JP5635396B2 - 抗がん活性を有する化合物 - Google Patents

抗がん活性を有する化合物 Download PDF

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Publication number
JP5635396B2
JP5635396B2 JP2010502609A JP2010502609A JP5635396B2 JP 5635396 B2 JP5635396 B2 JP 5635396B2 JP 2010502609 A JP2010502609 A JP 2010502609A JP 2010502609 A JP2010502609 A JP 2010502609A JP 5635396 B2 JP5635396 B2 JP 5635396B2
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JP
Japan
Prior art keywords
amino
dione
optionally substituted
trifluoromethyl
methyl
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JP2010502609A
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English (en)
Japanese (ja)
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JP2010523644A5 (enExample
JP2010523644A (ja
Inventor
拓己 河邊
拓己 河邊
真知代 石垣
真知代 石垣
卓治 佐藤
卓治 佐藤
清香 山本
清香 山本
容子 長谷川
容子 長谷川
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Canbas Co Ltd
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Canbas Co Ltd
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Publication of JP2010523644A5 publication Critical patent/JP2010523644A5/ja
Application granted granted Critical
Publication of JP5635396B2 publication Critical patent/JP5635396B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2010502609A 2007-04-11 2008-04-11 抗がん活性を有する化合物 Active JP5635396B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91125807P 2007-04-11 2007-04-11
US60/911,258 2007-04-11
PCT/IB2008/003036 WO2009031040A2 (en) 2007-04-11 2008-04-11 Compounds with anti-cancer activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013176324A Division JP2014012706A (ja) 2007-04-11 2013-08-28 抗がん活性を有する化合物

Publications (3)

Publication Number Publication Date
JP2010523644A JP2010523644A (ja) 2010-07-15
JP2010523644A5 JP2010523644A5 (enExample) 2011-05-12
JP5635396B2 true JP5635396B2 (ja) 2014-12-03

Family

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Family Applications (2)

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JP2010502609A Active JP5635396B2 (ja) 2007-04-11 2008-04-11 抗がん活性を有する化合物
JP2013176324A Withdrawn JP2014012706A (ja) 2007-04-11 2013-08-28 抗がん活性を有する化合物

Family Applications After (1)

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JP2013176324A Withdrawn JP2014012706A (ja) 2007-04-11 2013-08-28 抗がん活性を有する化合物

Country Status (17)

Country Link
US (2) US8084454B2 (enExample)
EP (4) EP4074704A1 (enExample)
JP (2) JP5635396B2 (enExample)
KR (1) KR101475311B1 (enExample)
CN (2) CN101720323A (enExample)
AU (1) AU2008294410B2 (enExample)
BR (2) BR122022005149B1 (enExample)
CA (4) CA3030510C (enExample)
DK (2) DK3567035T3 (enExample)
ES (3) ES2732230T3 (enExample)
HU (2) HUE029370T2 (enExample)
IL (4) IL309201A (enExample)
MX (3) MX374896B (enExample)
NZ (1) NZ580237A (enExample)
RU (1) RU2482111C2 (enExample)
WO (1) WO2009031040A2 (enExample)
ZA (1) ZA200906960B (enExample)

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JP2021512165A (ja) 2018-01-29 2021-05-13 コグノス・セラピューティクス・インコーポレイテッド ボルテゾミブの腫瘍内送達
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JP7325425B2 (ja) 2018-02-08 2023-08-14 ネオンク テクノロジーズ インク． 血液脳関門を透過性にする方法
EP4153599B1 (en) 2020-05-22 2024-03-13 Boehringer Ingelheim International GmbH Process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate
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EP4415700A4 (en) * 2021-10-15 2025-12-24 Univ Missouri P1B TYPE ATPASES INHIBITORS
CN114425054A (zh) * 2022-01-20 2022-05-03 中国人民解放军军事科学院军事医学研究院 一种蛋白酶体抑制剂Bortezomib在抗辐射损伤中的用途
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Also Published As

Publication number Publication date
ES2732230T3 (es) 2019-12-12
AU2008294410B2 (en) 2012-09-06
IL242883B (en) 2022-01-01
HUE059861T2 (hu) 2023-01-28
DK2152692T3 (en) 2016-09-26
CN105175394B (zh) 2018-06-08
KR101475311B1 (ko) 2014-12-23
US8415357B2 (en) 2013-04-09
ES2594704T3 (es) 2016-12-22
KR20090128560A (ko) 2009-12-15
CA2913840A1 (en) 2009-03-12
HK1139143A1 (zh) 2010-09-10
EP3567035B1 (en) 2022-06-01
RU2482111C2 (ru) 2013-05-20
EP2152692B1 (en) 2016-06-15
IL309201A (en) 2024-02-01
US20110092514A1 (en) 2011-04-21
US8084454B2 (en) 2011-12-27
BRPI0810911B1 (pt) 2022-05-17
CA3188320A1 (en) 2009-03-12
ES2927954T3 (es) 2022-11-14
EP3088397A1 (en) 2016-11-02
MX391154B (es) 2025-03-21
CA3030510C (en) 2023-03-14
CN105175394A (zh) 2015-12-23
JP2014012706A (ja) 2014-01-23
EP4074704A1 (en) 2022-10-19
BRPI0810911A2 (pt) 2021-03-30
ZA200906960B (en) 2010-12-29
CA2684037C (en) 2016-02-16
NZ580237A (en) 2012-06-29
US20080275057A1 (en) 2008-11-06
EP2152692A2 (en) 2010-02-17
EP2152692B9 (en) 2020-03-25
WO2009031040A3 (en) 2009-05-14
MX2009011025A (es) 2010-01-25
RU2009141619A (ru) 2011-05-20
AU2008294410A1 (en) 2009-03-12
CN101720323A (zh) 2010-06-02
IL289165B1 (en) 2024-01-01
CA3030510A1 (en) 2009-03-12
IL201380A0 (en) 2010-05-31
DK3567035T3 (da) 2022-09-05
MX374896B (es) 2025-03-04
MX2020009403A (es) 2022-03-31
EP3567035A1 (en) 2019-11-13
WO2009031040A2 (en) 2009-03-12
BR122022005149B1 (pt) 2022-09-27
EP3088397B1 (en) 2019-04-10
CA2684037A1 (en) 2009-03-12
CA2913840C (en) 2019-03-05
IL289165A (en) 2022-02-01
IL289165B2 (en) 2024-05-01
JP2010523644A (ja) 2010-07-15
HUE029370T2 (hu) 2017-02-28

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