JP5650791B2 - 熱交換を行ない光学的に検出する化学反応アセンブリ - Google Patents
熱交換を行ない光学的に検出する化学反応アセンブリ Download PDFInfo
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Description
化学反応のために熱の伝導を制御する装置は、核酸の部分を増幅する熱サイクルPCRのような合成反応に適用できる。この系統的分類法では、DNAの鋳型(テンプレート)が、熱的に安定なDNAポリメラーゼ、例えば、TaqDNAポリメラーゼ、ヌクレオチド三燐酸塩、および異なる配列をもつ2つのオリゴヌクレオチドとともに使用されて、鋳型DNAの対向する鎖上にある配列を補間し、増幅されるべきDNAの部分の側面に位置する(「プライマー」)。反応成分は高温(例えば、95℃)と、次のより低い温度(プライマーのアニーリングに対しては40〜60℃、重合に対しては70〜75℃である。)との間でサイクルする。脱交雑温度とアニール温度と重合温度との間で繰返されるサイクルは、鋳型DNAの指数関数的な増幅をもたらす。
図1は本発明による熱交換反応チャンバの内部を示し、熱交換反応チャンバは化学反応のための試料を収容するようになっている。この反応チャンバは、最良の熱伝導性および試料の有効な光学的観察のために設計されている。この薄肉形状は、熱伝導のために大きな表面を与えることによって最適な熱反応速度に貢献している。表面は温度調節要素と密接するようになっている。さらに、小さな壁または大きな壁が反応チャンバ内に窓を備えて、反応試料の全てが光学的に検出され得る。加えて、この反応チャンバは広範囲の反応容積に適する。
反応容器は、反応チャンバ内の混合物を加熱または冷却するための熱スリーブと和合できる。熱スリーブは、反応チャンバの壁と密接させることによって、反応チャンバ内の温度変化を引き起こすように設計されている。
光学アセンブリは、熱スリーブを受け入れるように形成されたユニットの中に作られ得る。このユニットは、付加的に、冷却システムのような環境温度を維持するためのシステムと、熱交換反応チャンバ内で行なわれる作業を調整するための様々な制御機構とを有し得る。
このような付加的な反応は、例えばポリメラーゼ連鎖反応は、熱的に循環する。或いは、付加的な反応は、例えば核酸配列をベースにした増幅(NASBA)は、単一の温度で行なわれる。さらに、このような反応は、広範で様々な増幅試薬と酵素を使用し、とりわけ、DNAリガーゼ,T7RNAポリメラーゼおよび/または逆転写酵素を含んでいる増幅試薬と酵素を使用する。加えて、ポリヌクレオチドの変性は、既知の化学的または物理的方法によって、単独あるいは熱的変化と組合せて達成される。この発明の装置で実施され得るポリヌクレオチド増幅反応は、限定するものではないが、(1)自立配列複製(3SR)および鎖置換増幅(SDA)のような標的ポリヌクレオチド増幅方法、(2)「有枝鎖」DNA増幅のような標的ポリヌクレオチドに取り付けられた信号の増幅に基づいた方法、(3)リガーゼ連鎖反応(LCR)およびQBレプリカーゼ増幅(QBR)のようなプローブDNAの増幅に基づいた方法、(4)配位子結合活性転写(LAT)および核酸配列ベース増幅(NASBA)のような転写ベースの方法、(5)修復連鎖反応(RCR)および循環プローブ反応(CPR)のような様々な他の増幅方法を含んでいる。
Claims (10)
- 2つの対向する主壁と、これらの主壁を互いに接合する複数の副壁とにより形成される、試料を保持するための反応チャンバを有する容器を製造するための方法であって、
a) i)上記反応チャンバの上記副壁を形成する剛性フレームであって、少なくとも2つの上記副壁が光透過性である、剛性フレームと、
ii)上記剛性フレームの開口を介して上記反応チャンバ内に流体を導入するためのポートと、
を有するハウジングを製造するステップと、
b)上記反応チャンバの少なくとも1つの上記主壁を形成するために、上記剛性フレームに少なくとも1つのシートまたはフィルムを取り付けるステップと
を備えていることを特徴とする方法。 - 請求項1に記載の方法において、
上記ステップb)は、上記反応チャンバの上記2つの対向する主壁を作るために、上記剛性フレームの対向する側部に2つのシートまたはフィルムを取り付けることを備えていることを特徴とする方法。 - 請求項2に記載の方法において、
上記反応容器は、2つの加熱表面の間に配置されたときに加熱されるようにデザインされ、上記2つの加熱表面は、上記剛性フレームに取り付けられた上記2つのシートまたはフィルムにそれぞれ接触し、そして、上記シートまたはフィルムの各々は、それぞれの上記加熱表面の形状に一致するのに充分な可撓性を有することを特徴とする方法。 - 請求項1乃至3のいずれか1つに記載の方法において、
上記ハウジングには上記ポートを上記反応チャンバに接続するチャンネルが備えられていて、上記反応チャンバ内の圧力を増加させるために、上記チャンネルに挿入可能なプラグを製造するステップをさらに備えていることを特徴とする方法。 - 請求項1乃至4のいずれか1つに記載の方法において、
光透過性である上記少なくとも2つの副壁のうちの少なくとも1つに光学要素を製造するためのステップをさらに備えていることを特徴とする方法。 - 請求項1乃至4のいずれか1つに記載の方法において、
光透過性である上記少なくとも2つの副壁の各々の表面に少なくとも1つのレンズを成形するステップをさらに備えていることを特徴とする方法。 - 請求項1乃至6のいずれか1つに記載の方法において、
上記剛性フレームは、光透過性である上記少なくとも2つの副壁の角度が互いにずらされるように製造されていることを特徴とする方法。 - 請求項7に記載の方法において、
光透過性である上記少なくとも2つの副壁は、互いに90度だけずらされていることを特徴とする方法。 - 請求項1乃至4のいずれか1つに記載の方法において、
光透過性である上記少なくとも2つの副壁上に光学要素またはコーティングを作るステップをさらに備えて、上記光学要素またはコーティングによって、或る波長の光のみが光透過性である上記少なくとも2つの副壁を通過できること
を特徴とする方法。 - 請求項1乃至9のいずれか1つに記載の方法において、
上記剛性フレームには、上記反応チャンバを形成する少なくとも4つの壁と、光透過性である上記少なくとも2つの副壁と、上記反応チャンバ内の光を反射する逆反射器付きで作られた上記少なくとも2つの副壁とが、備えられていることを特徴とする方法。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US80873397A | 1997-02-28 | 1997-02-28 | |
US80832797A | 1997-02-28 | 1997-02-28 | |
US08/808,325 | 1997-02-28 | ||
US08/808,325 US5958349A (en) | 1997-02-28 | 1997-02-28 | Reaction vessel for heat-exchanging chemical processes |
US08/808,733 | 1997-02-28 | ||
US08/808,327 | 1997-02-28 |
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JP2011268248A Division JP5628141B2 (ja) | 1997-02-28 | 2011-12-07 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
