JP5677951B2 - 抗癌活性を有する２−デオキシ単糖の新規なアセテート - Google Patents

抗癌活性を有する２−デオキシ単糖の新規なアセテート Download PDF

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JP5677951B2
JP5677951B2 JP2011517467A JP2011517467A JP5677951B2 JP 5677951 B2 JP5677951 B2 JP 5677951B2 JP 2011517467 A JP2011517467 A JP 2011517467A JP 2011517467 A JP2011517467 A JP 2011517467A JP 5677951 B2 JP5677951 B2 JP 5677951B2
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glucose
mmol
autophagy
benzyl
glucal
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Japanese (ja)
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JP2011527678A5 (https=
JP2011527678A (ja
Inventor
プリーベ、ワルデマー
シブルスキー、マルチン
フォクト、イザベラ
スコラ、スタインスロー
コンラッド、チャールズ
マッデン、ティモシー
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University of Texas System
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2011517467A 2008-07-11 2009-06-25 抗癌活性を有する２−デオキシ単糖の新規なアセテート Expired - Fee Related JP5677951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7996808P 2008-07-11 2008-07-11
US61/079,968 2008-07-11
PCT/US2009/048675 WO2010005799A2 (en) 2008-07-11 2009-06-25 Novel acetates of 2-deoxy monosaccharides with anticancer activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015000024A Division JP5890043B2 (ja) 2008-07-11 2015-01-05 抗癌活性を有する２−デオキシ単糖の新規なアセテート

Publications (3)

Publication Number Publication Date
JP2011527678A JP2011527678A (ja) 2011-11-04
JP2011527678A5 JP2011527678A5 (https=) 2012-08-09
JP5677951B2 true JP5677951B2 (ja) 2015-02-25

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ID=41507670

Family Applications (2)

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JP2011517467A Expired - Fee Related JP5677951B2 (ja) 2008-07-11 2009-06-25 抗癌活性を有する２−デオキシ単糖の新規なアセテート
JP2015000024A Expired - Fee Related JP5890043B2 (ja) 2008-07-11 2015-01-05 抗癌活性を有する２−デオキシ単糖の新規なアセテート

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JP2015000024A Expired - Fee Related JP5890043B2 (ja) 2008-07-11 2015-01-05 抗癌活性を有する２−デオキシ単糖の新規なアセテート

Country Status (10)

Country Link
US (1) US8927506B2 (https=)
EP (1) EP2310020B1 (https=)
JP (2) JP5677951B2 (https=)
CN (1) CN102149388B (https=)
DK (1) DK2310020T3 (https=)
ES (1) ES2628180T3 (https=)
HU (1) HUE033210T2 (https=)
LT (1) LT2310020T (https=)
PL (1) PL2310020T3 (https=)
WO (1) WO2010005799A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
ES2628180T3 (es) 2008-07-11 2017-08-02 Board Of Regents, The University Of Texas System Nuevos acetatos de 2-desoxi monosacáridos con actividad anticancerosa
WO2012097052A2 (en) * 2011-01-11 2012-07-19 Intertech Bio, Llc Monosaccharide-based compounds for the treatment of proliferative and inflammatory dermatological diseases
WO2012142615A2 (en) * 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders
EP2837389A1 (en) * 2012-04-12 2015-02-18 Gifu University Medicinal composition for treating infarction
PL2981270T3 (pl) 2013-04-05 2022-05-09 Board Of Regents, The University Of Texas System Estry 2-deoksy-monosacharydów o działaniu przeciwproliferacyjnym
WO2020035782A1 (en) * 2018-08-13 2020-02-20 Dermin Sp. Z O.O. Molecular probes for analysis of metabolism of glycolysis inhibitors prodrugs and synthesis methods therefore
BR112022018536A2 (pt) * 2020-03-16 2022-11-29 Univ Texas Método para o tratamento de infecções virais com monossacarídeos tipo hexose e seus análogos

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56103197A (en) 1980-01-21 1981-08-18 Wakamoto Pharmaceut Co Ltd Novel d-glucose derivative and antitumor agent containing the same as active constitutent
JPS58167582A (ja) 1982-03-29 1983-10-03 Takeda Chem Ind Ltd 糖ケタ−ルの製造法
US6319695B1 (en) 1991-10-15 2001-11-20 The Scripps Research Insitute Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
ID16479A (id) 1995-06-23 1997-10-02 Oxford Glycosciences Uk Ltd Senyawa-senyawa pengobatan
EE200200565A (et) 2000-03-31 2004-06-15 Angiogene Pharmaceuticals Ltd. Vaskulaarse kahjustava toimega kombinatsioonravi
US6670330B1 (en) 2000-05-01 2003-12-30 Theodore J. Lampidis Cancer chemotherapy with 2-deoxy-D-glucose
JP2004536819A (ja) 2001-06-11 2004-12-09 トランジション・セラピューティックス・インコーポレーテッド ウイルス性、増殖性および炎症性の疾患の治療のためにビタミンｂ１２および治療薬を用いた複合治療
WO2003018598A2 (en) 2001-08-30 2003-03-06 University College Dublin Monosaccharide derivatives
WO2003082301A1 (en) 2002-03-29 2003-10-09 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
WO2004062604A2 (en) * 2003-01-10 2004-07-29 Threshold Pharmaceuticals, Inc. Treatment of cancer with 2-deoxyglucose
CA2431425A1 (en) 2003-06-05 2004-12-05 Angiogene, Inc. Epas1 gene transfer to improve cell therapy
US20050143336A1 (en) 2003-12-30 2005-06-30 Board Of Regents, The University Of Texas System Methods and compositions for improved non-viral gene therapy
WO2006024492A2 (en) 2004-08-30 2006-03-09 Interstitial Therapeutics Medical implant provided with inhibitors of atp synthesis
BRPI0708273A2 (pt) 2006-02-24 2011-05-24 Univ Texas uso de compostos de hexoses
WO2007100728A2 (en) 2006-02-24 2007-09-07 University Of Miami Mannose derivatives for killing tumor cells
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
EP1881000A1 (en) 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents
WO2008131024A1 (en) 2007-04-17 2008-10-30 Board Of Regents, The University Of Texas System Iodo-hexose compounds useful to treat cancer
ES2628180T3 (es) 2008-07-11 2017-08-02 Board Of Regents, The University Of Texas System Nuevos acetatos de 2-desoxi monosacáridos con actividad anticancerosa
WO2012142615A2 (en) 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders

Also Published As

Publication number Publication date
EP2310020A2 (en) 2011-04-20
EP2310020A4 (en) 2012-04-25
JP5890043B2 (ja) 2016-03-22
JP2015091849A (ja) 2015-05-14
CN102149388B (zh) 2014-11-05
US20110160151A1 (en) 2011-06-30
US8927506B2 (en) 2015-01-06
CN102149388A (zh) 2011-08-10
PL2310020T3 (pl) 2017-10-31
JP2011527678A (ja) 2011-11-04
HUE033210T2 (hu) 2017-11-28
WO2010005799A2 (en) 2010-01-14
LT2310020T (lt) 2017-07-25
EP2310020B1 (en) 2017-03-15
ES2628180T3 (es) 2017-08-02
DK2310020T3 (en) 2017-06-26
WO2010005799A3 (en) 2010-04-29

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