DK3567035T3 - N-substituerede 2,5-dioxo-azolin-forbindelser til anvendelse ved behandling af cancer - Google Patents
N-substituerede 2,5-dioxo-azolin-forbindelser til anvendelse ved behandling af cancer Download PDFInfo
- Publication number
- DK3567035T3 DK3567035T3 DK19167943.0T DK19167943T DK3567035T3 DK 3567035 T3 DK3567035 T3 DK 3567035T3 DK 19167943 T DK19167943 T DK 19167943T DK 3567035 T3 DK3567035 T3 DK 3567035T3
- Authority
- DK
- Denmark
- Prior art keywords
- dioxo
- cancer
- substituted
- treatment
- azoline compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91125807P | 2007-04-11 | 2007-04-11 | |
| EP16165912.3A EP3088397B1 (en) | 2007-04-11 | 2008-04-11 | Compounds that abrogate the cell cycle g2 checkpoint for use in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3567035T3 true DK3567035T3 (da) | 2022-09-05 |
Family
ID=39939984
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19167943.0T DK3567035T3 (da) | 2007-04-11 | 2008-04-11 | N-substituerede 2,5-dioxo-azolin-forbindelser til anvendelse ved behandling af cancer |
| DK08829410.3T DK2152692T3 (en) | 2007-04-11 | 2008-04-11 | EXTERNAL anti-cancer activity |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08829410.3T DK2152692T3 (en) | 2007-04-11 | 2008-04-11 | EXTERNAL anti-cancer activity |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8084454B2 (enExample) |
| EP (4) | EP2152692B9 (enExample) |
| JP (2) | JP5635396B2 (enExample) |
| KR (1) | KR101475311B1 (enExample) |
| CN (2) | CN101720323A (enExample) |
| AU (1) | AU2008294410B2 (enExample) |
| BR (2) | BR122022005149B1 (enExample) |
| CA (4) | CA2684037C (enExample) |
| DK (2) | DK3567035T3 (enExample) |
| ES (3) | ES2927954T3 (enExample) |
| HU (2) | HUE029370T2 (enExample) |
| IL (4) | IL289165B2 (enExample) |
| MX (3) | MX391154B (enExample) |
| NZ (1) | NZ580237A (enExample) |
| RU (1) | RU2482111C2 (enExample) |
| WO (1) | WO2009031040A2 (enExample) |
| ZA (1) | ZA200906960B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101720323A (zh) * | 2007-04-11 | 2010-06-02 | 三井有限公司 | 具有抗癌活性的化合物 |
| US8227202B2 (en) | 2008-07-10 | 2012-07-24 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
| EP3620154A1 (en) | 2009-02-06 | 2020-03-11 | University Of Southern California | Therapeutic compositions comprising monoterpenes |
| US20100215644A1 (en) * | 2009-02-25 | 2010-08-26 | Nodality, Inc. A Delaware Corporation | Analysis of nodes in cellular pathways |
| EP2542082B8 (en) | 2010-03-03 | 2020-06-17 | Neonc Technologies Inc. | PHARMACEUTICAL COMPOSITIONS COMPRISING (S)-perillyl alcohol |
| US20160038600A1 (en) | 2012-08-03 | 2016-02-11 | Neonc Technologies Inc. | Pharmaceutical compositions comprising poh derivatives |
| CN105078973B (zh) | 2010-08-27 | 2020-10-09 | 尼昂克技术公司 | 包含poh衍生物的药物组合物 |
| CN103517892B (zh) | 2010-12-17 | 2016-01-27 | 尼昂克技术公司 | 使用异紫苏醇的方法和装置 |
| WO2013020024A2 (en) * | 2011-08-03 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Maleimide compounds and methods of treatment |
| US9814693B2 (en) | 2012-05-09 | 2017-11-14 | Delmar Pharmaceuticals, Inc. | Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies |
| WO2013187462A1 (ja) | 2012-06-14 | 2013-12-19 | 第一三共株式会社 | ピペリジニルピラゾロピリジン誘導体 |
| CA2899399A1 (en) * | 2013-01-30 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Amino-substituted isothiazoles |
| WO2016090355A2 (en) * | 2014-12-05 | 2016-06-09 | Massachusetts Institute Of Technology | Catechol-rich polymers from n-substituted maleimides |
| CA2970954C (en) * | 2015-01-26 | 2023-10-31 | Ottawa Hospital Research Institute | Compositions and methods for viral sensitization |
