JP5695089B2 - 特に、血中グルコースを測定するための、測定装置および測定方法 - Google Patents
特に、血中グルコースを測定するための、測定装置および測定方法 Download PDFInfo
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N21/3151—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using two sources of radiation of different wavelengths
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3155—Measuring in two spectral ranges, e.g. UV and visible
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
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Description
Claims (15)
- 光源(22)および検出器(24)を含む光度測定ユニット(16)、並びに分析物の光学的検出のため光源(22)および検出器(24)の間のビーム経路(18)に配置され得る、体液が適用できる分析用試験要素(14)を有し、前記光源(22)が、パルス化された変調光(28)を放出するための第一波長帯で発動できる第一エミッタ(26)と蛍光物質の形態をとりそして第二波長帯で蛍光(32)を放出するためにパルス化された第一エミッタ(26)により励起される第二エミッタ(30)を含み、ここで両エミッタが、試験要素(14)の測定表面(34)の方へ共同して方向付けられることを特徴とする、血中グルコース測定のための測定装置。
- 前記変調光(28)が、パルス持続期間を有しおよび前記蛍光(32)が、蛍光寿命サイクルで減衰し、および蛍光寿命サイクルが、パルス持続期間より複数回大きいことを特徴とする、請求項1に記載の測定装置。
- 前記第一エミッタ(26)が、UV領域について、発光ダイオードの発光の形式であることを特徴とする、請求項1または2に記載の測定装置。
- 前記第二エミッタ(30)が、可視蛍光(32)を放出するために光学的に励起され得ることを特徴とする、請求項1‐3のいずれか一項に記載の測定装置。
- 前記第二エミッタ(30)が、前記第一エミッタ(26)の放出表面に蛍光性の層として適用されることを特徴とする、請求項1‐4のいずれか一項に記載の測定装置。
- 前記検出器(24)が、変調光および蛍光(28、32)の集合的検出のための受光器(40)を含むことを特徴とする、請求項1‐5のいずれか一項に記載の測定装置。
- 前記検出器(24)が、測定値の波長選択的測定のための2のアンプチャンネル(42,44)を含むことを特徴とする、請求項1‐6のいずれか一項に記載の測定装置。
- 前記検出器(24)が、前記変調光(28)により発生する変調光シグナルコンポーネントを検出するための前記変調光(28)のパルス周波数で調節できるロックインアンプ(46)を含むことを特徴とする、請求項1‐7のいずれか一項に記載の測定装置。
- 前記検出器(24)が、前記変調光(28)および蛍光(32)により発生する複合シグナルを検出するためのインテグレータ(48)として機能するアンプを含むことを特徴とする、請求項1‐8のいずれか一項に記載の測定装置。
- 前記検出器(24)が、前記複合シグナルから前記変調光シグナルコンポーネントを減算するために前記変調光および/または前記蛍光の前記シグナルコンポーネントを測定するためのシグナルプロセッサ(50)を含むことを特徴とする、請求項1‐9のいずれか一項に記載の測定装置。
- 前記光度測定ユニット(16)が、携帯式装置(12)中に統合され、および前記試験要素(14)が、前記携帯式装置(12)で一回使用のための使い捨てとして設計されることを特徴とする、請求項1‐10のいずれか一項に記載の測定装置。
- 前記試験要素(14)が、光学ユニット(36)により前記光源(22)と結合でき、および光学的結合が、前記波長帯の一つで分離シグナル評価により監視できることを特徴とする、請求項1‐11のいずれか一項に記載の測定装置。
- 体液が、使い捨て要素として使用され得る試験要素(14)に適用され、および前記試験要素(14)が、光源(22)および検出器(24)を含む光度測定ユニット(16)により光学的にスキャンされ、前記光源(22)の第一エミッタ(26)が、パルス化された変調光(28)を放出するために第一波長帯で発動し、および蛍光物質により形成された第二エミッタ(30)が、変調光(28)上に重なる蛍光(32)を放出するためにパルス化した第一エミッタ(26)により第二波長帯で励起され、ここで両エミッタが試験要素(14)の測定表面(34)の方に共同して方向付けられることを特徴とする、血中グルコースを測定するための測定方法。
- 前記変調光(28)に関するシグナルコンポーネントが、ロックインアンプ(46)によって検出されることを特徴とする、請求項13に記載の測定方法。
- 一の波長帯で、体液中の分析物についての測定値が検出され、および他の波長帯で、コントロール値が、前記試験要素(14)と前記光度測定ユニット(16)との光学的結合の状態の変化を検出するために測定されることを特徴とする、請求項13または14に記載の測定方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10152018.7 | 2010-01-28 | ||
EP10152018A EP2362207A1 (de) | 2010-01-28 | 2010-01-28 | Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung |
PCT/EP2011/051168 WO2011092259A1 (de) | 2010-01-28 | 2011-01-27 | Messsystem und messverfahren insbesondere zur blutzuckerbestimmung |
Publications (3)
Publication Number | Publication Date |
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JP2013518270A JP2013518270A (ja) | 2013-05-20 |
JP2013518270A5 JP2013518270A5 (ja) | 2014-03-13 |
JP5695089B2 true JP5695089B2 (ja) | 2015-04-01 |
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Application Number | Title | Priority Date | Filing Date |
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JP2012550448A Active JP5695089B2 (ja) | 2010-01-28 | 2011-01-27 | 特に、血中グルコースを測定するための、測定装置および測定方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8373851B2 (ja) |
EP (2) | EP2362207A1 (ja) |
JP (1) | JP5695089B2 (ja) |
KR (1) | KR101385786B1 (ja) |
CN (1) | CN102713569B (ja) |
HK (1) | HK1172397A1 (ja) |
WO (1) | WO2011092259A1 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5665811B2 (ja) * | 2012-08-02 | 2015-02-04 | 国立大学法人九州大学 | 光誘起蛍光測定器 |
KR102245011B1 (ko) * | 2013-11-28 | 2021-04-27 | 에프. 호프만-라 로슈 아게 | 체액에서의 분석물의 농도를 결정하기 위한 방법 및 디바이스 |
CA2957540A1 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
US20170038299A1 (en) * | 2015-08-07 | 2017-02-09 | Sentinel Monitoring Systems, Inc. | Online process monitoring |
