JP5665740B2 - デアセチラーゼ阻害剤およびその使用 - Google Patents

デアセチラーゼ阻害剤およびその使用 Download PDF

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Publication number
JP5665740B2
JP5665740B2 JP2011520034A JP2011520034A JP5665740B2 JP 5665740 B2 JP5665740 B2 JP 5665740B2 JP 2011520034 A JP2011520034 A JP 2011520034A JP 2011520034 A JP2011520034 A JP 2011520034A JP 5665740 B2 JP5665740 B2 JP 5665740B2
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certain embodiments
moiety
substituted
unsubstituted
stereoisomer
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Japanese (ja)
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JP2011529048A5 (enExample
JP2011529048A (ja
Inventor
ウェイピン タン，
ウェイピン タン，
ジェームズ エリオット ブラッドナー，
ジェームズ エリオット ブラッドナー，
スチュアート エル． シュレイバー，
スチュアート エル． シュレイバー，
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2011520034A 2008-07-23 2009-07-22 デアセチラーゼ阻害剤およびその使用 Expired - Fee Related JP5665740B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8289908P 2008-07-23 2008-07-23
US61/082,899 2008-07-23
PCT/US2009/004235 WO2010011296A2 (en) 2008-07-23 2009-07-22 Deacetylase inhibitors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014043515A Division JP2014101380A (ja) 2008-07-23 2014-03-06 デアセチラーゼ阻害剤およびその使用

Publications (3)

Publication Number Publication Date
JP2011529048A JP2011529048A (ja) 2011-12-01
JP2011529048A5 JP2011529048A5 (enExample) 2012-09-06
JP5665740B2 true JP5665740B2 (ja) 2015-02-04

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Family Applications (2)

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JP2011520034A Expired - Fee Related JP5665740B2 (ja) 2008-07-23 2009-07-22 デアセチラーゼ阻害剤およびその使用
JP2014043515A Pending JP2014101380A (ja) 2008-07-23 2014-03-06 デアセチラーゼ阻害剤およびその使用

Family Applications After (1)

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JP2014043515A Pending JP2014101380A (ja) 2008-07-23 2014-03-06 デアセチラーゼ阻害剤およびその使用

Country Status (10)

Country Link
US (2) US8440716B2 (enExample)
EP (1) EP2321264B1 (enExample)
JP (2) JP5665740B2 (enExample)
KR (1) KR101708946B1 (enExample)
CN (1) CN102164888B (enExample)
AU (1) AU2009274549B2 (enExample)
CA (1) CA2731730C (enExample)
IL (1) IL210804A (enExample)
RU (1) RU2515611C2 (enExample)
WO (1) WO2010011296A2 (enExample)

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KR20220119653A (ko) 2019-12-20 2022-08-30 테나야 테라퓨틱스, 인코포레이티드 플루오로알킬-옥사디아졸 및 이의 용도
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