| AU2016219257B2 (en) | 2015-02-12 | 2020-06-25 | University Of Southern California | Pharmaceutical compositions comprising perillyl alcohol derivatives |
| BR112018068681A2 (pt) | 2016-03-16 | 2019-01-15 | Bayer Cropscience Ag | derivados de n-(cianobenzil)-6-(ciclopropil-carbonilamino)-4-(fenil)-piridina-2-carboxamida e compostos relacionados como pesticidas e agentes de proteção de plantas |
| USD915100S1 (en) | 2016-03-31 | 2021-04-06 | Ocean 22, Llc | Spooled item holding device |
| USD801721S1 (en) | 2016-03-31 | 2017-11-07 | Patricia Grayson Briden | Spooled item holding device |
| TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| US12419832B2 (en) | 2018-01-29 | 2025-09-23 | Cognos Therapeutics, Inc. | Intratumoral delivery of bortezomib |
| JOP20200187A1 (ar) | 2018-02-02 | 2020-07-29 | Boehringer Ingelheim Int | مشتقات ترايازولو بيريميدين للاستخدام كمثبطات جريلين o- أسيل ترانسفيراز (goat) |
| KR20200116978A (ko) | 2018-02-02 | 2020-10-13 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로서의 벤질-치환된, (피리딘-3-일)메틸-치환된 또는 (피리딘-4-일)메틸-치환된 옥사디아졸로피리딘 유도체 |
| JP7325425B2 (ja) | 2018-02-08 | 2023-08-14 | ネオンク テクノロジーズ インク． | 血液脳関門を透過性にする方法 |
| ES2991340T3 (es) | 2020-05-22 | 2024-12-03 | Boehringer Ingelheim Int | Procedimiento continuo de fabricación de 7-amino-5-metil-[1,2,5]oxadiazolo[3,4-b]piridín-carboxilato de alquilo |
| PL4153599T3 (pl) | 2020-05-22 | 2024-07-15 | Boehringer Ingelheim International Gmbh | Sposób wytwarzania 7-amino-5-metylo-[1,2,5]oksadiazolo[3,4-b]pirydynokarboksylanu alkilu |
| US20250017889A1 (en) * | 2021-10-15 | 2025-01-16 | The Curators Of The University Of Missouri | Inhibitors of p1b-type atpases |
| CN114425054A (zh) * | 2022-01-20 | 2022-05-03 | 中国人民解放军军事科学院军事医学研究院 | 一种蛋白酶体抑制剂Bortezomib在抗辐射损伤中的用途 |
| CN120247782B (zh) * | 2025-06-04 | 2025-08-19 | 北京颖泰嘉和生物科技股份有限公司 | 氟吡菌酰胺类化合物及其制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5564557A (en) * | 1978-11-08 | 1980-05-15 | Mitsui Toatsu Chem Inc | Diphenyl ether compound and herbicide containing the same |
| IL81307A0 (en) * | 1986-01-23 | 1987-08-31 | Union Carbide Agricult | Method for reducing moisture loss from plants and increasing crop yield utilizing nitrogen containing heterocyclic compounds and some novel polysubstituted pyridine derivatives |
| US5635966A (en) * | 1994-01-11 | 1997-06-03 | Hewlett-Packard Company | Edge feed ink delivery thermal inkjet printhead structure and method of fabrication |
| JPH07224032A (ja) * | 1994-02-09 | 1995-08-22 | Mitsui Petrochem Ind Ltd | Ｎ−アリールオキシフタルイミド誘導体、その製造方 法及びそれを有効成分として含有する除草剤 |
| JPH07244032A (ja) * | 1994-03-01 | 1995-09-19 | Ishikawajima Harima Heavy Ind Co Ltd | 溶接部検査装置 |
| US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| CA2230896A1 (en) * | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| CA2245029A1 (en) * | 1998-03-13 | 1999-09-13 | University Of British Columbia | Granulatimide compounds as g2 checkpoint inhibitors |
| US6205557B1 (en) | 1998-06-09 | 2001-03-20 | At&T Corp. | Redundant call processing |
| CA2352196A1 (en) * | 1998-11-24 | 2000-06-02 | Basf Aktiengesellschaft | Fungicides containing pyrrolidones as their active agents |
| DK1218494T3 (da) | 1999-09-22 | 2005-08-08 | Canbas Co Ltd | Præparater og fremgangsmåder til inhibering af C2-cellecyklusstandsning og sensibilisering af celler til DNA-beskadigende midler |
| ATE279110T1 (de) * | 2000-02-26 | 2004-10-15 | Basf Ag | Fungizide mittel enthaltend als wirkstoffe pyrrolidone und deren verwendung bei der behandlung von pflanzen |
| JP2002318434A (ja) * | 2001-04-23 | 2002-10-31 | Konica Corp | ハロゲン化銀写真感光材料、処理方法、および画像形成方法 |
