CN102149388B - 具有抗癌活性的新型2-脱氧单糖乙酸酯 - Google Patents

具有抗癌活性的新型2-脱氧单糖乙酸酯 Download PDF

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Publication number
CN102149388B
CN102149388B CN200980135924.XA CN200980135924A CN102149388B CN 102149388 B CN102149388 B CN 102149388B CN 200980135924 A CN200980135924 A CN 200980135924A CN 102149388 B CN102149388 B CN 102149388B
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autophagy
glucose
ddd
cancer
mmol
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Chinese (zh)
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CN102149388A (zh
Inventor
W·普里布
M·塞布尔斯基
I·富克特
S·斯科拉
C·康拉德
T·马登
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University of Texas System
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN200980135924.XA 2008-07-11 2009-06-25 具有抗癌活性的新型2-脱氧单糖乙酸酯 Active CN102149388B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7996808P 2008-07-11 2008-07-11
US61/079968 2008-07-11
PCT/US2009/048675 WO2010005799A2 (en) 2008-07-11 2009-06-25 Novel acetates of 2-deoxy monosaccharides with anticancer activity

Publications (2)

Publication Number Publication Date
CN102149388A CN102149388A (zh) 2011-08-10
CN102149388B true CN102149388B (zh) 2014-11-05

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CN200980135924.XA Active CN102149388B (zh) 2008-07-11 2009-06-25 具有抗癌活性的新型2-脱氧单糖乙酸酯

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Country Link
US (1) US8927506B2 (https=)
EP (1) EP2310020B1 (https=)
JP (2) JP5677951B2 (https=)
CN (1) CN102149388B (https=)
DK (1) DK2310020T3 (https=)
ES (1) ES2628180T3 (https=)
HU (1) HUE033210T2 (https=)
LT (1) LT2310020T (https=)
PL (1) PL2310020T3 (https=)
WO (1) WO2010005799A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
ES2628180T3 (es) 2008-07-11 2017-08-02 Board Of Regents, The University Of Texas System Nuevos acetatos de 2-desoxi monosacáridos con actividad anticancerosa
WO2012097052A2 (en) * 2011-01-11 2012-07-19 Intertech Bio, Llc Monosaccharide-based compounds for the treatment of proliferative and inflammatory dermatological diseases
WO2012142615A2 (en) * 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders
EP2837389A1 (en) * 2012-04-12 2015-02-18 Gifu University Medicinal composition for treating infarction
PL2981270T3 (pl) 2013-04-05 2022-05-09 Board Of Regents, The University Of Texas System Estry 2-deoksy-monosacharydów o działaniu przeciwproliferacyjnym
WO2020035782A1 (en) * 2018-08-13 2020-02-20 Dermin Sp. Z O.O. Molecular probes for analysis of metabolism of glycolysis inhibitors prodrugs and synthesis methods therefore
BR112022018536A2 (pt) * 2020-03-16 2022-11-29 Univ Texas Método para o tratamento de infecções virais com monossacarídeos tipo hexose e seus análogos

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
WO2001082926A1 (en) * 2000-05-01 2001-11-08 Lampidis Theodore J Manipulation of oxidative phosphorylation for hypersensitizing tumor cells to glycolytic inhibitors
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents

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JPS56103197A (en) 1980-01-21 1981-08-18 Wakamoto Pharmaceut Co Ltd Novel d-glucose derivative and antitumor agent containing the same as active constitutent
JPS58167582A (ja) 1982-03-29 1983-10-03 Takeda Chem Ind Ltd 糖ケタ−ルの製造法
US6319695B1 (en) 1991-10-15 2001-11-20 The Scripps Research Insitute Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
EE200200565A (et) 2000-03-31 2004-06-15 Angiogene Pharmaceuticals Ltd. Vaskulaarse kahjustava toimega kombinatsioonravi
JP2004536819A (ja) 2001-06-11 2004-12-09 トランジション・セラピューティックス・インコーポレーテッド ウイルス性、増殖性および炎症性の疾患の治療のためにビタミンｂ１２および治療薬を用いた複合治療
WO2003018598A2 (en) 2001-08-30 2003-03-06 University College Dublin Monosaccharide derivatives
WO2003082301A1 (en) 2002-03-29 2003-10-09 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
CA2431425A1 (en) 2003-06-05 2004-12-05 Angiogene, Inc. Epas1 gene transfer to improve cell therapy
US20050143336A1 (en) 2003-12-30 2005-06-30 Board Of Regents, The University Of Texas System Methods and compositions for improved non-viral gene therapy
WO2006024492A2 (en) 2004-08-30 2006-03-09 Interstitial Therapeutics Medical implant provided with inhibitors of atp synthesis
BRPI0708273A2 (pt) 2006-02-24 2011-05-24 Univ Texas uso de compostos de hexoses
WO2007100728A2 (en) 2006-02-24 2007-09-07 University Of Miami Mannose derivatives for killing tumor cells
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
WO2008131024A1 (en) 2007-04-17 2008-10-30 Board Of Regents, The University Of Texas System Iodo-hexose compounds useful to treat cancer
ES2628180T3 (es) 2008-07-11 2017-08-02 Board Of Regents, The University Of Texas System Nuevos acetatos de 2-desoxi monosacáridos con actividad anticancerosa
WO2012142615A2 (en) 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
WO2001082926A1 (en) * 2000-05-01 2001-11-08 Lampidis Theodore J Manipulation of oxidative phosphorylation for hypersensitizing tumor cells to glycolytic inhibitors
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hydrolysis of (2-Deoxy-beta-D-glucopyranosyl)pyridinium Salts;HUANG,X et al;《J.Am.Chem.Soc.》;19951231;第117卷(第43期);第10614-10621页 *

Also Published As

Publication number Publication date
EP2310020A2 (en) 2011-04-20
EP2310020A4 (en) 2012-04-25
JP5890043B2 (ja) 2016-03-22
JP2015091849A (ja) 2015-05-14
US20110160151A1 (en) 2011-06-30
JP5677951B2 (ja) 2015-02-25
US8927506B2 (en) 2015-01-06
CN102149388A (zh) 2011-08-10
PL2310020T3 (pl) 2017-10-31
JP2011527678A (ja) 2011-11-04
HUE033210T2 (hu) 2017-11-28
WO2010005799A2 (en) 2010-01-14
LT2310020T (lt) 2017-07-25
EP2310020B1 (en) 2017-03-15
ES2628180T3 (es) 2017-08-02
DK2310020T3 (en) 2017-06-26
WO2010005799A3 (en) 2010-04-29

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