JP5649584B2 - Ｈｉｆヒドロキシラーゼ阻害剤としてのチオクロメン誘導体 - Google Patents
Ｈｉｆヒドロキシラーゼ阻害剤としてのチオクロメン誘導体 Download PDFInfo
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- JP5649584B2 JP5649584B2 JP2011536447A JP2011536447A JP5649584B2 JP 5649584 B2 JP5649584 B2 JP 5649584B2 JP 2011536447 A JP2011536447 A JP 2011536447A JP 2011536447 A JP2011536447 A JP 2011536447A JP 5649584 B2 JP5649584 B2 JP 5649584B2
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- substituted
- hydroxy
- oxo
- thiochromene
- amino
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 193
- 125000000217 alkyl group Chemical group 0.000 claims description 178
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- 125000000547 substituted alkyl group Chemical group 0.000 claims description 119
- 125000003107 substituted aryl group Chemical group 0.000 claims description 102
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- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 4
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11497108P | 2008-11-14 | 2008-11-14 | |
| US61/114,971 | 2008-11-14 | ||
| PCT/US2009/064065 WO2010056767A1 (en) | 2008-11-14 | 2009-11-11 | Thiochromene derivatives as hip hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
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| JP2012508752A JP2012508752A (ja) | 2012-04-12 |
| JP2012508752A5 JP2012508752A5 (https=) | 2012-12-27 |
| JP5649584B2 true JP5649584B2 (ja) | 2015-01-07 |
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| US (2) | US8927591B2 (https=) |
| EP (1) | EP2370422B1 (https=) |
| JP (1) | JP5649584B2 (https=) |
| CN (2) | CN105037323A (https=) |
| AU (1) | AU2009314155B2 (https=) |
| IL (1) | IL212762A (https=) |
| NZ (1) | NZ592741A (https=) |
| WO (1) | WO2010056767A1 (https=) |
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| WO2010056767A1 (en) | 2008-11-14 | 2010-05-20 | Fibrogen, Inc. | Thiochromene derivatives as hip hydroxylase inhibitors |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
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| CN103608346B (zh) | 2011-02-02 | 2016-06-15 | 菲布罗根有限公司 | 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物 |
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| JP6506390B2 (ja) | 2014-09-02 | 2019-04-24 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | キノリノン系化合物及びその薬物への使用 |
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2009314155A1 (en) | 2010-05-20 |
| EP2370422A1 (en) | 2011-10-05 |
| CN102272117A (zh) | 2011-12-07 |
| US20150182528A1 (en) | 2015-07-02 |
| CN105037323A (zh) | 2015-11-11 |
| NZ592741A (en) | 2013-03-28 |
| IL212762A (en) | 2017-09-28 |
| US20110305776A1 (en) | 2011-12-15 |
| EP2370422B1 (en) | 2019-06-05 |
| CN102272117B (zh) | 2015-06-17 |
| IL212762A0 (en) | 2011-07-31 |
| US9149476B2 (en) | 2015-10-06 |
| US8927591B2 (en) | 2015-01-06 |
| WO2010056767A1 (en) | 2010-05-20 |
| WO2010056767A8 (en) | 2010-09-23 |
| JP2012508752A (ja) | 2012-04-12 |
| AU2009314155B2 (en) | 2015-10-08 |
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