| FR2826653B1 (fr) * | 2001-06-29 | 2005-10-14 | Servier Lab | Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4919598B2 (ja) * | 2002-06-06 | 2012-04-18 | 株式会社 キャンバス | Ｄｎａ損傷誘発性細胞周期ｇ２チェックポイントを排除し、そして／またはｄｎａ損傷処置の抗癌活性を増強する化合物 |
| WO2005024755A2 (en) | 2002-12-31 | 2005-03-17 | Deciphera Pharmaceuticals, Llc. | Medicaments for the treatment of neurodegenerative disorders or diabetes |
| US7572816B2 (en) * | 2003-08-01 | 2009-08-11 | Auspex Pharmaceuticals, Inc. | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders |
| EP1724263B1 (en) * | 2004-03-10 | 2014-03-05 | Kureha Corporation | Basic amine compound and use thereof |
| AU2005230847B2 (en) * | 2004-03-31 | 2012-11-08 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| CA2594657A1 (en) * | 2005-02-08 | 2006-08-17 | Merck & Co., Inc. | Inhibitors of checkpoint kinases |
| JP4976394B2 (ja) * | 2005-08-17 | 2012-07-18 | シェーリング コーポレイション | 新規な高親和性のキノリンベースのキナーゼリガンド |
| WO2007053765A2 (en) * | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted cycloalkylpyrrolones as allosteric modulators of glucokinase |
| CA2647862A1 (en) * | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | Acid secretion inhibitor |
| WO2008110891A2 (en) | 2007-03-09 | 2008-09-18 | Orchid Research Laboratories Limited, | New heterocyclic compounds |
| CN101720323A (zh) | 2007-04-11 | 2010-06-02 | 三井有限公司 | 具有抗癌活性的化合物 |
-
2008
- 2008-04-11 CN CN200880019414A patent/CN101720323A/zh active Pending
- 2008-04-11 JP JP2010502609A patent/JP5635396B2/ja active Active
- 2008-04-11 WO PCT/IB2008/003036 patent/WO2009031040A2/en not_active Ceased
- 2008-04-11 EP EP08829410.3A patent/EP2152692B9/en active Active
- 2008-04-11 IL IL289165A patent/IL289165B2/en unknown
- 2008-04-11 MX MX2020009403A patent/MX391154B/es unknown
- 2008-04-11 CA CA2684037A patent/CA2684037C/en active Active
- 2008-04-11 BR BR122022005149-9A patent/BR122022005149B1/pt active IP Right Grant
- 2008-04-11 ES ES19167943T patent/ES2927954T3/es active Active
- 2008-04-11 EP EP19167943.0A patent/EP3567035B1/en active Active
- 2008-04-11 HU HUE08829410A patent/HUE029370T2/hu unknown
- 2008-04-11 RU RU2009141619/04A patent/RU2482111C2/ru active
- 2008-04-11 EP EP16165912.3A patent/EP3088397B1/en active Active
- 2008-04-11 AU AU2008294410A patent/AU2008294410B2/en active Active
- 2008-04-11 BR BRPI0810911-7A patent/BRPI0810911B1/pt active IP Right Grant
- 2008-04-11 ES ES16165912T patent/ES2732230T3/es active Active
- 2008-04-11 CA CA3030510A patent/CA3030510C/en active Active
- 2008-04-11 MX MX2015016591A patent/MX374896B/es unknown
- 2008-04-11 ES ES08829410.3T patent/ES2594704T3/es active Active
- 2008-04-11 IL IL309201A patent/IL309201A/en unknown
- 2008-04-11 HU HUE19167943A patent/HUE059861T2/hu unknown
- 2008-04-11 CN CN201510578313.XA patent/CN105175394B/zh active Active
- 2008-04-11 MX MX2009011025A patent/MX2009011025A/es unknown
- 2008-04-11 US US12/082,643 patent/US8084454B2/en active Active
- 2008-04-11 NZ NZ580237A patent/NZ580237A/en unknown
- 2008-04-11 CA CA3188320A patent/CA3188320A1/en active Pending
- 2008-04-11 DK DK19167943.0T patent/DK3567035T3/da active
- 2008-04-11 CA CA2913840A patent/CA2913840C/en active Active
- 2008-04-11 EP EP22176177.8A patent/EP4074704A1/en not_active Withdrawn
- 2008-04-11 DK DK08829410.3T patent/DK2152692T3/en active
- 2008-04-11 KR KR1020097023566A patent/KR101475311B1/ko active Active
-
2009
- 2009-10-06 ZA ZA2009/06960A patent/ZA200906960B/en unknown
- 2009-10-11 IL IL201380A patent/IL201380A0/en active IP Right Grant
-
2010
- 2010-11-19 US US12/950,297 patent/US8415357B2/en active Active
-
2013
- 2013-08-28 JP JP2013176324A patent/JP2014012706A/ja not_active Withdrawn
-
2015
- 2015-12-02 IL IL242883A patent/IL242883B/en unknown
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