US10441174B2 (en) * | 2016-02-17 | 2019-10-15 | Tesseract Health, Inc. | Sensor and device for lifetime imaging and detection applications |
BR112019012540A2 (pt) | 2016-12-22 | 2019-11-12 | Quantum-Si Incorporated | fotodetector integrado com pixel de acondicionamento direto |
GB2569554A (en) * | 2017-12-19 | 2019-06-26 | Sumitomo Chemical Co | Apparatus |
EP3811610A1 (en) | 2018-06-22 | 2021-04-28 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
WO2020209834A1 (en) * | 2019-04-08 | 2020-10-15 | Hewlett-Packard Development Company, L.P. | Devices for retaining articles |
CN112578108B (zh) * | 2020-12-11 | 2022-02-18 | 上海柏辰生物科技有限公司 | 一种生物健康研究用免疫芯片激光扫描系统 |
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US3647299A (en) | 1970-04-20 | 1972-03-07 | American Optical Corp | Oximeter |
US4935346A (en) * | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
US5089229A (en) * | 1989-11-22 | 1992-02-18 | Vettest S.A. | Chemical analyzer |
US5758644A (en) | 1995-06-07 | 1998-06-02 | Masimo Corporation | Manual and automatic probe calibration |
JP4271747B2 (ja) * | 1997-07-07 | 2009-06-03 | 株式会社朝日ラバー | 発光ダイオード用透光性被覆材及び蛍光カラー光源 |
US6623670B2 (en) * | 1997-07-07 | 2003-09-23 | Asahi Rubber Inc. | Method of molding a transparent coating member for light-emitting diodes |
US6121050A (en) | 1997-08-29 | 2000-09-19 | Han; Chi-Neng Arthur | Analyte detection systems |
KR20010000545A (ko) | 2000-10-05 | 2001-01-05 | 유태경 | 펌핑 층이 집적된 다 파장 AlGaInN계 반도체LED 소자 및 그 제조 방법 |
JP4569030B2 (ja) * | 2001-04-23 | 2010-10-27 | 東ソー株式会社 | 外部光下で計測可能な蛍光検出方法、および装置 |
US6836332B2 (en) * | 2001-09-25 | 2004-12-28 | Tennessee Scientific, Inc. | Instrument and method for testing fluid characteristics |
US6697655B2 (en) | 2001-10-05 | 2004-02-24 | Mortara Instrument, Inc. | Low power pulse oximeter |
MXPA04011103A (es) * | 2002-05-16 | 2005-02-14 | Hoffmann La Roche | Metodo y sistema de reaccion con un complejo de enzima-coenzima no regenerable. |
US20050049468A1 (en) | 2003-09-03 | 2005-03-03 | Sven-Erik Carlson | Increasing the performance of an optical pulsoximeter |
US20080291455A1 (en) * | 2003-11-07 | 2008-11-27 | Kyle Harold Holland | Active Light Sensor |
US7190985B2 (en) * | 2004-02-25 | 2007-03-13 | Nellcor Puritan Bennett Inc. | Oximeter ambient light cancellation |
GB0421793D0 (en) * | 2004-10-01 | 2004-11-03 | Univ Aston | Sensing device |
EP2063257A3 (en) * | 2007-11-22 | 2010-02-10 | Johannes Kepler Universität Linz | Single particle detection by using alternating excitation schemes |
GB2464105A (en) * | 2008-10-01 | 2010-04-07 | Thorn Security | A Particle Detector |
JP5289884B2 (ja) * | 2008-10-01 | 2013-09-11 | オリンパス株式会社 | レーザ顕微鏡装置 |
US8602567B2 (en) * | 2009-09-29 | 2013-12-10 | Wavien, Inc. | Multiplexing light pipe having enhanced brightness |
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2010
- 2010-01-28 EP EP10152018A patent/EP2362207A1/de not_active Withdrawn
-
2011
- 2011-01-27 JP JP2012550448A patent/JP5695089B2/ja active Active
- 2011-01-27 EP EP11700860.7A patent/EP2529199B1/de active Active
- 2011-01-27 WO PCT/EP2011/051168 patent/WO2011092259A1/de active Application Filing
- 2011-01-27 CN CN201180007563.8A patent/CN102713569B/zh active Active
- 2011-01-27 KR KR1020127017081A patent/KR101385786B1/ko active IP Right Grant
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2012
- 2012-07-02 US US13/540,001 patent/US8373851B2/en active Active
- 2012-12-20 HK HK12113182.7A patent/HK1172397A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2529199B1 (de) | 2015-06-10 |
KR101385786B1 (ko) | 2014-04-16 |
WO2011092259A1 (de) | 2011-08-04 |
JP2013518270A (ja) | 2013-05-20 |
CN102713569B (zh) | 2014-12-31 |
HK1172397A1 (en) | 2013-04-19 |
EP2362207A1 (de) | 2011-08-31 |
KR20120099109A (ko) | 2012-09-06 |
CN102713569A (zh) | 2012-10-03 |
US20130003043A1 (en) | 2013-01-03 |
US8373851B2 (en) | 2013-02-12 |
EP2529199A1 (de) | 2012-12-05 |
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