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JP2013208612A JP2013208612A (ja) | 2013-10-10 |
JP5650791B2 true JP5650791B2 (ja) | 2015-01-07 |
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JP53515598A Expired - Lifetime JP4308325B2 (ja) | 1997-02-28 | 1998-03-02 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
JP2008077173A Expired - Lifetime JP4954130B2 (ja) | 1997-02-28 | 2008-03-25 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
JP2011268248A Expired - Lifetime JP5628141B2 (ja) | 1997-02-28 | 2011-12-07 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
JP2013096939A Expired - Lifetime JP5650791B2 (ja) | 1997-02-28 | 2013-05-02 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
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JP53515598A Expired - Lifetime JP4308325B2 (ja) | 1997-02-28 | 1998-03-02 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
JP2008077173A Expired - Lifetime JP4954130B2 (ja) | 1997-02-28 | 2008-03-25 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
JP2011268248A Expired - Lifetime JP5628141B2 (ja) | 1997-02-28 | 2011-12-07 | 熱交換を行ない光学的に検出する化学反応アセンブリ |
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US (3) | US6565815B1 (ja) |
EP (3) | EP2333520B1 (ja) |
JP (4) | JP4308325B2 (ja) |
AT (1) | ATE509263T1 (ja) |
AU (1) | AU6343398A (ja) |
CA (1) | CA2282623C (ja) |
DK (3) | DK0963545T3 (ja) |
ES (2) | ES2544455T3 (ja) |
WO (1) | WO1998038487A2 (ja) |
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1998
- 1998-03-02 AT AT98907683T patent/ATE509263T1/de active
- 1998-03-02 AU AU63433/98A patent/AU6343398A/en not_active Abandoned
- 1998-03-02 DK DK98907683.1T patent/DK0963545T3/da active
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- 1998-03-02 EP EP10181334.3A patent/EP2333520B1/en not_active Expired - Lifetime
- 1998-03-02 WO PCT/US1998/003962 patent/WO1998038487A2/en active Application Filing
- 1998-03-02 EP EP20100181257 patent/EP2308995B1/en not_active Expired - Lifetime
- 1998-03-02 EP EP98907683A patent/EP0963545B1/en not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
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EP2308995A2 (en) | 2011-04-13 |
EP2308995B1 (en) | 2015-05-06 |
ES2544455T3 (es) | 2015-08-31 |
JP2013208612A (ja) | 2013-10-10 |
EP0963545B1 (en) | 2011-05-11 |
CA2282623A1 (en) | 1998-09-03 |
EP2333520A3 (en) | 2011-11-16 |
JP4308325B2 (ja) | 2009-08-05 |
JP4954130B2 (ja) | 2012-06-13 |
WO1998038487A3 (en) | 1998-11-19 |
ES2505331T3 (es) | 2014-10-09 |
US20080254532A1 (en) | 2008-10-16 |
CA2282623C (en) | 2007-05-22 |
EP2308995A3 (en) | 2011-05-18 |
EP0963545A2 (en) | 1999-12-15 |
EP2333520A2 (en) | 2011-06-15 |
JP2008221213A (ja) | 2008-09-25 |
DK0963545T3 (da) | 2011-07-25 |
DK2333520T3 (da) | 2014-09-29 |
US9316590B2 (en) | 2016-04-19 |
ATE509263T1 (de) | 2011-05-15 |
US6565815B1 (en) | 2003-05-20 |
US8029733B2 (en) | 2011-10-04 |
WO1998038487A2 (en) | 1998-09-03 |
JP2002507145A (ja) | 2002-03-05 |
DK2308995T3 (da) | 2015-08-03 |
EP2333520B1 (en) | 2014-06-25 |
JP2012106242A (ja) | 2012-06-07 |
US20140093430A1 (en) | 2014-04-03 |
JP5628141B2 (ja) | 2014-11-19 |
AU6343398A (en) | 1998-09-18 |
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