Drugs 0.000 title claims description 41
- 239000003429 antifungal agent Substances 0.000 title claims description 36
- 238000000034 method Methods 0.000 title claims description 26
- 230000000843 anti-fungal effect Effects 0.000 title claims description 10
- 239000003966 growth inhibitor Substances 0.000 title claims 3
- 230000002401 inhibitory effect Effects 0.000 title claims 2
- -1 amide compound Chemical class 0.000 claims description 97
- 239000000126 substance Substances 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 9
- 241000228245 Aspergillus niger Species 0.000 claims description 3
- 241001136494 Talaromyces funiculosus Species 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 description 53
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- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 28
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- 238000006243 chemical reaction Methods 0.000 description 16
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- GPZYYYGYCRFPBU-UHFFFAOYSA-N 6-Hydroxyflavone Chemical compound C=1C(=O)C2=CC(O)=CC=C2OC=1C1=CC=CC=C1 GPZYYYGYCRFPBU-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- KLQPJWWHRBKZAA-UHFFFAOYSA-N C(C(C)C)NC(CCCCCCCC=C)=O Chemical compound C(C(C)C)NC(CCCCCCCC=C)=O KLQPJWWHRBKZAA-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 235000019484 Rapeseed oil Nutrition 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000006096 absorbing agent Substances 0.000 description 3
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- IKUCZBBSELVBOO-UHFFFAOYSA-N dec-9-enoyl chloride Chemical compound ClC(=O)CCCCCCCC=C IKUCZBBSELVBOO-UHFFFAOYSA-N 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
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- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- XPFVYQJUAUNWIW-UHFFFAOYSA-N furfuryl alcohol Chemical compound OCC1=CC=CO1 XPFVYQJUAUNWIW-UHFFFAOYSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- UXJMDSSXCNYLKF-UHFFFAOYSA-N n-(2-methylpropyl)octanamide Chemical compound CCCCCCCC(=O)NCC(C)C UXJMDSSXCNYLKF-UHFFFAOYSA-N 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
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- 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
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- 239000011630 iodine Substances 0.000 description 1
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- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
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- FKEGHFZKKSLOCS-UHFFFAOYSA-N non-8-enoyl chloride Chemical compound ClC(=O)CCCCCCC=C FKEGHFZKKSLOCS-UHFFFAOYSA-N 0.000 description 1
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- JMOJBNHCDPEKHY-UHFFFAOYSA-N oct-7-enoyl chloride Chemical compound ClC(=O)CCCCCC=C JMOJBNHCDPEKHY-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
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- 239000003960 organic solvent Substances 0.000 description 1
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- IGEIPFLJVCPEKU-UHFFFAOYSA-N pentan-2-amine Chemical compound CCCC(C)N IGEIPFLJVCPEKU-UHFFFAOYSA-N 0.000 description 1
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- 239000003208 petroleum Substances 0.000 description 1
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
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- 230000002265 prevention Effects 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 description 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 150000003839 salts Chemical class 0.000 description 1
- BHRZNVHARXXAHW-UHFFFAOYSA-N sec-butylamine Chemical compound CCC(C)N BHRZNVHARXXAHW-UHFFFAOYSA-N 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
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- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
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- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical group C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
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- AQZSPJRLCJSOED-UHFFFAOYSA-M trimethyl(octyl)azanium;chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(C)C AQZSPJRLCJSOED-UHFFFAOYSA-M 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
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Description
(1)下記一般式(1)で示されるアミド化合物を含有することを特徴とする、防カビ剤。
(2)前記一般式(1)において、X1およびX2のいずれか一方が、イソブチル基であり、他方が水素原子であるか、または、X1およびX2が、相互に結合して、飽和5〜6員環を形成することを特徴とする、前記(1)に記載の防カビ剤、
(3)前記一般式(1)において、Yが、炭素数6または7のアルキレン基であることを特徴とする、前記(1)または(2)に記載の防カビ剤、
(4)前記(1)〜(3)のいずれか一つに記載の防カビ剤を用いることを特徴とする、防カビ方法、
(5) 下記化学式(2)で示されるアミド化合物
化学式(2):
上記一般式(1)において、X1またはX2で示される分岐アルキル基としては、例えば、イソプロピル、イソブチル、sec−ブチル、tert−ブチル、イソペンチル、sec−ペンチル、イソヘキシル、sec−ヘキシル、イソヘプチル、sec−ヘプチルなどの炭素数3〜7の分岐状アルキル基が挙げられる。
化学式(2):
反応式(1):
上記一般式(1)で示されるアミドを合成するには、まず、カルボン酸(5)と、ハロゲン化剤とを、反応させ、カルボン酸ハロゲン化物(6)を調製する。
9−デセン酸(2.9g、0.017mol)に、塩化チオニール(8mL)を加え、水浴上で2時間還流した。その後、過剰の塩化チオニールを減圧下で留去し、9−デセン酸クロリドを得た。
電子衝突質量スペクトル(EIMS) m/z(%):225(M+,39)、182(27)、128(46)、115(100)
合成例2
オクタン酸(5.2g、0.036mol)に、塩化チオニール(12mL)を加え、水浴上で2時間還流した。その後、過剰の塩化チオニールを減圧下で留去し、オクタン酸クロリドを得た。
EIMS m/z(%):199(M+,14)、144(37)、127(51)、125(51)、115(100)
合成例3
オクタン酸(4.4g、0.031mol)に、塩化チオニール(12mL)を加え、水浴上で2時間還流した。その後、過剰の塩化チオニールを減圧下で留去し、オクタン酸クロリドを得た。
EIMS m/z(%):211(M+,11)、140(32)、127(100)、84(26)
実施例1
合成例1で合成されたN−イソブチルデック−9−エンアミドを、アセトンで希釈して、濃度が、10mg/mL(10000ppm)となるように調製し、防カビ剤(液剤)を得た。
合成例2で合成されたN−イソブチルオクタンアミドを、アセトンで希釈して、濃度が、10mg/mL(10000ppm)となるように調製し、防カビ剤(液剤)を得た。
合成例3で合成された1−(ピペリジン−1−イル)オクタン−1−オンを、アセトンで希釈して、濃度が、10mg/mL(10000ppm)となるように調製し、防カビ剤(液剤)を得た。
実施例1〜3で調製された防カビ剤を、それぞれ、直径8mmのろ紙(ペーパーディスク抗生物質検定用)に対して、40μLずつ滴下し、風乾させた。
なお、表1には、各カビ剤を含有しないろ紙を用いた結果も、コントロールとして併せて示している。
Claims (5)
- 下記化学式(2)で示されるアミド化合物および/または下記化学式(4)で示されるアミド化合物を有効成分として含有することを特徴とする、防カビ剤。
化学式(2):
化学式(4):
- 請求項1に記載の防カビ剤を用いることを特徴とする、防カビ方法。
- 下記化学式(3)で示されるアミド化合物を有効成分として含有することを特徴とする、アスペルギルス ニガーおよび/またはペニシリウム フニクロサムの生育阻止剤。
化学式(3):
- 請求項3に記載の生育阻止剤を用いることを特徴とする、アスペルギルス ニガーおよび/またはペニシリウム フニクロサムの生育阻止方法。
- 下記化学式(2)で示されるアミド化合物。
化学式(2):
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